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Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells

  • Authors:
    • Ming-Shan Chen
    • Zhi-Yong Chong
    • Cheng Huang
    • Hsiu-Chen Huang
    • Pin-Hsuan Su
    • Jui-Chieh Chen
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Ditmanson Medical Foundation Chia‑Yi Christian Hospital, Chiayi 60002, Taiwan, R.O.C., Department of Biochemical Science and Technology, National Chiayi University, Chiayi 600355, Taiwan, R.O.C., Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C., Department of Applied Science, National Tsing Hua University South Campus, Hsinchu 30014, Taiwan, R.O.C.
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 72
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    Published online on: April 8, 2024
       https://doi.org/10.3892/or.2024.8731
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Abstract

Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor. Currently, the predominant clinical treatment is the combination of surgical resection with concurrent radiotherapy and chemotherapy, using temozolomide (TMZ) as the primary chemotherapy drug. Lidocaine, a widely used amide‑based local anesthetic, has been found to have a significant anticancer effect. It has been reported that aberrant hepatocyte growth factor (HGF)/mesenchymal‑epithelial transition factor (MET) signaling plays a role in the progression of brain tumors. However, it remains unclear whether lidocaine can regulate the MET pathway in GBM. In the present study, the clinical importance of the HGF/MET pathway was analyzed using bioinformatics. By establishing TMZ‑resistant cell lines, the impact of combined treatment with lidocaine and TMZ was investigated. Additionally, the effects of lidocaine on cellular function were also examined and confirmed using knockdown techniques. The current findings revealed that the HGF/MET pathway played a key role in brain cancer, and its activation in GBM was associated with increased malignancy and poorer patient outcomes. Elevated HGF levels and activation of its receptor were found to be associated with TMZ resistance in GBM cells. Lidocaine effectively suppressed the HGF/MET pathway, thereby restoring TMZ sensitivity in TMZ‑resistant cells. Furthermore, lidocaine also inhibited cell migration. Overall, these results indicated that inhibiting the HGF/MET pathway using lidocaine can enhance the sensitivity of GBM cells to TMZ and reduce cell migration, providing a potential basis for developing novel therapeutic strategies for GBM.
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Copy and paste a formatted citation
Spandidos Publications style
Chen M, Chong Z, Huang C, Huang H, Su P and Chen J: Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells. Oncol Rep 51: 72, 2024.
APA
Chen, M., Chong, Z., Huang, C., Huang, H., Su, P., & Chen, J. (2024). Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells. Oncology Reports, 51, 72. https://doi.org/10.3892/or.2024.8731
MLA
Chen, M., Chong, Z., Huang, C., Huang, H., Su, P., Chen, J."Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells". Oncology Reports 51.5 (2024): 72.
Chicago
Chen, M., Chong, Z., Huang, C., Huang, H., Su, P., Chen, J."Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells". Oncology Reports 51, no. 5 (2024): 72. https://doi.org/10.3892/or.2024.8731
Copy and paste a formatted citation
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Spandidos Publications style
Chen M, Chong Z, Huang C, Huang H, Su P and Chen J: Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells. Oncol Rep 51: 72, 2024.
APA
Chen, M., Chong, Z., Huang, C., Huang, H., Su, P., & Chen, J. (2024). Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells. Oncology Reports, 51, 72. https://doi.org/10.3892/or.2024.8731
MLA
Chen, M., Chong, Z., Huang, C., Huang, H., Su, P., Chen, J."Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells". Oncology Reports 51.5 (2024): 72.
Chicago
Chen, M., Chong, Z., Huang, C., Huang, H., Su, P., Chen, J."Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells". Oncology Reports 51, no. 5 (2024): 72. https://doi.org/10.3892/or.2024.8731
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