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Review

Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review)

  • Authors:
    • Raquel González‑Garza
    • Adrián Gutiérrez‑González
    • Mario César Salinas‑Carmona
    • Manuel Mejía‑Torres
  • View Affiliations / Copyright

    Affiliations: Immunology Service, University Hospital ‘José Eleuterio González’, Autonomous University of Nuevo León, Monterrey, Nuevo León 64460, México, Urology Service, University Hospital ‘José Eleuterio González’, Autonomous University of Nuevo León, Monterrey, Nuevo León 64460, México
  • Article Number: 164
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    Published online on: October 14, 2024
       https://doi.org/10.3892/or.2024.8823
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Abstract

Renal cell carcinoma (RCC) is a highly aggressive neoplastic disease of the renal parenchyma that is characterized by an intrinsic resistance to cytotoxic chemotherapy; for this reason, curative treatment is only achieved through surgical intervention in its early stages. The successful treatment of advanced or metastatic RCC will require the combined use of novel targeted therapies such as tyrosine kinase inhibitors, vascular endothelial growth factor blockers and immune checkpoint blockade therapies. Unfortunately, not all patients are candidates for such treatments, and at present, it is not possible to predict a patient's therapeutic response or likelihood to develop treatment‑associated complications. The present review described the literature focusing on the use of biomarkers for predicting patients' responses to therapies that induce immune checkpoint blockade in RCC.
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1 

Padala SA and Barsouk A, Thandra KC, Saginala K, Mohammed A, Vakiti A, Rawla P and Barsouk A: Epidemiology of renal cell carcinoma. World J Oncol. 11:79–87. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024. View Article : Google Scholar : PubMed/NCBI

3 

Bukavina L, Bensalah K, Bray F, Carlo M, Challacombe B, Karam JA, Kassouf W, Mitchell T, Montironi R and O'Brien T: Epidemiology of renal cell carcinoma: 2022 update. Eur Urol. 82:529–542. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Musaddaq B, Musaddaq T, Gupta A, Ilyas S and von Stempel C: Renal cell carcinoma: The evolving role of imaging in the 21st century. Semin Ultrasound CT MR. 41:344–350. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Scosyrev E, Messing EM, Sylvester R and Van Poppel H: Exploratory subgroup analyses of renal function and overall survival in european organization for research and treatment of cancer randomized trial of Nephron-sparing surgery versus radical nephrectomy. Eur Urol Focus. 3:599–605. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Goswami PR, Singh G, Patel T and Dave R: The WHO 2022 classification of renal neoplasms (5th Edition): Salient updates. Cureus. 16:e584702024.PubMed/NCBI

7 

Didwaniya N, Edmonds RJ, Fang X, Silberstein PT and Subbiah S: Survival outcomes in metastatic renal carcinoma based on histological subtypes: SEER database analysis. J Clin Oncol. 29:381. 2011. View Article : Google Scholar

8 

Morais C, Gobe G, Johnson DW and Healy H: Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinoma. Apoptosis. 15:412–425. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Toth C, Funke S, Nitsche V, Liverts A, Zlachevska V, Gasis M, Wiek C, Hanenberg H, Mahotka C, Schirmacher P and Heikaus S: The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): The crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling. Cell Commun Signal. 15:162017. View Article : Google Scholar : PubMed/NCBI

10 

Yang WZ, Zhou H and Yan Y: XIAP underlies apoptosis resistance of renal cell carcinoma cells. Mol Med Rep. 17:125–130. 2018.PubMed/NCBI

11 

Wang L, Fu B, Hou DY, Lv YL, Yang G, Li C, Shen JC, Kong B, Zheng LB, Qiu Y, et al: PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy. Biomaterials. 296:1220602023. View Article : Google Scholar : PubMed/NCBI

12 

Diamond E, Molina AM, Carbonaro M, Akhtar NH, Giannakakou P, Tagawa ST and Nanus DM: Cytotoxic chemotherapy in the treatment of advanced renal cell carcinoma in the era of targeted therapy. Crit Rev Oncol Hematol. 96:518–526. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Saliby RM, Saad E, Kashima S, Schoenfeld DA and Braun DA: Update on biomarkers in renal cell carcinoma. Am Soc Clin Oncol Educ Book. 44:e4307342024. View Article : Google Scholar : PubMed/NCBI

14 

Lam JS, Pantuck AJ, Belldegrun AS and Figlin RA: Protein expression profiles in renal cell carcinoma: Staging, prognosis, and patient selection for clinical trials. Clin Cancer Res. 13((2 Pt 2)): 703s–708s. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Lee JN, Chun SY, Ha YS, Choi KH, Yoon GS, Kim HT, Kim TH, Yoo ES, Kim BW and Kwon TG: Target molecule expression profiles in metastatic renal cell carcinoma: Development of individual targeted therapy. Tissue Eng Regen Med. 13:416–427. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Patard JJ, Leray E, Rioux-Leclercq N, Cindolo L, Ficarra V, Zisman A, De La Taille A, Tostain J, Artibani W, Abbou CC, et al: Prognostic value of histologic subtypes in renal cell carcinoma: A multicenter experience. J Clin Oncol. 23:2763–2771. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Heng DY, Xie W, Regan MM, Harshman LC, Bjarnason GA, Vaishampayan UN, Mackenzie M, Wood L, Donskov F, Tan MH, et al: External validation and comparison with other models of the International Metastatic Renal-Cell Carcinoma Database Consortium prognostic model: A population-based study. Lancet Oncol. 14:141–148. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Kattan MW, Reuter V, Motzer RJ, Katz J and Russo P: A Postoperative prognostic nomogram for renal cell carcinoma. J Urol. 166:63–67. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

20 

Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, et al: Nivolumab versus everolimus in advanced Renal-cell carcinoma. N Engl J Med. 373:1803–1813. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, et al: Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N Engl J Med. 378:1277–1290. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Motzer R, Alekseev B, Rha SY, Porta C, Eto M, Powles T, Grünwald V, Hutson TE, Kopyltsov E, Méndez-Vidal MJ, et al: Lenvatinib plus pembrolizumab or everolimus for advanced renal cell carcinoma. N Engl J Med. 384:1289–1300. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Motzer RJ, Penkov K, Haanen J, Rini B, Albiges L, Campbell MT, Venugopal B, Kollmannsberger C, Negrier S, Uemura M, et al: Avelumab plus axitinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med. 380:1103–1115. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B, et al: Pembrolizumab plus axitinib versus sunitinib for advanced Renal-cell carcinoma. N Engl J Med. 380:1116–1127. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Rini BI, Powles T, Atkins MB, Escudier B, McDermott DF, Suarez C, Bracarda S, Stadler WM, Donskov F, Lee JL, et al: Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): A multicentre, open-label, phase 3, randomised controlled trial. The Lancet. 393:2404–2415. 2019. View Article : Google Scholar

26 

Vogelzang NJ, Olsen MR, McFarlane JJ, Arrowsmith E, Bauer TM, Jain RK, Somer B, Lam ET, Kochenderfer MD, Molina A, et al: Safety and efficacy of nivolumab in patients with advanced Non-clear cell renal cell carcinoma: Results from the Phase IIIb/IV CheckMate 374 study. Clin Genitourin Cancer. 18:461–468.e3. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Tykodi SS, Gordan LN, Alter RS, Arrowsmith E, Harrison MR, Percent I, Singal R, Van Veldhuizen P, George DJ, Hutson T, et al: Safety and efficacy of nivolumab plus ipilimumab in patients with advanced non-clear cell renal cell carcinoma: Results from the phase 3b/4 CheckMate 920 trial. J Immunother Cancer. 10:e0038442022. View Article : Google Scholar : PubMed/NCBI

28 

Pal SK, Albiges L, Tomczak P, Suárez C, Voss MH, de Velasco G, Chahoud J, Mochalova A, Procopio G, Mahammedi H, et al: Atezolizumab plus cabozantinib versus cabozantinib monotherapy for patients with renal cell carcinoma after progression with previous immune checkpoint inhibitor treatment (CONTACT-03): A multicentre, randomised, Open-label, phase 3 trial. The Lancet. 402:185–195. 2023. View Article : Google Scholar

29 

Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT, Zurawski B, Oyervides Juárez VM, Hsieh JJ, Basso U, Shah AY, et al: Nivolumab plus cabozantinib versus sunitinib for advanced renal-cell carcinoma. N Engl J Med. 384:829–841. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Choueiri TK, Tomczak P, Park SH, Venugopal B, Ferguson T, Chang YH, Hajek J, Symeonides SN, Lee JL, Sarwar N, et al: Adjuvant pembrolizumab after nephrectomy in renal-cell carcinoma. N Engl J Med. 385:683–694. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Monjaras-Avila CU, Lorenzo-Leal AC, Luque-Badillo AC, D'Costa N, Chavez-Muñoz C and Bach H: The tumor immune microenvironment in clear cell renal cell carcinoma. Int J Mol Sci. 24:79462023. View Article : Google Scholar : PubMed/NCBI

32 

Karras P, Black JRM, McGranahan N and Marine JC: Decoding the interplay between genetic and Non-genetic drivers of metastasis. Nature. 629:543–554. 2024. View Article : Google Scholar : PubMed/NCBI

33 

Ucche S and Hayakawa Y: Immunological aspects of cancer cell metabolism. Int J Mol Sci. 25:52882024. View Article : Google Scholar : PubMed/NCBI

34 

Bucciol G, Delafontaine S, Meyts I and Poli C: Inborn errors of immunity: A field without frontiers. Immunol Rev. 322:15–27. 2024. View Article : Google Scholar : PubMed/NCBI

35 

Kramer G, Blair T, Bambina S, Kaur AP, Alice A, Baird J, Friedman D, Dowdell AK, Tomura M, Grassberger C, et al: Fluorescence tracking demonstrates T cell recirculation is transiently impaired by radiation therapy to the tumor. Sci Rep. 14:119092024. View Article : Google Scholar : PubMed/NCBI

36 

Tan D, Miao D, Zhao C, Shi J, Lv Q, Xiong Z, Yang H and Zhang X: Comprehensive analyses of A 12-metabolism-associated gene signature and its connection with tumor metastases in clear cell renal cell carcinoma. BMC Cancer. 23:2642023. View Article : Google Scholar : PubMed/NCBI

37 

Wu Y and Li X: Senescence gene expression in clear cell renal cell carcinoma: Role of tumor immune microenvironment and senescence-associated survival prediction. Medicine (Baltimore). 102:e352222023. View Article : Google Scholar : PubMed/NCBI

38 

Zhang Q, Lin B, Chen H, Ye Y, Huang Y, Chen Z and Li J: Lipid Metabolism-related gene expression in the immune microenvironment predicts prognostic outcomes in renal cell carcinoma. Front Immunol. 14:13242052023. View Article : Google Scholar : PubMed/NCBI

39 

Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M and Mafakher L: Renal cell carcinoma: An overview of the epidemiology, diagnosis, and treatment. G Ital Nefrol. 39:2022–vol3. 2022.PubMed/NCBI

40 

Mickisch G, Bier H, Bergler W, Bak M, Tschada R and Alken P: P-170 glycoprotein, glutathione and associated enzymes in relation to chemoresistance of primary human renal cell carcinomas. Urol Int. 45:170–176. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Guo Y, Schoell MC and Freeman RS: The von Hippel-lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIMEL. Oncogene. 28:18642009. View Article : Google Scholar : PubMed/NCBI

42 

Büscheck F, Fraune C, Simon R, Kluth M, Hube-Magg C, Möller-Koop C, Sarper I, Ketterer K, Henke T, Eichelberg C, et al: Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes. Oncotarget. 11:237–249. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Ascierto ML, McMiller TL, Berger AE, Danilova L, Anders RA, Netto GJ, Xu H, Pritchard TS, Fan J, Cheadle C, et al: The intratumoral balance between metabolic and immunologic gene expression is associated with Anti-PD-1 response in patients with renal cell carcinoma. Cancer Immunol Res. 4:726–733. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Rooney MS, Shukla SA, Wu CJ, Getz G and Hacohen N: Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell. 160:48–61. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Möller K, Fraune C, Blessin NC, Lennartz M, Kluth M, Hube-Magg C, Lindhorst L, Dahlem R, Fisch M, Eichenauer T, et al: Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint Therapy-naive clear cell renal cell cancer. Int Urol Nephrol. 53:2493–2503. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Nishida K, Nojima S, Yamamoto Y, Kato T, Hatano K, et al: Tumour grade significantly correlates with total dysfunction of tumour Tissue-infiltrating lymphocytes in renal cell carcinoma. Sci Rep. 10:62202020. View Article : Google Scholar : PubMed/NCBI

47 

Wang Y, Yin C, Geng L and Cai W: Immune infiltration landscape in clear cell renal cell carcinoma implications. Front Oncol. 10:4916212021. View Article : Google Scholar : PubMed/NCBI

48 

Sabrina S, Takeda Y, Kato T, Naito S, Ito H, Takai Y, Ushijima M, Narisawa T, Kanno H, Sakurai T, et al: Initial myeloid cell status is associated with clinical outcomes of renal cell carcinoma. Biomedicines. 11:12962023. View Article : Google Scholar : PubMed/NCBI

49 

Liu B, Chen X, Zhan Y, Wu B and Pan S: Identification of a gene signature for renal cell Carcinoma-associated fibroblasts mediating cancer progression and affecting prognosis. Front Cell Dev Biol. 8:6046272021. View Article : Google Scholar : PubMed/NCBI

50 

Zhang Y, Chen X, Fu Q, Wang F, Zhou X, Xiang J, He N, Hu Z and Jin X: Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma. Cancer Cell Int. 21:6672021. View Article : Google Scholar : PubMed/NCBI

51 

Ballesteros PÁ, Chamorro J, Román-Gil MS, Pozas J, Gómez Dos Santos V, Granados ÁR, Grande E, Alonso-Gordoa T and Molina-Cerrillo J: Molecular mechanisms of resistance to immunotherapy and antiangiogenic treatments in clear cell renal cell carcinoma. Cancers. 13:59812021. View Article : Google Scholar : PubMed/NCBI

52 

Derosa L, Hellmann MD, Spaziano M, Halpenny D, Fidelle M, Rizvi H, Long N, Plodkowski AJ, Arbour KC, Chaft JE, et al: Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and Non-small-cell lung cancer. Ann Oncol. 29:1437–1444. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 359:91–97. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Xing Y and Hogquist KA: T-cell tolerance: Central and peripheral. Cold Spring Harb Perspect Biol. 4:a0069572012. View Article : Google Scholar : PubMed/NCBI

55 

Braun DA, Street K, Burke KP, Cookmeyer DL, Denize T, Pedersen CB, Gohil SH, Schindler N, Pomerance L, Hirsch L, et al: Progressive immune dysfunction with advancing disease stage in renal cell carcinoma. Cancer Cell. 39:632–648.e8. 2021. View Article : Google Scholar : PubMed/NCBI

56 

McKay RR, Bossé D, Xie W, Wankowicz SAM, Flaifel A, Brandao R, Lalani AA, Martini DJ, Wei XX, Braun DA, et al: The clinical activity of PD-1/PD-L1 inhibitors in metastatic non-clear cell renal cell carcinoma. Cancer Immunol Res. 6:758–765. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Pichler R, Siska PJ, Tymoszuk P, Martowicz A, Untergasser G, Mayr R, Weber F, Seeber A, Kocher F, Barth DA, et al: A chemokine network of T cell exhaustion and metabolic reprogramming in renal cell carcinoma. Front Immunol. 14:10951952023. View Article : Google Scholar : PubMed/NCBI

58 

Wang DY, Salem JE, Cohen JV, Chandra S, Menzer C, Ye F, Zhao S, Das S, Beckermann KE, Ha L, et al: Fatal toxic effects associated with immune checkpoint inhibitors. JAMA Oncol. 4:1721–1728. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Lin E, Liu X, Liu Y, Zhang Z, Xie L, Tian K, Liu J and Yu Y: Roles of the dynamic tumor immune microenvironment in the individualized treatment of advanced clear cell renal cell carcinoma. Front Immunol. 12:6533582021. View Article : Google Scholar : PubMed/NCBI

60 

Ishihara H, Takagi T, Kondo T, Fukuda H, Tachibana H, Yoshida K, Iizuka J, Okumi M, Ishida H and Tanabe K: Predictive impact of an early change in serum C-reactive protein levels in nivolumab therapy for metastatic renal cell carcinoma. Urol Oncol Semin Orig Investig. 38:526–532. 2020.

61 

Noguchi G, Nakaigawa N, Umemoto S, Kobayashi K, Shibata Y, Tsutsumi S, Yasui M, Ohtake S, Suzuki T, Osaka K, et al: C-reactive protein at 1 month after treatment of nivolumab as a predictive marker of efficacy in advanced renal cell carcinoma. Cancer Chemother Pharmacol. 86:75–85. 2020. View Article : Google Scholar : PubMed/NCBI

62 

Yano Y, Ohno T, Komura K, Fukuokaya W, Uchimoto T, Adachi T, Hirasawa Y, Hashimoto T, Yoshizawa A, Yamazaki S, et al: Serum C-reactive protein level predicts overall survival for clear cell and Non-clear cell renal cell carcinoma treated with ipilimumab plus nivolumab. Cancers. 14:56592022. View Article : Google Scholar : PubMed/NCBI

63 

Tomita Y, Larkin J, Venugopal B, Haanen J, Kanayama H, Eto M, Grimm MO, Fujii Y, Umeyama Y, Huang B, et al: Association of C-reactive protein with efficacy of avelumab plus axitinib in advanced renal cell carcinoma: Long-term follow-up results from JAVELIN renal 101. ESMO Open. 7:1005642022. View Article : Google Scholar : PubMed/NCBI

64 

Kim JH, Kim GH, Ryu YM, Kim SY, Kim HD, Yoon SK, Cho YM and Lee JL: Clinical implications of the tumor microenvironment using multiplexed immunohistochemistry in patients with advanced or metastatic renal cell carcinoma treated with nivolumab plus ipilimumab. Front Oncol. 12:9695692022. View Article : Google Scholar : PubMed/NCBI

65 

Sammarco E, Rossetti M, Salfi A, Bonato A, Viacava P, Masi G, Galli L and Faviana P: Tumor microenvironment and clinical efficacy of first line Immunotherapy-based combinations in metastatic renal cell carcinoma. Med Oncol. 41:1502024. View Article : Google Scholar : PubMed/NCBI

66 

Kazama A, Bilim V, Tasaki M, Anraku T, Kuroki H, Shirono Y, Murata M, Hiruma K and Tomita Y: Tumor-infiltrating immune cell status predicts successful response to immune checkpoint inhibitors in renal cell carcinoma. Sci Rep. 12:203862022. View Article : Google Scholar : PubMed/NCBI

67 

Herrmann T, Ginzac A, Molnar I, Bailly S, Durando X and Mahammedi H: Eosinophil counts as a relevant prognostic marker for response to nivolumab in the management of renal cell carcinoma: A retrospective study. Cancer Med. 10:6705–6713. 2021. View Article : Google Scholar : PubMed/NCBI

68 

Atkins MB, Jegede OA, Haas NB, McDermott DF, Bilen MA, Stein M, Sosman JA, Alter R, Plimack ER, Ornstein M, et al: Phase II study of nivolumab and salvage Nivolumab/Ipilimumab in Treatment-naive patients with advanced clear cell renal cell carcinoma (HCRN GU16-260-Cohort A). J Clin Oncol. 40:2913–2923. 2022. View Article : Google Scholar : PubMed/NCBI

69 

Motzer RJ, Choueiri TK, McDermott DF, Powles T, Vano YA, Gupta S, Yao J, Han C, Ammar R, Papillon-Cavanagh S, et al: Biomarker analysis from CheckMate 214: Nivolumab plus ipilimumab versus sunitinib in renal cell carcinoma. J Immunother Cancer. 10:e0043162022. View Article : Google Scholar : PubMed/NCBI

70 

Brown LC, Zhu J, Desai K, Kinsey E, Kao C, Lee YH, Pabla S, Labriola MK, Tran J, Dragnev KH, et al: Evaluation of tumor microenvironment and biomarkers of immune checkpoint inhibitor response in metastatic renal cell carcinoma. J Immunother Cancer. 10:e0052492022. View Article : Google Scholar : PubMed/NCBI

71 

Kato R, Jinnouchi N, Tuyukubo T, Ikarashi D, Matsuura T, Maekawa S, Kato Y, Kanehira M, Takata R, Ishida K and Obara W: TIM3 expression on tumor cells predicts response to anti-PD-1 therapy for renal cancer. Transl Oncol. 14:1009182020. View Article : Google Scholar : PubMed/NCBI

72 

Koh Y, Nakano K, Katayama K, Yamamichi G, Yumiba S, Tomiyama E, Matsushita M, Hayashi Y, Yamamoto Y, Kato T, et al: Early dynamics of circulating tumor DNA predict clinical response to immune checkpoint inhibitors in metastatic renal cell carcinoma. Int J Urol. 29:462–469. 2022. View Article : Google Scholar : PubMed/NCBI

73 

Incorvaia L, Fanale D, Badalamenti G, Brando C, Bono M, De Luca I, Algeri L, Bonasera A, Corsini LR, Scurria S, et al: A ‘Lymphocyte MicroRNA Signature’ as predictive biomarker of immunotherapy response and plasma PD-1/PD-L1 expression levels in patients with metastatic renal cell carcinoma: Pointing towards epigenetic reprogramming. Cancers. 12:33962020. View Article : Google Scholar : PubMed/NCBI

74 

Pan Q, Liu R, Zhang X, Cai L, Li Y, Dong P, Gao J, Liu Y and He L: CXCL14 as a potential marker for immunotherapy response prediction in renal cell carcinoma. Ther Adv Med Oncol. 15:175883592312179662023. View Article : Google Scholar : PubMed/NCBI

75 

Pabla S, Seager RJ, Van Roey E, Gao S, Hoefer C, Nesline MK, DePietro P, Burgher B, Andreas J, Giamo V, et al: Integration of tumor inflammation, cell proliferation, and traditional biomarkers improves prediction of immunotherapy resistance and response. Biomark Res. 9:562021. View Article : Google Scholar : PubMed/NCBI

76 

Schalper KA, Carleton M, Zhou M, Chen T, Feng Y, Huang SP, Walsh AM, Baxi V, Pandya D, Baradet T, et al: Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors. Nat Med. 26:688–692. 2020. View Article : Google Scholar : PubMed/NCBI

77 

Ivanova E, Asadullina D, Rakhimov R, Izmailov A, Izmailov A, Gilyazova G, Galimov S, Pavlov V, Khusnutdinova E and Gilyazova I: Exosomal miRNA-146a is downregulated in clear cell renal cell carcinoma patients with severe immune-related adverse events. Noncoding RNA Res. 7:159–163. 2022. View Article : Google Scholar : PubMed/NCBI

78 

Petitprez F, Ayadi M, de Reyniès A, Fridman WH, Sautès-Fridman C and Job S: Review of prognostic expression markers for clear cell renal cell carcinoma. Front Oncol. 11:6430652021. View Article : Google Scholar : PubMed/NCBI

79 

Lee A, Lee HJ, Huang HH, Tay KJ, Lee LS, Sim SPA, Ho SSH, Yuen SPJ and Chen K: Prognostic significance of inflammation-associated blood cell markers in nonmetastatic clear cell renal cell carcinoma. Clin Genitourin Cancer. 18:304–313. 2020. View Article : Google Scholar : PubMed/NCBI

80 

Teishima J, Inoue S, Hayashi T and Matsubara A: Current status of prognostic factors in patients with metastatic renal cell carcinoma. Int J Urol. 26:608–617. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
González‑Garza R, Gutiérrez‑González A, Salinas‑Carmona MC and Mejía‑Torres M: Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review). Oncol Rep 52: 164, 2024.
APA
González‑Garza, R., Gutiérrez‑González, A., Salinas‑Carmona, M.C., & Mejía‑Torres, M. (2024). Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review). Oncology Reports, 52, 164. https://doi.org/10.3892/or.2024.8823
MLA
González‑Garza, R., Gutiérrez‑González, A., Salinas‑Carmona, M. C., Mejía‑Torres, M."Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review)". Oncology Reports 52.6 (2024): 164.
Chicago
González‑Garza, R., Gutiérrez‑González, A., Salinas‑Carmona, M. C., Mejía‑Torres, M."Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review)". Oncology Reports 52, no. 6 (2024): 164. https://doi.org/10.3892/or.2024.8823
Copy and paste a formatted citation
x
Spandidos Publications style
González‑Garza R, Gutiérrez‑González A, Salinas‑Carmona MC and Mejía‑Torres M: Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review). Oncol Rep 52: 164, 2024.
APA
González‑Garza, R., Gutiérrez‑González, A., Salinas‑Carmona, M.C., & Mejía‑Torres, M. (2024). Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review). Oncology Reports, 52, 164. https://doi.org/10.3892/or.2024.8823
MLA
González‑Garza, R., Gutiérrez‑González, A., Salinas‑Carmona, M. C., Mejía‑Torres, M."Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review)". Oncology Reports 52.6 (2024): 164.
Chicago
González‑Garza, R., Gutiérrez‑González, A., Salinas‑Carmona, M. C., Mejía‑Torres, M."Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review)". Oncology Reports 52, no. 6 (2024): 164. https://doi.org/10.3892/or.2024.8823
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