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Article

A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules

  • Authors:
    • Vijaya Iragavarapu‑Charyulu
    • Rojesh Shakya
    • Philip Robinson
    • Esther Guzmán
    • Anastasia Tyulmenkova
    • Jose Labrador Pino
    • Ceylan Isgor
  • View Affiliations / Copyright

    Affiliations: Department of Basic Sciences, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431‑0991, USA, Department of Clinical Sciences, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431‑0991, USA, Harbor Branch Oceanographic Institute at Florida Atlantic University, 5600 US 1 North, Fort Pierce, FL 34946‑7331, USA
  • Article Number: 31
    |
    Published online on: December 22, 2023
       https://doi.org/10.3892/or.2023.8690
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Abstract

Patients with end‑stage metastatic disease have limited treatment options and those diagnosed with triple negative breast cancer (Her2, Estrogen receptor, Progesterone receptor) have a poor prognosis. Using a triple negative mammary tumor model selected for brain metastasis (4T1Br4) in the mouse, treatment options that may increase survival when therapeutics are applied at post‑metastasis were assessed. Anti‑parasitic benzimidazoles (BZs) destabilize microtubules, inhibit metabolic pathways, reduce cell proliferation, and induce apoptosis in tumor cells. Co‑administration of two BZs was selected, oxfendazole (OFZ) and parbendazole (PBZ), shown to overcome resistance development in anthelmintic effects by imposing metabolic delay to assess if multiple BZ approach is also suitable to enhance anticancer effects. It has been previously reported that treatment of mammary tumor‑bearing mice at an early stage with chitin microparticles (CMPs) decreased tumor growth and metastases by enhancing both innate M1 macrophage and TH1 adaptive immune response. Oral administration of CMPs was previously revealed to affect the gut in intestinal inflammation. A combination BZ (OFZ/PBZ) and CMP treatment was tested to target tumor development and metastasis and effects were compared in response to monotherapies of the same compounds or to untreated mice. The results demonstrated increased survival, decreased tumor cell proliferation, decreased metastasis in lungs and brain, increased levels of fecal SCFAs butyric, acetic, propionic and valeric acids with increased butyric and propionic acid levels in brain biopsies in combination treated compared with untreated mice. At the primary tumor, SCFA receptor FFAR2 expression was increased in combination treatment compared with untreated mice, suggestive of a non‑invasive cancer phenotype. The superior cytotoxic effects of OFZ/PBZ were confirmed as opposed to single treatment with OFZ or PBZ using 3D spheroids generated from a human breast cancer cell line, MDA‑MB‑468. These data are compelling for treatment option possibility even at late stages of metastasized breast cancer.
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1 

Bou Zerdan M, Ghorayeb T, Saliba F, Allam S, Bou Zerdan M, Yaghi M, Bilani N, Jaafar R and Nahleh Z: Triple negative breast cancer: Updates on classification and treatment in 2021. Cancers (Basel). 14:12532022. View Article : Google Scholar : PubMed/NCBI

2 

Li X, Yang J, Peng L, Sahin AA, Huo L, Ward KC, O'Regan R, Torres MA and Meisel JL: Triple-negative breast cancer has worse overall survival and cause-specific survival than non-triple-negative breast cancer. Breast Cancer Res Treat. 161:279–287. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Jhan JR and Andrechek ER: Triple-negative breast cancer and the potential for targeted therapy. Pharmacogenomics. 18:1595–1609. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Tutt ANJ, Garber JE and Geyer CE Jr: Adjuvant olaparib in BRCA-mutated breast cancer. Reply. N Engl J Med. 385:14402021.PubMed/NCBI

5 

Yin J, Zhou C, Wang G and Gu J: Treatment for triple-negative breast cancer: An umbrella review of meta-analyses. Int J Gen Med. 15:5901–5914. 2022. View Article : Google Scholar : PubMed/NCBI

6 

Zagami P and Carey LA: Triple negative breast cancer: Pitfalls and progress. NPJ Breast Cancer. 8:952022. View Article : Google Scholar : PubMed/NCBI

7 

Baranova A, Krasnoselskyi M, Starikov V, Kartashov S, Zhulkevych I, Vlasenko V, Oleshko K, Bilodid O, Sadchikova M and Vinnyk Y: Triple-negative breast cancer: Current treatment strategies and factors of negative prognosis. J Med Life. 15:153–161. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Pedersen RN, Esen BÖ, Mellemkjær L, Christiansen P, Ejlertsen B, Lash TL, Nørgaard M and Cronin-Fenton D: The incidence of breast cancer recurrence 10–32 years after primary diagnosis. J Natl Cancer Inst. 114:391–399. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Landry I, Sumbly V and Vest M: Advancements in the treatment of triple-negative breast cancer: A narrative review of the literature. Cureus. 14:e219702022.PubMed/NCBI

10 

Buchta Rosean C, Bostic RR, Ferey JCM, Feng TY, Azar FN, Tung KS, Dozmorov MG, Smirnova E, Bos PD and Rutkowski MR: Preexisting commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer. Cancer Res. 79:3662–3675. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Kim CH: Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids. Cell Mol Immunol. 18:1161–1171. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Rossi T, Vergara D, Fanini F, Maffia M, Bravaccini S and Pirini F: Microbiota-derived metabolites in tumor progression and metastasis. Int J Mol Sci. 21:57862020. View Article : Google Scholar : PubMed/NCBI

13 

Thirunavukkarasan M, Wang C, Rao A, Hind T, Teo YR, Siddiquee AA, Goghari MAI, Kumar AP and Herr DR: Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells. PLoS One. 12:e01863342017. View Article : Google Scholar : PubMed/NCBI

14 

Son DS, Lee ES and Adunyah SE: The antitumor potentials of benzimidazole anthelmintics as repurposing drugs. Immune Netw. 20:e292020. View Article : Google Scholar : PubMed/NCBI

15 

Bai RY, Staedtke V, Wanjiku T, Rudek MA, Joshi A, Gallia GL and Riggins GJ: Brain penetration and efficacy of different mebendazole polymorphs in a mouse brain tumor model. Clin Cancer Res. 21:3462–3470. 2015. View Article : Google Scholar : PubMed/NCBI

16 

De Witt M, Gamble A, Hanson D, Markowitz D, Powell C, Al Dimassi S, Atlas M, Boockvar J, Ruggieri R and Symons M: Repurposing mebendazole as a replacement for vincristine for the treatment of brain tumors. Mol Med. 23:50–56. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Bai RY, Staedtke V, Aprhys CM, Gallia GL and Riggins GJ: Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro Oncol. 13:974–982. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Zhang L, Bochkur Dratver M, Yazal T, Dong K, Nguyen A, Yu G, Dao A, Bochkur Dratver M, Duhachek-Muggy S, Bhat K, et al: Mebendazole potentiates radiation therapy in triple-negative breast cancer. Int J Radiat Oncol Biol Phys. 103:195–207. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Gao P, Dang CV and Watson J: Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. J Am Assoc Lab Anim Sci. 47:37–40. 2008.PubMed/NCBI

20 

Choi HS, Ko YS, Jin H, Kang KM, Ha IB, Jeong H, Song HN, Kim HJ and Jeong BK: Anticancer effect of benzimidazole derivatives, especially mebendazole, on triple-negative breast cancer (TNBC) and radiotherapy-resistant TNBC in vivo and in vitro. Molecules. 26:51182021. View Article : Google Scholar : PubMed/NCBI

21 

Laudisi F, Marônek M, Di Grazia A, Monteleone G and Stolfi C: Repositioning of anthelmintic drugs for the treatment of cancers of the digestive system. Int J Mol Sci. 21:49572020. View Article : Google Scholar : PubMed/NCBI

22 

Hori A, Imaeda Y, Kubo K and Kusaka M: Novel benzimidazole derivatives selectively inhibit endothelial cell growth and suppress angiogenesis in vitro and in vivo. Cancer Lett. 183:53–60. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Mrkvová Z, Uldrijan S, Pombinho A, Bartůněk P and Slaninová I: Benzimidazoles downregulate Mdm2 and MdmX and activate p53 in MdmX overexpressing tumor cells. Molecules. 24:21522019. View Article : Google Scholar : PubMed/NCBI

24 

Zhang D and Kanakkanthara A: Beyond the paclitaxel and vinca alkaloids: Next generation of plant-derived microtubule-targeting agents with potential anticancer activity. Cancers (Basel). 12:17212020. View Article : Google Scholar : PubMed/NCBI

25 

Falzone L, Bordonaro R and Libra M: SnapShot: Cancer chemotherapy. Cell. 186:1816–1816.e1. 2023. View Article : Google Scholar

26 

McGrogan BT, Gilmartin B, Carney DN and McCann A: Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta. 1785:96–132. 2008.PubMed/NCBI

27 

Dhyani P, Quispe C, Sharma E, Bahukhandi A, Sati P, Attri DC, Szopa A, Sharifi-Rad J, Docea AO, Mardare I, et al: Anticancer potential of alkaloids: A key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 22:2062022. View Article : Google Scholar : PubMed/NCBI

28 

Singh R, Bal MS, Singla LD and Kaur P: Detection of anthelmintic resistance in sheep and goat against fenbendazole by faecal egg count reduction test. J Parasit Dis. 41:463–466. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Hennessy DR, Steel JW, Prichard RK and Lacey E: The effect of co-administration of parbendazole on the disposition of oxfendazole in sheep. J Vet Pharmacol Ther. 15:10–18. 1992. View Article : Google Scholar : PubMed/NCBI

30 

Hennessy DR, Lacey E, Prichard RK and Steel JW: Potentiation of the anthelmintic activity of oxfendazole by parbendazole. J Vet Pharmacol Ther. 8:270–275. 1985. View Article : Google Scholar : PubMed/NCBI

31 

Gonzalez AE, Codd EE, Horton J, Garcia HH and Gilman RH: Oxfendazole: A promising agent for the treatment and control of helminth infections in humans. Expert Rev Anti Infect Ther. 17:51–56. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Xu D, Tian W, Jiang C, Huang Z and Zheng S: The anthelmintic agent oxfendazole inhibits cell growth in non-small cell lung cancer by suppressing c-Src activation. Mol Med Rep. 19:2921–2926. 2019.PubMed/NCBI

33 

Florio R, Veschi S, Di Giacomo V, Pagotto S, Carradori S, Verginelli F, Cirilli R, Casulli A, Grassadonia A, Tinari N, et al: The benzimidazole-based anthelmintic parbendazole: A repurposed drug candidate that synergizes with gemcitabine in pancreatic cancer. Cancers (Basel). 11:20422019. View Article : Google Scholar : PubMed/NCBI

34 

Libreros S, Garcia-Areas R, Keating P, Gazaniga N, Robinson P, Humbles A and Iragavarapu-Charyulu VL: Allergen induced pulmonary inflammation enhances mammary tumor growth and metastasis: Role of CHI3L1. J Leukoc Biol. 97:929–940. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Cai Y, Zhou J and Webb DC: Treatment of mice with fenbendazole attenuates allergic airways inflammation and Th2 cytokine production in a model of asthma. Immunol Cell Biol. 87:623–629. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Goff SL and Danforth DN: The role of immune cells in breast tissue and immunotherapy for the treatment of breast cancer. Clin Breast Cancer. 21:e63–e73. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Libreros S, Garcia-Areas R and Iragavarapu-Charyulu V: CHI3L1 plays a role in cancer through enhanced production of pro-inflammatory/pro-tumorigenic and angiogenic factors. Immunol Res. 57:99–105. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Kim SH, Redvers RP, Chi LH, Ling X, Lucke AJ, Reid RC, Fairlie DP, Martin ACBM, Anderson RL, Denoyer D and Pouliot N: Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis. Dis Model Mech. 11:DMM0348502018. View Article : Google Scholar : PubMed/NCBI

39 

Holliday DL and Speirs V: Choosing the right cell line for breast cancer research. Breast Cancer Res. 13:2152011. View Article : Google Scholar : PubMed/NCBI

40 

Kim JB, Urban K, Cochran E, Lee S, Ang A, Rice B, Bata A, Campbell K, Coffee R, Gorodinsky A, et al: Non-invasive detection of a small number of bioluminescent cancer cells in vivo. PLoS One. 5:e93642010. View Article : Google Scholar : PubMed/NCBI

41 

Erny D, Hrabě de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, et al: Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 18:965–977. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Strong P, Clark H and Reid K: Intranasal application of chitin microparticles down-regulates symptoms of allergic hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus fumigatus in murine models of allergy. Clin Exp Allergy. 32:1794–1800. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Nishiyama A, Tsuji S, Yamashita M, Henriksen RA, Myrvik QN and Shibata Y: Phagocytosis of N-acetyl-D-glucosamine particles, a Th1 adjuvant, by RAW 264.7 cells results in MAPK activation and TNF-alpha, but not IL-10, production. Cell Immunol. 239:103–112. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Workman P, Balmain A, Hickman JA, McNally NJ, Rohas AM, Mitchison NA, Pierrepoint CG, Raymond R, Rowlatt C, Stephens TC, et al: UKCCCR guidelines for the welfare of animals in experimental neoplasia. Lab Anim. 22:195–201. 1988. View Article : Google Scholar : PubMed/NCBI

45 

Montgomery C: Oncologic and toxicologic research: Alleviation and control of pain and distress in laboratory animals. Cancer Bull. 42:230–237. 1990.

46 

Ullman-Culleré MH and Foltz CJ: Body condition scoring: A rapid and accurate method for assessing health status in mice. Lab Anim Sci. 49:319–323. 1999.PubMed/NCBI

47 

Isgor C and Watson SJ: Estrogen receptor alpha and beta mRNA expressions by proliferating and differentiating cells in the adult rat dentate gyrus and subventricular zone. Neuroscience. 134:847–856. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Shihan MH, Novo SG, Le Marchand SJ, Wang Y and Duncan MK: A simple method for quantitating confocal fluorescent images. Biochem Biophys Rep. 25:1009162021.PubMed/NCBI

49 

Han J, Lin K, Sequeira C and Borchers CH: An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography-tandem mass spectrometry. Anal Chim Acta. 854:86–94. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Saha S, Day-Walsh P, Shehata E and Kroon PA: Development and validation of a LC-MS/MS technique for the analysis of short chain fatty acids in tissues and biological fluids without derivatisation using isotope labelled internal standards. Molecules 26: 6444, 2021. https://doi.org/10.3390/molecules26216444

51 

Nagatomo R, Kaneko H, Kamatsuki S, Ichimura-Shimizu M, Ishimaru N, Tsuneyama K and Inoue K: Short-chain fatty acids profiling in biological samples from a mouse model of Sjögren's syndrome based on derivatized LC-MS/MS assay. J Chromatogr B Analyt Technol Biomed Life Sci. 1210:1234322022. View Article : Google Scholar : PubMed/NCBI

52 

Guzmán EA, Pitts TP, Winder PL and Wright AE: The marine natural product furospinulosin 1 induces apoptosis in MDA-MB-231 triple negative breast cancer cell spheroids, but not in cells grown traditionally with longer treatment. Mar Drugs. 19:2492021. View Article : Google Scholar : PubMed/NCBI

53 

Das GC, Holiday D, Gallardo R and Haas C: Taxol-induced cell cycle arrest and apoptosis: Dose-response relationship in lung cancer cells of different wild-type p53 status and under isogenic condition. Cancer Lett. 165:147–153. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Mikhail AS, Eetezadi S and Allen C: Multicellular tumor spheroids for evaluation of cytotoxicity and tumor growth inhibitory effects of nanomedicines in vitro: A comparison of docetaxel-loaded block copolymer micelles and Taxotere®. PLoS One. 8:e626302013. View Article : Google Scholar : PubMed/NCBI

55 

Adcock AF, Trivedi G, Edmondson R, Spearman C and Yang L: Three-dimensional (3D) cell cultures in cell-based assays for in-vitro evaluation of anticancer drugs. J Anal Bioanal Tech. 6:2472015. View Article : Google Scholar

56 

Sazonova EV, Kopeina GS, Imyanitov EN and Zhivotovsky B: Platinum drugs and taxanes: Can we overcome resistance? Cell Death Discov. 7:1552021. View Article : Google Scholar : PubMed/NCBI

57 

Mann J, Yang N, Montpetit R, Kirschenman R, Lemieux H and Goping IS: BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis. Sci Rep. 10:3552020. View Article : Google Scholar : PubMed/NCBI

58 

Wang TH, Wang HS and Soong YK: Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together. Cancer. 88:2619–2628. 2000. View Article : Google Scholar : PubMed/NCBI

59 

Yang G, Chen S, Deng B, Tan C, Deng J, Zhu G, Yin Y and Ren W: Implication of G protein-coupled receptor 43 in intestinal inflammation: A mini-review. Front Immunol. 9:14342018. View Article : Google Scholar : PubMed/NCBI

60 

Spagnuolo PA, Hu J, Hurren R, Wang X, Gronda M, Sukhai MA, Di Meo A, Boss J, Ashali I, Beheshti Zavareh R, et al: The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood. 115:4824–4833. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Furtado LFV, de Paiva Bello ACP and Rabelo ÉML: Benzimidazole resistance in helminths: From problem to diagnosis. Acta Trop. 162:95–102. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Moudi M, Go R, Yien CYS and Nazre M: Vinca alkaloids. Int J Prev Med. 4:1231–1235. 2013.PubMed/NCBI

63 

Zhou J and Giannakakou P: Targeting microtubules for cancer chemotherapy. Curr Med Chem Anticancer Agents. 5:65–71. 2005. View Article : Google Scholar : PubMed/NCBI

64 

Redman E, Whitelaw F, Tait A, Burgess C, Bartley Y, Skuce PJ, Jackson F and Gilleard JS: The emergence of resistance to the benzimidazole anthlemintics in parasitic nematodes of livestock is characterised by multiple independent hard and soft selective sweeps. PLoS Negl Trop Dis. 9:e00034942015. View Article : Google Scholar : PubMed/NCBI

65 

Lv Y, Ma X, Du Y and Feng J: Understanding patterns of brain metastasis in triple-negative breast cancer and exploring potential therapeutic targets. Onco Targets Ther. 14:589–607. 2021. View Article : Google Scholar : PubMed/NCBI

66 

Syriac AK, Nandu NS and Leone JP: Central nervous system metastases from triple-negative breast cancer: Current treatments and future prospective. Breast Cancer (Dove Med Press). 14:1–13. 2022.PubMed/NCBI

67 

Dogra N, Kumar A and Mukhopadhyay T: Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Sci Rep. 8:119262018. View Article : Google Scholar : PubMed/NCBI

68 

Mirzaei R, Afaghi A, Babakhani S, Sohrabi MR, Hosseini-Fard SR, Babolhavaeji K, Khani Ali Akbari S, Yousefimashouf R and Karampoor S: Role of microbiota-derived short-chain fatty acids in cancer development and prevention. Biomed Pharmacother. 139:1116192021. View Article : Google Scholar : PubMed/NCBI

69 

Feitelson MA, Arzumanyan A, Medhat A and Spector I: Short-chain fatty acids in cancer pathogenesis. Cancer Metastasis Rev. 42:677–698. 2023. View Article : Google Scholar : PubMed/NCBI

70 

Dutta J, Tripathi S and Dutta PK: Progress in antimicrobial activities of chitin, chitosan and its oligosaccharides: A systematic study needs for food applications. Food Sci Technol Int. 18:3–34. 2012. View Article : Google Scholar : PubMed/NCBI

71 

Nagatani K, Wang S, Llado V, Lau CW, Li Z, Mizoguchi A, Nagler CR, Shibata Y, Reinecker HC, Mora JR and Mizoguchi E: Chitin microparticles for the control of intestinal inflammation. Inflamm Bowel Dis. 18:1698–1710. 2012. View Article : Google Scholar : PubMed/NCBI

72 

Tedelind S, Westberg F, Kjerrulf M and Vidal A: Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: A study with relevance to inflammatory bowel disease. World J Gastroenterol. 13:2826–2832. 2007. View Article : Google Scholar : PubMed/NCBI

73 

Liu Q, Tian X, Maruyama D, Arjomandi M and Prakash A: Lung immune tone via gut-lung axis: Gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2 and FFAR3 expression. Am J Physiol Lung Cell Mol Physiol. 321:L65–L68. 2021. View Article : Google Scholar : PubMed/NCBI

74 

Logsdon AF, Erickson MA, Rhea EM, Salameh TS and Banks WA: Gut reactions: How the blood-brain barrier connects the microbiome and the brain. Exp Biol Med (Maywood). 243:159–165. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W and Kunz-Schughart LA: Multicellular tumor spheroids: An underestimated tool is catching up again. J Biotechnol. 148:3–15. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Edmondson R, Broglie JJ, Adcock AF and Yang L: Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors. Assay Drug Dev Technol. 12:207–218. 2014. View Article : Google Scholar : PubMed/NCBI

77 

Riedl A, Schlederer M, Pudelko K, Stadler M, Walter S, Unterleuthner D, Unger C, Kramer N, Hengstschläger M, Kenner L, et al: Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses. J Cell Sci. 130:203–218. 2017.PubMed/NCBI

78 

Rahimifard M, Bagheri Z, Hadjighassem M, Jaktaji RP, Behroodi E, Haghi-Aminjan H, Movahed MA, Latifi H, Hosseindoost S, Zarghi A and Pourahmad J: Investigation of anti-cancer effects of new pyrazino[1,2-a]benzimidazole derivatives on human glioblastoma cells through 2D in vitro model and 3D-printed microfluidic device. Life Sci. 302:1205052022. View Article : Google Scholar : PubMed/NCBI

79 

Zhang X, Zhao J, Gao X, Pei D and Gao C: Anthelmintic drug albendazole arrests human gastric cancer cells at the mitotic phase and induces apoptosis. Exp Ther Med. 13:595–603. 2017. View Article : Google Scholar : PubMed/NCBI

80 

Liu H, Sun H, Zhang B, Liu S, Deng S, Weng Z, Zuo B, Yang J and He Y: 18F-FDG PET imaging for monitoring the early anti-tumor effect of albendazole on triple-negative breast cancer. Breast Cancer. 27:372–380. 2020. View Article : Google Scholar : PubMed/NCBI

81 

Dogra N and Mukhopadhyay T: Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: A novel antiproliferative agent with a potential therapeutic implication. J Biol Chem. 287:30625–30640. 2012. View Article : Google Scholar : PubMed/NCBI

82 

Pinto LC, Mesquita FP, Soares BM, da Silva EL, Puty B, de Oliveira EHC, Burbano RR and Montenegro RC: Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell line (AGP01). Toxicol In Vitro. 60:305–312. 2019. View Article : Google Scholar : PubMed/NCBI

83 

Chen Q, Li Y, Zhou X and Li R: Oxibendazole inhibits prostate cancer cell growth. Oncol Lett. 15:2218–2226. 2018.PubMed/NCBI

84 

Zhou F, Du J and Wang J: Albendazole inhibits HIF-1α-dependent glycolysis and VEGF expression in non-small cell lung cancer cells. Mol Cell Biochem. 428:171–178. 2017. View Article : Google Scholar : PubMed/NCBI

85 

Sung SJ, Kim HK, Hong YK and Joe YA: Autophagy is a potential target for enhancing the anti-angiogenic effect of mebendazole in endothelial cells. Biomol Ther (Seoul). 27:117–125. 2019. View Article : Google Scholar : PubMed/NCBI

86 

Kralova V, Hanušová V, Caltová K, Špaček P, Hochmalová M, Skálová L and Rudolf E: Flubendazole and mebendazole impair migration and epithelial to mesenchymal transition in oral cell lines. Chem Biol Interact. 293:124–132. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Iragavarapu‑Charyulu V, Shakya R, Robinson P, Guzmán E, Tyulmenkova A, Pino JL and Isgor C: A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules. Oncol Rep 51: 31, 2024.
APA
Iragavarapu‑Charyulu, V., Shakya, R., Robinson, P., Guzmán, E., Tyulmenkova, A., Pino, J.L., & Isgor, C. (2024). A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules. Oncology Reports, 51, 31. https://doi.org/10.3892/or.2023.8690
MLA
Iragavarapu‑Charyulu, V., Shakya, R., Robinson, P., Guzmán, E., Tyulmenkova, A., Pino, J. L., Isgor, C."A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules". Oncology Reports 51.2 (2024): 31.
Chicago
Iragavarapu‑Charyulu, V., Shakya, R., Robinson, P., Guzmán, E., Tyulmenkova, A., Pino, J. L., Isgor, C."A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules". Oncology Reports 51, no. 2 (2024): 31. https://doi.org/10.3892/or.2023.8690
Copy and paste a formatted citation
x
Spandidos Publications style
Iragavarapu‑Charyulu V, Shakya R, Robinson P, Guzmán E, Tyulmenkova A, Pino JL and Isgor C: A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules. Oncol Rep 51: 31, 2024.
APA
Iragavarapu‑Charyulu, V., Shakya, R., Robinson, P., Guzmán, E., Tyulmenkova, A., Pino, J.L., & Isgor, C. (2024). A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules. Oncology Reports, 51, 31. https://doi.org/10.3892/or.2023.8690
MLA
Iragavarapu‑Charyulu, V., Shakya, R., Robinson, P., Guzmán, E., Tyulmenkova, A., Pino, J. L., Isgor, C."A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules". Oncology Reports 51.2 (2024): 31.
Chicago
Iragavarapu‑Charyulu, V., Shakya, R., Robinson, P., Guzmán, E., Tyulmenkova, A., Pino, J. L., Isgor, C."A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules". Oncology Reports 51, no. 2 (2024): 31. https://doi.org/10.3892/or.2023.8690
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