Open Access

Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)

  • Authors:
    • Yukun Han
    • Yiling Wang
    • Tongtong Lv
    • Qing Yang
    • Dezhou Cheng
    • Jinxin Li
    • Wei Wang
    • Jinbai Huang
    • Xiaochun Peng
  • View Affiliations

  • Published online on: October 14, 2024     https://doi.org/10.3892/or.2024.8824
  • Article Number: 165
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Bone metastasis (BM) is a common complication of cancer and contributes to a higher mortality rate in patients with cancer. The treatment of BM remains a significant challenge for oncologists worldwide. The colony‑stimulating factor (CSF) has an important effect on the metastasis of multiple cancers. In vitro studies have shown that CSF acts as a cytokine, promoting the colony formation of hematopoietic cells by activating granulocytes and macrophages. Other studies have shown that CSF not only promotes cancer aggressiveness but also correlates with the development and prognosis of various types of cancer. In recent years, the effect of CSF on BM has been primarily investigated using cellular and animal models, with limited clinical studies available. The present review discussed the composition and function of CSF, as well as its role in the progression of BM across various types of cancer. The mechanisms by which osteoclast‑ and osteoblast‑mediated BM occur are comprehensively described. In addition, the mechanisms of action of emerging therapeutic agents are explored for their potential clinical applications. However, further clinical studies are required to validate these findings.
View Figures
View References

Related Articles

Journal Cover

December-2024
Volume 52 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Han Y, Wang Y, Lv T, Yang Q, Cheng D, Li J, Wang W, Huang J and Peng X: Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review). Oncol Rep 52: 165, 2024.
APA
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J. ... Peng, X. (2024). Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review). Oncology Reports, 52, 165. https://doi.org/10.3892/or.2024.8824
MLA
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J., Wang, W., Huang, J., Peng, X."Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)". Oncology Reports 52.6 (2024): 165.
Chicago
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J., Wang, W., Huang, J., Peng, X."Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)". Oncology Reports 52, no. 6 (2024): 165. https://doi.org/10.3892/or.2024.8824