Open Access

Roles of long non‑coding RNA SNHG16 in human digestive system cancer (Review)

  • Authors:
    • Lujie Zhao
    • Yuling Kan
    • Lu Wang
    • Jiquan Pan
    • Yun Li
    • Haiyan Zhu
    • Zhongfa Yang
    • Lin Xiao
    • Xinhua Fu
    • Fujun Peng
    • Haipeng Ren
  • View Affiliations

  • Published online on: June 28, 2024     https://doi.org/10.3892/or.2024.8765
  • Article Number: 106
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incidence of tumors in the human digestive system is relatively high, including esophageal cancer, liver cancer, pancreatic cancer, gastric cancer and colorectal cancer. These malignancies arise from a complex interplay of environmental and genetic factors. Among them, long non‑coding RNAs (lncRNAs), which cannot be translated into proteins, serve an important role in the development, progression, migration and prognosis of tumors. Small nucleolar RNA host gene 16 (SNHG16) is a typical lncRNA, and its relationship with digestive system tumors has been widely explored. The prevailing hypothesis suggests that the principal molecular mechanism of SNHG16 in digestive system tumors involves it functioning as a competitive endogenous RNA that interacts with other proteins, regulates various genes and influences a downstream target molecule. The present review summarizes recent research on the relationship between SNHG16 and numerous types of digestive system cancer, encompassing its biological functions, underlying mechanisms and potential clinical implications. Furthermore, it outlines the association between SNHG16 expression and pertinent risk factors, such as smoking, infection and diet. The present review indicated the promise of SNHG16 as a potential biomarker and therapeutic target in human digestive system cancer.
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August-2024
Volume 52 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao L, Kan Y, Wang L, Pan J, Li Y, Zhu H, Yang Z, Xiao L, Fu X, Peng F, Peng F, et al: Roles of long non‑coding RNA SNHG16 in human digestive system cancer (Review). Oncol Rep 52: 106, 2024
APA
Zhao, L., Kan, Y., Wang, L., Pan, J., Li, Y., Zhu, H. ... Ren, H. (2024). Roles of long non‑coding RNA SNHG16 in human digestive system cancer (Review). Oncology Reports, 52, 106. https://doi.org/10.3892/or.2024.8765
MLA
Zhao, L., Kan, Y., Wang, L., Pan, J., Li, Y., Zhu, H., Yang, Z., Xiao, L., Fu, X., Peng, F., Ren, H."Roles of long non‑coding RNA SNHG16 in human digestive system cancer (Review)". Oncology Reports 52.2 (2024): 106.
Chicago
Zhao, L., Kan, Y., Wang, L., Pan, J., Li, Y., Zhu, H., Yang, Z., Xiao, L., Fu, X., Peng, F., Ren, H."Roles of long non‑coding RNA SNHG16 in human digestive system cancer (Review)". Oncology Reports 52, no. 2 (2024): 106. https://doi.org/10.3892/or.2024.8765