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Article Open Access

Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle

  • Authors:
    • Peng Sun
    • Hanqing Huang
    • Jian-Chao Ma
    • Binyang Feng
    • Yiqing Zhang
    • Genggeng Qin
    • Weian Zeng
    • Zhong-Kai Cui
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 155
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    Published online on: September 27, 2024
       https://doi.org/10.3892/or.2024.8814
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Abstract

Breast cancer is the most prevalent cancer among women worldwide, characterized by a high mortality rate and propensity for metastasis. Although surgery is the standard treatment for breast cancer, there is still no effective method to inhibit tumor metastasis and improve the prognosis of patients with breast cancer after surgery. Propofol, one of the most widely used intravenous anesthetics in surgery, has exhibited a positive association with improved survival outcomes in patients with breast cancer post‑surgery. However, the underlying molecular mechanism remains to be elucidated. The present study revealed that triple negative breast cancer cells, MDA‑MB‑231 and 4T1, exposed to propofol exhibited a significant decrease in cell viability. Notably, propofol exhibited minimal cytotoxic effects on HUVECs under the same conditions. Furthermore, propofol significantly inhibited the migration and invasion ability of MDA‑MB‑231 and 4T1 cells. Propofol promoted apoptosis in 4T1 cells through upregulation of Bax and cleaved caspase 3, while downregulating B‑cell lymphoma‑extra large. Concomitantly, propofol induced cell cycle arrest of 4T1 cells by downregulating cyclin E2 and phosphorylated cell division cycle 6. Furthermore, propofol exhibited excellent anticancer efficacy in a 4T1 breast cancer allograft mouse model. The present study sheds light on the potential of propofol as an old medicine with a novel use for breast cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Sun P, Huang H, Ma J, Feng B, Zhang Y, Qin G, Zeng W and Cui Z: Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle. Oncol Rep 52: 155, 2024.
APA
Sun, P., Huang, H., Ma, J., Feng, B., Zhang, Y., Qin, G. ... Cui, Z. (2024). Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle. Oncology Reports, 52, 155. https://doi.org/10.3892/or.2024.8814
MLA
Sun, P., Huang, H., Ma, J., Feng, B., Zhang, Y., Qin, G., Zeng, W., Cui, Z."Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle". Oncology Reports 52.5 (2024): 155.
Chicago
Sun, P., Huang, H., Ma, J., Feng, B., Zhang, Y., Qin, G., Zeng, W., Cui, Z."Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle". Oncology Reports 52, no. 5 (2024): 155. https://doi.org/10.3892/or.2024.8814
Copy and paste a formatted citation
x
Spandidos Publications style
Sun P, Huang H, Ma J, Feng B, Zhang Y, Qin G, Zeng W and Cui Z: Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle. Oncol Rep 52: 155, 2024.
APA
Sun, P., Huang, H., Ma, J., Feng, B., Zhang, Y., Qin, G. ... Cui, Z. (2024). Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle. Oncology Reports, 52, 155. https://doi.org/10.3892/or.2024.8814
MLA
Sun, P., Huang, H., Ma, J., Feng, B., Zhang, Y., Qin, G., Zeng, W., Cui, Z."Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle". Oncology Reports 52.5 (2024): 155.
Chicago
Sun, P., Huang, H., Ma, J., Feng, B., Zhang, Y., Qin, G., Zeng, W., Cui, Z."Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle". Oncology Reports 52, no. 5 (2024): 155. https://doi.org/10.3892/or.2024.8814
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