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Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review)

  • Authors:
    • Voraporn Yongprayoon
    • Napasporn Wattanakul
    • Winnada Khomate
    • Nathakrit Apithanangsiri
    • Tarathip Kasitipradit
    • Danupon Nantajit
    • Mahvash Tavassoli
  • View Affiliations / Copyright

    Affiliations: Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok 10210, Thailand, Centre for Host Microbiome Interactions, King's College London, London SE1 1UL, UK
    Copyright: © Yongprayoon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 74
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    Published online on: April 12, 2024
       https://doi.org/10.3892/or.2024.8733
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Abstract

As a member of BET (bromodomain and extra-terminal) protein family, BRD4 (bromodomain‑containing protein 4) is a chromatin‑associated protein that interacts with acetylated histones and actively recruits regulatory proteins, leading to the modulation of gene expression and chromatin remodeling. The cellular and epigenetic functions of BRD4 implicate normal development, fibrosis and inflammation. BRD4 has been suggested as a potential therapeutic target as it is often overexpressed and plays a critical role in regulating gene expression programs that drive tumor cell proliferation, survival, migration and drug resistance. To address the roles of BRD4 in cancer, several drugs that specifically target BRD4 have been developed. Inhibition of BRD4 has shown promising results in preclinical models, with several BRD4 inhibitors undergoing clinical trials for the treatment of various cancers. Head and neck squamous cell carcinoma (HNSCC), a heterogeneous group of cancers, remains a health challenge with a high incidence rate and poor prognosis. Conventional therapies for HNSCC often cause adverse effects to the patients. Targeting BRD4, therefore, represents a promising strategy to sensitize HNSCC to chemo‑ and radiotherapy allowing de‑intensification of the current therapeutic regime and subsequent reduced side effects. However, further studies are required to fully understand the underlying mechanisms of action of BRD4 in HNSCC in order to determine the optimal dosing and administration of BRD4‑targeted drugs for the treatment of patients with HNSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Yongprayoon V, Wattanakul N, Khomate W, Apithanangsiri N, Kasitipradit T, Nantajit D and Tavassoli M: Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review). Oncol Rep 51: 74, 2024.
APA
Yongprayoon, V., Wattanakul, N., Khomate, W., Apithanangsiri, N., Kasitipradit, T., Nantajit, D., & Tavassoli, M. (2024). Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review). Oncology Reports, 51, 74. https://doi.org/10.3892/or.2024.8733
MLA
Yongprayoon, V., Wattanakul, N., Khomate, W., Apithanangsiri, N., Kasitipradit, T., Nantajit, D., Tavassoli, M."Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review)". Oncology Reports 51.6 (2024): 74.
Chicago
Yongprayoon, V., Wattanakul, N., Khomate, W., Apithanangsiri, N., Kasitipradit, T., Nantajit, D., Tavassoli, M."Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review)". Oncology Reports 51, no. 6 (2024): 74. https://doi.org/10.3892/or.2024.8733
Copy and paste a formatted citation
x
Spandidos Publications style
Yongprayoon V, Wattanakul N, Khomate W, Apithanangsiri N, Kasitipradit T, Nantajit D and Tavassoli M: Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review). Oncol Rep 51: 74, 2024.
APA
Yongprayoon, V., Wattanakul, N., Khomate, W., Apithanangsiri, N., Kasitipradit, T., Nantajit, D., & Tavassoli, M. (2024). Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review). Oncology Reports, 51, 74. https://doi.org/10.3892/or.2024.8733
MLA
Yongprayoon, V., Wattanakul, N., Khomate, W., Apithanangsiri, N., Kasitipradit, T., Nantajit, D., Tavassoli, M."Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review)". Oncology Reports 51.6 (2024): 74.
Chicago
Yongprayoon, V., Wattanakul, N., Khomate, W., Apithanangsiri, N., Kasitipradit, T., Nantajit, D., Tavassoli, M."Targeting BRD4: Potential therapeutic strategy for head and neck squamous cell carcinoma (Review)". Oncology Reports 51, no. 6 (2024): 74. https://doi.org/10.3892/or.2024.8733
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