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Review Open Access

Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review)

  • Authors:
    • Yuxuan Shi
    • Xiangyi Lin
    • Jinwen Wang
    • Zhiqing Zhou
    • Sijie Chen
    • Guoan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong‑Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 55
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    Published online on: February 15, 2024
       https://doi.org/10.3892/or.2024.8714
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Abstract

It is now widely accepted that there is a specific metabolic pattern in tumor cells termed the Warburg effect, which causes tumor cells to tend to use glycolysis for energy. Hypoxia‑inducible factor (HIF) 1α is involved in these metabolic patterns as a key molecule promoting glycolysis. In addition, there is now increasing evidence that targeting this metabolic pattern of the tumor to cut off the energy source of the tumor tissue is an effective therapeutic modality. However, different molecules are involved in the regulation of the HIF‑1α/glycolysis axis in different tumor tissues. This review focused on non‑small cell lung cancer (NSCLC) to elucidate the currently known signaling pathways centered on the HIF‑1α/glycolysis axis and to identify the key molecules that can serve as therapeutic targets. It also summarized the effective methods of treatment of NSCLC by inhibition of HIF‑1α/glycolysis that have emerged in recent years.
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Copy and paste a formatted citation
Spandidos Publications style
Shi Y, Lin X, Wang J, Zhou Z, Chen S and Chen G: Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review). Oncol Rep 51: 55, 2024.
APA
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., & Chen, G. (2024). Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review). Oncology Reports, 51, 55. https://doi.org/10.3892/or.2024.8714
MLA
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., Chen, G."Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review)". Oncology Reports 51.4 (2024): 55.
Chicago
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., Chen, G."Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review)". Oncology Reports 51, no. 4 (2024): 55. https://doi.org/10.3892/or.2024.8714
Copy and paste a formatted citation
x
Spandidos Publications style
Shi Y, Lin X, Wang J, Zhou Z, Chen S and Chen G: Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review). Oncol Rep 51: 55, 2024.
APA
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., & Chen, G. (2024). Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review). Oncology Reports, 51, 55. https://doi.org/10.3892/or.2024.8714
MLA
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., Chen, G."Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review)". Oncology Reports 51.4 (2024): 55.
Chicago
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., Chen, G."Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review)". Oncology Reports 51, no. 4 (2024): 55. https://doi.org/10.3892/or.2024.8714
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