Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November-2024 Volume 52 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2024 Volume 52 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors

  • Authors:
    • Yuqing Yang
    • Fang Wang
    • Yuqin Li
    • Ruxi Chen
    • Xiangyu Wang
    • Jiahong Chen
    • Xi Lin
    • Haipeng Zhang
    • Youwei Huang
    • Rui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Jinan University, Guangzhou, Guangdong 510632, P.R. China, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Institute of Evolution and Marine Biodiversity, Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, P.R. China, The Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing 100191, P.R. China, Department of Oncology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 154
    |
    Published online on: September 26, 2024
       https://doi.org/10.3892/or.2024.8813
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lack of effective tumor‑specific delivery systems remains an unmet clinical challenge for the employment of chemotherapy using cytotoxic drugs. Extracellular vesicles (EVs) have recently been investigated for their potential as an efficient drug‑delivery platform, due to their good biodistribution, biocompatibility and low immunogenicity. In the present study, the formulation of GE11 peptide‑modified EVs (GE11‑EVs) loaded with doxorubicin (Dox‑GE11‑EVs), was developed to target epidermal growth factor receptor (EGFR)‑positive tumor cells. The results obtained demonstrated that GE11‑EVs exhibited highly efficient targeting and drug delivery to EGFR‑positive tumor cells compared with non‑modified EVs. Furthermore, treatment with Dox‑GE11‑EVs led to a significantly inhibition of cell proliferation and increased apoptosis of EGFR‑positive tumor cells compared with Dox‑EVs and free Dox treatments. In addition, it was observed that treatment with either free Dox or Dox‑EVs exhibited a high level of cytotoxicity to normal cells, whereas treatment with Dox‑GE11‑EVs had only a limited effect on cell viability of normal cells. Taken together, the findings of the present study demonstrated that the engineered Dox‑GE11‑EVs can treat EGFR‑positive tumors more accurately and have higher safety than traditional tumor therapies.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Michod D and Widmann C: DNA-damage sensitizers: Potential new therapeutical tools to improve chemotherapy. Crit Rev Oncol Hematol. 63:160–171. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Arrighetti N, Corbo C, Evangelopoulos M, Pasto A, Zuco V and Tasciotti E: Exosome-like nanovectors for drug delivery in cancer. Curr Med Chem. 26:6132–6148. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B and Simons M: Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 319:1244–1247. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Hossen S, Hossain MK, Basher MK, Mia MNH, Rahman MT and Uddin MJ: Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review. J Adv Res. 15:1–18. 2018. View Article : Google Scholar : PubMed/NCBI

5 

van den Boorn JG, Schlee M, Coch C and Hartmann G: SiRNA delivery with exosome nanoparticles. Nat Biotechnol. 29:325–326. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Wu JY, Li YJ, Hu XB, Huang S, Luo S, Tang T and Xiang DX: Exosomes and biomimetic nanovesicles-mediated anti-glioblastoma therapy: A head-to-head comparison. J Control Release. 336:510–521. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Woodburn JR: The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther. 82:241–250. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Ohno S, Takanashi M, Sudo K, Ueda S, Ishikawa A, Matsuyama N, Fujita K, Mizutani T, Ohgi T, Ochiya T, et al: Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther. 21:185–191. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Li Z, Zhao R, Wu X, Sun Y, Yao M, Li J, Xu Y and Gu J: Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics. FASEB J. 19:1978–1985. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Fang Y, Yang W, Cheng L, Meng F, Zhang J and Zhong Z: EGFR-targeted multifunctional polymersomal doxorubicin induces selective and potent suppression of orthotopic human liver cancer in vivo. Acta Biomater. 64:323–333. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Guo Z, Sui J, Li Y, Wei Q, Wei C, Xiu L, Zhu R, Sun Y, Hu J and Li JL: GE11 peptide-decorated acidity-responsive micelles for improved drug delivery and enhanced combination therapy of metastatic breast cancer. J Mater Chem B. 10:9266–9279. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Zou Y, Xia Y, Meng F, Zhang J and Zhong Z: GE11-Directed functional polymersomal doxorubicin as an advanced alternative to clinical liposomal formulation for ovarian cancer treatment. Mol Pharm. 15:3664–3671. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Wang P, Wang H, Huang Q, Peng C, Yao L, Chen H, Qiu Z, Wu Y, Wang L and Chen W: Exosomes from M1-Polarized macrophages enhance paclitaxel antitumor activity by activating macrophages-mediated inflammation. Theranostics. 9:1714–1727. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Zhang Y, Zhang L, Du LS, Liu CL and Chen YY: Distributed energy-efficient target tracking algorithm based on event-triggered strategy for sensor networks. Iet Control Theory Appl. 13:1564–1570. 2019. View Article : Google Scholar

15 

Hui B, Lu C, Wang J, Xu Y, Yang Y, Ji H, Li X, Xu L, Wang J, Tang W, et al: Engineered exosomes for co-delivery of PGM5-AS1 and oxaliplatin to reverse drug resistance in colon cancer. J Cell Physiol. 237:911–933. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Yu M, Gai C, Li Z, Ding D, Zheng J, Zhang W, Lv S and Li W: Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells. Cancer Sci. 110:3173–3182. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Duan WR, Garner DS, Williams SD, Funckes-Shippy CL, Spath IS and Blomme EA: Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts. J Pathol. 199:221–228. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Kang PM and Izumo S: Apoptosis in heart failure: Is there light at the end of the tunnel (TUNEL)? J Card Fail. 6:43–46. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Sharma R, Iovine C, Agarwal A and Henkel R: TUNEL assay-Standardized method for testing sperm DNA fragmentation. Andrologia. 53:e137382021. View Article : Google Scholar : PubMed/NCBI

20 

Short B: TUNEL vision spots apoptotic cells. J Cell Biol. 208:72015. View Article : Google Scholar : PubMed/NCBI

21 

Stickney Z, Losacco J, McDevitt S, Zhang Z and Lu B: Development of exosome surface display technology in living human cells. Biochem Biophys Res Commun. 472:53–59. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Debbi L, Guo S, Safina D and Levenberg S: Boosting extracellular vesicle secretion. Biotechnol Adv. 59:1079832022. View Article : Google Scholar : PubMed/NCBI

23 

Wang J, Tang W, Yang M, Yin Y, Li H, Hu F, Tang L, Ma X, Zhang Y and Wang Y: Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy. Biomaterials. 273:1207842021. View Article : Google Scholar : PubMed/NCBI

24 

Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB and Miller CR: EGFR, the Lazarus target for precision oncology in glioblastoma. Neuro Oncol. 24:2035–2062. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Salomon DS, Brandt R, Ciardiello F and Normanno N: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol. 19:183–232. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Qi Y, Liu B, Sun Q, Xiong X and Chen Q: Immune checkpoint targeted therapy in glioma: Status and hopes. Front Immunol. 11:5788772020. View Article : Google Scholar : PubMed/NCBI

27 

Yuan D, Zhao Y, Banks WA, Bullock KM, Haney M, Batrakova E and Kabanov AV: Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. Biomaterials. 142:1–12. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Wei T, Xiaojun X and Peilong C: Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways. Biomed Pharmacother. 121:1091392020. View Article : Google Scholar : PubMed/NCBI

29 

Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J and Chen J: DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling. Cell Res. 28:833–854. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Gao S, Tan H and Gang J: Inhibition of hepatocellular carcinoma cell proliferation through regulation of the Cell Cycle, AGE-RAGE, and Leptin signaling pathways by a compound formulation comprised of andrographolide, wogonin, and oroxylin A derived from Andrographis Paniculata(Burm.f.) Nees. J Ethnopharmacol. 329:1180012024. View Article : Google Scholar : PubMed/NCBI

31 

Gao SY, Tan HX and Li D: Oridonin suppresses gastric cancer SGC-7901 cell proliferation by targeting the TNF-alpha/androgen receptor/TGF-beta signalling pathway axis. J Cell Mol Med. 27:2661–2674. 2023. View Article : Google Scholar : PubMed/NCBI

32 

Mondal J, Pillarisetti S, Junnuthula V, Saha M, Hwang SR, Park IK and Lee YK: Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications. J Control Release. 353:1127–1149. 2023. View Article : Google Scholar : PubMed/NCBI

33 

Bagalkot V, Farokhzad OC, Langer R and Jon S: An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed Engl. 45:8149–8152. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Zhang C, Song J, Lou L, Qi X, Zhao L, Fan B, Sun G, Lv Z, Fan Z, Jiao B and Yang J: Doxorubicin-loaded nanoparticle coated with endothelial cells-derived exosomes for immunogenic chemotherapy of glioblastoma. Bioeng Transl Med. 6:e102032020. View Article : Google Scholar : PubMed/NCBI

35 

Liang GF, Zhu YL, Ali DJ, Tian T, Xu H, Si K, Sun B, Chen B and Xiao Z: Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer. J Nanobiotechnol. 18:102020. View Article : Google Scholar

36 

Rayamajhi S, Nguyen TDT, Marasini R and Aryal S: Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery. Acta Biomater. 94:482–494. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Zhou X, Zhuang Y, Liu X, Gu Y, Wang J, Shi Y, Zhang L, Li R, Zhao Y, Chen H, et al: Study on tumour cell-derived hybrid exosomes as dasatinib nanocarriers for pancreatic cancer therapy. Artif Cells Nanomed Biotechnol. 51:532–546. 2023. View Article : Google Scholar : PubMed/NCBI

38 

Gao S, Gang J, Yu M, Xin G and Tan H: Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer. BMC Cancer. 21:7912021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Wang F, Li Y, Chen R, Wang X, Chen J, Lin X, Zhang H, Huang Y, Wang R, Wang R, et al: Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors. Oncol Rep 52: 154, 2024.
APA
Yang, Y., Wang, F., Li, Y., Chen, R., Wang, X., Chen, J. ... Wang, R. (2024). Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors. Oncology Reports, 52, 154. https://doi.org/10.3892/or.2024.8813
MLA
Yang, Y., Wang, F., Li, Y., Chen, R., Wang, X., Chen, J., Lin, X., Zhang, H., Huang, Y., Wang, R."Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors". Oncology Reports 52.5 (2024): 154.
Chicago
Yang, Y., Wang, F., Li, Y., Chen, R., Wang, X., Chen, J., Lin, X., Zhang, H., Huang, Y., Wang, R."Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors". Oncology Reports 52, no. 5 (2024): 154. https://doi.org/10.3892/or.2024.8813
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Wang F, Li Y, Chen R, Wang X, Chen J, Lin X, Zhang H, Huang Y, Wang R, Wang R, et al: Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors. Oncol Rep 52: 154, 2024.
APA
Yang, Y., Wang, F., Li, Y., Chen, R., Wang, X., Chen, J. ... Wang, R. (2024). Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors. Oncology Reports, 52, 154. https://doi.org/10.3892/or.2024.8813
MLA
Yang, Y., Wang, F., Li, Y., Chen, R., Wang, X., Chen, J., Lin, X., Zhang, H., Huang, Y., Wang, R."Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors". Oncology Reports 52.5 (2024): 154.
Chicago
Yang, Y., Wang, F., Li, Y., Chen, R., Wang, X., Chen, J., Lin, X., Zhang, H., Huang, Y., Wang, R."Engineered extracellular vesicles with polypeptide for targeted delivery of doxorubicin against EGFR‑positive tumors". Oncology Reports 52, no. 5 (2024): 154. https://doi.org/10.3892/or.2024.8813
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team