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The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)

  • Authors:
    • Chaozhe Wang
    • Xidi Wang
    • Danfeng Zhang
    • Xiaolin Sun
    • Yunhua Wu
    • Jing Wang
    • Qing Li
    • Guosheng Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, College of Basic Medicine, Binzhou Medical University, Yantai, Shandong 2640032, P.R. China, Department of Laboratory Medicine, Zhangqiu People's Hospital, Jinan, Shandong 250200, P.R. China, Department of Laboratory Medicine, Lixia People's Hospital, Jinan, Shandong 250013, P.R. China, Department of Laboratory Medicine, Zibo First Hospital, Zibo, Shandong 255200, P.R. China, Department of Immunology, Shandong Yinfeng Academy of Life Science, Jinan, Shandong 250013, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 190
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    Published online on: September 12, 2023
       https://doi.org/10.3892/or.2023.8627
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Abstract

The characteristics of monocyte/macrophage lineage are diversity and plasticity, mainly manifested by M1 and M2 subtypes in the body tissues, and playing different roles in the immunity. In the polarization process of macrophages, the classic molecular mechanism is related to sequential transcription factors. Whether in tumor or inflammatory local microenvironment, the pathological factors of the local microenvironment often affect the polarization of M1 and M2 macrophages, and participate in the occurrence and development of these pathological processes. In recent years, a growing number of research results demonstrated that non‑coding RNA (ncRNA) also participates in the polarization process of macrophages, in addition to traditional cytokines and transcriptional regulation signal pathway molecules. Among numerous ncRNAs, microRNAs (miRNAs) have attracted more attention from scholars both domestically and internationally, and significant progress has been made in basic and clinical research. Therefore, for improved understanding of the molecular mechanism of miRNAs in macrophage polarization and analysis of the potential value of this regulatory pathway in tumor and inflammatory intervention therapy, a comprehensive review of the progress of relevant literature research was conducted and some viewpoints and perspectives were proposed.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Wang X, Zhang D, Sun X, Wu Y, Wang J, Li Q and Jiang G: The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review). Oncol Rep 50: 190, 2023.
APA
Wang, C., Wang, X., Zhang, D., Sun, X., Wu, Y., Wang, J. ... Jiang, G. (2023). The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review). Oncology Reports, 50, 190. https://doi.org/10.3892/or.2023.8627
MLA
Wang, C., Wang, X., Zhang, D., Sun, X., Wu, Y., Wang, J., Li, Q., Jiang, G."The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)". Oncology Reports 50.4 (2023): 190.
Chicago
Wang, C., Wang, X., Zhang, D., Sun, X., Wu, Y., Wang, J., Li, Q., Jiang, G."The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)". Oncology Reports 50, no. 4 (2023): 190. https://doi.org/10.3892/or.2023.8627
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Wang X, Zhang D, Sun X, Wu Y, Wang J, Li Q and Jiang G: The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review). Oncol Rep 50: 190, 2023.
APA
Wang, C., Wang, X., Zhang, D., Sun, X., Wu, Y., Wang, J. ... Jiang, G. (2023). The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review). Oncology Reports, 50, 190. https://doi.org/10.3892/or.2023.8627
MLA
Wang, C., Wang, X., Zhang, D., Sun, X., Wu, Y., Wang, J., Li, Q., Jiang, G."The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)". Oncology Reports 50.4 (2023): 190.
Chicago
Wang, C., Wang, X., Zhang, D., Sun, X., Wu, Y., Wang, J., Li, Q., Jiang, G."The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)". Oncology Reports 50, no. 4 (2023): 190. https://doi.org/10.3892/or.2023.8627
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