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Review Open Access

Hedgehog pathway and cancer: A new area (Review)

  • Authors:
    • Deyi Shen
    • Yuwei Xia
    • Yuhan Fu
    • Qiaochang Cao
    • Wenqian Chen
    • Ying Zhu
    • Kaibo Guo
    • Leitao Sun
  • View Affiliations / Copyright

    Affiliations: The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310006, P.R. China, The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Cancer Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 116
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    Published online on: July 10, 2024
       https://doi.org/10.3892/or.2024.8775
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Abstract

In years of research on classical pathways, the composition, information transmission mechanism, crosstalk with other pathways, and physiological and pathological effects of hedgehog (HH) pathway have been gradually clarified. HH also plays a critical role in tumor formation and development. According to the update of interpretation of tumor phenotypes, the latest relevant studies have been sorted out, to explore the specific mechanism of HH pathway in regulating different tumor phenotypes through gene mutation and signal regulation. The drugs and natural ingredients involved in regulating HH pathway were also reviewed; five approved drugs and drugs under research exert efficacy by blocking HH pathway, and at least 22 natural components have potential to treat tumors by HH pathway. Nevertheless, there is a deficiency of existing studies. The present review confirmed the great potential of HH pathway in future cancer treatment with factual basis.
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Copy and paste a formatted citation
Spandidos Publications style
Shen D, Xia Y, Fu Y, Cao Q, Chen W, Zhu Y, Guo K and Sun L: Hedgehog pathway and cancer: A new area (Review). Oncol Rep 52: 116, 2024.
APA
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y. ... Sun, L. (2024). Hedgehog pathway and cancer: A new area (Review). Oncology Reports, 52, 116. https://doi.org/10.3892/or.2024.8775
MLA
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y., Guo, K., Sun, L."Hedgehog pathway and cancer: A new area (Review)". Oncology Reports 52.3 (2024): 116.
Chicago
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y., Guo, K., Sun, L."Hedgehog pathway and cancer: A new area (Review)". Oncology Reports 52, no. 3 (2024): 116. https://doi.org/10.3892/or.2024.8775
Copy and paste a formatted citation
x
Spandidos Publications style
Shen D, Xia Y, Fu Y, Cao Q, Chen W, Zhu Y, Guo K and Sun L: Hedgehog pathway and cancer: A new area (Review). Oncol Rep 52: 116, 2024.
APA
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y. ... Sun, L. (2024). Hedgehog pathway and cancer: A new area (Review). Oncology Reports, 52, 116. https://doi.org/10.3892/or.2024.8775
MLA
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y., Guo, K., Sun, L."Hedgehog pathway and cancer: A new area (Review)". Oncology Reports 52.3 (2024): 116.
Chicago
Shen, D., Xia, Y., Fu, Y., Cao, Q., Chen, W., Zhu, Y., Guo, K., Sun, L."Hedgehog pathway and cancer: A new area (Review)". Oncology Reports 52, no. 3 (2024): 116. https://doi.org/10.3892/or.2024.8775
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