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Article Open Access

MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression

  • Authors:
    • Rhafaela Lima Causin
    • André Van Helvoort Lengert
    • Izabela Natalia Faria Gomes
    • Ana Julia Aguiar De Freitas
    • Marcela Nunes Rosa
    • Ricardo Dos Reis
    • Rui Manuel Reis
    • Márcia Maria Chiquitelli Marques
  • View Affiliations / Copyright

    Affiliations: Molecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos, São Paulo 14784-400, Brazil, Molecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos, São Paulo 14784‑400, Brazil, Department of Gynecological Oncology, Barretos Cancer Hospital, Barretos, São Paulo 14784-400, Brazil
    Copyright: © Causin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 109
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    Published online on: April 13, 2023
       https://doi.org/10.3892/or.2023.8546
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Abstract

MicroRNAs (miRNAs or miRs) play essential roles in the initiation and progression of human tumors, including cervical cancer. However, the mechanisms underlying their actions in cervical cancer remain unclear. The present study aimed to evaluate the functional role of miR‑130a‑3p in cervical cancer. Cervical cancer cells were transfected with a miRNA inhibitor (anti‑miR‑130a‑3p) and a negative control. Adhesion‑independent cell proliferation, migration and invasion were evaluated. The findings presented herein demonstrated that miR‑130a‑3p was overexpressed in HeLa, SiHa, CaSki, C‑4I and HCB‑514 cervical cancer cells. The inhibition of miR‑130a‑3p significantly reduced the proliferation, migration and invasion of cervical cancer cells. The canonical delta‑like Notch1 ligand (DLL1) was identified as a possible direct target of miR‑103a‑3p. The DLL1 gene was further found to be significantly downregulated in cervical cancer tissues. On the whole, the present study demonstrates that miR‑130a‑3p contributes to the proliferation, migration and invasion of cervical cancer cells. Therefore, miR‑130a‑3p may be used as a biomarker to determine cervical cancer progression.
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Copy and paste a formatted citation
Spandidos Publications style
Causin RL, Van Helvoort Lengert A, Gomes IN, De Freitas AJ, Rosa MN, Dos Reis R, Reis RM and Marques MM: MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression. Oncol Rep 49: 109, 2023.
APA
Causin, R.L., Van Helvoort Lengert, A., Gomes, I.N., De Freitas, A.J., Rosa, M.N., Dos Reis, R. ... Marques, M.M. (2023). MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression. Oncology Reports, 49, 109. https://doi.org/10.3892/or.2023.8546
MLA
Causin, R. L., Van Helvoort Lengert, A., Gomes, I. N., De Freitas, A. J., Rosa, M. N., Dos Reis, R., Reis, R. M., Marques, M. M."MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression". Oncology Reports 49.5 (2023): 109.
Chicago
Causin, R. L., Van Helvoort Lengert, A., Gomes, I. N., De Freitas, A. J., Rosa, M. N., Dos Reis, R., Reis, R. M., Marques, M. M."MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression". Oncology Reports 49, no. 5 (2023): 109. https://doi.org/10.3892/or.2023.8546
Copy and paste a formatted citation
x
Spandidos Publications style
Causin RL, Van Helvoort Lengert A, Gomes IN, De Freitas AJ, Rosa MN, Dos Reis R, Reis RM and Marques MM: MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression. Oncol Rep 49: 109, 2023.
APA
Causin, R.L., Van Helvoort Lengert, A., Gomes, I.N., De Freitas, A.J., Rosa, M.N., Dos Reis, R. ... Marques, M.M. (2023). MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression. Oncology Reports, 49, 109. https://doi.org/10.3892/or.2023.8546
MLA
Causin, R. L., Van Helvoort Lengert, A., Gomes, I. N., De Freitas, A. J., Rosa, M. N., Dos Reis, R., Reis, R. M., Marques, M. M."MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression". Oncology Reports 49.5 (2023): 109.
Chicago
Causin, R. L., Van Helvoort Lengert, A., Gomes, I. N., De Freitas, A. J., Rosa, M. N., Dos Reis, R., Reis, R. M., Marques, M. M."MicroRNA‑130a‑3p inhibition suppresses cervical cancer cell progression". Oncology Reports 49, no. 5 (2023): 109. https://doi.org/10.3892/or.2023.8546
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