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Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer

  • Authors:
    • Anna Nasulewicz-Goldeman
    • Waldemar Goldeman
    • Diana Papiernik
    • Marcin Nowak
    • Ewa Mrówczyńska
    • Joanna Wietrzyk
  • View Affiliations / Copyright

    Affiliations: Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53‑114 Wroclaw, Poland, Department of Organic Chemistry, Wroclaw University of Science and Technology, 50‑370 Wroclaw, Poland, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50‑366 Wroclaw, Poland
    Copyright: © Nasulewicz-Goldeman et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 135
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    Published online on: May 18, 2023
       https://doi.org/10.3892/or.2023.8572
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Abstract

Breast cancer is one of the major causes of cancer‑related mortality among women worldwide. It metastasizes to distant organs, particularly to bone tissue. Nitrogen‑containing bisphosphonates are mainly used as an adjuvant therapy to inhibit skeletal‑related events; however, there is increasing evidence to suggest that these compounds also exert antitumor effects. In previous studies, the authors synthesized two novel aminomethylidenebisphosphonates (BPs), namely benzene‑1,4‑bis[aminomethylidene(bisphosphonic)] acid (WG12399C) and naphthalene‑1,5‑bis[aminomethylidene(bisphosphonic)] acid (WG12592A). Both BPs exhibited notable antiresorptive activity in a mouse model of osteoporosis. The present study aimed to assess the in vivo anticancer activity of WG12399C and WG12592A in 4T1 breast adenocarcinoma model. WG12399C exerted an anti‑metastatic effect by reducing the number of spontaneous lung metastases by ~66% in comparison to the control. In the experimental metastasis model of 4T1‑luc2‑tdTomato cells, this compound reduced the incidence of tumor metastases in the lungs by approximately half in comparison to the control. Both WG12399C and WG12595A also significantly reduced the size and/or number of bone metastatic foci. Their pro‑apoptotic and anti‑proliferative activity may, at least in part, explain the observed effects. Incubation with WG12399C induced an almost 6‑fold increase in caspase‑3 activity in 4T1 cells. Moreover, cells treated with WG12399C or WG12595A exhibited a 2‑fold reduction in invasiveness through Matrigel. Furthermore, both the BPs were able to sensitize the 4T1 cells to cytostatics. In summary, the results of the present study indicate that the examined aminomethylidene‑BPs may be of particular interest in the context of combined treatment in breast cancer therapy.
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View References

1 

Breast cancer. https://www.who.int/news-room/fact-sheets/detail/breast-cancer

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Gainford MC, Dranitsaris G and Clemons M: Recent developments in bisphosphonates for patients with metastatic breast cancer. BMJ. 330:769–773. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Coleman RE: Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 12:6243s–6249s. 2006. View Article : Google Scholar : PubMed/NCBI

5 

D'Oronzo S, Wood S and Brown JE: The use of bisphosphonates to treat skeletal complications in solid tumours. Bone. 147:1159072021. View Article : Google Scholar : PubMed/NCBI

6 

Goldvaser H and Amir E: Role of bisphosphonates in breast cancer therapy. Curr Treat Options Oncol. 20:262019. View Article : Google Scholar : PubMed/NCBI

7 

Boissier S, Ferreras M, Peyruchaud O, Magnetto S, Ebetino FH, Colombel M, Delmas P, Delaissé JM and Clézardin P: Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res. 60:2949–2954. 2000.PubMed/NCBI

8 

Senaratne SG, Pirianov G, Mansi JL, Arnett TR and Colston KW: Bisphosphonates induce apoptosis in human breast cancer cell lines. Br J Cancer. 82:1459–1468. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Buranrat B and Bootha S: Antiproliferative and antimigratory activities of bisphosphonates in human breast cancer cell line MCF-7. Oncol Lett. 18:1246–1258. 2019.PubMed/NCBI

10 

Misso G, Porru M, Stoppacciaro A, Castellano M, De Cicco F, Leonetti C, Santini D and Caraglia M: Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid. Cancer Biol Ther. 13:1491–1500. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Tanaka Y, Iwasaki M, Murata-Hirai K, Matsumoto K, Hayashi K, Okamura H, Sugie T, Minato N, Morita CT and Toi M: Anti-tumor activity and immunotherapeutic potential of a bisphosphonate prodrug. Sci Rep. 7:59872017. View Article : Google Scholar : PubMed/NCBI

12 

Dhesy-Thind S, Fletcher GG, Blanchette PS, Clemons MJ, Dillmon MS, Frank ES, Gandhi S, Gupta R, Mates M, Moy B, et al: Use of adjuvant bisphosphonates and other bone-modifying agents in breast cancer: A cancer care Ontario and American society of clinical oncology clinical practice guideline. J Clin Oncol. 35:2062–2081. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S and Senkus E; ESMO Guidelines Committee. Electronic address, : simpleclinicalguidelines@esmo.org: Early breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up†. Ann Oncol. 30:1194–1220. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Goldeman W, Kluczyński A and Soroka M: The preparation of N-substituted aminomethylidenebisphosphonates and their tetraalkyl esters via reaction of isonitriles with trialkyl phosphites and hydrogen chloride. Part 1. Tetrahedron Lett. 53:5290–5292. 2012. View Article : Google Scholar

15 

Goldeman W and Nasulewicz-Goldeman A: Synthesis and antiproliferative activity of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids. Bioorg Med Chem Lett. 24:3475–3479. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Nasulewicz-Goldeman A, Goldeman W, Mrówczyńska E and Wietrzyk J: Biological effects of aromatic bis[aminomethylidenebis(phosphonic)] acids in osteoclast precursors in vitro. Chem Biol Drug Des. 94:1835–1848. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Nasulewicz-Goldeman A, Goldeman W, Nikodem A, Nowak M, Papiernik D, Goszczyński TM and Wietrzyk J: Aromatic bis[aminomethylidenebis(phosphonic)] acids prevent ovariectomy-induced bone loss and suppress osteoclastogenesis in mice. Int J Mol Sci. 22:95902021. View Article : Google Scholar : PubMed/NCBI

18 

Singh SK, Manne N, Ray PC and Pal M: Synthesis of imidazol-1-yl-acetic acid hydrochloride: A key intermediate for zoledronic acid. Beilstein J Org Chem. 4:422008. View Article : Google Scholar : PubMed/NCBI

19 

Balathasan L, Beech JS and Muschel RJ: Ultrasonography-guided intracardiac injection: An improvement for quantitative brain colonization assays. Am J Pathol. 183:26–34. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Hiraga T, Williams PJ, Ueda A, Tamura D and Yoneda T: Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clin Cancer Res. 10:4559–4567. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Blazejczyk A, Switalska M, Chlopicki S, Marcinek A, Gebicki J, Nowak M, Nasulewicz-Goldeman A and Wietrzyk J: 1-methylnicotinamide and its structural analog 1,4-dimethylpyridine for the prevention of cancer metastasis. J Exp Clin Cancer Res. 35:1102016. View Article : Google Scholar : PubMed/NCBI

22 

Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S and Boyd MR: New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst. 82:1107–1112. 1990. View Article : Google Scholar : PubMed/NCBI

23 

Chou TC and Talalay P: Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors. Eur J Biochem. 115:207–216. 1981. View Article : Google Scholar : PubMed/NCBI

24 

Chou TC and Talalay P: Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 22:27–55. 1984. View Article : Google Scholar : PubMed/NCBI

25 

Features T and Information G: Bioware ultra cell line NCI-H460-luc2. 2–3. 2010.http://www.caliperls.com/assets/027/8876.pdf

26 

Zhang Z, Hu Z, Gupta J, Krimmel JD, Gerseny HM, Berg AF, Robbins JS, Du H, Prabhakar B and Seth P: Intravenous administration of adenoviruses targeting transforming growth factor beta signaling inhibits established bone metastases in 4T1 mouse mammary tumor model in an immunocompetent syngeneic host. Cancer Gene Ther. 19:630–636. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Campbell JP, Merkel AR, Masood-Campbell SK, Elefteriou F and Sterling JA: Models of bone metastasis. J Vis Exp. e42602012.PubMed/NCBI

28 

Werbeck JL, Thudi NK, Martin CK, Premanandan C, Yu L, Ostrowksi MC and Rosol TJ: Tumor microenvironment regulates metastasis and metastasis genes of mouse MMTV-PymT mammary cancer cells in vivo. Vet Pathol. 51:868–881. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Zhou Z, Qutaish M, Han Z, Schur RM, Liu Y, Wilson DL and Lu ZR: MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent. Nat Commun. 6:79842015. View Article : Google Scholar : PubMed/NCBI

30 

Denoyelle C, Hong L, Vannier JP, Soria J and Soria C: New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects. Br J Cancer. 88:1631–1640. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Goffinet M, Thoulouzan M, Pradines A, Lajoie-Mazenc I, Weinbaum C, Faye JC and Séronie-Vivien S: Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells. BMC Cancer. 6:602006. View Article : Google Scholar : PubMed/NCBI

32 

Iguchi T, Miyakawa Y, Yamamoto K, Kizaki M and Ikeda Y: Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. Cell Signal. 15:719–727. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Okamoto S, Jiang Y, Kawamura K, Shingyoji M, Tada Y, Sekine I, Takiguchi Y, Tatsumi K, Kobayashi H, Shimada H, et al: Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions. Cell Death Dis. 5:e15172014. View Article : Google Scholar : PubMed/NCBI

34 

Diel IJ, Solomayer EF, Costa SD, Gollan C, Goerner R, Wallwiener D, Kaufmann M and Bastert G: Reduction in new metastases in breast cancer with adjuvant clodronate treatment. N Engl J Med. 339:357–363. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Saarto T, Blomqvist C, Virkkunen P and Elomaa I: Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-Year results of a randomized controlled trial. J Clin Oncol. 19:10–17. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Kohno N, Aogi K, Minami H, Nakamura S, Asaga T, Iino Y, Watanabe T, Goessl C, Ohashi Y and Takashima S: Zoledronic acid significantly reduces skeletal complications compared with placebo in Japanese women with bone metastases from breast cancer: A randomized, placebo-controlled trial. J Clin Oncol. 23:3314–3321. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Lawson MA, Xia Z, Barnett BL, Triffitt JT, Phipps RJ, Dunford JE, Locklin RM, Ebetino FH and Russell RG: Differences between bisphosphonates in binding affinities for hydroxyapatite. J Biomed Mater Res B Appl Biomater. 92:149–155. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Hortobagyi GN, Theriault RL, Porter L, Blayney D, Lipton A, Sinoff C, Wheeler H, Simeone JF, Seaman J and Knight RD: Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 aredia breast cancer study group. N Engl J Med. 335:1785–1792. 1996. View Article : Google Scholar : PubMed/NCBI

39 

Steinman RA, Brufsky AM and Oesterreich S: Zoledronic acid effectiveness against breast cancer metastases-a role for estrogen in the microenvironment? Breast Cancer Res. 14:2132012. View Article : Google Scholar : PubMed/NCBI

40 

Farhoodi HP, Segaliny AI, Wagoner ZW, Cheng JL, Liu L and Zhao W: Optimization of a syngeneic murine model of bone metastasis. J Bone Oncol. 23:1002982020. View Article : Google Scholar : PubMed/NCBI

41 

Michigami T, Hiraga T, Williams PJ, Niewolna M, Nishimura R, Mundy GR and Yoneda T: The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs. Breast Cancer Res Treat. 75:249–258. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Ottewell PD, Mönkkönen H, Jones M, Lefley DV, Coleman RE and Holen I: Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer. J Natl Cancer Inst. 100:1167–1178. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Santini D, Vincenzi B, Dicuonzo G, Avvisati G, Massacesi C, Battistoni F, Gavasci M, Rocci L, Tirindelli MC, Altomare V, et al: Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients. Clin Cancer Res. 9:2893–2897. 2003.PubMed/NCBI

44 

Bellone F, Catalano A, Sottile AR, Gaudio A, Loddo S, Corica F and Morabito N: Early Changes of VEGF levels after zoledronic acid in women with postmenopausal osteoporosis: A potential role of vitamin D. Front Med (Lausanne). 8:7484382021. View Article : Google Scholar : PubMed/NCBI

45 

Luckman SP, Hughes DE, Coxon FP, Graham R, Russell G and Rogers MJ: Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including ras. J Bone Miner Res. 13:581–589. 1998. View Article : Google Scholar : PubMed/NCBI

46 

Benford HL, Frith JC, Auriola S, Mönkkönen J and Rogers MJ: Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: Biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. Mol Pharmacol. 56:131–140. 1999. View Article : Google Scholar : PubMed/NCBI

47 

Russell RGG, Watts NB, Ebetino FH and Rogers MJ: Mechanisms of action of bisphosphonates: Similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 19:733–759. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Suyama K, Noguchi Y, Tanaka T, Yoshida T, Shibata T, Saito Y and Tatsuno I: Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7. Oncol Rep. 18:1291–1298. 2007.PubMed/NCBI

49 

Miwa A, Takezako N, Hayakawa H, Hayakawa M, Tominaga S and Yanagisawa K: YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation. Am J Hematol. 87:1084–1088. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Benassi MS, Chiechi A, Ponticelli F, Pazzaglia L, Gamberi G, Zanella L, Manara MC, Perego P, Ferrari S and Picci P: Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells. Cancer Lett. 250:194–205. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Matsumoto S, Kimura S, Segawa H, Kuroda J, Yuasa T, Sato K, Nogawa M, Tanaka F, Maekawa T and Wada H: Efficacy of the third-generation bisphosphonate, zoledronic acid alone and combined with anti-cancer agents against small cell lung cancer cell lines. Lung Cancer. 47:31–39. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Koto K, Murata H, Kimura S, Horie N, Matsui T, Nishigaki Y, Ryu K, Sakabe T, Itoi M, Ashihara E, et al: Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents. Oncol Rep. 24:233–239. 2010.PubMed/NCBI

53 

Ottewell PD, Deux B, Mönkkb̈nen H, Cross S, Coleman RE, Clezardin P and Holen I: Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo. Clin Cancer Res. 14:4658–4666. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Van Beek ER, Lowik CWGM, Van Wijngaarden J, Ebetino FH and Papapoulos SE: Synergistic effect of bisphosphonate and docetaxel on the growth of bone metastasis in an animal model of established metastatic bone disease. Breast Cancer Res Treat. 118:307–313. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, Song H and Wu L: Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway. Drug Des Devel Ther. 12:3021–3031. 2018. View Article : Google Scholar : PubMed/NCBI

56 

Wang L, Liu Y, Zhou Y, Wang J, Tu L, Sun Z, Wang X and Luo F: Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways. J Exp Clin Cancer Res. 38:932019. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Nasulewicz-Goldeman A, Goldeman W, Papiernik D, Nowak M, Mrówczyńska E and Wietrzyk J: Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer. Oncol Rep 50: 135, 2023.
APA
Nasulewicz-Goldeman, A., Goldeman, W., Papiernik, D., Nowak, M., Mrówczyńska, E., & Wietrzyk, J. (2023). Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer. Oncology Reports, 50, 135. https://doi.org/10.3892/or.2023.8572
MLA
Nasulewicz-Goldeman, A., Goldeman, W., Papiernik, D., Nowak, M., Mrówczyńska, E., Wietrzyk, J."Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer". Oncology Reports 50.1 (2023): 135.
Chicago
Nasulewicz-Goldeman, A., Goldeman, W., Papiernik, D., Nowak, M., Mrówczyńska, E., Wietrzyk, J."Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer". Oncology Reports 50, no. 1 (2023): 135. https://doi.org/10.3892/or.2023.8572
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Spandidos Publications style
Nasulewicz-Goldeman A, Goldeman W, Papiernik D, Nowak M, Mrówczyńska E and Wietrzyk J: Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer. Oncol Rep 50: 135, 2023.
APA
Nasulewicz-Goldeman, A., Goldeman, W., Papiernik, D., Nowak, M., Mrówczyńska, E., & Wietrzyk, J. (2023). Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer. Oncology Reports, 50, 135. https://doi.org/10.3892/or.2023.8572
MLA
Nasulewicz-Goldeman, A., Goldeman, W., Papiernik, D., Nowak, M., Mrówczyńska, E., Wietrzyk, J."Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer". Oncology Reports 50.1 (2023): 135.
Chicago
Nasulewicz-Goldeman, A., Goldeman, W., Papiernik, D., Nowak, M., Mrówczyńska, E., Wietrzyk, J."Anti‑metastatic activity of aromatic aminomethylidenebisphosphonates in a mouse model of 4T1 cell‑derived breast cancer". Oncology Reports 50, no. 1 (2023): 135. https://doi.org/10.3892/or.2023.8572
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