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Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)

  • Authors:
    • Tian Xinyuan
    • Yu Lei
    • Shi Jianping
    • Zhao Rongwei
    • Shi Ruiwen
    • Zhang Ye
    • Zhao Jing
    • Tian Chunfang
    • Cui Hongwei
    • Guan Haibin
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010107, P.R. China, Department of Pharmacy, Traditional Chinese Medicine Hospital of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia Autonomous Region 010020, P.R. China, School of Traditional Chinese Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010107, P.R. China, Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China, Department of Oncology, Traditional Chinese Medicine Hospital of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia Autonomous Region 010020, P.R. China, Department of Scientific Research, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010020, P.R. China
    Copyright: © Xinyuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 181
    |
    Published online on: August 22, 2023
       https://doi.org/10.3892/or.2023.8618
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Abstract

As a protector of human health, the gut microbiota plays an important role in the development of the immune system during childhood, and the regulation of dietary habits, metabolism and immune system during adulthood. Dysregulated gut flora is not pathogenic, but it can weaken the protective effect of the immune system and cause various diseases. The tumor microenvironment is a physiological environment formed during tumor growth, which provides nutrients and growth factors necessary for tumor growth. As an important factor affecting the tumor microenvironment, the intestinal microflora affects the development of tumors through the mechanisms of gut and microflora metabolites, gene toxins and signaling pathways. The present article aimed to review the components and mechanisms of action, clinical applications, and biological targets of gut microbiota in the regulation of the tumor microenvironment. The present review provides novel insights for the future use of intestinal flora, to regulate the tumor microenvironment, to intervene in the occurrence, development, treatment and prognosis of tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Xinyuan T, Lei Y, Jianping S, Rongwei Z, Ruiwen S, Ye Z, Jing Z, Chunfang T, Hongwei C, Haibin G, Haibin G, et al: Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review). Oncol Rep 50: 181, 2023.
APA
Xinyuan, T., Lei, Y., Jianping, S., Rongwei, Z., Ruiwen, S., Ye, Z. ... Haibin, G. (2023). Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review). Oncology Reports, 50, 181. https://doi.org/10.3892/or.2023.8618
MLA
Xinyuan, T., Lei, Y., Jianping, S., Rongwei, Z., Ruiwen, S., Ye, Z., Jing, Z., Chunfang, T., Hongwei, C., Haibin, G."Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)". Oncology Reports 50.4 (2023): 181.
Chicago
Xinyuan, T., Lei, Y., Jianping, S., Rongwei, Z., Ruiwen, S., Ye, Z., Jing, Z., Chunfang, T., Hongwei, C., Haibin, G."Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)". Oncology Reports 50, no. 4 (2023): 181. https://doi.org/10.3892/or.2023.8618
Copy and paste a formatted citation
x
Spandidos Publications style
Xinyuan T, Lei Y, Jianping S, Rongwei Z, Ruiwen S, Ye Z, Jing Z, Chunfang T, Hongwei C, Haibin G, Haibin G, et al: Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review). Oncol Rep 50: 181, 2023.
APA
Xinyuan, T., Lei, Y., Jianping, S., Rongwei, Z., Ruiwen, S., Ye, Z. ... Haibin, G. (2023). Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review). Oncology Reports, 50, 181. https://doi.org/10.3892/or.2023.8618
MLA
Xinyuan, T., Lei, Y., Jianping, S., Rongwei, Z., Ruiwen, S., Ye, Z., Jing, Z., Chunfang, T., Hongwei, C., Haibin, G."Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)". Oncology Reports 50.4 (2023): 181.
Chicago
Xinyuan, T., Lei, Y., Jianping, S., Rongwei, Z., Ruiwen, S., Ye, Z., Jing, Z., Chunfang, T., Hongwei, C., Haibin, G."Advances in the role of gut microbiota in the regulation of the tumor microenvironment (Review)". Oncology Reports 50, no. 4 (2023): 181. https://doi.org/10.3892/or.2023.8618
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