Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
December-2023 Volume 50 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2023 Volume 50 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
    • Supplementary_Data3.pdf
    • Supplementary_Data4.pdf
Article Open Access

Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner

  • Authors:
    • Da Young Lee
    • Sanghoon Lee
    • Young Sik Kim
    • Soonbum Park
    • Sang-Mun Bae
    • Eun A Cho
    • Eun-Jung Park
    • Hyun Ho Park
    • Sang-Yeob Kim
    • Insuk So
    • Jung Nyeo Chun
    • Ju-Hong Jeon
  • View Affiliations / Copyright

    Affiliations: Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea, ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine, Seoul 05535, Republic of Korea, Department of Food and Nutrition, Gachon University College of BioNano Technology, Gyeonggi‑do 13120, Republic of Korea, College of Pharmacy, Chung‑Ang University, Seoul 06974, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 218
    |
    Published online on: October 25, 2023
       https://doi.org/10.3892/or.2023.8655
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The treatment of advanced prostate cancer remains a formidable challenge due to the limited availability of effective treatment options. Therefore, it is imperative to identify promising druggable targets that provide substantial clinical benefits and to develop effective treatment strategies to overcome therapeutic resistance. Cyclosporin A (CsA) showed an anticancer effect on prostate cancer in cultured cell and xenograft models. E2F8 was identified as a master transcription factor that regulated a clinically significant CsA specific gene signature. The expression of E2F8 increased during prostate cancer progression and high levels of E2F8 expression are associated with a poor prognosis in patients with prostate cancer. MELK was identified as a crucial upstream regulator of E2F8 expression through the transcriptional regulatory network and Bayesian network analyses. Knockdown of E2F8 or MELK inhibited cell growth and colony formation in prostate cancer cells. High expression levels of E2F8 and androgen receptor (AR) are associated with a worse prognosis in patients with prostate cancer compared with low levels of both genes. The inhibition of E2F8 improved the response to AR blockade therapy. These results suggested that CsA has potential as an effective anticancer treatment for prostate cancer, while also revealing the oncogenic role of E2F8 and its association with clinical outcomes in prostate cancer. These results provided valuable insight into the development of therapeutic and diagnostic approaches for prostate cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Carceles-Cordon M, Kelly WK, Gomella L, Knudsen KE, Rodriguez-Bravo V and Domingo-Domenech J: Cellular rewiring in lethal prostate cancer: The architect of drug resistance. Nat Rev Urol. 17:292–307. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Attard G, Parker C, Eeles RA, Schröder F, Tomlins SA, Tannock I, Drake CG and de Bono JS: Prostate cancer. Lancet. 387:70–82. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Litwin MS and Tan HJ: The diagnosis and treatment of prostate cancer: A review. JAMA. 317:2532–2542. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Sandhu S, Moore CM, Chiong E, Beltran H, Bristow RG and Williams SG: Prostate cancer. Lancet. 398:1075–1090. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Yap TA, Smith AD, Ferraldeschi R, Al-Lazikani B, Workman P and de Bono JS: Drug discovery in advanced prostate cancer: Translating biology into therapy. Nat Rev Drug Discov. 15:699–718. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Ku SY, Gleave ME and Beltran H: Towards precision oncology in advanced prostate cancer. Nat Rev Urol. 16:645–654. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Matsuda S and Koyasu S: Mechanisms of action of cyclosporine. Immunopharmacology. 47:119–125. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Tedesco D and Haragsim L: Cyclosporine: A review. J Transplant. 2012:2303862012.PubMed/NCBI

9 

Periyasamy S, Hinds T Jr, Shemshedini L, Shou W and Sanchez ER: FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. Oncogene. 29:1691–1701. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Lee CR, Chun JN, Kim SY, Park S, Kim SH, Park EJ, Kim IS, Cho NH, Kim IG, So I, et al: Cyclosporin A suppresses prostate cancer cell growth through CaMKKβ/AMPK-mediated inhibition of mTORC1 signaling. Biochem Pharmacol. 84:425–431. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Krishnamurthy A, Dasari A, Noonan AM, Mehnert JM, Lockhart AC, Leong S, Capasso A, Stein MN, Sanoff HK, Lee JJ, et al: Phase Ib results of the rational combination of selumetinib and cyclosporin A in advanced solid tumors with an expansion cohort in metastatic colorectal cancer. Cancer Res. 78:5398–5407. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Flores C, Fouquet G, Moura IC, Maciel TT and Hermine O: Lessons to learn from low-dose cyclosporin-A: A new approach for unexpected clinical applications. Front Immunol. 10:5882019. View Article : Google Scholar : PubMed/NCBI

13 

Isshiki Y, Tanaka H, Suzuki Y and Yoshida Y: Cyclosporine is a potential curative treatment option for advanced thymoma. Exp Hematol Oncol. 6:132017. View Article : Google Scholar : PubMed/NCBI

14 

Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, et al: Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell. 14:62–75. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Park SA, Platt J, Lee JW, López-Giráldez F, Herbst RS and Koo JS: E2F8 as a novel therapeutic target for lung cancer. J Natl Cancer Inst. 107:djv1512015. View Article : Google Scholar : PubMed/NCBI

16 

Deng Q, Wang Q, Zong WY, Zheng DL, Wen YX, Wang KS, Teng XM, Zhang X, Huang J and Han ZG: E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation. Cancer Res. 70:782–791. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Lee DY, Chun JN, Cho M, So I and Jeon JH: Emerging role of E2F8 in human cancer. Biochim Biophys Acta Mol Basis Dis. 1869:1667452023. View Article : Google Scholar : PubMed/NCBI

18 

Kim SH, Lee S, Piccolo SR, Allen-Brady K, Park EJ, Chun JN, Kim TW, Cho NH, Kim IG, So I and Jeon JH: Menthol induces cell-cycle arrest in PC-3 cells by down-regulating G2/M genes, including polo-like kinase 1. Biochem Biophys Res Commun. 422:436–441. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Chun JN, Kim SY, Park EJ, Kwon EJ, Bae DJ, Kim IS, Kim HK, Park JK, Lee SW, Park HH, et al: Schisandrin B suppresses TGFβ1-induced stress fiber formation by inhibiting myosin light chain phosphorylation. J Ethnopharmacol. 152:364–371. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Lee S, Chun JN, Kim SH, So I and Jeon JH: Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer. Biochem Biophys Res Commun. 441:1005–1010. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Lee S, Park YR, Kim SH, Park EJ, Kang MJ, So I, Chun JN and Jeon JH: Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 5:2899–2908. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Chun JN, Park S, Lee S, Kim JK, Park EJ, Kang M, Kim HK, Park JK, So I and Jeon JH: Schisandrol B and schisandrin B inhibit TGFβ1-mediated NF-κB activation via a Smad-independent mechanism. Oncotarget. 9:3121–3130. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Johnson WE, Li C and Rabinovic A: Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 8:118–127. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Lee S, Piccolo SR and Allen-Brady K: Robust meta-analysis shows that glioma transcriptional subtyping complements traditional approaches. Cell Oncol (Dordr). 37:317–329. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Floratos A, Smith K, Ji Z, Watkinson J and Califano A: geWorkbench: An open source platform for integrative genomics. Bioinformatics. 26:1779–1780. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Margolin AA, Nemenman I, Basso K, Wiggins C, Stolovitzky G, Dalla Favera R and Califano A: ARACNE: An algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics. 7 (Suppl 1):S72006. View Article : Google Scholar : PubMed/NCBI

27 

Tusher VG, Tibshirani R and Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 98:5116–5121. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Kig C, Beullens M, Beke L, Van Eynde A, Linders JT, Brehmer D and Bollen M: Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells. J Biol Chem. 292:127862017. View Article : Google Scholar : PubMed/NCBI

30 

Kim SH, Kim SY, Park EJ, Kim J, Park HH, So I, Kim SJ and Jeon JH: Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner. Biochem Biophys Res Commun. 406:30–35. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Kuang J, Yan X, Genders AJ, Granata C and Bishop DJ: An overview of technical considerations when using quantitative real-time PCR analysis of gene expression in human exercise research. PLoS One. 13:e01964382018. View Article : Google Scholar : PubMed/NCBI

32 

Wang J, Wang Y, Shen F, Xu Y, Zhang Y, Zou X, Zhou J and Chen Y: Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target of cervical cancer. Cancer Med. 7:5665–5678. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Ramsey J, Glymour M, Sanchez-Romero R and Glymour C: A million variables and more: the fast greedy equivalence search algorithm for learning high-dimensional graphical causal models, with an application to functional magnetic resonance images. Int J Data Sci Anal. 3:121–129. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Goldman MJ, Craft B, Hastie M, Repečka K, McDade F, Kamath A, Banerjee A, Luo Y, Rogers D, Brooks AN, et al: Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 38:675–678. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Balwierz PJ, Pachkov M, Arnold P, Gruber AJ, Zavolan M and van Nimwegen E: ISMARA: Automated modeling of genomic signals as a democracy of regulatory motifs. Genome Res. 24:869–884. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Park YR, Chun JN, So I, Kim HJ, Baek S, Jeon JH and Shin SY: Data-driven analysis of TRP channels in cancer: Linking variation in gene expression to clinical significance. Cancer Genomics Proteomics. 13:83–90. 2016.PubMed/NCBI

37 

Park S, Lim JM, Chun JN, Lee S, Kim TM, Kim DW, Kim SY, Bae DJ, Bae SM, So I, et al: Altered expression of fucosylation pathway genes is associated with poor prognosis and tumor metastasis in non-small cell lung cancer. Int J Oncol. 56:559–567. 2020.PubMed/NCBI

38 

Yu J, Smith VA, Wang PP, Hartemink AJ and Jarvis ED: Advances to Bayesian network inference for generating causal networks from observational biological data. Bioinformatics. 20:3594–3603. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Wang YX and Huang H: Review on statistical methods for gene network reconstruction using expression data. J Theor Biol. 362:53–61. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Chun JN, Cho M, Park S, So I and Jeon JH: The conflicting role of E2F1 in prostate cancer: A matter of cell context or interpretational flexibility? Biochim Biophys Acta Rev Cancer. 1873:1883362020. View Article : Google Scholar : PubMed/NCBI

41 

Taplin ME, Bubley GJ, Shuster TD, Frantz ME, Spooner AE, Ogata GK, Keer HN and Balk SP: Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med. 332:1393–1398. 1995. View Article : Google Scholar : PubMed/NCBI

42 

Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, et al: The mutational landscape of lethal castration-resistant prostate cancer. Nature. 487:239–243. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Shafi AA, Yen AE and Weigel NL: Androgen receptors in hormone-dependent and castration-resistant prostate cancer. Pharmacol Ther. 140:223–238. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G, et al: Integrative clinical genomics of advanced prostate cancer. Cell. 161:1215–1228. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Kuner R, Fälth M, Pressinotti NC, Brase JC, Puig SB, Metzger J, Gade S, Schäfer G, Bartsch G, Steiner E, et al: The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer. J Mol Med (Berl). 91:237–248. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Jurmeister S, Ramos-Montoya A, Sandi C, Pértega-Gomes N, Wadhwa K, Lamb AD, Dunning MJ, Attig J, Carroll JS, Fryer LG, et al: Identification of potential therapeutic targets in prostate cancer through a cross-species approach. EMBO Mol Med. 10:e82742018. View Article : Google Scholar : PubMed/NCBI

47 

Sharma NL, Massie CE, Ramos-Montoya A, Zecchini V, Scott HE, Lamb AD, MacArthur S, Stark R, Warren AY, Mills IG and Neal DE: The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man. Cancer Cell. 23:35–47. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lee DY, Lee S, Kim YS, Park S, Bae S, Cho EA, Park E, Park HH, Kim S, So I, So I, et al: Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner. Oncol Rep 50: 218, 2023.
APA
Lee, D.Y., Lee, S., Kim, Y.S., Park, S., Bae, S., Cho, E.A. ... Jeon, J. (2023). Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner. Oncology Reports, 50, 218. https://doi.org/10.3892/or.2023.8655
MLA
Lee, D. Y., Lee, S., Kim, Y. S., Park, S., Bae, S., Cho, E. A., Park, E., Park, H. H., Kim, S., So, I., Chun, J. N., Jeon, J."Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner". Oncology Reports 50.6 (2023): 218.
Chicago
Lee, D. Y., Lee, S., Kim, Y. S., Park, S., Bae, S., Cho, E. A., Park, E., Park, H. H., Kim, S., So, I., Chun, J. N., Jeon, J."Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner". Oncology Reports 50, no. 6 (2023): 218. https://doi.org/10.3892/or.2023.8655
Copy and paste a formatted citation
x
Spandidos Publications style
Lee DY, Lee S, Kim YS, Park S, Bae S, Cho EA, Park E, Park HH, Kim S, So I, So I, et al: Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner. Oncol Rep 50: 218, 2023.
APA
Lee, D.Y., Lee, S., Kim, Y.S., Park, S., Bae, S., Cho, E.A. ... Jeon, J. (2023). Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner. Oncology Reports, 50, 218. https://doi.org/10.3892/or.2023.8655
MLA
Lee, D. Y., Lee, S., Kim, Y. S., Park, S., Bae, S., Cho, E. A., Park, E., Park, H. H., Kim, S., So, I., Chun, J. N., Jeon, J."Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner". Oncology Reports 50.6 (2023): 218.
Chicago
Lee, D. Y., Lee, S., Kim, Y. S., Park, S., Bae, S., Cho, E. A., Park, E., Park, H. H., Kim, S., So, I., Chun, J. N., Jeon, J."Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner". Oncology Reports 50, no. 6 (2023): 218. https://doi.org/10.3892/or.2023.8655
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team