Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
June-2023 Volume 49 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2023 Volume 49 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells

  • Authors:
    • Yu Gyung Kim
    • Chaeeun Seong
    • Kyoung-Ah Cho
    • Sang Min Lee
    • Tae-Jun Kim
    • Hyeon Ji Kim
    • Jin-Hwa Cho
    • Won Jung
    • Sungil Jang
    • Jae-Cheon Shin
    • Kyung-Ha Lee
    • Jin-Seok Byun
    • Do-Yeon Kim
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea, Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea, Department of Oral Medicine, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea, Department of Oral Biochemistry, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea, Advanced Bio‑Convergence Center, Pohang Technopark, Pohang 37668, Republic of Korea, Department of Molecular Biology, Pusan National University, Busan 46241, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 122
    |
    Published online on: May 2, 2023
       https://doi.org/10.3892/or.2023.8559
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oral squamous cell carcinoma (OSCC) is a tumor with a poor prognosis and a high recurrence rate. Despite its high annual incidence worldwide, appropriate therapeutic strategies have not yet been developed. Consequently, the 5‑year survival rate for OSCC is low when advanced stages or recurrence is diagnosed. Forkhead transcriptional factor O1 (FoxO1) is a key mediator for maintaining cellular homeostasis. FoxO1 can function as a tumor suppressor as well as an oncogene depending on the cancer type. Therefore, the precise molecular functions of FoxO1 need to be validated, considering intracellular factors and the extracellular environment. To the best of our knowledge, however, the roles of FoxO1 in OSCC have not yet been defined. The present study examined FoxO1 levels under pathological conditions (oral lichen planus and oral cancer) and selected an appropriate OSCC cell line (YD‑9). Crispr/Cas9 was used to generate FoxO1‑deficient YD‑9 cells in which the protein levels of phospho ERK and phospho STAT3 were upregulated, promoting cancer proliferation and migration. In addition, FoxO1 reduction increased the levels of the cell proliferation markers phospho H3 (Ser10) and PCNA. FoxO1 loss significantly reduced cellular ROS levels and apoptosis in YD‑9 cells. Collectively, the present study demonstrated that FoxO1 exerted an anti‑tumor effect by suppressing proliferation and migration/invasion but promoting oxidative stress‑linked cell death in YD‑9 OSCC cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Rivera C: Essentials of oral cancer. Int J Clin Exp Pathol. 8:11884–11894. 2015.PubMed/NCBI

2 

Weckx A, Riekert M, Grandoch A, Schick V, Zöller JE and Kreppel M: Time to recurrence and patient survival in recurrent oral squamous cell carcinoma. Oral Oncol. 94:8–13. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Omar E: Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma-a systematic review. Head Face Med. 11:62015. View Article : Google Scholar : PubMed/NCBI

4 

Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller JE and Kreppel M: Analysis of clinicopathological risk factors for locoregional recurrence of oral squamous cell carcinoma-retrospective analysis of 517 patients. J Craniomaxillofac Surg. 45:1749–1753. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Collado M and Serrano M: Senescence in tumours: Evidence from mice and humans. Nat Rev Cancer. 10:51–57. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Yadav RK, Chauhan AS, Zhuang L and Gan B: FoxO transcription factors in cancer metabolism. Semin Cancer Biol. 50:65–76. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Chae YC, Kim JY, Park JW, Kim KB, Oh H, Lee KH and Seo SB: FOXO1 degradation via G9a-mediated methylation promotes cell proliferation in colon cancer. Nucleic Acids Res. 47:1692–1705. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Dong T, Zhang Y, Chen Y, Liu P, An T, Zhang J, Yang H, Zhu W and Yang X: FOXO1 inhibits the invasion and metastasis of hepatocellular carcinoma by reversing ZEB2-induced epithelial-mesenchymal transition. Oncotarget. 8:1703–1713. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida-Araki K, Hisatsune H, Nishikawa S, Nakayama K, Nakayama K, et al: Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 279:34741–34749. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Cancer Genome Atlas Research Network, . The molecular taxonomy of primary prostate cancer. Cell. 163:1011–1025. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Trinh DL, Scott DW, Morin RD, Mendez-Lago M, An J, Jones SJ, Mungall AJ, Zhao Y, Schein J, Steidl C, et al: Analysis of FOXO1 mutations in diffuse large B-cell lymphoma. Blood. 121:3666–3674. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Hornsveld M, Smits LMM, Meerlo M, van Amersfoort M, Groot Koerkamp MJA, van Leenen D, Kloet DEA, Holstege FCP, Derksen PWB, Burgering BMT and Dansen TB: FOXO transcription factors both suppress and support breast cancer progression. Cancer Res. 78:2356–2369. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Sanjana NE, Shalem O and Zhang F: Improved vectors and genome-wide libraries for CRISPR screening. Nat Methods. 11:783–784. 2014. View Article : Google Scholar : PubMed/NCBI

15 

van der Meij EH and van der Waal I: Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med. 32:507–512. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Shi W, Yang J, Li S, Shan X, Liu X, Hua H, Zhao C, Feng Z, Cai Z, Zhang L and Zhou D: Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5. Oncotarget. 6:40172–40185. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

20 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45((W1)): W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Lee EJ, Kim J, Lee SA, Kim EJ, Chun YC, Ryu MH and Yook JI: Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells. Exp Mol Med. 37:379–390. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Gene Ontology Consortium: The gene ontology resource: Enriching a GOld mine. Nucleic Acids Res. 49(D1): D325–D334. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Mi H, Muruganujan A, Ebert D, Huang X and Thomas PD: PANTHER version 14: More genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools. Nucleic Acids Res. 47(D1): D419–D426. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Birkenkamp-Demtröder K, Hahn SA, Mansilla F, Thorsen K, Maghnouj A, Christensen R, Øster B and Ørntoft TF: Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells. PLoS One. 8:e735932013. View Article : Google Scholar : PubMed/NCBI

26 

Sequeira I and Watt FM: The role of keratins in modulating carcinogenesis via communication with cells of the immune system. Cell Stress. 3:136–138. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Wu H, Wang K, Liu W and Hao Q: PTEN overexpression improves cisplatin-resistance of human ovarian cancer cells through upregulating KRT10 expression. Biochem Biophys Res Commun. 444:141–146. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Gkouveris I, Nikitakis N, Karanikou M, Rassidakis G and Sklavounou A: Erk1/2 activation and modulation of STAT3 signaling in oral cancer. Oncol Rep. 32:2175–2182. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D and Anania FA: Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res. 67:2497–2507. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Ponugoti B, Xu F, Zhang C, Tian C, Pacios S and Graves DT: FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress. J Cell Biol. 203:327–343. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Kesarwala AH, Krishna MC and Mitchell JB: Oxidative stress in oral diseases. Oral Dis. 22:9–18. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Olmos Y, Sánchez-Gómez FJ, Wild B, García-Quintans N, Cabezudo S, Lamas S and Monsalve M: SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex. Antioxid Redox Signal. 19:1507–1521. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Wang Q, Sztukowska M, Ojo A, Scott DA, Wang H and Lamont RJ: FOXO responses to Porphyromonas gingivalis in epithelial cells. Cell Microbiol. 17:1605–1617. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Filomeni G, De Zio D and Cecconi F: Oxidative stress and autophagy: The clash between damage and metabolic needs. Cell Death Differ. 22:377–388. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y and Li Y: Inflammation and tumor progression: Signaling pathways and targeted intervention. Signal Transduct Target Ther. 6:2632021. View Article : Google Scholar : PubMed/NCBI

36 

Xie L, Ushmorov A, Leithäuser F, Guan H, Steidl C, Färbinger J, Pelzer C, Vogel MJ, Maier HJ, Gascoyne RD, et al: FOXO1 is a tumor suppressor in classical Hodgkin lymphoma. Blood. 119:3503–3511. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Duan X, Kong Z, Liu Y, Zeng Z, Li S, Wu W, Ji W, Yang B, Zhao Z and Zeng G: β-Arrestin2 contributes to cell viability and proliferation via the down-regulation of FOXO1 in castration-resistant prostate cancer. J Cell Physiol. 230:2371–2381. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Lin A, Yao J, Zhuang L, Wang D, Han J, Lam EW and Gan B: The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene. 33:3183–3194. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Kode A, Mosialou I, Manavalan SJ, Rathinam CV, Friedman RA, Teruya-Feldstein J, Bhagat G, Berman E and Kousteni S: FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice. Leukemia. 30:1–13. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Han GH, Chay DB, Nam S, Cho H, Chung JY and Kim JH: Prognostic implications of forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) in epithelial ovarian cancer. BMC Cancer. 19:12022019. View Article : Google Scholar : PubMed/NCBI

41 

Vasquez YM, Mazur EC, Li X, Kommagani R, Jiang L, Chen R, Lanz RB, Kovanci E, Gibbons WE and DeMayo FJ: FOXO1 is required for binding of PR on IRF4, novel transcriptional regulator of endometrial stromal decidualization. Mol Endocrinol. 29:421–433. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, et al: HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell. 12:230–238. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Sabharwal SS, Waypa GB, Marks JD and Schumacker PT: Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling. Biochem J. 456:337–346. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Dwivedi R, Pandey R, Chandra S and Mehrotra D: Dendritic cell-based immunotherapy: A potential player in oral cancer therapeutics. Immunotherapy. 15:457–469. 2023. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim YG, Seong C, Cho K, Lee SM, Kim T, Kim HJ, Cho J, Jung W, Jang S, Shin J, Shin J, et al: Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells. Oncol Rep 49: 122, 2023.
APA
Kim, Y.G., Seong, C., Cho, K., Lee, S.M., Kim, T., Kim, H.J. ... Kim, D. (2023). Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells. Oncology Reports, 49, 122. https://doi.org/10.3892/or.2023.8559
MLA
Kim, Y. G., Seong, C., Cho, K., Lee, S. M., Kim, T., Kim, H. J., Cho, J., Jung, W., Jang, S., Shin, J., Lee, K., Byun, J., Kim, D."Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells". Oncology Reports 49.6 (2023): 122.
Chicago
Kim, Y. G., Seong, C., Cho, K., Lee, S. M., Kim, T., Kim, H. J., Cho, J., Jung, W., Jang, S., Shin, J., Lee, K., Byun, J., Kim, D."Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells". Oncology Reports 49, no. 6 (2023): 122. https://doi.org/10.3892/or.2023.8559
Copy and paste a formatted citation
x
Spandidos Publications style
Kim YG, Seong C, Cho K, Lee SM, Kim T, Kim HJ, Cho J, Jung W, Jang S, Shin J, Shin J, et al: Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells. Oncol Rep 49: 122, 2023.
APA
Kim, Y.G., Seong, C., Cho, K., Lee, S.M., Kim, T., Kim, H.J. ... Kim, D. (2023). Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells. Oncology Reports, 49, 122. https://doi.org/10.3892/or.2023.8559
MLA
Kim, Y. G., Seong, C., Cho, K., Lee, S. M., Kim, T., Kim, H. J., Cho, J., Jung, W., Jang, S., Shin, J., Lee, K., Byun, J., Kim, D."Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells". Oncology Reports 49.6 (2023): 122.
Chicago
Kim, Y. G., Seong, C., Cho, K., Lee, S. M., Kim, T., Kim, H. J., Cho, J., Jung, W., Jang, S., Shin, J., Lee, K., Byun, J., Kim, D."Anti‑tumor properties of FoxO1 in YD‑9 oral squamous cell carcinoma cells". Oncology Reports 49, no. 6 (2023): 122. https://doi.org/10.3892/or.2023.8559
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team