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Article

Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer

  • Authors:
    • Moussa Ndiaye
    • Gora Diop
    • Celine Derbois
    • Jean-Louis Spadoni
    • Josselin Noirel
    • Raissa Medina‑Santos
    • Cedric Coulonges
    • Magali Torres
    • Alioune Dieye
    • Mbacke Sembene
    • Jean-François Deleuze
    • Alain Toledano
    • Ahmadou Dem
    • Jean-François Zagury
    • Sigrid Le Clerc
  • View Affiliations / Copyright

    Affiliations: Department of Animal Biology, Sciences and Techniques Faculty, Cheikh Anta DIOP University, 10700 Dakar, Senegal, National Research Center for Human Genetics (CNRGH), Genomics Institute‑CEA, 91057 Evry, France, Genomics Laboratory, Bio‑informatics and Molecular Chemistry (Laboratory no. EA7528), National Art and Crafts Conservatory, HESAM University, 75003 Paris, France, Aix Marseille University, INSERM, Laboratory TAGC, UMR U1090, 13288 Marseille, France, Immunology Service, Medicine University of Pharmacy and Odontology, Cheikh Anta DIOP University, 10700 Dakar, Senegal, Integrative Health Chair, National Art and Crafts Conservatory, HESAM University, 75003 Paris, France, Cancerology Service, Aristide Le Dantec Hospital, Joliot‑Curie Institute, 10200 Dakar, Senegal
  • Article Number: 118
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    Published online on: April 27, 2023
       https://doi.org/10.3892/or.2023.8555
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Abstract

Cervical cancer (CC) is a multifactorial disease of which human papillomavirus (HPV) is the main etiological agent. Despite cervical Pap smear screening and anti‑HPV vaccination, CC remains a major public health issue. Identification of specific gene expression signatures in the blood could allow better insight into the immune response of CC and could provide valuable information for the development of novel biomarkers. The present study performed a transcriptomic analysis of peripheral blood mononuclear cells (PBMCs) from Senegalese patients with CC (n=31), low‑grade cervical intraepithelial neoplasia (CIN1; n=27) and from healthy control (CTR) subjects (n=29). Individuals in the CIN1 and CTR groups exhibited similar patterns in gene expression. A total of 182 genes were revealed to be differentially expressed in patients with CC compared with individuals in the CIN1 and CTR groups. The IL1R2, IL18R1, MMP9 and FKBP5 genes were the most upregulated, whereas the T‑cell receptor α gene TRA was the most downregulated in the CC group compared with in the CIN1 and CTR groups. The pathway enrichment analysis of the differentially expressed genes revealed pathways directly and indirectly linked to inflammation. To the best of our knowledge, the present study is the first large transcriptomic study on CC performed using PBMCs from African women; the results revealed the involvement of genes and pathways related to inflammation, most notably the IL‑1 pathway, and the involvement of downregulation of the T‑cell receptor α, a key component of the immune response. Several of the stated genes have already been reported in other cancer studies as putative blood biomarkers, thus reinforcing the requirement for deeper investigation. These findings may aid in the development of innovative clinical biomarkers for CC prevention and should be further replicated in other populations.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Woodman CB, Collins S, Winter H, Bailey A, Ellis J, Prior P, Yates M, Rollason TP and Young LS: Natural history of cervical human papillomavirus infection in young women: A longitudinal cohort study. Lancet. 357:1831–1836. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Hammer A, Rositch A, Qeadan F, Gravitt PE and Blaakaer J: Age-specific prevalence of HPV16/18 genotypes in cervical cancer: A systematic review and meta-analysis. Int J Cancer. 138:2795–2803. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Doorbar J, Quint W, Banks L, Bravo IG, Stoler M, Broker TR and Stanley MA: The biology and life-cycle of human papillomaviruses. Vaccine. 30 (Suppl 5):F55–F70. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Duensing S and Münger K: Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins. Int J Cancer. 109:157–162. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Kjellberg L, Hallmans G, Ahren AM, Johansson R, Bergman F, Wadell G, Angström T and Dillner J: Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection. Br J Cancer. 82:1332–1338. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Agarwal SM, Raghav D, Singh H and Raghava GPS: CCDB: A curated database of genes involved in cervix cancer. Nucleic Acids Res. 39:D975–D979. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Almonte M, Sasieni P and Cuzick J: Incorporating human papillomavirus testing into cytological screening in the era of prophylactic vaccines. Best Pract Res Clin Obstet Gynaecol. 25:617–629. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Meggiolaro A, Unim B, Semyonov L, Miccoli S, Maffongelli E and La Torre G: The role of Pap test screening against cervical cancer: A systematic review and meta-analysis. Clin Ter. 167:124–139. 2016.PubMed/NCBI

10 

Leinonen M, Nieminen P, Kotaniemi-Talonen L, Malila N, Tarkkanen J, Laurila P and Anttila A: Age-specific evaluation of primary human papillomavirus screening vs. conventional cytology in a randomized setting. J Natl Cancer Inst. 101:1612–1623. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, et al: Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: A randomised, double-blind trial. Lancet. 390:2143–2159. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Polonijo AN and Carpiano RM: Social inequalities in adolescent human papillomavirus (HPV) vaccination: A test of fundamental cause theory. Soc Sci Med. 82:115–125. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Dasari S, Wudayagiri R and Valluru L: Cervical cancer: Biomarkers for diagnosis and treatment. Clin Chim Acta. 445:7–11. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Kulasingam V, Pavlou MP and Diamandis EP: Integrating high-throughput technologies in the quest for effective biomarkers for ovarian cancer. Nat Rev Cancer. 10:371–378. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Ganepola GA, Nizin J, Rutledge JR and Chang DH: Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer. World J Gastrointest Oncol. 6:83–97. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Xu Y, Xu Q, Yang L, Ye X, Liu F, Wu F, Ni S, Tan C, Cai G, Meng X, et al: Identification and validation of a blood-based 18-gene expression signature in colorectal cancer. Clin Cancer Res. 19:3039–3049. 2013. View Article : Google Scholar : PubMed/NCBI

17 

R Core Team, . R: A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna: 2018, https://www.R-project.org/

18 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

19 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Royal Statistical Society: Series B (Methodological). 57:289–300. 1995.

20 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Zuo Z, Hu H, Xu Q, Luo X, Peng D, Zhu K, Zhao Q, Xie Y and Ren J: BBCancer: An expression atlas of blood-based biomarkers in the early diagnosis of cancers. Nucleic Acids Res. 48:D789–D796. 2020.PubMed/NCBI

22 

Ma Q, Shao Y, Chen W, Quan C, Zhu Y, Xu X, Zhou Z and Wang S: Discovery of candidate gene expression signatures in peripheral blood for the screening of cervical cancer. Biomark Med. 14:109–118. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Sotiriou C and Piccart MJ: Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care? Nat Rev Cancer. 7:545–553. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Carrero YN, Callejas DE and Mosquera JA: In situ immunopathological events in human cervical intraepithelial neoplasia and cervical cancer: Review. Transl Oncol. 14:1010582021. View Article : Google Scholar : PubMed/NCBI

25 

Colotta F, Dower SK, Sims JE and Mantovani A: The type II ‘decoy’ receptor: A novel regulatory pathway for interleukin 1. Immunol Today. 15:562–566. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Dinarello CA: Interleukin-18. Methods. 19:121–132. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Niu F, Wang T, Li J, Yan M, Li D, Li B and Jin T: The impact of genetic variants in IL1R2 on cervical cancer risk among Uygur females from China: A case-control study. Mol Genet Genomic Med. 7:e005162019. View Article : Google Scholar : PubMed/NCBI

28 

Mhatre S, Wang Z, Nagrani R, Badwe R, Chiplunkar S, Mittal B, Yadav S, Zhang H, Chung CC, Patil P, et al: Common genetic variation and risk of gallbladder cancer in India: A case-control genome-wide association study. Lancet Oncol. 18:535–544. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Laios A, O'Toole SA, Flavin R, Martin C, Ring M, Gleeson N, D'Arcy T, McGuinness EP, Sheils O, Sheppard BL and O'Leary JJ: An integrative model for recurrence in ovarian cancer. Mol Cancer. 7:82008. View Article : Google Scholar : PubMed/NCBI

30 

Autenshlyus A, Arkhipov S, Mikhailova E, Marinkin I, Arkhipova V and Varaksin N: The relationship between cytokine production, CSF2RA, and IL1R2 expression in mammary adenocarcinoma, tumor histopathological parameters, and lymph node metastasis. Technol Cancer Res Treat. 18:15330338198836262019. View Article : Google Scholar : PubMed/NCBI

31 

Lee SJ, Cho YS, Cho MC, Shim JH, Lee KA, Ko KK, Choe YK, Park SN, Hoshino T, Kim S, et al: Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-gamma production in human peripheral blood mononuclear and NK cells. J Immunol. 167:497–504. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, et al: IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature. 583:609–614. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Huang H: Matrix metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: Recent advances. Sensors (Basel). 18:E32492018. View Article : Google Scholar

34 

Li Y, Wu T, Zhang B, Yao Y and Yin G: Matrix metalloproteinase-9 is a prognostic marker for patients with cervical cancer. Med Oncol. 29:3394–3399. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Zajkowska M, Zbucka-Krętowska M, Sidorkiewicz I, Lubowicka E, Będkowska GE, Gacuta E, Szmitkowski M and Ławicki S: Human plasma levels of vascular endothelial growth factor, matrix metalloproteinase 9, and tissue inhibitor of matrix metalloproteinase 1 and their applicability as tumor markers in diagnoses of cervical cancer based on ROC analysis. Cancer Control. 25:10732748187893572018. View Article : Google Scholar : PubMed/NCBI

36 

Jiang W, Cazacu S, Xiang C, Zenklusen JC, Fine HA, Berens M, Armstrong B, Brodie C and Mikkelsen T: FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. Neoplasia. 10:235–243. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Davis MM and Bjorkman PJ: T-cell antigen receptor genes and T-cell recognition. Nature. 334:395–402. 1988. View Article : Google Scholar : PubMed/NCBI

38 

Hanahan D: Hallmarks of cancer: New dimensions. Cancer Discov. 12:31–46. 2022. View Article : Google Scholar : PubMed/NCBI

39 

Tsimberidou AM, Van Morris K, Vo HH, Eck S, Lin YF, Rivas JM and Andersson BS: T-cell receptor-based therapy: An innovative therapeutic approach for solid tumors. J Hematol Oncol. 14:1022021. View Article : Google Scholar : PubMed/NCBI

40 

Feng M, Wang Y, Chen K, Bian Z, Jinfang Wu and Gao Q: IL-17A promotes the migration and invasiveness of cervical cancer cells by coordinately activating MMPs expression via the p38/NF-κB signal pathway. PLoS One. 9:e1085022014. View Article : Google Scholar : PubMed/NCBI

41 

Lafontaine DL and DTollervey D: The function and synthesis of ribosomes. Nat Rev Mol Cell Biol. 2:514–520. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Vyleta ML, Wong J and Magun BE: Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome. PLoS One. 7:e360442012. View Article : Google Scholar : PubMed/NCBI

43 

Kartikasari AER, Huertas CS, Mitchell A and Plebanski M: Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis. Front Oncol. 11:6921422021. View Article : Google Scholar : PubMed/NCBI

44 

Rachinger N, Fischer S, Böhme I, Linck-Paulus L, Kuphal S, Kappelmann-Fenzl M and Bosserhoff AK: Loss of gene information: discrepancies between RNA sequencing, cDNA microarray, and qRT-PCR. Int J Mol Sci. 22:93492021. View Article : Google Scholar : PubMed/NCBI

45 

Hemmat N and Bannazadeh Baghi H: Association of human papillomavirus infection and inflammation in cervical cancer. Pathog Dis. 77:ftz0482019. View Article : Google Scholar : PubMed/NCBI

46 

Vitkauskaite A, Urboniene D, Celiesiute J, Jariene K, Skrodeniene E, Nadisauskiene RJ and Vaitkiene D: Circulating inflammatory markers in cervical cancer patients and healthy controls. J Immunotoxicol. 17:105–109. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Todoric J, Antonucci L and Karin M: Targeting inflammation in cancer prevention and therapy. Cancer Prev Res (Phila). 9:895–905. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Grabosch SM, Shariff OM and Helm CW: Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia. Cochrane Database Syst Rev. 2:CD0041212018.PubMed/NCBI

49 

Lin CL, Lee CH, Chen CM, Cheng CW, Chen PN, Ying TH and Hsieh YH: Protodioscin induces apoptosis through ROS-mediated endoplasmic reticulum stress via the JNK/p38 activation pathways in human cervical cancer cells. Cell Physiol Biochem. 46:322–334. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Ye Y, Wang X, Jeschke U and von Schönfeldt V: COX-2-PGE2-EPs in gynecological cancers. Arch Gynecol Obstet. 301:1365–1375. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Yim EK, Lee MJ, Lee KH, Um SJ and Park JS: Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines. Int J Gynecol Cancer. 16:2023–2031. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Bhatla N, Berek JS, Cuello Fredes M, Denny LA, Grenman S, Karunaratne K, Kehoe ST, Konishi I, Olawaiye AB, Prat J, et al: Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynaecol Obstet. 145:129–135. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ndiaye M, Diop G, Derbois C, Spadoni J, Noirel J, Medina‑Santos R, Coulonges C, Torres M, Dieye A, Sembene M, Sembene M, et al: Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer. Oncol Rep 49: 118, 2023.
APA
Ndiaye, M., Diop, G., Derbois, C., Spadoni, J., Noirel, J., Medina‑Santos, R. ... Le Clerc, S. (2023). Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer. Oncology Reports, 49, 118. https://doi.org/10.3892/or.2023.8555
MLA
Ndiaye, M., Diop, G., Derbois, C., Spadoni, J., Noirel, J., Medina‑Santos, R., Coulonges, C., Torres, M., Dieye, A., Sembene, M., Deleuze, J., Toledano, A., Dem, A., Zagury, J., Le Clerc, S."Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer". Oncology Reports 49.6 (2023): 118.
Chicago
Ndiaye, M., Diop, G., Derbois, C., Spadoni, J., Noirel, J., Medina‑Santos, R., Coulonges, C., Torres, M., Dieye, A., Sembene, M., Deleuze, J., Toledano, A., Dem, A., Zagury, J., Le Clerc, S."Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer". Oncology Reports 49, no. 6 (2023): 118. https://doi.org/10.3892/or.2023.8555
Copy and paste a formatted citation
x
Spandidos Publications style
Ndiaye M, Diop G, Derbois C, Spadoni J, Noirel J, Medina‑Santos R, Coulonges C, Torres M, Dieye A, Sembene M, Sembene M, et al: Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer. Oncol Rep 49: 118, 2023.
APA
Ndiaye, M., Diop, G., Derbois, C., Spadoni, J., Noirel, J., Medina‑Santos, R. ... Le Clerc, S. (2023). Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer. Oncology Reports, 49, 118. https://doi.org/10.3892/or.2023.8555
MLA
Ndiaye, M., Diop, G., Derbois, C., Spadoni, J., Noirel, J., Medina‑Santos, R., Coulonges, C., Torres, M., Dieye, A., Sembene, M., Deleuze, J., Toledano, A., Dem, A., Zagury, J., Le Clerc, S."Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer". Oncology Reports 49.6 (2023): 118.
Chicago
Ndiaye, M., Diop, G., Derbois, C., Spadoni, J., Noirel, J., Medina‑Santos, R., Coulonges, C., Torres, M., Dieye, A., Sembene, M., Deleuze, J., Toledano, A., Dem, A., Zagury, J., Le Clerc, S."Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer". Oncology Reports 49, no. 6 (2023): 118. https://doi.org/10.3892/or.2023.8555
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