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Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1

  • Authors:
    • Jie Zhang
    • Ye Wang
    • Shiyang Hou
    • Xiaoqian Chi
    • Danyang Ding
    • Mei Xue
    • Mengqiao Zhang
    • Jing Wang
    • Junfang Shuai
    • Haiying Sun
    • Qiang Gao
    • Chunbo Kang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Center of Gastrointestinal Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, P.R. China, Department of Gastroenterology and Hepatology, Center of Gastrointestinal Rehabilitation, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 82
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    Published online on: April 23, 2024
       https://doi.org/10.3892/or.2024.8741
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Abstract

Colorectal cancer (CRC) is one of the most common malignancies worldwide. The 5‑year survival rate of patients diagnosed with the early stages of the disease is markedly higher than that of patients in the advanced stages. Therefore, identifying novel biomarkers and drug targets for CRC is critical for clinical practice. Zinc finger protein 169 (ZNF169) is a crucial transcription factor, and its role in CRC remains to be explored. The present study aimed to investigate the clinical relevance, function and underlying mechanisms of ZNF169 in CRC growth and proliferation. The Cancer Genome Atlas (TCGA) database was utilized to analyze the clinical relevance of ZNF169 in patients with CRC. Immunohistochemical staining was performed on tissue samples from patients with CRC to detect the expression of ZNF169. The HCT‑116, HT‑29 and RKO cell lines were employed for in vitro experiments. The overexpression and knockdown of ZNF169 were achieved by transfecting the cells with lentivirus and small interfering RNAs, respectively. Cell Counting Kit‑8, colony formation and EdU staining assays were applied to investigate the function of ZNF169 in CRC cells. Dual luciferase activity and chromatin immunoprecipitation (ChIP)‑quantitative PCR (qPCR) assays were performed to identify the regulatory effects of ZNF169 on the ankyrin repeat and zinc‑finger domain‑containing 1 (ANKZF1; also known as ZNF744) gene. Reverse transcription‑quantitative PCR and western blot analysis were performed to measure mRNA and protein expression, respectively. The analysis of TCGA data revealed a positive correlation between ZNF169 and ANKZF1, with the overexpression of ANKZF1 being associated with a poor prognosis of patients with CRC. The experimental results demonstrated that ZNF169 was expression upregulated in CRC tissue compared with that in normal colon tissue. Gain‑of‑function and loss‑of‑function experiments revealed that ZNF169 enhanced the intensity of EdU staining, promoting the growth and proliferation of CRC cells. Furthermore, the overexpression of ZNF169 potentiated the transcriptional activity of the ANKZF1 gene, while the knockdown of ZNF169 produced the opposite results. ChIP‑qPCR confirmed the interaction between ZNF169 and the promoter sequence of ANKZF1. Rescue experiments revealed that ZNF169 accelerated CRC cell growth and proliferation through the upregulation of ANKZF1. Furthermore, there was a positive correlation identified between ZNF169 and ANKZF1, and upregulation of ANKZF1 expression was associated with the poor prognosis of patients with CRC. On the whole, the present study demonstrates that ZNF169 contributes to CRC malignancy by potentiating the expression of ANKZF1. Thus, the regulation of ZNF169 and/or ANKZF1 expression may represent a viable strategy for the treatment patients with CRC with a high expression of ZNF169.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Wu X, Lin H and Li S: Prognoses of different pathological subtypes of colorectal cancer at different stages: A population-based retrospective cohort study. BMC Gastroenterol. 19:1642019. View Article : Google Scholar : PubMed/NCBI

3 

Kanth P and Inadomi JM: Screening and prevention of colorectal cancer. BMJ. 374:n18552021. View Article : Google Scholar : PubMed/NCBI

4 

de Assis J, Coutinho L, Oyeyemi IT, Oyeyemi OT and Grenfell RFEQ: Diagnostic and therapeutic biomarkers in colorectal cancer: A review. Am J Cancer Res. 12:661–680. 2022.PubMed/NCBI

5 

Sardo E, Napolitano S, Della Corte CM, Ciardiello D, Raucci A, Arrichiello G, Troiani T, Ciardiello F, Martinelli E and Martini G: Multi-Omic approaches in colorectal cancer beyond genomic data. J Pers Med. 12:1282022. View Article : Google Scholar : PubMed/NCBI

6 

Zhu G, Jin L, Sun W, Wang S and Liu N: Proteomics of post-translational modifications in colorectal cancer: Discovery of new biomarkers. Biochim Biophys Acta Rev Cancer. 1877:1887352022. View Article : Google Scholar : PubMed/NCBI

7 

Salita T, Rustam Y, Mouradov D, Sieber OM and Reid GE: Reprogrammed lipid metabolism and the Lipid-Associated hallmarks of colorectal cancer. Cancers (Basel). 14:37142022. View Article : Google Scholar : PubMed/NCBI

8 

Yang M, Yang H, Ji L, Hu X, Tian G, Wang B and Yang J: A multi-omics machine learning framework in predicting the survival of colorectal cancer patients. Comput Biol Med. 146:1055162022. View Article : Google Scholar : PubMed/NCBI

9 

Dekker E, Tanis PJ, Vleugels JLA, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Andrei P, Battuello P, Grasso G, Rovera E, Tesio N and Bardelli A: Integrated approaches for precision oncology in colorectal cancer: The more you know, the better. Semin Cancer Biol. 84:199–213. 2022. View Article : Google Scholar : PubMed/NCBI

11 

Ashktorab H and Brim H: Colorectal cancer subtyping. Nat Rev Cancer. 22:68–69. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Li J, Ma X, Chakravarti D, Shalapour S and DePinho RA: Genetic and biological hallmarks of colorectal cancer. Genes Dev. 35:787–820. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Sagaert X, Vanstapel A and Verbeek S: Tumor heterogeneity in colorectal cancer: What do we know so far? Pathobiology. 85:72–84. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Bu S, Lv Y, Liu Y, Qiao S and Wang H: Zinc finger proteins in neuro-related diseases progression. Front Neurosci. 15:7605672021. View Article : Google Scholar : PubMed/NCBI

15 

Cassandri M, Smirnov A, Novelli F, Pitolli C, Agostini M, Malewicz M, Melino G and Raschellà G: Zinc-finger proteins in health and disease. Cell Death Discov. 3:170712017. View Article : Google Scholar : PubMed/NCBI

16 

Jen J and Wang YC: Zinc finger proteins in cancer progression. J Biomed Sci. 23:532016. View Article : Google Scholar : PubMed/NCBI

17 

Ecco G, Imbeault M and Trono D: KRAB zinc finger proteins. Development. 144:2719–2729. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Li X, Han M, Zhang H, Liu F, Pan Y, Zhu J, Liao Z, Chen X and Zhang B: Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma. Biomark Res. 10:22022. View Article : Google Scholar : PubMed/NCBI

19 

Chidambaram A, Gailani M, Gerrard B, Stewart C, Goldstein A, Chumakov I, Bale AE and Dean M: Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. Genes Chromosomes Cancer. 18:212–218. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Levanat S, Chidambaram A, Wicking C, Bray-Ward P, Pressman C, Toftgard R, Gailani MR, Myers JC, Wainwright B, Dean M and Bale AE: Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: Placement of a novel zinc finger gene within the NBCCS and ESS1 region. Cytogenet Cell Genet. 76:208–213. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, et al: Analysis of the human Tissue-specific expression by Genome-Wide integration of transcriptomics and Antibody-based proteomics. Mol Cell Proteomics. 13:397–406. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Bose S, Morgan LJ, Booth DR, Goudie DR, Ferguson-Smith MA and Richards FM: The elusive multiple self-healing squamous epithelioma (MSSE) gene: Further mapping, analysis of candidates, and loss of heterozygosity. Oncogene. 25:806–812. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Joazeiro CAP: Ribosomal stalling during translation: Providing substrates for Ribosome-Associated protein quality control. Annu Rev Cell Dev Biol. 33:343–368. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Stapf C, Cartwright E, Bycroft M, Hofmann K and Buchberger A: The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. J Biol Chem. 286:38670–38678. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Zhou X, Shang YN, Lu R, Fan CW and Mo XM: High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer. Future Oncol. 15:2093–2106. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Sajadi M, Fazilti M, Nazem H, Mahdevar M and Ghaedi K: The expression changes of transcription factors including ANKZF1, LEF1, CASZ1 and ATOH1 as a predictor of survival rate in colorectal cancer: A large-scale analysis. Cancer Cell Int. 22:3392022. View Article : Google Scholar : PubMed/NCBI

27 

van Haaften-Visser DY, Harakalova M, Mocholi E, van Montfrans JM, Elkadri A, Rieter E, Fiedler K, van Hasselt PM, Triffaux EMM, van Haelst MM, et al: Ankyrin repeat and zinc-finger domain-containing 1 mutations are associated with infantile-onset inflammatory bowel disease. J Biol Chem. 292:7904–7920. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Ye Q, Liu J and Xie K: Zinc finger proteins and regulation of the hallmarks of cancer. Histol Histopathol. 34:1097–1109. 2019.PubMed/NCBI

31 

Mokry M, Hatzis P, Schuijers J, Lansu N, Ruzius FP, Clevers H and Cuppen E: Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes. Nucleic Acids Res. 40:148–158. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Gaudet P, Livstone MS, Lewis SE and Thomas PD: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 12:449–462. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Schier AC and Taatjes DJ: Structure and mechanism of the RNA polymerase II transcription machinery. Gene Dev. 34:465–488. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Turcot V, Lu YC, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, et al: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 50:766–767. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Ewing AD, Cheetham SW, McGill JJ, Sharkey M, Walker R, West JA, West MJ and Summers KM: Microdeletion of 9q22.3: A patient with minimal deletion size associated with a severe phenotype. Am J Med Genet A. 185:2070–2083. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Bhattacharya S and Ghosh MK: HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. Cell Oncol. 38:265–277. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP and Parzen H: Architecture of the human interactome defines protein communities and disease networks. Nature. 545:505–509. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Cheng K, Xie G, Khurana S, Heath J, Drachenberg CB, Timmons J, Shah N and Raufman JP: Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia. Mol Cancer. 13:772014. View Article : Google Scholar : PubMed/NCBI

39 

Xie G, Peng Z, Liang J, Larabee SM, Drachenberg CB, Yfantis H and Raufman JP: Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene. JCI Insight. 7:e1508942022. View Article : Google Scholar : PubMed/NCBI

40 

Lei T, Gao Y, Duan Y, Cui C, Zhang L and Si M: Inhibition of zinc finger protein 367 exerts a tumor suppressive role in colorectal cancer by affecting the activation of oncogenic YAP1 signaling. Environ Toxicol. 36:2278–2290. 2021. View Article : Google Scholar : PubMed/NCBI

41 

Hahn S, Jackstadt R, Siemens H, Hünten S and Hermeking H: SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. Embo J. 32:3079–3095. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Taank Y and Agnihotri N: Understanding the regulation of beta-catenin expression and activity in colorectal cancer carcinogenesis: Beyond destruction complex. Clin Transl Oncol. 23:2448–2459. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Taniuchi T, Mortensen ER, Ferguson A, Greenson J and Merchant JL: Overexpression of ZBP-89, a zinc finger DNA binding protein, in gastric cancer. Biochem Biophys Res Commun. 233:154–160. 1997. View Article : Google Scholar : PubMed/NCBI

44 

Rieber MS, Zangemeister-Wittke U and Rieber M: p53-Independent induc tion-independent induction of apoptosis in human melanoma cells by a bcl-2/bcl-xL bispecific antisense oligonucleotide. Clin Cancer Res. 7:1446–1451. 2001.PubMed/NCBI

45 

Serova M, Calvo F, Lokiec F, Koeppel F, Poindessous V, Larsen AK, Laar ES, Waters SJ, Cvitkovic E and Raymond E: Characterizations of irofulven cytotoxicity in combination with cisplatin and oxaliplatin in human colon, breast, and ovarian cancer cells. Cancer Chemoth Pharm. 57:491–499. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Bandrés E, Malumbres R, Cubedo E, Honorato B, Zarate R, Labarga A, Gabisu U, Sola JJ and García-Foncillas J: A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients. Oncol Rep. 17:1089–1094. 2007.PubMed/NCBI

47 

Essien BE, Sundaresan S, Ocadiz-Ruiz R, Chavis A, Tsao AC, Tessier AJ, Hayes MM, Photenhauer A, Saqui-Salces M, Kang AJ, et al: Transcription factor ZBP-89 drives a feedforward loop of β-Catenin expression in colorectal cancer. Cancer Res. 76:6877–6887. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Mei H, Zhao L, Li W, Zheng Z, Tang D, Lu X and He Y: Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity. J Cell Mol Med. 24:12065–12081. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Lai A and Park M: Time-course transcriptomic analysis of a panel of MET receptor tyrosine kinase-inhibited gastric cancer cell lines, This is version 1.0 of an annotated derivative of the original dataset, which can be found in GSE54532. Version 1.0. Signaling Pathways Project Datasets. 2014.

50 

Szatmari I, Pap A, Rühl R, Ma JX, Illarionov PA, Besra GS, Rajnavolgyi E, Dezso B and Nagy L: PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 203:2351–2362. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Sajadi M, Fazilti M, Nazem H, Mahdevar M and Ghaedi K: The expression changes of transcription factors including ANKZF1, LEF1, CASZ1, and ATOH1 as a predictor of survival rate in colorectal cancer: A large-scale analysis. Cancer Cell Int. 22:3392022. View Article : Google Scholar : PubMed/NCBI

52 

Chen P, Li Z, Liang Y, Wei M, Jiang H, Chen S and Zhao Z: Identification of Hypoxia-Associated signature in colon cancer to assess tumor immune microenvironment and predict prognosis based on 14 Hypoxia-Associated genes. Int J Gen Med. 16:2503–2518. 2023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Wang Y, Hou S, Chi X, Ding D, Xue M, Zhang M, Wang J, Shuai J, Sun H, Sun H, et al: Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1. Oncol Rep 51: 82, 2024.
APA
Zhang, J., Wang, Y., Hou, S., Chi, X., Ding, D., Xue, M. ... Kang, C. (2024). Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1. Oncology Reports, 51, 82. https://doi.org/10.3892/or.2024.8741
MLA
Zhang, J., Wang, Y., Hou, S., Chi, X., Ding, D., Xue, M., Zhang, M., Wang, J., Shuai, J., Sun, H., Gao, Q., Kang, C."Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1". Oncology Reports 51.6 (2024): 82.
Chicago
Zhang, J., Wang, Y., Hou, S., Chi, X., Ding, D., Xue, M., Zhang, M., Wang, J., Shuai, J., Sun, H., Gao, Q., Kang, C."Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1". Oncology Reports 51, no. 6 (2024): 82. https://doi.org/10.3892/or.2024.8741
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Wang Y, Hou S, Chi X, Ding D, Xue M, Zhang M, Wang J, Shuai J, Sun H, Sun H, et al: Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1. Oncol Rep 51: 82, 2024.
APA
Zhang, J., Wang, Y., Hou, S., Chi, X., Ding, D., Xue, M. ... Kang, C. (2024). Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1. Oncology Reports, 51, 82. https://doi.org/10.3892/or.2024.8741
MLA
Zhang, J., Wang, Y., Hou, S., Chi, X., Ding, D., Xue, M., Zhang, M., Wang, J., Shuai, J., Sun, H., Gao, Q., Kang, C."Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1". Oncology Reports 51.6 (2024): 82.
Chicago
Zhang, J., Wang, Y., Hou, S., Chi, X., Ding, D., Xue, M., Zhang, M., Wang, J., Shuai, J., Sun, H., Gao, Q., Kang, C."Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1". Oncology Reports 51, no. 6 (2024): 82. https://doi.org/10.3892/or.2024.8741
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