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Repurposing the antipsychotic drug penfluridol for cancer treatment (Review)

  • Authors:
    • Asma Ali Ibrahim Mze
    • Amirah Abdul Rahman
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Sungai Buloh, Selangor 47000, Malaysia
    Copyright: © Ali Ibrahim Mze et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 174
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    Published online on: October 25, 2024
       https://doi.org/10.3892/or.2024.8833
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Abstract

Cancer is one of the most prevalent diseases and the leading cause of death worldwide. Despite the improved survival rates of cancer in recent years, the current available treatments often face resistance and side effects. Drug repurposing represents a cost‑effective and efficient alternative to cancer treatment. Recent studies revealed that penfluridol (PF), an antipsychotic drug, is a promising anticancer agent. In the present study, a scoping review was conducted to ascertain the anticancer properties of PF. For this, a literature search was performed using the Scopus, PubMed and Web of Science databases with the search string ‘penfluridol’ AND ‘cancer’. A total of 23 original articles with in vivo and/or in vitro studies on the effect of PF on cancer were included in the scoping review. The outcome of the analysis demonstrated the anticancer potential of PF. PF significantly inhibited cell proliferation, metastasis and invasion while inducing apoptosis and autophagy in vivo and across a spectrum of cancer cell lines, including breast, lung, pancreatic, glioblastoma, gallbladder, bladder, oesophageal, leukaemia and renal cancers. However, research on PF derivatives with high anticancer activities and reduced neurological side effects may be necessary.
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1 

Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A and Bray F: Cancer statistics for the year 2020: An overview. Int J Cancer. Apr 5–2021.(Epub ahead of print). View Article : Google Scholar

2 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

3 

World Health Organization (WHO), . Cancer. WHO; Geneva: 2022

4 

Chen S, Cao Z, Prettner K, Kuhn M, Yang J, Jiao L, Wang Z, Li W, Geldsetzer P, Bärnighausen T, et al: Estimates and projections of the global economic cost of 29 cancers in 204 countries and territories from 2020 to 2050. JAMA Oncol. 9:465–472. 2023. View Article : Google Scholar : PubMed/NCBI

5 

Gordon N, Stemmer SM, Greenberg D and Goldstein DA: Trajectories of injectable cancer drug costs after launch in the United States. J Clin Oncol. 36:319–325. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Hendouei N, Saghafi F, Shadfar F and Hosseinimehr SJ: Molecular mechanisms of anti-psychotic drugs for improvement of cancer treatment. Eur J Pharmacol. 856:1724022019. View Article : Google Scholar : PubMed/NCBI

7 

Qu LG, Brand NR, Chao A and Ilbawi AM: Interventions addressing barriers to delayed cancer diagnosis in low- and middle-income countries: A systematic review. Oncologist. 25:e1382–e1395. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Masuda T, Tsuruda Y, Matsumoto Y, Uchida H, Nakayama KI and Mimori K: Drug repositioning in cancer: The current situation in Japan. Cancer Sci. 111:1039–1046. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Wouters OJ, McKee M and Luyten J: Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009–2018. JAMA. 323:844–853. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Low ZY, Farouk IA and Lal SK: Drug Repositioning: New approaches and future prospects for life-debilitating diseases and the COVID-19 pandemic outbreak. Viruses. 12:10582020. View Article : Google Scholar : PubMed/NCBI

11 

Brown JS: Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer. Neurosci Biobehav Rev. 141:1048092022. View Article : Google Scholar : PubMed/NCBI

12 

Vlachos N, Lampros M, Voulgaris S and Alexiou GA: Repurposing antipsychotics for cancer treatment. Biomedicines. 9:17852021. View Article : Google Scholar : PubMed/NCBI

13 

Shaw V, Srivastava S and Srivastava SK: Repurposing antipsychotics of the diphenylbutylpiperidine class for cancer therapy. Semin Cancer Biol. 68:75–83. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Varalda M, Antona A, Bettio V, Vachamaram A, Yellenki V, Massarotti A, Baldanzi G and Capello D: Psychotropic drugs show anticancer activity by disrupting mitochondrial and lysosomal function. Front Oncol. 10:5621962020. View Article : Google Scholar : PubMed/NCBI

15 

Soares BG and Lima MS: Penfluridol for schizophrenia. Cochrane Database Syst Rev. 2006:CD0029232006.PubMed/NCBI

16 

Chokhawala K and Lee S: Antipsychotic medications. StatPearls [Internet]. StatPearls Publishing; Treasure Island, FL: 2023

17 

Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsley T, Weeks L, et al: PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 169:467–473. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Mak S and Thomas A: Steps for conducting a scoping review. J Grad Med Educ. 14:565–567. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Arksey H and O'Malley L: Scoping studies: Towards a methodological framework. Int J Soc Res Methodol. 8:19–32. 2005. View Article : Google Scholar

20 

Hedrick E, Li XX and Safe S: Penfluridol represses integrin expression in breast cancer through induction of reactive oxygen species and downregulation of Sp transcription factors. Mol Cancer Ther. 16:205–216. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Gupta N, Gupta P and Srivastava S: Penfluridol overcomes paclitaxel resistance in metastatic breast cancer. Sci Rep. 9:50662019. View Article : Google Scholar : PubMed/NCBI

22 

Ranjan A, Gupta P and Srivastava SK: Penfluridol: An antipsychotic agent suppresses metastatic tumor growth in triple-negative breast cancer by inhibiting integrin signaling axis. Cancer Res. 76:877–890. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Srivastava S, Zahra FT, Gupta N, Tullar PE, Srivastava SK and Mikelis CM: Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis. Int J Mol Sci. 21:7552020. View Article : Google Scholar : PubMed/NCBI

24 

Lai TC, Lee YL, Lee WJ, Hung WY, Cheng GZ, Chen JQ, Hsiao M, Chien MH and Chang JH: Synergistic tumor inhibition via energy elimination by repurposing penfluridol and 2-Deoxy-D-Glucose in lung cancer. Cancers (Basel). 14:27502022. View Article : Google Scholar : PubMed/NCBI

25 

Hung WY, Chang JH, Cheng Y, Cheng GZ, Huang HC, Hsiao M, Chung CL, Lee WJ and Chien MH: Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response. Cell Death Dis. 10:5382019. View Article : Google Scholar : PubMed/NCBI

26 

Xue Q, Liu Z, Feng Z, Xu Y, Zuo W, Wang Q, Gao T, Zeng J, Hu X, Jia F, et al: Penfluridol: An antipsychotic agent suppresses lung cancer cell growth and metastasis by inducing G0/G1 arrest and apoptosis. Biomed Pharmacother. 121:1095982020. View Article : Google Scholar : PubMed/NCBI

27 

Hung WY, Lee WJ, Cheng GZ, Tsai CH, Yang YC, Lai TC, Chen JQ, Chung CL, Chang JH and Chien MH: Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway. Cell Oncol (Dordr). 44:1087–1103. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Ranjan A, German N, Mikelis C, Srivenugopal K and Srivastava SK: Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer. Tumour Biol. 39:10104283177055172017. View Article : Google Scholar : PubMed/NCBI

29 

Ranjan A and Srivastava SK: Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis. Sci Rep. 6:261652016. View Article : Google Scholar : PubMed/NCBI

30 

Dandawate P, Kaushik G, Ghosh C, Standing D, Ali Sayed AA, Choudhury S, Subramaniam D, Manzardo A, Banerjee T, Santra S, et al: Diphenylbutylpiperidine Antipsychotic Drugs Inhibit Prolactin Receptor Signaling to Reduce Growth of Pancreatic Ductal Adenocarcinoma in Mice. Gastroenterology. 158:1433–1449.e27. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Chien W, Sun QY, Lee KL, Ding LW, Wuensche P, Torres-Fernandez LA, Tan SZ, Tokatly I, Zaiden N, Poellinger L, et al: Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer. Mol Oncol. 9:889–905. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Ranjan A and Srivastava SK: Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1. Oncotarget. 8:32960–32976. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Kim H, Chong K, Ryu BK, Park KJ, Yu MO, Lee J, Chung S, Choi S, Park MJ, Chung YG and Kang SH: Repurposing penfluridol in combination with temozolomide for the treatment of glioblastoma. Cancers (Basel). 11:13102019. View Article : Google Scholar : PubMed/NCBI

34 

Ranjan A, Wright S and Srivastava SK: Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth. Oncotarget. 8:47632–47641. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Hu J, Cao J, Jin R, Zhang B, Topatana W, Juengpanich S, Li S, Chen T, Lu Z, Cai X and Chen M: Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth. Cell Commun Signal. 20:1052022. View Article : Google Scholar : PubMed/NCBI

36 

van der Horst G, van de Merbel AF, Ruigrok E, van der Mark MH, Ploeg E, Appelman L, Tvingsholm S, Jäätelä M, van Uhm J, Kruithof-de Julio M, et al: Cationic amphiphilic drugs as potential anticancer therapy for bladder cancer. Mol Oncol. 14:3121–3134. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Zheng C, Yu X, Liang Y, Zhu Y, He Y, Liao L, Wang D, Yang Y, Yin X, Li A, et al: Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner. Acta Pharm Sin B. 12:1271–1287. 2022. View Article : Google Scholar : PubMed/NCBI

38 

Wu SY, Wen YC, Ku CC, Yang YC, Chow JM, Yang SF, Lee WJ and Chien MH: Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses. J Biomed Sci. 26:632019. View Article : Google Scholar : PubMed/NCBI

39 

Tung MC, Lin YW, Lee WJ, Wen YC, Liu YC, Chen JQ, Hsiao M, Yang YC and Chien MH: Targeting DRD2 by the antipsychotic drug, penfluridol, retards growth of renal cell carcinoma via inducing stemness inhibition and autophagy-mediated apoptosis. Cell Death Dis. 13:4002022. View Article : Google Scholar : PubMed/NCBI

40 

Wu LL, Liu YY, Li ZX, Zhao Q, Wang X, Yu Y, Wang YY, Wang YQ and Luo F: Anti-tumor effects of penfluridol through dysregulation of cholesterol homeostasis. Asian Pac J Cancer Prev. 15:489–494. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Du J, Shang J, Chen F, Zhang Y, Yin N, Xie T, Zhang H, Yu J and Liu F: A CRISPR/Cas9-Based screening for non-homologous end joining inhibitors reveals ouabain and penfluridol as radiosensitizers. Mol Cancer Ther. 17:419–431. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Verbruggen FJ, Van Nueten JM and Schaper WK: The pharmacology of penfluridol (R 16341) a new potent and orally long-acting neuroleptic drug. Eur J Pharmacol. 11:139–154. 1970. View Article : Google Scholar : PubMed/NCBI

43 

Airoldi L, Marcucci F, Mussini E and Garattini S: Distribution of penfluridol in rats and mice. Eur J Pharmacol. 25:291–295. 1974. View Article : Google Scholar : PubMed/NCBI

44 

Andrade C: Psychotropic drugs with long half-lives: Implications for drug discontinuation, occasional missed doses, dosing interval, and pregnancy planning. J Clin Psychiatry. 83:22f145932022. View Article : Google Scholar : PubMed/NCBI

45 

Bhattacharyya R, Bhadra R, Roy U, Bhattacharyya S, Pal J and Saha SS: Resurgence of penfluridol: Merits and demerits. East J Psychiatry. 18:23–29. 2015. View Article : Google Scholar

46 

Nikvarz N, Vahedian M and Khalili N: Chlorpromazine versus penfluridol for schizophrenia. Cochrane database Syst Rev. 9:CD0118312017.PubMed/NCBI

47 

Wang RI, Larson C and Treul SJ: Study of penfluridol and chlorpromazine in the treatment of chronic schizophrenia. J Clin Pharmacol. 22:236–242. 1982. View Article : Google Scholar : PubMed/NCBI

48 

Andrade C: The practical importance of half-life in psychopharmacology. J Clin Psychiatry. 83:22f145842022. View Article : Google Scholar : PubMed/NCBI

49 

Clarke Z: Penfluridol. Elsevier; New York, NY: pp. 1–4. 2007

50 

Enyeart JJ, Biagi BA, Day RN, Sheu SS and Maurer RA: Blockade of low and high threshold Ca2+ channels by diphenylbutylpiperidine antipsychotics linked to inhibition of prolactin gene expression. J Biol Chem. 265:16373–16379. 1990. View Article : Google Scholar : PubMed/NCBI

51 

Cabrera M, Gomez N, Remes Lenicov F, Echeverría E, Shayo C, Moglioni A, Fernández N and Davio C: G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone compound. PLoS One. 10:e01368782015. View Article : Google Scholar : PubMed/NCBI

52 

Abbas T and Dutta A: p21 in cancer: Intricate networks and multiple activities. Nat Rev Cancer. 9:400–414. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Boudreau RT, Conrad DM and Hoskin DW: Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase. Cell Signal. 19:139–151. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Nakamura H and Takada K: Reactive oxygen species in cancer: Current findings and future directions. Cancer Sci. 112:3945–3952. 2021. View Article : Google Scholar : PubMed/NCBI

55 

Yang H, Villani RM, Wang H, Simpson MJ, Roberts MS, Tang M and Liang X: The role of cellular reactive oxygen species in cancer chemotherapy. J Exp Clin Cancer Res. 37:2662018. View Article : Google Scholar : PubMed/NCBI

56 

Shah MA and Rogoff HA: Implications of reactive oxygen species on cancer formation and its treatment. Semin Oncol. 48:238–245. 2021. View Article : Google Scholar : PubMed/NCBI

57 

Singh R and Manna PP: Reactive oxygen species in cancer progression and its role in therapeutics. Explor Med. 3:43–57. 2022. View Article : Google Scholar

58 

Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, Galasso G, Castoria G and Migliaccio A: ROS in cancer therapy: The bright side of the moon. Exp Mol Med. 52:192–203. 2020. View Article : Google Scholar : PubMed/NCBI

59 

Kim SJ, Kim HS and Seo YR: Understanding of ROS-Inducing strategy in anticancer therapy. Oxid Med Cell Longev. 2019:53816922019. View Article : Google Scholar : PubMed/NCBI

60 

Miller DM, Thomas SD, Islam A, Muench D and Sedoris K: c-Myc and cancer metabolism. Clin Cancer Res. 18:5546–5553. 2012. View Article : Google Scholar : PubMed/NCBI

61 

Gao FY, Li XT, Xu K, Wang RT and Guan XX: c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment. Cell Commun Signal. 21:282023. View Article : Google Scholar : PubMed/NCBI

62 

Safe S: Specificity Proteins (Sp) and Cancer. Int J Mol Sci. 24:51642023. View Article : Google Scholar : PubMed/NCBI

63 

Vellingiri B, Iyer M, Devi Subramaniam M, Jayaramayya K, Siama Z, Giridharan B, Narayanasamy A, Abdal Dayem A and Cho SG: Understanding the role of the transcription factor sp1 in ovarian cancer: From theory to practice. Int J Mol Sci. 21:11532020. View Article : Google Scholar : PubMed/NCBI

64 

Dufour S, Broders-Bondon F and Bondurand N: Chapter 13 - β1-Integrin Function and Interplay during Enteric Nervous System Development. Academic Press; Boston, MA: pp. 153–166. 2015

65 

Bergonzini C, Kroese K, Zweemer AJM and Danen EHJ: Targeting integrins for cancer therapy-disappointments and opportunities. Front cell Dev Biol. 10:8638502022. View Article : Google Scholar : PubMed/NCBI

66 

Valdembri D and Serini G: The roles of integrins in cancer. Fac Rev. 10:452021. View Article : Google Scholar : PubMed/NCBI

67 

Yousefi H, Vatanmakanian M, Mahdiannasser M, Mashouri L, Alahari NV, Monjezi MR, Ilbeigi S and Alahari SK: Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance. Oncogene. 40:1043–1063. 2021. View Article : Google Scholar : PubMed/NCBI

68 

Desgrosellier JS and Cheresh DA: Integrins in cancer: Biological implications and therapeutic opportunities. Nat Rev Cancer. 10:9–22. 2010. View Article : Google Scholar : PubMed/NCBI

69 

Kim SY: Cancer energy metabolism: Shutting power off cancer factory. Biomol Ther (Seoul). 26:39–44. 2018. View Article : Google Scholar : PubMed/NCBI

70 

Chelakkot C, Chelakkot VS, Shin Y and Song K: Modulating glycolysis to improve cancer therapy. Int J Mol Sci. 24:26062023. View Article : Google Scholar : PubMed/NCBI

71 

Fadaka A, Ajiboye B, Ojo O, Adewale O, Olayide I and Emuowhochere R: Biology of glucose metabolization in cancer cells. J Oncol Sci. 3:45–51. 2017. View Article : Google Scholar

72 

Lu J, Chen S, Bai X, Liao M, Qiu Y, Zheng LL and Yu H: Targeting cholesterol metabolism in Cancer: From molecular mechanisms to therapeutic implications. Biochem Pharmacol. 218:1159072023. View Article : Google Scholar : PubMed/NCBI

73 

Fan YJ and Zong WX: The cellular decision between apoptosis and autophagy. Chin J Cancer. 32:121–129. 2013.PubMed/NCBI

74 

Das S, Shukla N, Singh SS, Kushwaha S and Shrivastava R: Mechanism of interaction between autophagy and apoptosis in cancer. Apoptosis. 26:512–533. 2021. View Article : Google Scholar : PubMed/NCBI

75 

Mulcahy Levy JM and Thorburn A: Autophagy in cancer: Moving from understanding mechanism to improving therapy responses in patients. Cell Death Differ. 27:843–857. 2020. View Article : Google Scholar : PubMed/NCBI

76 

Koukourakis MI, Kalamida D, Giatromanolaki A, Zois CE, Sivridis E, Pouliliou S, Mitrakas A, Gatter KC and Harris AL: Autophagosome Proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines. PLoS One. 10:e01376752015. View Article : Google Scholar : PubMed/NCBI

77 

Fares J, Fares MY, Khachfe HH, Salhab HA and Fares Y: Molecular principles of metastasis: A hallmark of cancer revisited. Signal Transduct Target Ther. 5:282020. View Article : Google Scholar : PubMed/NCBI

78 

Ribatti D, Tamma R and Annese T: Epithelial-Mesenchymal transition in cancer: A historical overview. Transl Oncol. 13:1007732020. View Article : Google Scholar : PubMed/NCBI

79 

Huang Y, Hong W and Wei X: The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol. 15:1292022. View Article : Google Scholar : PubMed/NCBI

80 

Liu ZL, Chen HH, Zheng LL, Sun LP and Shi L: Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduct Target Ther. 8:1982023. View Article : Google Scholar : PubMed/NCBI

81 

Yang Y and Cao Y: The impact of VEGF on cancer metastasis and systemic disease. Semin Cancer Biol. 86((Pt 3)): 251–261. 2022. View Article : Google Scholar : PubMed/NCBI

82 

Zhang L, Zhang M, Wang L, Li J, Yang T, Shao Q, Liang X, Ma M, Zhang N, Jing M, et al: Identification of CCL4 as an immune-related prognostic biomarker associated with tumor proliferation and the tumor microenvironment in clear cell renal cell carcinoma. Front Oncol. 11:6946642021. View Article : Google Scholar : PubMed/NCBI

83 

Rezayatmand H, Razmkhah M and Razeghian-Jahromi I: Drug resistance in cancer therapy: The Pandora's Box of cancer stem cells. Stem Cell Res Ther. 13:1812022. View Article : Google Scholar : PubMed/NCBI

84 

Zheng HC: The molecular mechanisms of chemoresistance in cancers. Oncotarget. 8:59950–59964. 2017. View Article : Google Scholar : PubMed/NCBI

85 

Gong L, Zhang Y, Liu C, Zhang M and Han S: Application of radiosensitizers in cancer radiotherapy. Int J Nanomedicine. 16:1083–1102. 2021. View Article : Google Scholar : PubMed/NCBI

86 

Ashraf-Uz-Zaman M, Shahi S, Akwii R, Sajib MS, Farshbaf MJ, Kallem RR, Putnam W, Wang W, Zhang R, Alvina K, et al: Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 209:1128662021. View Article : Google Scholar : PubMed/NCBI

87 

Ashraf-Uz-Zaman M, Sajib MS, Cucullo L, Mikelis CM and German NA: Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity. Bioorg Med Chem Lett. 28:3652–3657. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ali Ibrahim Mze A and Abdul Rahman A: Repurposing the antipsychotic drug penfluridol for cancer treatment (Review). Oncol Rep 52: 174, 2024.
APA
Ali Ibrahim Mze, A., & Abdul Rahman, A. (2024). Repurposing the antipsychotic drug penfluridol for cancer treatment (Review). Oncology Reports, 52, 174. https://doi.org/10.3892/or.2024.8833
MLA
Ali Ibrahim Mze, A., Abdul Rahman, A."Repurposing the antipsychotic drug penfluridol for cancer treatment (Review)". Oncology Reports 52.6 (2024): 174.
Chicago
Ali Ibrahim Mze, A., Abdul Rahman, A."Repurposing the antipsychotic drug penfluridol for cancer treatment (Review)". Oncology Reports 52, no. 6 (2024): 174. https://doi.org/10.3892/or.2024.8833
Copy and paste a formatted citation
x
Spandidos Publications style
Ali Ibrahim Mze A and Abdul Rahman A: Repurposing the antipsychotic drug penfluridol for cancer treatment (Review). Oncol Rep 52: 174, 2024.
APA
Ali Ibrahim Mze, A., & Abdul Rahman, A. (2024). Repurposing the antipsychotic drug penfluridol for cancer treatment (Review). Oncology Reports, 52, 174. https://doi.org/10.3892/or.2024.8833
MLA
Ali Ibrahim Mze, A., Abdul Rahman, A."Repurposing the antipsychotic drug penfluridol for cancer treatment (Review)". Oncology Reports 52.6 (2024): 174.
Chicago
Ali Ibrahim Mze, A., Abdul Rahman, A."Repurposing the antipsychotic drug penfluridol for cancer treatment (Review)". Oncology Reports 52, no. 6 (2024): 174. https://doi.org/10.3892/or.2024.8833
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