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Review Open Access

The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review)

  • Authors:
    • Zhinan Cheng
    • Hongwei Cui
    • Yaqi Wang
    • Jin Yang
    • Chunyang Lin
    • Xiaoyu Shi
    • Yuxiu Zou
    • Jing Chen
    • Xiaoqiong Jia
    • Liqing Su
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010000, P.R. China, Scientific Research Department, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Inner Mongolia Cancer Center, Hohhot, Inner Mongolia Autonomous Region 010000, P.R. China, Laboratory of Molecular Tumor Diagnosis, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010000, P.R. China, Children's Ultrasound Department, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Oncology, Bayan Nur Hospital, Bayan Nur, Inner Mongolia Autonomous Region 015000, P.R. China, Department of Medicine, Ordos Institute of Technology, Ordos, Inner Mongolia Autonomous Region 017000, P.R. China, Department of Medical Oncology, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Huimin, Hohhot, Inner Mongolia Autonomous Region 010000, P.R. China, Department of Respiratory Medicine, Affiliated Hospital of Inner Mongolia Medical University, Huimin, Hohhot, Inner Mongolia Autonomous Region 010000, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 16
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    Published online on: December 5, 2023
       https://doi.org/10.3892/or.2023.8675
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Abstract

Lung cancer is currently the second most common type of cancer with the second incidence rate and the first mortality rate worldwide. Non‑small cell lung cancer (NSCLC) accounts for ~85% of the total number of cases of lung cancers. Concerning the treatment of NSCLC, targeted therapy has become a research hotspot in recent years because of its favorable efficacy, high selectivity and minimal adverse reactions. Among the drugs used in targeted therapy, the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the most common and are categorized into four generations. The use of first and second‑generation drugs leads to drug resistance within 8‑14 months. This resistance is primarily caused by the T790M mutation, which is the most observed mechanism. A third‑generation drug has been developed to address this issue and a fourth‑generation drug is expected to overcome multiple resistance mechanisms, including third‑generation drug resistance. However, the fourth‑generation drug has not been launched yet. At present, multiple third‑generation targeted drugs have been launched globally, with three being launched in China and several being at research and clinical trial stages. The present article provides a review of the development process, mechanism of action and clinical trials of the third‑generation EGFR‑TKIs, aiming to provide some reference and suggestions for the clinical treatment of NSCLC and scientific research on third‑generation targeted drugs.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng Z, Cui H, Wang Y, Yang J, Lin C, Shi X, Zou Y, Chen J, Jia X, Su L, Su L, et al: The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review). Oncol Rep 51: 16, 2024.
APA
Cheng, Z., Cui, H., Wang, Y., Yang, J., Lin, C., Shi, X. ... Su, L. (2024). The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review). Oncology Reports, 51, 16. https://doi.org/10.3892/or.2023.8675
MLA
Cheng, Z., Cui, H., Wang, Y., Yang, J., Lin, C., Shi, X., Zou, Y., Chen, J., Jia, X., Su, L."The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review)". Oncology Reports 51.1 (2024): 16.
Chicago
Cheng, Z., Cui, H., Wang, Y., Yang, J., Lin, C., Shi, X., Zou, Y., Chen, J., Jia, X., Su, L."The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review)". Oncology Reports 51, no. 1 (2024): 16. https://doi.org/10.3892/or.2023.8675
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Z, Cui H, Wang Y, Yang J, Lin C, Shi X, Zou Y, Chen J, Jia X, Su L, Su L, et al: The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review). Oncol Rep 51: 16, 2024.
APA
Cheng, Z., Cui, H., Wang, Y., Yang, J., Lin, C., Shi, X. ... Su, L. (2024). The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review). Oncology Reports, 51, 16. https://doi.org/10.3892/or.2023.8675
MLA
Cheng, Z., Cui, H., Wang, Y., Yang, J., Lin, C., Shi, X., Zou, Y., Chen, J., Jia, X., Su, L."The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review)". Oncology Reports 51.1 (2024): 16.
Chicago
Cheng, Z., Cui, H., Wang, Y., Yang, J., Lin, C., Shi, X., Zou, Y., Chen, J., Jia, X., Su, L."The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review)". Oncology Reports 51, no. 1 (2024): 16. https://doi.org/10.3892/or.2023.8675
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