Open Access

Targeting the deubiquitinase USP2 for malignant tumor therapy (Review)

  • Authors:
    • Shilong Zhang
    • Yi Guo
    • Shenjie Zhang
    • Zhi Wang
    • Yewei Zhang
    • Shi Zuo
  • View Affiliations

  • Published online on: August 7, 2023     https://doi.org/10.3892/or.2023.8613
  • Article Number: 176
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The ubiquitin‑proteasome system is a major degradation pathway for >80% of proteins in vivo. Deubiquitylases, which remove ubiquitinated tags to stabilize substrate proteins, are important components involved in regulating the degradation of ubiquitinated proteins. In addition, they serve multiple roles in tumor development by participating in physiological processes such as protein metabolism, cell cycle regulation, DNA damage repair and gene transcription. The present review systematically summarized the role of ubiquitin‑specific protease 2 (USP2) in malignant tumors and the specific molecular mechanisms underlying the involvement of USP2 in tumor‑associated pathways. USP2 reverses ubiquitin‑mediated degradation of proteins and is involved in aberrant proliferation, migration, invasion, apoptosis and drug resistance of tumors. Additionally, the present review summarized studies reporting on the use of USP2 as a therapeutic target for malignancies such as breast, liver, ovarian, colorectal, bladder and prostate cancers and glioblastoma and highlights the current status of pharmacological research on USP2. The clinical significance of USP2 as a therapeutic target for malignant tumors warrants further investigation.
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October-2023
Volume 50 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang S, Guo Y, Zhang S, Wang Z, Zhang Y and Zuo S: Targeting the deubiquitinase <em>USP2</em> for malignant tumor therapy (Review). Oncol Rep 50: 176, 2023
APA
Zhang, S., Guo, Y., Zhang, S., Wang, Z., Zhang, Y., & Zuo, S. (2023). Targeting the deubiquitinase <em>USP2</em> for malignant tumor therapy (Review). Oncology Reports, 50, 176. https://doi.org/10.3892/or.2023.8613
MLA
Zhang, S., Guo, Y., Zhang, S., Wang, Z., Zhang, Y., Zuo, S."Targeting the deubiquitinase <em>USP2</em> for malignant tumor therapy (Review)". Oncology Reports 50.4 (2023): 176.
Chicago
Zhang, S., Guo, Y., Zhang, S., Wang, Z., Zhang, Y., Zuo, S."Targeting the deubiquitinase <em>USP2</em> for malignant tumor therapy (Review)". Oncology Reports 50, no. 4 (2023): 176. https://doi.org/10.3892/or.2023.8613