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Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)

  • Authors:
    • Honglian Yu
    • Qiang Bian
    • Xin Wang
    • Xinzhe Wang
    • Luhao Lai
    • Zhichun Wu
    • Zhankui Zhao
    • Bo Ban
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272029, P.R. China, Collaborative Innovation Center, Jining Medical University, Jining, Shandong 272067, P.R. China, Department of Urology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272029, P.R. China, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 45
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    Published online on: January 18, 2024
       https://doi.org/10.3892/or.2024.8704
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Abstract

Bone marrow stromal cell antigen 2 (BST2) is a type II transmembrane protein that serves critical roles in antiretroviral defense in the innate immune response. In addition, it has been suggested that BST2 is highly expressed in various types of human cancer and high BST2 expression is related to different clinicopathological parameters in cancer. The molecular mechanism underlying BST2 as a potential tumor biomarker in human solid tumors has been reported on; however, to the best of our knowledge, there has been no review published on the molecular mechanism of BST2 in human solid tumors. The present review focuses on human BST2 expression, structure and functions; the molecular mechanisms of BST2 in breast cancer, hepatocellular carcinoma, gastrointestinal tumor and other solid tumors; the therapeutic potential of BST2; and the possibility of BST2 as a potential marker. BST2 is involved in cell membrane integrity and lipid raft formation, which can activate epidermal growth factor receptor signaling pathways, providing a potential mechanistic link between BST2 and tumorigenesis. Notably, BST2 may be considered a universal tumor biomarker and a potential therapeutical target.
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1 

Goto T, Kennel SJ, Abe M, Takishita M, Kosaka M, Solomon A and Saito S: A novel membrane antigen selectively expressed on terminally differentiated human B cells. Blood. 84:1922–1930. 1984. View Article : Google Scholar : PubMed/NCBI

2 

Neil SJ, Zang T and Bieniasz PD: Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature. 451:425–430. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Mahauad-Fernandez WD and Okeoma CM: The role of BST-2/Tetherin in host protection and disease manifestation. Immun Inflamm Dis. 4:4–23. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Cai D, Cao J, Li Z, Zheng X, Yao Y, Li W and Yuan Z: Up-regulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis. BMC Cancer. 9:1022009. View Article : Google Scholar : PubMed/NCBI

5 

Jourdan M, Caraux A, Caron G, Robert N, Fiol G, Reme T, Bolloré K, Vendrell JP, Le Gallou S, Mourcin F, et al: Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation. J Immunol. 187:3931–3941. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Jourdan M, Caraux A, De Vos J, Fiol G, Larroque M, Cognot C, Bret C, Duperray C, Hose D and Klein B: An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization. Blood. 114:5173–5181. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Erikson E, Adam T, Schmidt S, Lehmann-Koch J, Over B, Goffinet C, Harter C, Bekeredjian-Ding I, Sertel S, Lasitschka F and Keppler OT: In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans. Proc Natl Acad Sci USA. 108:13688–13693. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ohtomo T, Sugamata Y, Ozaki Y, Ono K, Yoshimura Y, Kawai S, Koishihara Y, Ozaki S, Kosaka M, Hirano T and Tsuchiya M: Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. Biochem Biophys Res Commun. 258:583–591. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Rew SB, Peggs K, Sanjuan I, Pizzey AR, Koishihara Y, Kawai S, Kosaka M, Ozaki S, Chain B and Yong KL: Generation of potent antitumor CTL from patients with multiple myeloma directed against HM1.24. Clin Cancer Res. 11:3377–3384. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Wong YF, Cheung TH, Lo KW, Yim SF, Siu NS, Chan SC, Ho TW, Wong KW, Yu MY, Wang VW, et al: Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling. Oncogene. 26:1971–1982. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Liu W, Li Y, Feng S, Guan Y and Cao Y: MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer. J Biochem. 168:159–170. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Kong Y, Xue Z, Wang H, Cui G, Chen A, Liu J, Wang J, Li X and Huang B: Identification of BST2 contributing to the development of glioblastoma based on bioinformatics analysis. Front Genet. 13:8901742022. View Article : Google Scholar : PubMed/NCBI

13 

Wang W, Nishioka Y, Ozaki S, Jalili A, Abe S, Kakiuchi S, Kishuku M, Minakuchi K, Matsumoto T and Sone S: HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody. Cancer Immunol Immunother. 58:967–976. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Kuang CM, Fu X, Hua YJ, Shuai WD, Ye ZH, Li Y, Peng QH, Li YZ, Chen S, Qian CN, et al: BST2 confers cisplatin resistance via NF-kappaB signaling in nasopharyngeal cancer. Cell Death Dis. 8:e28742017. View Article : Google Scholar : PubMed/NCBI

15 

Fang KH, Kao HK, Chi LM, Liang Y, Liu SC, Hseuh C, Liao CT, Yen TC, Yu JS and Chang KP: Overexpression of BST2 is associated with nodal metastasis and poorer prognosis in oral cavity cancer. Laryngoscope. 124:E354–E360. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Jin H, Zhang L, Wang S and Qian L: BST2 promotes growth and induces gefitinib resistance in oral squamous cell carcinoma via regulating the EGFR pathway. Arch Med Sci. 17:1772–1782. 2019.PubMed/NCBI

17 

Liu G, Du X, Xiao L, Zeng Q and Liu Q: Activation of FGD5-AS1 promotes progression of cervical cancer through regulating BST2 to inhibit macrophage M1 Polarization. J Immunol Res. 2021:58572142021. View Article : Google Scholar : PubMed/NCBI

18 

Sayeed A, Luciani-Torres G, Meng Z, Bennington JL, Moore DH and Dairkee SH: Aberrant regulation of the BST2 (Tetherin) promoter enhances cell proliferation and apoptosis evasion in high grade breast cancer cells. PLoS One. 8:e671912013. View Article : Google Scholar : PubMed/NCBI

19 

Lei C, Hou Y and Chen J: Specificity protein 1-activated bone marrow stromal cell antigen 2 accelerates pancreatic cancer cell proliferation and migration. Exp Ther Med. 22:14592021. View Article : Google Scholar : PubMed/NCBI

20 

Xu X, Wang Y, Xue F, Guan E, Tian F, Xu J and Zhang H: BST2 promotes tumor growth via multiple pathways in hepatocellular carcinoma. Cancer Invest. 38:329–337. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Kim SC, Hong CW, Jang SG, Kim YA, Yoo BC, Shin YK, Jeong SY, Ku JL and Park JG: Establishment and characterization of paired primary and peritoneal seeding human colorectal cancer cell lines: Identification of genes that mediate metastatic potential. Transl Oncol. 11:1232–1243. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Mukai S, Oue N, Oshima T, Mukai R, Tatsumoto Y, Sakamoto N, Sentani K, Tanabe K, Egi H, Hinoi T, et al: Overexpression of Transmembrane Protein BST2 is associated with poor survival of patients with esophageal, gastric, or colorectal cancer. Ann Surg Oncol. 24:594–602. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Yang LL, Wu L, Yu GT, Zhang WF, Liu B and Sun ZJ: CD317 signature in head and neck cancer indicates poor prognosis. J Dent Res. 97:787–794. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Yang LQ, Hu HY, Han Y, Tang ZY, Gao J, Zhou QY, Liu YX, Chen HS, Xu TN, Ao L, et al: CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription. Cancer Gene Ther. 29:1895–1907. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Shigematsu Y, Oue N, Nishioka Y, Sakamoto N, Sentani K, Sekino Y, Mukai S, Teishima J, Matsubara A and Yasui W: Overexpression of the transmembrane protein BST-2 induces Akt and Erk phosphorylation in bladder cancer. Oncol Lett. 14:999–1004. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Cheng J, Liu Z, Deng T, Lu Z, Liu M, Lu X, Adeshakin FO, Yan D, Zhang G and Wan X: CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection. Mol Immunol. 129:94–102. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Masuyama N, Kuronita T, Tanaka R, Muto T, Hirota Y, Takigawa A, Fujita H, Aso Y, Amano J and Tanaka Y: HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin. J Biol Chem. 284:15927–15941. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Naushad W, Mahauad-Fernandez WD and Okeoma CM: Structural determinant of BST-2-mediated regulation of breast cancer cell motility: A role for cytoplasmic tail tyrosine residues. Oncotarget. 8:110221–110233. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Andrew AJ, Miyagi E, Kao S and Strebel K: The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. Retrovirology. 6:802009. View Article : Google Scholar : PubMed/NCBI

30 

Swiecki M, Scheaffer SM, Allaire M, Fremont DH, Colonna M and Brett TJ: Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release. J Biol Chem. 286:2987–2997. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Perez-Caballero D, Zang T, Ebrahimi A, McNatt MW, Gregory DA, Johnson MC and Bieniasz PD: Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell. 139:499–511. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Kupzig S, Korolchuk V, Rollason R, Sugden A, Wilde A and Banting G: BST-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic. 4:694–709. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Edgar JR, Manna PT, Nishimura S, Banting G and Robinson MS: Tetherin is an exosomal tether. Elife. 5:e171802016. View Article : Google Scholar : PubMed/NCBI

34 

Tokarev A, Suarez M, Kwan W, Fitzpatrick K, Singh R and Guatelli J: Stimulation of NF-kappaB activity by the HIV restriction factor BST2. J Virol. 87:2046–2057. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Billcliff PG, Rollason R, Prior I, Owen DM, Gaus K and Banting G: CD317/tetherin is an organiser of membrane microdomains. J Cell Sci. 126((Pt 7)): 1553–1564. 2013.PubMed/NCBI

36 

Billcliff PG, Gorleku OA, Chamberlain LH and Banting G: The cytosolic N-terminus of CD317/tetherin is a membrane microdomain exclusion motif. Biol Open. 2:1253–1263. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Jones DR and Varela-Nieto I: The role of glycosyl-phosphatidylinositol in signal transduction. Int J Biochem Cell Biol. 30:313–326. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Muller GA and Muller TD: (Patho)physiology of glycosylphosphatidylinositol-anchored proteins I: Localization at plasma membranes and extracellular compartments. Biomolecules. 13:8552023. View Article : Google Scholar : PubMed/NCBI

39 

Galao RP, Le Tortorec A, Pickering S, Kueck T and Neil SJ: Innate sensing of HIV-1 assembly by Tetherin induces NF-kappaB-dependent proinflammatory responses. Cell Host Microbe. 12:633–644. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Holmgren AM, Miller KD, Cavanaugh SE and Rall GF: Bst2/tetherin is induced in neurons by type I interferon and viral infection but is dispensable for protection against neurotropic viral challenge. J Virol. 89:11011–11018. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Rahmani W, Chung H, Sinha S, Bui-Marinos MP, Arora R, Jaffer A, Corcoran JA, Biernaskie J and Chun J: Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids. iScience. 25:1038182022. View Article : Google Scholar : PubMed/NCBI

42 

Cao W, Bover L, Cho MW, Wen XX, Hanabuchi S, Bao MS, Rosen DB, Wang YH, Shaw JL, Du Q, et al: Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med. 206:1603–1614. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Cao W and Bover L: Signaling and ligand interaction of ILT7: Receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev. 234:163–176. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Yi E, Oh J, Kang HR, Song MJ and Park SH: BST2 inhibits infection of influenza A virus by promoting apoptosis of infected cells. Biochem Biophys Res Commun. 509:414–420. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Ge Y, Dombkowski AA, LaFiura KM, Tatman D, Yedidi RS, Stout ML, Buck SA, Massey G, Becton DL, Weinstein HJ, et al: Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia. Blood. 107:1570–1581. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Mahauad-Fernandez WD and Okeoma CM: B49, a BST-2-based peptide, inhibits adhesion and growth of breast cancer cells. Sci Rep. 8:43052018. View Article : Google Scholar : PubMed/NCBI

47 

Oue N, Sentani K, Sakamoto N, Uraoka N and Yasui W: Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells. Int J Clin Oncol. 24:771–778. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Prat A, Pineda E, Adamo B, Galvan P, Fernandez A, Gaba L, Díez M, Viladot M, Arance A and Muñoz M: Clinical implications of the intrinsic molecular subtypes of breast cancer. Breast. 24 (Suppl 2):S26–S35. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Mahauad-Fernandez WD, Naushad W, Panzner TD, Bashir A, Lal G and Okeoma CM: BST-2 promotes survival in circulation and pulmonary metastatic seeding of breast cancer cells. Sci Rep. 8:176082018. View Article : Google Scholar : PubMed/NCBI

50 

Woodman N, Pinder SE, Tajadura V, Le Bourhis X, Gillett C, Delannoy P, Burchell JM and Julien S: Two E-selectin ligands, BST-2 and LGALS3BP, predict metastasis and poor survival of ER-negative breast cancer. Int J Oncol. 49:265–275. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Deng H, Guan X, Gong L, Zeng J, Zhang H, Chen MY and Li G: CBX6 is negatively regulated by EZH2 and plays a potential tumor suppressor role in breast cancer. Sci Rep. 9:1972019. View Article : Google Scholar : PubMed/NCBI

52 

Xu S, Liu Y, Ma H, Fang S, Wei S, Li X, Lu Z, Zheng Y, Liu T, Zhu X, et al: A novel signature integrated of immunoglobulin, glycosylation and anti-viral genes to predict prognosis for breast cancer. Front Genet. 13:8347312022. View Article : Google Scholar : PubMed/NCBI

53 

Du Y, Yuan S, Zhuang X, Zhang Q and Qiao T: Multiomics differences in lung squamous cell carcinoma patients with high radiosensitivity index compared with those with low radiosensitivity index. Dis Markers. 2021:37666592021. View Article : Google Scholar : PubMed/NCBI

54 

Mahauad-Fernandez WD, DeMali KA, Olivier AK and Okeoma CM: Bone marrow stromal antigen 2 expressed in cancer cells promotes mammary tumor growth and metastasis. Breast Cancer Res. 16:4932014. View Article : Google Scholar : PubMed/NCBI

55 

Mahauad-Fernandez WD, Borcherding NC, Zhang W and Okeoma CM: Bone marrow stromal antigen 2 (BST-2) DNA is demethylated in breast tumors and breast cancer cells. PLoS One. 10:e01239312015. View Article : Google Scholar : PubMed/NCBI

56 

Yi EH, Yoo H, Noh KH, Han S, Lee H, Lee JK, Won C, Kim BH, Kim MH, Cho CH and Ye SK: BST-2 is a potential activator of invasion and migration in tamoxifen-resistant breast cancer cells. Biochem Biophys Res Commun. 435:685–690. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Jones PH, Mahauad-Fernandez WD, Madison MN and Okeoma CM: BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer. Virology. 444:124–139. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Mahauad-Fernandez WD and Okeoma CM: Cysteine-linked dimerization of BST-2 confers anoikis resistance to breast cancer cells by negating proapoptotic activities to promote tumor cell survival and growth. Cell Death Dis. 8:e26872017. View Article : Google Scholar : PubMed/NCBI

59 

Shi Y, Castro-Gonzalez S, Chen Y and Serra-Moreno R: Effects of the SUMO Ligase BCA2 on metabolic activity, cell proliferation, cell migration, cell cycle, and the regulation of NF-kappaB and IRF1 in different breast epithelial cellular contexts. Front Cell Dev Biol. 9:7114812021. View Article : Google Scholar : PubMed/NCBI

60 

Becker M, Sommer A, Kratzschmar JR, Seidel H, Pohlenz HD and Fichtner I: Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM. Mol Cancer Ther. 4:151–168. 2005. View Article : Google Scholar : PubMed/NCBI

61 

Ma JH, Qin L and Li X: Role of STAT3 signaling pathway in breast cancer. Cell Commun Signal. 18:332020. View Article : Google Scholar : PubMed/NCBI

62 

Andzinski L, Kasnitz N, Stahnke S, Wu CF, Gereke M, von Kockritz-Blickwede M, Schilling B, Brandau S, Weiss S and Jablonska J: Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. Int J Cancer. 138:1982–1993. 2016. View Article : Google Scholar : PubMed/NCBI

63 

Pylaeva E, Lang S and Jablonska J: The essential role of type I interferons in differentiation and activation of tumor-associated neutrophils. Front Immunol. 7:6292016. View Article : Google Scholar : PubMed/NCBI

64 

García-Pras E, Fernández-Iglesias A, Gracia-Sancho J and Pérez-Del-Pulgar S: Cell death in hepatocellular carcinoma: Pathogenesis and therapeutic opportunities. Cancers (Basel). 14:482021. View Article : Google Scholar : PubMed/NCBI

65 

Tayob N, Kanwal F, Alsarraj A, Hernaez R and El-Serag HB: The Performance of AFP, AFP-3, DCP as biomarkers for detection of hepatocellular carcinoma (HCC): A phase 3 biomarker study in the United States. Clin Gastroenterol Hepatol. 21:415–423.e4. 2023. View Article : Google Scholar : PubMed/NCBI

66 

Wang Y and Deng B: Hepatocellular carcinoma: Molecular mechanism, targeted therapy, and biomarkers. Cancer Metastasis Rev. 42:629–652. 2023. View Article : Google Scholar : PubMed/NCBI

67 

Zhang J, Zheng B, Zhou X, Zheng T, Wang H, Wang Y and Zhang W: Increased BST-2 expression by HBV infection promotes HBV-associated HCC tumorigenesis. J Gastrointest Oncol. 12:694–710. 2021. View Article : Google Scholar : PubMed/NCBI

68 

Zhang G, Li X, Chen Q, Li J, Ruan Q, Chen YH, Yang X and Wan X: CD317 Activates EGFR by regulating its association with lipid rafts. Cancer Res. 79:2220–2231. 2019. View Article : Google Scholar : PubMed/NCBI

69 

Pan XB, Han JC, Cong X and Wei L: BST2/tetherin inhibits dengue virus release from human hepatoma cells. PLoS One. 7:e510332012. View Article : Google Scholar : PubMed/NCBI

70 

Dafa-Berger A, Kuzmina A, Fassler M, Yitzhak-Asraf H, Shemer-Avni Y and Taube R: Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin. Virology. 428:98–111. 2012. View Article : Google Scholar : PubMed/NCBI

71 

Pan XB, Qu XW, Jiang D, Zhao XL, Han JC and Wei L: BST2/Tetherin inhibits hepatitis C virus production in human hepatoma cells. Antiviral Res. 98:54–60. 2013. View Article : Google Scholar : PubMed/NCBI

72 

Mollinedo F and Gajate C: Lipid rafts as signaling hubs in cancer cell survival/death and invasion: Implications in tumor progression and therapy. Thematic Review Series: Biology of Lipid Rafts. J Lipid Res. 61:611–635. 2020. View Article : Google Scholar : PubMed/NCBI

73 

Arnold M, Abnet CC, Neale RE, Vignat J, Giovannucci EL, McGlynn KA and Bray F: Global burden of 5 major types of gastrointestinal cancer. Gastroenterology. 159:335–349.e15. 2020. View Article : Google Scholar : PubMed/NCBI

74 

Liu W, Cao Y, Guan Y and Zheng C: BST2 promotes cell proliferation, migration and induces NF-kappaB activation in gastric cancer. Biotechnol Lett. 40:1015–1027. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Hinoi T, Okajima M, Graff JM and Yasui W: Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap: Expression of DSC2 in gastric cancer with intestinal phenotype. J Pathol. 221:275–284. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Rodriguez A, Corchete LA, Alcazar JA, Montero JC, Rodriguez M, Chinchilla-Tabora LM, Vidal Tocino R, Moyano C, Muñoz-Bravo S, Sayagués JM and Abad M: Dysregulated expression of three genes in colorectal cancer stratifies patients into three risk groups. Cancers (Basel). 14:40762022. View Article : Google Scholar : PubMed/NCBI

77 

Chiang SF, Kan CY, Hsiao YC, Tang R, Hsieh LL, Chiang JM, Tsai WS, Yeh CY, Hsieh PS, Liang Y, et al: Bone marrow stromal antigen 2 is a novel plasma biomarker and prognosticator for colorectal carcinoma: A secretome-based verification study. Dis Markers. 2015:8740542015. View Article : Google Scholar : PubMed/NCBI

78 

Shen C, Luo C, Xu Z, Liang Q, Cai Y, Peng B, Yan Y and Xia F: Molecular patterns based on immunogenomic signatures stratify the prognosis of colon cancer. Front Bioeng Biotechnol. 10:8200922022. View Article : Google Scholar : PubMed/NCBI

79 

Chu CH, Chang SC, Wang HH, Yang SH, Lai KC and Lee TC: Prognostic values of EPDR1 hypermethylation and its inhibitory function on tumor invasion in colorectal cancer. Cancers (Basel). 10:3932018. View Article : Google Scholar : PubMed/NCBI

80 

He X, Chen H, Zhong X, Wang Y, Hu Z, Huang H, Zhao S, Wei P, Shi D and Li D: BST2 induced macrophage M2 polarization to promote the progression of colorectal cancer. Int J Biol Sci. 19:331–345. 2023. View Article : Google Scholar : PubMed/NCBI

81 

Casarrubios M, Provencio M, Nadal E, Insa A, Del Rosario Garcia-Campelo M, Lazaro-Quintela M, Dómine M, Majem M, Rodriguez-Abreu D, Martinez-Marti A, et al: Tumor microenvironment gene expression profiles associated to complete pathological response and disease progression in resectable NSCLC patients treated with neoadjuvant chemoimmunotherapy. J Immunother Cancer. 10:e0053202022. View Article : Google Scholar : PubMed/NCBI

82 

Chen YC, Lin MC, Hsiao CC, Zheng YX, Chen KD, Sung MT, Chen CJ, Wang TY, Lin YY, Chang HC, et al: Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma. Oncotarget. 8:45710–45724. 2017. View Article : Google Scholar : PubMed/NCBI

83 

Zhou Y, Tang L, Chen Y, Zhang Y and Zhuang W: An immune panel signature predicts prognosis of lung adenocarcinoma patients and correlates with immune microenvironment. Front Cell Dev Biol. 9:7979842021. View Article : Google Scholar : PubMed/NCBI

84 

Wang W, Nishioka Y, Ozaki S, Jalili A, Verma VK, Hanibuchi M, Abe S, Minakuchi K, Matsumoto T and Sone S: Chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells. Lung Cancer. 63:23–31. 2009. View Article : Google Scholar : PubMed/NCBI

85 

Wainwright DA, Balyasnikova IV, Han Y and Lesniak MS: The expression of BST2 in human and experimental mouse brain tumors. Exp Mol Pathol. 91:440–446. 2011. View Article : Google Scholar : PubMed/NCBI

86 

Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, et al: Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer. Int J Cancer. 132:472–484. 2013. View Article : Google Scholar : PubMed/NCBI

87 

Pham QT, Oue N, Yamamoto Y, Shigematsu Y, Sekino Y, Sakamoto N, Sentani K, Uraoka N, Tiwari M and Yasui W: The Expression of BTS-2 enhances cell growth and invasiveness in renal cell carcinoma. Anticancer Res. 37:2853–2860. 2017.PubMed/NCBI

88 

Pan XQ, Huang W, Jin LW, Lin HZ and Xu XY: A novel pyroptosis-related prognostic signature for risk stratification and clinical prognosis in clear cell renal cell carcinoma. Dis Markers. 2022:80938372022. View Article : Google Scholar : PubMed/NCBI

89 

Yamada Y, Arai T, Sugawara S, Okato A, Kato M, Kojima S, Yamazaki K, Naya Y, Ichikawa T and Seki N: Impact of novel oncogenic pathways regulated by antitumor miR-451a in renal cell carcinoma. Cancer Sci. 109:1239–1253. 2018. View Article : Google Scholar : PubMed/NCBI

90 

Januchowski R, Sterzynska K, Zawierucha P, Rucinski M, Swierczewska M, Partyka M, Bednarek-Rajewska K, Brązert M, Nowicki M, Zabel M and Klejewski A: Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines. Oncotarget. 8:49944–49958. 2017. View Article : Google Scholar : PubMed/NCBI

91 

Zhang H, Cai Y, Zheng L, Zhang Z, Lin X and Jiang N: LncRNA BISPR promotes the progression of thyroid papillary carcinoma by regulating miR-21-5p. Int J Immunopathol Pharmacol. 32:20587384187726522018. View Article : Google Scholar : PubMed/NCBI

92 

Milutin Gasperov N, Farkas SA, Nilsson TK and Grce M: Epigenetic activation of immune genes in cervical cancer. Immunol Lett. 162((2 Pt B)): 256–257. 2014. View Article : Google Scholar : PubMed/NCBI

93 

Etcheverry A, Aubry M, de Tayrac M, Vauleon E, Boniface R, Guenot F, Saikali S, Hamlat A, Riffaud L, Menei P, et al: DNA methylation in glioblastoma: Impact on gene expression and clinical outcome. BMC Genomics. 11:7012010. View Article : Google Scholar : PubMed/NCBI

94 

Kawai S, Azuma Y, Fujii E, Furugaki K, Ozaki S, Matsumoto T, Kosaka M and Yamada-Okabe H: Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models. Cancer Sci. 99:2461–2466. 2008. View Article : Google Scholar : PubMed/NCBI

95 

Gu G, Zhao D, Yin Z and Liu P: BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. J Cell Biochem. 113:1013–1021. 2012. View Article : Google Scholar : PubMed/NCBI

96 

Yoo H, Park SH, Ye SK and Kim M: IFN-γ-induced BST2 mediates monocyte adhesion to human endothelial cells. Cell Immunol. 267:23–29. 2011. View Article : Google Scholar : PubMed/NCBI

97 

Sibler E, He Y, Ducoli L, Rihs V, Sidler P, Puig-Moreno C, Frey J, Fujimoto N, Detmar M and Dieterich LC: Immunomodulatory responses of subcapsular sinus floor lymphatic endothelial cells in tumor-draining lymph nodes. Cancers (Basel). 14:36022022. View Article : Google Scholar : PubMed/NCBI

98 

Werner TA, Forster CM, Dizdar L, Verde PE, Raba K, Schott M, Knoefel WT and Krieg A: CXCR4/CXCR7/CXCL12 axis promotes an invasive phenotype in medullary thyroid carcinoma. Br J Cancer. 117:1837–1845. 2017. View Article : Google Scholar : PubMed/NCBI

99 

Bian S, Zhao Y, Li F, Lu S, He Z, Wang S, Bai X, Zhao D, Liu M and Wang J: Total ginsenosides induce autophagic cell death in cervical cancer cells accompanied by downregulation of bone marrow stromal antigen-2. Exp Ther Med. 22:6672021. View Article : Google Scholar : PubMed/NCBI

100 

Cheng J, Zhang G, Deng T, Liu Z, Zhang M, Zhang P, Adeshakin FO, Niu X, Yan D, Wan X and Yu G: CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation. Cell Death Dis. 14:3332023. View Article : Google Scholar : PubMed/NCBI

101 

Yang LL, Mao L, Wu H, Chen L, Deng WW, Xiao Y, Li H, Zhang L and Sun ZJ: pDC depletion induced by CD317 blockade drives the antitumor immune response in head and neck squamous cell carcinoma. Oral Oncol. 96:131–139. 2019. View Article : Google Scholar : PubMed/NCBI

102 

Jin S, Sun Y, Liang X, Gu X, Ning J, Xu Y, Chen S and Pan L: Emerging new therapeutic antibody derivatives for cancer treatment. Signal Transduct Target Ther. 7:392022. View Article : Google Scholar : PubMed/NCBI

103 

Wu RQ, Lao XM, Chen DP, Qin H, Mu M, Cao WJ, Deng J, Wan CC, Zhan WY, Wang JC, et al: Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma. Immunity. 56:180–192.e11. 2023. View Article : Google Scholar : PubMed/NCBI

104 

Rimassa L, Finn RS and Sangro B: Combination immunotherapy for hepatocellular carcinoma. J Hepatol. 79:506–515. 2023. View Article : Google Scholar : PubMed/NCBI

105 

Staudinger M, Glorius P, Burger R, Kellner C, Klausz K, Gunther A, Repp R, Klapper W, Gramatzki M and Peipp M: The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells. Blood Cancer J. 4:e2192014. View Article : Google Scholar : PubMed/NCBI

106 

Hundemer M, Schmidt S, Condomines M, Lupu A, Hose D, Moos M, Cremer F, Kleist C, Terness P, Belle S, et al: Identification of a new HLA-A2-restricted T-cell, epitope within HM1.24 as immunotherapy target for multiple myeloma. Exp Hematol. 34:486–496. 2006. View Article : Google Scholar : PubMed/NCBI

107 

Hiramatsu K, Serada S, Kobiyama K, Nakagawa S, Morimoto A, Matsuzaki S, Ueda Y, Fujimoto M, Yoshino K, Ishii KJ, et al: CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody. Cancer Sci. 106:1474–1478. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu H, Bian Q, Wang X, Wang X, Lai L, Wu Z, Zhao Z and Ban B: Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review). Oncol Rep 51: 45, 2024.
APA
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z. ... Ban, B. (2024). Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review). Oncology Reports, 51, 45. https://doi.org/10.3892/or.2024.8704
MLA
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z., Zhao, Z., Ban, B."Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)". Oncology Reports 51.3 (2024): 45.
Chicago
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z., Zhao, Z., Ban, B."Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)". Oncology Reports 51, no. 3 (2024): 45. https://doi.org/10.3892/or.2024.8704
Copy and paste a formatted citation
x
Spandidos Publications style
Yu H, Bian Q, Wang X, Wang X, Lai L, Wu Z, Zhao Z and Ban B: Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review). Oncol Rep 51: 45, 2024.
APA
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z. ... Ban, B. (2024). Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review). Oncology Reports, 51, 45. https://doi.org/10.3892/or.2024.8704
MLA
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z., Zhao, Z., Ban, B."Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)". Oncology Reports 51.3 (2024): 45.
Chicago
Yu, H., Bian, Q., Wang, X., Wang, X., Lai, L., Wu, Z., Zhao, Z., Ban, B."Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review)". Oncology Reports 51, no. 3 (2024): 45. https://doi.org/10.3892/or.2024.8704
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