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Review Open Access

Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)

  • Authors:
    • Yukun Han
    • Yiling Wang
    • Tongtong Lv
    • Qing Yang
    • Dezhou Cheng
    • Jinxin Li
    • Wei Wang
    • Jinbai Huang
    • Xiaochun Peng
  • View Affiliations / Copyright

    Affiliations: Nuclear Medicine Department, The First Affiliated Hospital of Yangtze University and Health Science Center of Yangtze University, Jingzhou, Hubei 434023, P.R. China, Department of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei 434023, P.R. China, Department of Rehabilitation Radiology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 165
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    Published online on: October 14, 2024
       https://doi.org/10.3892/or.2024.8824
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Abstract

Bone metastasis (BM) is a common complication of cancer and contributes to a higher mortality rate in patients with cancer. The treatment of BM remains a significant challenge for oncologists worldwide. The colony‑stimulating factor (CSF) has an important effect on the metastasis of multiple cancers. In vitro studies have shown that CSF acts as a cytokine, promoting the colony formation of hematopoietic cells by activating granulocytes and macrophages. Other studies have shown that CSF not only promotes cancer aggressiveness but also correlates with the development and prognosis of various types of cancer. In recent years, the effect of CSF on BM has been primarily investigated using cellular and animal models, with limited clinical studies available. The present review discussed the composition and function of CSF, as well as its role in the progression of BM across various types of cancer. The mechanisms by which osteoclast‑ and osteoblast‑mediated BM occur are comprehensively described. In addition, the mechanisms of action of emerging therapeutic agents are explored for their potential clinical applications. However, further clinical studies are required to validate these findings.
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Copy and paste a formatted citation
Spandidos Publications style
Han Y, Wang Y, Lv T, Yang Q, Cheng D, Li J, Wang W, Huang J and Peng X: Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review). Oncol Rep 52: 165, 2024.
APA
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J. ... Peng, X. (2024). Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review). Oncology Reports, 52, 165. https://doi.org/10.3892/or.2024.8824
MLA
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J., Wang, W., Huang, J., Peng, X."Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)". Oncology Reports 52.6 (2024): 165.
Chicago
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J., Wang, W., Huang, J., Peng, X."Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)". Oncology Reports 52, no. 6 (2024): 165. https://doi.org/10.3892/or.2024.8824
Copy and paste a formatted citation
x
Spandidos Publications style
Han Y, Wang Y, Lv T, Yang Q, Cheng D, Li J, Wang W, Huang J and Peng X: Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review). Oncol Rep 52: 165, 2024.
APA
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J. ... Peng, X. (2024). Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review). Oncology Reports, 52, 165. https://doi.org/10.3892/or.2024.8824
MLA
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J., Wang, W., Huang, J., Peng, X."Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)". Oncology Reports 52.6 (2024): 165.
Chicago
Han, Y., Wang, Y., Lv, T., Yang, Q., Cheng, D., Li, J., Wang, W., Huang, J., Peng, X."Effect of colony‑stimulating factor in the mechanism of bone metastasis development (Review)". Oncology Reports 52, no. 6 (2024): 165. https://doi.org/10.3892/or.2024.8824
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