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Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer

  • Authors:
    • Hiromichi Murase
    • Yoichi Matsuo
    • Yuki Denda
    • Keisuke Nonoyama
    • Tomokatsu Kato
    • Yoshinaga Aoyama
    • Yuichi Hayashi
    • Hiroyuki Imafuji
    • Kenta Saito
    • Mamoru Morimoto
    • Ryo Ogawa
    • Hiroki Takahashi
    • Akira Mitsui
    • Masahiro Kimura
    • Shuji Takiguchi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho‑cho, Mizuho‑ku, Nagoya, Aichi 4678601, Japan
    Copyright: © Murase et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 164
    |
    Published online on: July 14, 2023
       https://doi.org/10.3892/or.2023.8601
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Abstract

Pancreatic cancer (PaCa) tends to be resistant to chemotherapy and is associated with a very poor prognosis. It has been previously reported by the authors that integrin‑linked kinase (ILK) is a prognostic factor in PaCa. ILK expression was examined in a newly established gemcitabine (Gem)‑resistant (Gem‑R) PaCa cell line and it was demonstrated that ILK expression was upregulated compared with that in Gem‑sensitive (Gem‑S) cells. In the present study, the effects of increased ILK expression in Gem‑R PaCa cells were evaluated and it was examined whether compound 22 (Cpd22), an ILK inhibitor, exerted antitumor effects not only in Gem‑S cells but also in Gem‑R cells. Reverse transcription‑quantitative polymerase chain reaction and western blotting revealed that ILK expression was higher in Gem‑R PaCa cells than in Gem‑S PaCa cells. Cpd22 inhibited the growth of PaCa cells in a concentration‑dependent manner. Cpd22 also inhibited the growth of Gem‑R PaCa cells. The invasive and angiogenic potential of Gem‑R PaCa cells was enhanced compared with that in Gem‑S cells; however, ILK small interfering RNA and Cpd22 treatment suppressed this enhancement of invasive potential compared with that in Gem‑S cells. The addition of Cpd22 to Gem also improved the sensitivity of Gem‑R cell lines to Gem. Furthermore, enhanced Akt signaling was associated with increased malignancy in Gem‑R cell lines. In conclusion, ILK was upregulated with resistance and may be involved in tumor angiogenesis, invasive potential, and chemotherapy resistance, which were all suppressed by Cpd22 treatment. Thus, Cpd22 may be a novel therapeutic agent for the treatment of PaCa.
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View References

1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Burris HA III, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, et al: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol. 15:2403–2413. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, Schramm H, Fahlke J, Zuelke C, Burkart C, et al: Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial. JAMA. 297:267–277. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, et al: Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 369:1691–1703. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW and Whang EE: RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Clin Cancer Res. 11:3433–3438. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Jia Z: Role of integrin-linked kinase in drug resistance of lung cancer. Onco Targets Ther. 8:1561–1565. 2015. View Article : Google Scholar : PubMed/NCBI

7 

McDonald PC and Dedhar S: New perspectives on the role of integrin-linked kinase (ILK) signaling in cancer metastasis. Cancers (Basel). 14:32092022. View Article : Google Scholar : PubMed/NCBI

8 

McDonald PC, Fielding AB and Dedhar S: Integrin-linked kinase-essential roles in physiology and cancer biology. J Cell Sci. 121:3121–3132. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Ning Z, Zhu X, Jiang Y, Gao A, Zou S, Gu C, He C, Chen Y, Ding WQ and Zhou J: Integrin-linked kinase is involved in the proliferation and invasion of esophageal squamous cell carcinoma. J Cancer. 11:324–333. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Ji C, Zhang M, Hu J, Cao C, Gu Q, Liu Y, Li X, Xu D, Ying L, Yang Y, et al: The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer. Cell Death Dis. 13:5772022. View Article : Google Scholar : PubMed/NCBI

11 

Li B, Wang X, Wang R, Rutz B, Ciotkowska A, Gratzke C, Herlemann A, Spek A, Tamalunas A, Waidelich R, et al: Inhibition of neurogenic and thromboxane A2-induced human prostate smooth muscle contraction by the integrin α2β1 inhibitor BTT-3033 and the integrin-linked kinase inhibitor Cpd22. Prostate. 80:831–849. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Sarı Kılıçaslan SM and İncesu Z: Effects of integrin-linked kinase on protein kinase b, glycogen synthase kinase-3β, and β-catenin molecules in ovarian cancer cells. Iran J Basic Med Sci. 24:1500–1508. 2021.PubMed/NCBI

13 

Yau CY, Wheeler JJ, Sutton KL and Hedley DW: Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer Res. 65:1497–1504. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Zeng S, Pöttler M, Lan B, Grützmann R, Pilarsky C and Yang H: Chemoresistance in Pancreatic Cancer. Int J Mol Sci. 20:45042019. View Article : Google Scholar : PubMed/NCBI

15 

Imafuji H, Matsuo Y, Ueda G, Omi K, Hayashi Y, Saito K, Tsuboi K, Morimoto M, Koide S, Ogawa R, et al: Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL8 production in pancreatic cancer. Oncol Rep. 41:3508–3516. 2019.PubMed/NCBI

16 

Bustin SA: Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. J Mol Endocrinol. 29:23–39. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Serrano I, McDonald PC, Lock F, Muller WJ and Dedhar S: Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase. Nat Commun. 4:29762013. View Article : Google Scholar : PubMed/NCBI

18 

Takanami I: Increased expression of integrin-linked kinase is associated with shorter survival in non-small cell lung cancer. BMC Cancer. 5:12005. View Article : Google Scholar : PubMed/NCBI

19 

Ahmed N, Riley C, Oliva K, Stutt E, Rice GE and Quinn MA: Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid. J Pathol. 201:229–237. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Marotta A, Parhar K, Owen D, Dedhar S and Salh B: Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. Br J Cancer. 88:1755–1762. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Bravou V, Klironomos G, Papadaki E, Stefanou D and Varakis J: Integrin-linked kinase (ILK) expression in human colon cancer. Br J Cancer. 89:2340–2341. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Ito R, Oue N, Zhu X, Yoshida K, Nakayama H, Yokozaki H and Yasui W: Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma. Virchows Arch. 442:118–123. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Peroukides S, Bravou V, Varakis J, Alexopoulos A, Kalofonos H and Papadaki H: ILK overexpression in human hepatocellular carcinoma and liver cirrhosis correlates with activation of Akt. Oncol Rep. 20:1337–1344. 2008.PubMed/NCBI

24 

Sawai H, Okada Y, Funahashi H, Matsuo Y, Takahashi H, Takeyama H and Manabe T: Integrin-linked kinase activity is associated with interleukin-1 alpha-induced progressive behavior of pancreatic cancer and poor patient survival. Oncogene. 25:3237–3246. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Canel M, Serrels A, Frame MC and Brunton VG: E-cadherin-integrin crosstalk in cancer invasion and metastasis. J Cell Sci. 126:393–401. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Troussard AA, Mawji NM, Ong C, Mui A, St–Arnaud R and Dedhar S: Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem. 278:22374–22378. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Qu Y, Hao C, Xu J, Cheng Z, Wang W and Liu H: ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway. Mol Med Rep. 16:5036–5042. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Schlieman MG, Fahy BN, Ramsamooj R, Beckett L and Bold RJ: Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br J Cancer. 89:2110–2115. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, et al: Identification of 4- (2- (4- amino- 1,2,5- oxadiazol- 3- yl)- 1- ethyl- 7- {[(3S)- 3-piperidinylmethyl]oxy}- 1H-imidazo[4,5-c]pyridin- 4-yl)- 2- methyl- 3- butyn- 2- ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem. 51:5663–5679. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Kato T, Matsuo Y, Ueda G, Murase H, Aoyama Y, Omi K, Hayashi Y, Imafuji H, Saito K, Morimoto M, et al: Enhanced CXCL12/CXCR4 signaling increases tumor progression in radiation-resistant pancreatic cancer. Oncol Rep. 47:682022. View Article : Google Scholar : PubMed/NCBI

31 

Maier HJ, Schmidt-Strassburger U, Huber MA, Wiedemann EM, Beug H and Wirth T: NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett. 295:214–228. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Zheng CC, Hu HF, Hong P, Zhang QH, Xu WW, He QY and Li B: Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer. Am J Cancer Res. 9:186–197. 2019.PubMed/NCBI

33 

Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J and Dedhar S: Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell. 5:79–90. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Stipa F, Lucandri G, Limiti MR, Bartolucci P, Cavallini M, Di Carlo V, D'Amato A, Ribotta G and Stipa S: Angiogenesis as a prognostic indicator in pancreatic ductal adenocarcinoma. Anticancer Res. 22:445–449. 2002.PubMed/NCBI

35 

Benckert C, Thelen A, Cramer T, Weichert W, Gaebelein G, Gessner R and Jonas S: Impact of microvessel density on lymph node metastasis and survival after curative resection of pancreatic cancer. Surg Today. 42:169–176. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Matsuo Y, Ochi N, Sawai H, Yasuda A, Takahashi H, Funahashi H, Takeyama H, Tong Z and Guha S: CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer. 124:853–861. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Grzesiak JJ, Smith KC, Burton DW, Deftos LJ and Bouvet M: GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. Int J Cancer. 114:522–530. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Wang L, Tang C, Cao H, Li K, Pang X, Zhong L, Dang W, Tang H, Huang Y, Wei L, et al: Activation of IL-8 via PI3K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells. Cancer Biol Ther. 16:1220–1230. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Tsoumas D, Nikou S, Giannopoulou E, Champeris Tsaniras S, Sirinian C, Maroulis I, Taraviras S, Zolota V, Kalofonos HP and Bravou V: ILK Expression in colorectal cancer is associated with EMT, Cancer stem cell markers and chemoresistance. Cancer Genomics Proteomics. 15:127–141. 2018.PubMed/NCBI

40 

Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS and Kalluri R: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 527:525–530. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Murase H, Matsuo Y, Denda Y, Nonoyama K, Kato T, Aoyama Y, Hayashi Y, Imafuji H, Saito K, Morimoto M, Morimoto M, et al: Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer. Oncol Rep 50: 164, 2023.
APA
Murase, H., Matsuo, Y., Denda, Y., Nonoyama, K., Kato, T., Aoyama, Y. ... Takiguchi, S. (2023). Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer. Oncology Reports, 50, 164. https://doi.org/10.3892/or.2023.8601
MLA
Murase, H., Matsuo, Y., Denda, Y., Nonoyama, K., Kato, T., Aoyama, Y., Hayashi, Y., Imafuji, H., Saito, K., Morimoto, M., Ogawa, R., Takahashi, H., Mitsui, A., Kimura, M., Takiguchi, S."Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer". Oncology Reports 50.3 (2023): 164.
Chicago
Murase, H., Matsuo, Y., Denda, Y., Nonoyama, K., Kato, T., Aoyama, Y., Hayashi, Y., Imafuji, H., Saito, K., Morimoto, M., Ogawa, R., Takahashi, H., Mitsui, A., Kimura, M., Takiguchi, S."Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer". Oncology Reports 50, no. 3 (2023): 164. https://doi.org/10.3892/or.2023.8601
Copy and paste a formatted citation
x
Spandidos Publications style
Murase H, Matsuo Y, Denda Y, Nonoyama K, Kato T, Aoyama Y, Hayashi Y, Imafuji H, Saito K, Morimoto M, Morimoto M, et al: Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer. Oncol Rep 50: 164, 2023.
APA
Murase, H., Matsuo, Y., Denda, Y., Nonoyama, K., Kato, T., Aoyama, Y. ... Takiguchi, S. (2023). Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer. Oncology Reports, 50, 164. https://doi.org/10.3892/or.2023.8601
MLA
Murase, H., Matsuo, Y., Denda, Y., Nonoyama, K., Kato, T., Aoyama, Y., Hayashi, Y., Imafuji, H., Saito, K., Morimoto, M., Ogawa, R., Takahashi, H., Mitsui, A., Kimura, M., Takiguchi, S."Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer". Oncology Reports 50.3 (2023): 164.
Chicago
Murase, H., Matsuo, Y., Denda, Y., Nonoyama, K., Kato, T., Aoyama, Y., Hayashi, Y., Imafuji, H., Saito, K., Morimoto, M., Ogawa, R., Takahashi, H., Mitsui, A., Kimura, M., Takiguchi, S."Upregulation of integrin‑linked kinase enhances tumor progression in gemcitabine‑resistant pancreatic cancer". Oncology Reports 50, no. 3 (2023): 164. https://doi.org/10.3892/or.2023.8601
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