Open Access

Repurposing the antipsychotic drug penfluridol for cancer treatment (Review)

  • Authors:
    • Asma Ali Ibrahim Mze
    • Amirah Abdul Rahman
  • View Affiliations

  • Published online on: October 25, 2024     https://doi.org/10.3892/or.2024.8833
  • Article Number: 174
  • Copyright: © Ali Ibrahim Mze et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is one of the most prevalent diseases and the leading cause of death worldwide. Despite the improved survival rates of cancer in recent years, the current available treatments often face resistance and side effects. Drug repurposing represents a cost‑effective and efficient alternative to cancer treatment. Recent studies revealed that penfluridol (PF), an antipsychotic drug, is a promising anticancer agent. In the present study, a scoping review was conducted to ascertain the anticancer properties of PF. For this, a literature search was performed using the Scopus, PubMed and Web of Science databases with the search string ‘penfluridol’ AND ‘cancer’. A total of 23 original articles with in vivo and/or in vitro studies on the effect of PF on cancer were included in the scoping review. The outcome of the analysis demonstrated the anticancer potential of PF. PF significantly inhibited cell proliferation, metastasis and invasion while inducing apoptosis and autophagy in vivo and across a spectrum of cancer cell lines, including breast, lung, pancreatic, glioblastoma, gallbladder, bladder, oesophageal, leukaemia and renal cancers. However, research on PF derivatives with high anticancer activities and reduced neurological side effects may be necessary.

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December-2024
Volume 52 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Ali Ibrahim Mze A and Abdul Rahman A: Repurposing the antipsychotic drug penfluridol for cancer treatment (Review). Oncol Rep 52: 174, 2024.
APA
Ali Ibrahim Mze, A., & Abdul Rahman, A. (2024). Repurposing the antipsychotic drug penfluridol for cancer treatment (Review). Oncology Reports, 52, 174. https://doi.org/10.3892/or.2024.8833
MLA
Ali Ibrahim Mze, A., Abdul Rahman, A."Repurposing the antipsychotic drug penfluridol for cancer treatment (Review)". Oncology Reports 52.6 (2024): 174.
Chicago
Ali Ibrahim Mze, A., Abdul Rahman, A."Repurposing the antipsychotic drug penfluridol for cancer treatment (Review)". Oncology Reports 52, no. 6 (2024): 174. https://doi.org/10.3892/or.2024.8833