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Review Open Access

Inhibition of FSP1: A new strategy for the treatment of tumors (Review)

  • Authors:
    • Qiangfang Dai
    • Xiaoli Wei
    • Jumei Zhao
    • Die Zhang
    • Yidan Luo
    • Yue Yang
    • Yang Xiang
    • Xiaolong Liu
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Yan'an University, Yan'an, Shaanxi 716000, P.R. China
    Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 105
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    Published online on: June 27, 2024
       https://doi.org/10.3892/or.2024.8764
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Abstract

Ferroptosis, a regulated form of cell death, is intricately linked to iron‑dependent lipid peroxidation. Recent evidence strongly supports the induction of ferroptosis as a promising strategy for treating cancers resistant to conventional therapies. A key player in ferroptosis regulation is ferroptosis suppressor protein 1 (FSP1), which promotes cancer cell resistance by promoting the production of the antioxidant form of coenzyme Q10. Of note, FSP1 confers resistance to ferroptosis independently of the glutathione (GSH) and glutathione peroxidase‑4 pathway. Therefore, targeting FSP1 to weaken its inhibition of ferroptosis may be a viable strategy for treating refractory cancer. This review aims to clarify the molecular mechanisms underlying ferroptosis, the specific pathway by which FSP1 suppresses ferroptosis and the effect of FSP1 inhibitors on cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Dai Q, Wei X, Zhao J, Zhang D, Luo Y, Yang Y, Xiang Y and Liu X: Inhibition of FSP1: A new strategy for the treatment of tumors (Review). Oncol Rep 52: 105, 2024.
APA
Dai, Q., Wei, X., Zhao, J., Zhang, D., Luo, Y., Yang, Y. ... Liu, X. (2024). Inhibition of FSP1: A new strategy for the treatment of tumors (Review). Oncology Reports, 52, 105. https://doi.org/10.3892/or.2024.8764
MLA
Dai, Q., Wei, X., Zhao, J., Zhang, D., Luo, Y., Yang, Y., Xiang, Y., Liu, X."Inhibition of FSP1: A new strategy for the treatment of tumors (Review)". Oncology Reports 52.2 (2024): 105.
Chicago
Dai, Q., Wei, X., Zhao, J., Zhang, D., Luo, Y., Yang, Y., Xiang, Y., Liu, X."Inhibition of FSP1: A new strategy for the treatment of tumors (Review)". Oncology Reports 52, no. 2 (2024): 105. https://doi.org/10.3892/or.2024.8764
Copy and paste a formatted citation
x
Spandidos Publications style
Dai Q, Wei X, Zhao J, Zhang D, Luo Y, Yang Y, Xiang Y and Liu X: Inhibition of FSP1: A new strategy for the treatment of tumors (Review). Oncol Rep 52: 105, 2024.
APA
Dai, Q., Wei, X., Zhao, J., Zhang, D., Luo, Y., Yang, Y. ... Liu, X. (2024). Inhibition of FSP1: A new strategy for the treatment of tumors (Review). Oncology Reports, 52, 105. https://doi.org/10.3892/or.2024.8764
MLA
Dai, Q., Wei, X., Zhao, J., Zhang, D., Luo, Y., Yang, Y., Xiang, Y., Liu, X."Inhibition of FSP1: A new strategy for the treatment of tumors (Review)". Oncology Reports 52.2 (2024): 105.
Chicago
Dai, Q., Wei, X., Zhao, J., Zhang, D., Luo, Y., Yang, Y., Xiang, Y., Liu, X."Inhibition of FSP1: A new strategy for the treatment of tumors (Review)". Oncology Reports 52, no. 2 (2024): 105. https://doi.org/10.3892/or.2024.8764
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