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Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review)

  • Authors:
    • Wanli Liu
    • Xianze Wang
    • Wenming Wu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 144
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    Published online on: August 26, 2024
       https://doi.org/10.3892/or.2024.8803
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Abstract

Interleukin‑17 (IL‑17), an inflammatory cytokine primarily secreted by T helper 17 cells, serves a crucial role in numerous inflammatory diseases and malignancies via its receptor, IL‑17R. In addition to stimulating inflammatory responses, IL‑17 exhibits dual functions in tumors, exerting both pro‑ and antitumor effects. Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy and accounts for >90% of pancreatic cancer cases. PDAC is characterized by a prominent stromal microenvironment with significant heterogeneity, which contributes to treatment resistance. IL‑17/IL‑17R signaling has a notable effect on tumorigenesis, the tumor microenvironment and treatment efficacy in various cancer types, including PDAC. However, the specific mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer remain uncertain. This review presents a brief overview of the current knowledge and recent advances in the role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer. Furthermore, the potential of IL‑17‑targeted therapeutic strategies for PDAC treatment is also discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Wang X and Wu W: Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review). Oncol Rep 52: 144, 2024.
APA
Liu, W., Wang, X., & Wu, W. (2024). Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review). Oncology Reports, 52, 144. https://doi.org/10.3892/or.2024.8803
MLA
Liu, W., Wang, X., Wu, W."Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review)". Oncology Reports 52.5 (2024): 144.
Chicago
Liu, W., Wang, X., Wu, W."Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review)". Oncology Reports 52, no. 5 (2024): 144. https://doi.org/10.3892/or.2024.8803
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Wang X and Wu W: Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review). Oncol Rep 52: 144, 2024.
APA
Liu, W., Wang, X., & Wu, W. (2024). Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review). Oncology Reports, 52, 144. https://doi.org/10.3892/or.2024.8803
MLA
Liu, W., Wang, X., Wu, W."Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review)". Oncology Reports 52.5 (2024): 144.
Chicago
Liu, W., Wang, X., Wu, W."Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review)". Oncology Reports 52, no. 5 (2024): 144. https://doi.org/10.3892/or.2024.8803
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