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Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment

  • Authors:
    • Zhongjie Yu
    • Jianhua Shi
    • Yuan Fang
    • Yi Zhao
    • Aotian Xu
    • Ning Li
  • View Affiliations / Copyright

    Affiliations: R&D, Qingdao Sino‑cell Biomedicine Co., Ltd., Qingdao, Shandong 266000, P.R. China, Phase I Clinical Research Center Affiliated, Linyi Tumor Hospital, Linyi, Shandong 276000, P.R. China, Clinical Trials Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 85
    |
    Published online on: April 26, 2024
       https://doi.org/10.3892/or.2024.8744
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Abstract

Cancer is the main cause of global mortality, and thus far, effective therapeutic strategies for cancer treatment are in high demand. Adoptive transfer of tumor‑infiltrating lymphocytes (TILs) represents a promising avenue in immunotherapy for the management of malignancies. The clinical safety and efficacy of TIL‑based therapy have been established through numerous rigorous clinical trials. However, the efficacy of TIL infusion in inducing an anti‑tumor response is limited to a subset of clinical patients with cancer. Therefore, there is an urgent need to develop innovative strategies aimed at enhancing the effectiveness of TIL‑based therapy. In the present review, the developmental history of TIL‑based therapy was systematically summarized and analyzed, while also presenting a unique perspective on enhancing the multi‑dimensional anti‑tumor capabilities of TILs. The insight and conclusions presented in this review may contribute to improving the efficacy of TIL‑based therapy and expediting its development.
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Copy and paste a formatted citation
Spandidos Publications style
Yu Z, Shi J, Fang Y, Zhao Y, Xu A and Li N: Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment. Oncol Rep 51: 85, 2024.
APA
Yu, Z., Shi, J., Fang, Y., Zhao, Y., Xu, A., & Li, N. (2024). Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment. Oncology Reports, 51, 85. https://doi.org/10.3892/or.2024.8744
MLA
Yu, Z., Shi, J., Fang, Y., Zhao, Y., Xu, A., Li, N."Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment". Oncology Reports 51.6 (2024): 85.
Chicago
Yu, Z., Shi, J., Fang, Y., Zhao, Y., Xu, A., Li, N."Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment". Oncology Reports 51, no. 6 (2024): 85. https://doi.org/10.3892/or.2024.8744
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Z, Shi J, Fang Y, Zhao Y, Xu A and Li N: Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment. Oncol Rep 51: 85, 2024.
APA
Yu, Z., Shi, J., Fang, Y., Zhao, Y., Xu, A., & Li, N. (2024). Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment. Oncology Reports, 51, 85. https://doi.org/10.3892/or.2024.8744
MLA
Yu, Z., Shi, J., Fang, Y., Zhao, Y., Xu, A., Li, N."Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment". Oncology Reports 51.6 (2024): 85.
Chicago
Yu, Z., Shi, J., Fang, Y., Zhao, Y., Xu, A., Li, N."Developing innovative strategies of tumor‑infiltrating lymphocyte therapy for tumor treatment". Oncology Reports 51, no. 6 (2024): 85. https://doi.org/10.3892/or.2024.8744
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