|
1
|
Huang J, Lucero-Prisno DE III, Zhang L, Xu
W, Wong SH, Ng SC and Wong MCS: Updated epidemiology of
gastrointestinal cancers in East Asia. Nat Rev Gastroenterol
Hepatol. 20:271–287. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Shah SC and Itzkowitz SH: Colorectal
cancer in inflammatory bowel disease: Mechanisms and management.
Gastroenterology. 162:715–730.e3. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Joshi SS and Badgwell BD: Current
treatment and recent progress in gastric cancer. CA Cancer J Clin.
71:264–279. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Zhu H, Ma X, Ye T, Wang H, Wang Z, Liu Q
and Zhao K: Esophageal cancer in China: Practice and research in
the new era. Int J Cancer. 152:1741–1751. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Wood LD, Canto MI, Jaffee EM and Simeone
DM: Pancreatic cancer: Pathogenesis, screening, diagnosis, and
treatment. Gastroenterology. 163:386–402.e1. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Liberti MV and Locasale JW: The Warburg
effect: How does it benefit cancer cells? Trends Biochem Sci.
41:211–218. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wang Y and Patti GJ: The Warburg effect: A
signature of mitochondrial overload. Trends Cell Biol.
33:1014–1020. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Li X, Yang Y, Zhang B, Lin X, Fu X, An Y,
Zou Y, Wang JX, Wang Z and Yu T: Lactate metabolism in human health
and disease. Signal Transduct Target Ther. 7:3052022. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Brooks GA: The science and translation of
lactate shuttle theory. Cell Metab. 27:757–785. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Rabinowitz JD and Enerbäck S: Lactate: The
ugly duckling of energy metabolism. Nat Metab. 2:566–571. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lv X, Lv Y and Dai X: Lactate, histone
lactylation and cancer hallmarks. Expert Rev Mol Med. 25:e72023.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Fan H, Yang F, Xiao Z, Luo H, Chen H, Chen
Z, Liu Q and Xiao Y: Lactylation: Novel epigenetic regulatory and
therapeutic opportunities. Am J Physiol Endocrinol Metab.
324:E330–E338. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wang T, Ye Z, Li Z, Jing DS, Fan GX, Liu
MQ, Zhuo QF, Ji SR, Yu XJ, Xu XW and Qin Y: Lactate-induced protein
lactylation: A bridge between epigenetics and metabolic
reprogramming in cancer. Cell Prolif. 56:e134782023. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Chen J, Cao X, Li B, Zhao Z, Chen S, Lai
SWT, Muend SA, Nossa GK, Wang L, Guo W, et al: Warburg effect is a
cancer immune evasion mechanism against macrophage
immunosurveillance. Front Immunol. 11:6217572021. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kes MMG, Van den Bossche J, Griffioen AW
and Huijbers EJM: Oncometabolites lactate and succinate drive
pro-angiogenic macrophage response in tumors. Biochim Biophys Acta
Rev Cancer. 1874:1884272020. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Cheung SM, Husain E, Masannat Y, Miller
ID, Wahle K, Heys SD and He J: Lactate concentration in breast
cancer using advanced magnetic resonance spectroscopy. Br J Cancer.
123:261–267. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hui S, Ghergurovich JM, Morscher RJ, Jang
C, Teng X, Lu W, Esparza LA, Reya T, Zhan L, Yanxiang Guo J, et al:
Glucose feeds the TCA cycle via circulating lactate. Nature.
551:115–118. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Nelson SJ, Kurhanewicz J, Vigneron DB,
Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok
R, Park I, et al: Metabolic imaging of patients with prostate
cancer using hyperpolarized [1-¹3C]pyruvate. Sci Transl
Med. 5:198ra082013. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Mortazavi Farsani SS and Verma V: Lactate
mediated metabolic crosstalk between cancer and immune cells and
its therapeutic implications. Front Oncol. 13:11755322023.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
San-Millán I and Brooks GA: Reexamining
cancer metabolism: Lactate production for carcinogenesis could be
the purpose and explanation of the Warburg effect. Carcinogenesis.
38:119–133. 2017.PubMed/NCBI
|
|
21
|
Petersen C, Nielsen MD, Andersen ES, Basse
AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB and
Pedersen SF: MCT1 and MCT4 expression and lactate flux activity
increase during white and brown adipogenesis and impact adipocyte
metabolism. Sci Rep. 7:131012017. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Zhang L, Xin C, Wang S, Zhuo S, Zhu J, Li
Z, Liu Y, Yang L and Chen Y: Lactate transported by MCT1 plays an
active role in promoting mitochondrial biogenesis and enhancing TCA
flux in skeletal muscle. Sci Adv. 10:eadn45082024. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Mai Z, Lin Y, Lin P, Zhao X and Cui L:
Modulating extracellular matrix stiffness: A strategic approach to
boost cancer immunotherapy. Cell Death Dis. 15:3072024. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Caslin HL, Abebayehu D, Pinette JA and
Ryan JJ: Lactate is a metabolic mediator that shapes immune cell
fate and function. Front Physiol. 12:6884852021. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zhang D, Tang Z, Huang H, Zhou G, Cui C,
Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, et al: Metabolic
regulation of gene expression by histone lactylation. Nature.
574:575–580. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Hu Y, He Z, Li Z, Wang Y, Wu N, Sun H,
Zhou Z, Hu Q and Cong X: Lactylation: The novel histone
modification influence on gene expression, protein function, and
disease. Clin Epigenetics. 16:722024. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Sun P, Ma L and Lu Z: Lactylation: Linking
the Warburg effect to DNA damage repair. Cell Metab. 36:1637–1639.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Liebner T, Kilic S, Walter J, Aibara H,
Narita T and Choudhary C: Acetylation of histones and non-histone
proteins is not a mere consequence of ongoing transcription. Nat
Commun. 15:49622024. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Shvedunova M and Akhtar A: Modulation of
cellular processes by histone and non-histone protein acetylation.
Nat Rev Mol Cell Biol. 23:329–349. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Xie N, Zhang L, Gao W, Huang C, Huber PE,
Zhou X, Li C, Shen G and Zou B: NAD+ metabolism:
Pathophysiologic mechanisms and therapeutic potential. Signal
Transduct Target Ther. 5:2272020. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Navas LE and Carnero A: NAD+
metabolism, stemness, the immune response, and cancer. Signal
Transduct Target Ther. 6:22021. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Chen AN, Luo Y, Yang YH, Fu JT, Geng XM,
Shi JP and Yang J: Lactylation, a novel metabolic reprogramming
code: Current status and prospects. Front Immunol. 12:6889102021.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Varner EL, Trefely S, Bartee D, von
Krusenstiern E, Izzo L, Bekeova C, O'Connor RS, Seifert EL, Wellen
KE, Meier JL and Snyder NW: Quantification of lactoyl-CoA
(lactyl-CoA) by liquid chromatography mass spectrometry in
mammalian cells and tissues. Open Biol. 10:2001872020. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Wang T, Chen K, Yao W, Zheng R, He Q, Xia
J, Li J, Shao Y, Zhang L, Huang L, et al: Acetylation of lactate
dehydrogenase B drives NAFLD progression by impairing lactate
clearance. J Hepatol. 74:1038–1052. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Wang N, Wang W, Wang X, Mang G, Chen J,
Yan X, Tong Z, Yang Q, Wang M, Chen L, et al: Histone lactylation
boosts reparative gene activation post-myocardial infarction. Circ
Res. 131:893–908. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Chen L, Huang L, Gu Y, Cang W, Sun P and
Xiang Y: Lactate-lactylation hands between metabolic reprogramming
and immunosuppression. Int J Mol Sci. 23:119432022. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Yu J, Chai P, Xie M, Ge S, Ruan J, Fan X
and Jia R: Histone lactylation drives oncogenesis by facilitating
m6A reader protein YTHDF2 expression in ocular melanoma.
Genome Biol. 22:852021. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Chen Y, Wu J, Zhai L, Zhang T, Yin H, Gao
H, Zhao F, Wang Z, Yang X, Jin M, et al: Metabolic regulation of
homologous recombination repair by MRE11 lactylation. Cell.
187:294–311.e21. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Zhang N, Zhang Y, Xu J, Wang P, Wu B, Lu
S, Lu X, You S, Huang X, Li M, et al: α-myosin heavy chain
lactylation maintains sarcomeric structure and function and
alleviates the development of heart failure. Cell Res. 33:679–698.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wang J, Yang P, Yu T, Gao M, Liu D, Zhang
J, Lu C, Chen X, Zhang X and Liu Y: Lactylation of PKM2 suppresses
inflammatory metabolic adaptation in pro-inflammatory macrophages.
Int J Biol Sci. 18:6210–6225. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Zhang Y, Song H, Li M and Lu P: Histone
lactylation bridges metabolic reprogramming and epigenetic rewiring
in driving carcinogenesis: Oncometabolite fuels oncogenic
transcription. Clin Transl Med. 14:e16142024. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Xiong J, He J, Zhu J, Pan J, Liao W, Ye H,
Wang H, Song Y, Du Y, Cui B, et al: Lactylation-driven
METTL3-mediated RNA m6A modification promotes
immunosuppression of tumor-infiltrating myeloid cells. Mol Cell.
82:1660–1677.e10. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Yang Z, Yan C, Ma J, Peng P, Ren X, Cai S,
Shen X, Wu Y, Zhang S, Wang X, et al: Lactylome analysis suggests
lactylation-dependent mechanisms of metabolic adaptation in
hepatocellular carcinoma. Nat Metab. 5:61–79. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Xin Q, Wang H, Li Q, Liu S, Qu K, Liu C
and Zhang J: Lactylation: A passing fad or the future of
posttranslational modification. Inflammation. 45:1419–1429. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Wang X, Fan W, Li N, Ma Y, Yao M, Wang G,
He S, Li W, Tan J, Lu Q and Hou S: YY1 lactylation in microglia
promotes angiogenesis through transcription activation-mediated
upregulation of FGF2. Genome Biol. 24:872023. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Xie B, Lin J, Chen X, Zhou X, Zhang Y, Fan
M, Xiang J, He N, Hu Z and Wang F: CircXRN2 suppresses tumor
progression driven by histone lactylation through activating the
Hippo pathway in human bladder cancer. Mol Cancer. 22:1512023.
View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Chen J, Zhang M, Liu Y, Zhao S, Wang Y,
Wang M, Niu W, Jin F and Li Z: Histone lactylation driven by
mROS-mediated glycolytic shift promotes hypoxic pulmonary
hypertension. J Mol Cell Biol. 14:mjac0732023. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Wang P, Xie D, Xiao T, Cheng C, Wang D,
Sun J, Wu M, Yang Y, Zhang A and Liu Q: H3K18 lactylation promotes
the progression of arsenite-related idiopathic pulmonary fibrosis
via YTHDF1/m6A/NREP. J Hazard Mater. 461:1325822024. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Galle E, Wong CW, Ghosh A, Desgeorges T,
Melrose K, Hinte LC, Castellano-Castillo D, Engl M, de Sousa JA,
Ruiz-Ojeda FJ, et al: H3K18 lactylation marks tissue-specific
active enhancers. Genome Biol. 23:2072022. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Wang Y, Qin L, Chen W, Chen Q, Sun J and
Wang G: Novel strategies to improve tumour therapy by targeting the
proteins MCT1, MCT4 and LAT1. Eur J Med Chem. 226:1138062021.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
She X, Wu Q, Rao Z, Song D, Huang C, Feng
S, Liu A, Liu L, Wan K, Li X, et al: SETDB1 methylates MCT1
promoting tumor progression by enhancing the lactate shuttle. Adv
Sci (Weinh). 10:e23018712023. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Hadjihambi A, Konstantinou C, Klohs J,
Monsorno K, Le Guennec A, Donnelly C, Cox IJ, Kusumbe A, Hosford
PS, Soffientini U, et al: Partial MCT1 invalidation protects
against diet-induced non-alcoholic fatty liver disease and the
associated brain dysfunction. J Hepatol. 78:180–190. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Wang F, Yi J, Chen Y, Bai X, Lu C, Feng S
and Zhou X: PRSS2 regulates EMT and metastasis via MMP-9 in gastric
cancer. Acta Histochem. 125:1520712023. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Hwang KE, Kim HJ, Song IS, Park C, Jung
JW, Park DS, Oh SH, Kim YS and Kim HR: Salinomycin suppresses
TGF-β1-induced EMT by down-regulating MMP-2 and MMP-9 via the
AMPK/SIRT1 pathway in non-small cell lung cancer. Int J Med Sci.
18:715–726. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Jiang J, Huang D, Jiang Y, Hou J, Tian M,
Li J, Sun L, Zhang Y, Zhang T, Li Z, et al: Lactate modulates
cellular metabolism through histone lactylation-mediated gene
expression in non-small cell lung cancer. Front Oncol.
11:6475592021. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Izzo LT and Wellen KE: Histone lactylation
links metabolism and gene regulation. Nature. 574:492–493. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Colegio OR, Chu NQ, Szabo AL, Chu T,
Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC,
Phillips GM, et al: Functional polarization of tumour-associated
macrophages by tumour-derived lactic acid. Nature. 513:559–563.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Wynn TA, Chawla A and Pollard JW:
Macrophage biology in development, homeostasis and disease. Nature.
496:445–455. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Irizarry-Caro RA, Mcdaniel MM, Overcast
GR, Jain VG, Troutman TD and Pasare C: TLR signaling adapter BCAP
regulates inflammatory to reparatory macrophage transition by
promoting histone lactylation. Proc Natl Acad Sci USA.
117:30628–30638. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Ivashkiv LB: The hypoxia-lactate axis
tempers inflammation. Nat Rev Immunol. 20:85–86. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Zhang F, Parayath NN, Ene CI, Stephan SB,
Koehne AL, Coon ME, Holland EC and Stephan MT: Genetic programming
of macrophages to perform anti-tumor functions using targeted mRNA
nanocarriers. Nat Commun. 10:39742019. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Dichtl S, Lindenthal L, Zeitler L, Behnke
K, Schlösser D, Strobl B, Scheller J, El Kasmi KC and Murray PJ:
Lactate and IL6 define separable paths of inflammatory metabolic
adaptation. Sci Adv. 7:eabg35052021. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Siska PJ, Singer K, Evert K, Renner K and
Kreutz M: The immunological Warburg effect: Can a
metabolic-tumor-stroma score (MeTS) guide cancer immunotherapy?
Immunol Rev. 295:187–202. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Wang ZH, Peng WB, Zhang P, Yang XP and
Zhou Q: Lactate in the tumour microenvironment: From immune
modulation to therapy. EBioMedicine. 73:1036272021. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Xia L, Oyang L, Lin J, Tan S, Han Y, Wu N,
Yi P, Tang L, Pan Q, Rao S, et al: The cancer metabolic
reprogramming and immune response. Mol Cancer. 20:282021.
View Article : Google Scholar : PubMed/NCBI
|
|
66
|
de la Cruz-López KG, Castro-Muñoz LJ,
Reyes-Hernández DO, García-Carrancá A and Manzo-Merino J: Lactate
in the regulation of tumor microenvironment and therapeutic
approaches. Front Oncol. 9:11432019. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Tay C, Tanaka A and Sakaguchi S:
Tumor-infiltrating regulatory T cells as targets of cancer
immunotherapy. Cancer Cell. 41:450–465. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Luo Y, Li L, Chen X, Gou H, Yan K and Xu
Y: Effects of lactate in immunosuppression and inflammation:
Progress and prospects. Int Rev Immunol. 41:19–29. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Lopez Krol A, Nehring HP, Krause FF, Wempe
A, Raifer H, Nist A, Stiewe T, Bertrams W, Schmeck B, Luu M, et al:
Lactate induces metabolic and epigenetic reprogramming of
pro-inflammatory Th17 cells. EMBO Rep. 23:e546852022. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Li W, Zhou C, Yu L, Hou Z, Liu H, Kong L,
Xu Y, He J, Lan J, Ou Q, et al: Tumor-derived lactate promotes
resistance to bevacizumab treatment by facilitating autophagy
enhancer protein RUBCNL expression through histone H3 lysine 18
lactylation (H3K18la) in colorectal cancer. Autophagy. 20:114–130.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Sun L, Zhang Y, Yang B, Sun S, Zhang P,
Luo Z, Feng T, Cui Z, Zhu T, Li Y, et al: Lactylation of METTL16
promotes cuproptosis via m6A-modification on FDX1 mRNA
in gastric cancer. Nat Commun. 14:65232023. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Ju J, Zhang H, Lin M, Yan Z, An L, Cao Z,
Geng D, Yue J, Tang Y, Tian L, et al: The alanyl-tRNA synthetase
AARS1 moonlights as a lactyltransferase to promote YAP signaling in
gastric cancer. J Clin Invest. 134:e1745872024. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Yang H, Zou X, Yang S, Zhang A, Li N and
Ma Z: Identification of lactylation related model to predict
prognostic, tumor infiltrating immunocytes and response of
immunotherapy in gastric cancer. Front Immunol. 14:11499892023.
View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Yang J, Ren B, Yang G, Wang H, Chen G, You
L, Zhang T and Zhao Y: The enhancement of glycolysis regulates
pancreatic cancer metastasis. Cell Mol Life Sci. 77:305–321. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Shirbandi K, Rikhtegar R, Khalafi M, Mirza
Aghazadeh Attari M, Rahmani F, Javanmardi P, Iraji S, Babaei Aghdam
Z and Rezaei Rashnoudi AM: Functional magnetic resonance
spectroscopy of lactate in Alzheimer disease: A comprehensive
review of Alzheimer disease pathology and the role of lactate. Top
Magn Reson Imaging. 32:15–26. 2023.PubMed/NCBI
|
|
76
|
Afshar M and van Hall G: LC-MS/MS method
for quantitative profiling of ketone bodies, α-keto acids, lactate,
pyruvate and their stable isotopically labelled tracers in human
plasma: An analytical panel for clinical metabolic kinetics and
interactions. J Chromatogr B Analyt Technol Biomed Life Sci.
1230:1239062023. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Faubert B, Li KY, Cai L, Hensley CT, Kim
J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, et al:
Lactate metabolism in human lung tumors. Cell. 171:358–371.e9.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Pivovarova AI and Macgregor GG:
Glucose-dependent growth arrest of leukemia cells by MCT1
inhibition: Feeding Warburg's sweet tooth and blocking acid export
as an anticancer strategy. Biomed Pharmacother. 98:173–179. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Saulle E, Spinello I, Quaranta MT,
Pasquini L, Pelosi E, Iorio E, Castelli G, Chirico M, Pisanu ME,
Ottone T, et al: Targeting lactate metabolism by inhibiting MCT1 or
MCT4 impairs leukemic cell proliferation, induces two different
related death-pathways and increases chemotherapeutic sensitivity
of acute myeloid leukemia cells. Front Oncol. 10:6214582021.
View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Todenhöfer T, Seiler R, Stewart C,
Moskalev I, Gao J, Ladhar S, Kamjabi A, Al Nakouzi N, Hayashi T,
Choi S, et al: Selective inhibition of the lactate transporter MCT4
reduces growth of invasive bladder cancer. Mol Cancer Ther.
17:2746–2755. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Xie Q, Zhu Z, He Y, Zhang Z, Zhang Y, Wang
Y, Luo J, Peng T, Cheng F, Gao J, et al: A lactate-induced
Snail/STAT3 pathway drives GPR81 expression in lung cancer cells.
Biochim Biophys Acta Mol Basis Dis. 1866:1655762020. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Brown TP, Bhattacharjee P, Ramachandran S,
Sivaprakasam S, Ristic B, Sikder MOF and Ganapathy V: The lactate
receptor GPR81 promotes breast cancer growth via a paracrine
mechanism involving antigen-presenting cells in the tumor
microenvironment. Oncogene. 39:3292–3304. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Yang H, Yang S, He J, Li W, Zhang A, Li N,
Zhou G and Sun B: Glucose transporter 3 (GLUT3) promotes
lactylation modifications by regulating lactate dehydrogenase A
(LDHA) in gastric cancer. Cancer Cell Int. 23:3032023. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Huang YF, Wang G, Ding L, Bai ZR, Leng Y,
Tian JW, Zhang JZ, Li YQ, Ahmad Qin YH, et al: Lactate-upregulated
NADPH-dependent NOX4 expression via HCAR1/PI3K pathway contributes
to ROS-induced osteoarthritis chondrocyte damage. Redox Biol.
67:1028672023. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Nareika A, He L, Game BA, Slate EH,
Sanders JJ, London SD, Lopes-Virella MF and Huang Y: Sodium lactate
increases LPS-stimulated MMP and cytokine expression in U937
histiocytes by enhancing AP-1 and NF-kappaB transcriptional
activities. Am J Physiol Endocrinol Metab. 289:E534–E542. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Long L, Xiong W, Lin F, Hou J, Chen G,
Peng T, He Y, Wang R, Xu Q and Huang Y: Regulating lactate-related
immunometabolism and EMT reversal for colorectal cancer liver
metastases using shikonin targeted delivery. J Exp Clin Cancer Res.
42:1172023. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Yang K, Fan M, Wang X, Xu J, Wang Y, Tu F,
Gill PS, Ha T, Liu L, Williams DL and Li C: Lactate promotes
macrophage HMGB1 lactylation, acetylation, and exosomal release in
polymicrobial sepsis. Cell Death Differ. 29:133–146. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Gu J, Zhou J, Chen Q, Xu X, Gao J, Li X,
Shao Q, Zhou B, Zhou H, Wei S, et al: Tumor metabolite lactate
promotes tumorigenesis by modulating MOESIN lactylation and
enhancing TGF-β signaling in regulatory T cells. Cell Rep.
39:1109862022. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Albogami SM, Al-Kuraishy HM, Al-Maiahy TJ,
Al-Buhadily AK, Al-Gareeb AI, Alorabi M, Alotaibi SS, De Waard M,
Sabatier JM, Saad HM and Batiha GE: Hypoxia-inducible factor 1 and
preeclampsia: A new perspective. Curr Hypertens Rep. 24:687–692.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
You L, Wu W, Wang X, Fang L, Adam V,
Nepovimova E, Wu Q and Kuca K: The role of hypoxia-inducible factor
1 in tumor immune evasion. Med Res Rev. 41:1622–1643. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Yang K, Xu J, Fan M, Tu F, Wang X, Ha T,
Williams DL and Li C: Lactate suppresses macrophage
pro-inflammatory response to LPS stimulation by inhibition of YAP
and NF-κB activation via GPR81-mediated signaling. Front Immunol.
11:5879132020. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Wei L, Yang X, Wang J, Wang Z, Wang Q,
Ding Y and Yu A: H3K18 lactylation of senescent microglia
potentiates brain aging and Alzheimer's disease through the NFκB
signaling pathway. J Neuroinflammation. 20:2082023. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Wang G, Zou X, Chen Q, Nong W, Miao W, Luo
H and Qu S: The relationship and clinical significance of
lactylation modification in digestive system tumors. Cancer Cell
Int. 24:2462024. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Huang H, Chen K, Zhu Y, Hu Z, Wang Y, Chen
J, Li Y, Li D and Wei P: A multi-dimensional approach to unravel
the intricacies of lactylation related signature for prognostic and
therapeutic insight in colorectal cancer. J Transl Med. 22:2112024.
View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Zha J, Zhang J, Lu J, Zhang G, Hua M, Guo
W, Yang J and Fan G: A review of lactate-lactylation in malignancy:
Its potential in immunotherapy. Front Immunol. 15:13849482024.
View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Su J, Zheng Z, Bian C, Chang S, Bao J, Yu
H, Xin Y and Jiang X: Functions and mechanisms of lactylation in
carcinogenesis and immunosuppression. Front Immunol.
14:12530642023. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Li X, Lu W, Hu Y, Wen S, Qian C, Wu W and
Huang P: Effective inhibition of nasopharyngeal carcinoma in
vitro and in vivo by targeting glycolysis with oxamate.
Int J Oncol. 43:1710–1718. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Manerba M, Di Ianni L, Govoni M, Roberti
M, Recanatini M and Di Stefano G: Lactate dehydrogenase inhibitors
can reverse inflammation induced changes in colon cancer cells. Eur
J Pharm Sci. 96:37–44. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Moreno-Sánchez R, Marín-Hernández Á, Del
Mazo-Monsalvo I, Saavedra E and Rodríguez-Enríquez S: Assessment of
the low inhibitory specificity of oxamate, aminooxyacetate and
dichloroacetate on cancer energy metabolism. Biochim Biophys Acta
Gen Subj. 1861:3221–3236. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Wigfield SM, Winter SC, Giatromanolaki A,
Taylor J, Koukourakis ML and Harris AL: PDK-1 regulates lactate
production in hypoxia and is associated with poor prognosis in head
and neck squamous cancer. Br J Cancer. 98:1975–1984. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Quanz M, Bender E, Kopitz C, Grünewald S,
Schlicker A, Schwede W, Eheim A, Toschi L, Neuhaus R, Richter C, et
al: Preclinical efficacy of the novel monocarboxylate transporter 1
inhibitor BAY-8002 and associated markers of resistance. Mol Cancer
Ther. 17:2285–2296. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Curtis NJ, Mooney L, Hopcroft L,
Michopoulos F, Whalley N, Zhong H, Murray C, Logie A, Revill M,
Byth KF, et al: Pre-clinical pharmacology of AZD3965, a selective
inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor
activity. Oncotarget. 8:69219–69236. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Polański R, Hodgkinson CL, Fusi A, Nonaka
D, Priest L, Kelly P, Trapani F, Bishop PW, White A, Critchlow SE,
et al: Activity of the monocarboxylate transporter 1 inhibitor
AZD3965 in small cell lung cancer. Clin Cancer Res. 20:926–937.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Colen CB, Shen Y, Ghoddoussi F, Yu P,
Francis TB, Koch BJ, Monterey MD, Galloway MP, Sloan AE and
Mathupala SP: Metabolic targeting of lactate efflux by malignant
glioma inhibits invasiveness and induces necrosis: An in vivo
study. Neoplasia. 13:620–632. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Ullah MS, Davies AJ and Halestrap AP: The
plasma membrane lactate transporter MCT4, but not MCT1, is
up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J
Biol Chem. 281:9030–9037. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Grasa L, Chueca E, Arechavaleta S,
García-González MA, Sáenz MÁ, Valero A, Hördnler C, Lanas Á and
Piazuelo E: Antitumor effects of lactate transport inhibition on
esophageal adenocarcinoma cells. J Physiol Biochem. 79:147–161.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Payen VL, Mina E, Van Hée VF, Porporato PE
and Sonveaux P: Monocarboxylate transporters in cancer. Mol Metab.
33:48–66. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Spinello I, Saulle E, Quaranta MT,
Pasquini L, Pelosi E, Castelli G, Ottone T, Voso MT, Testa U and
Labbaye C: The small-molecule compound AC-73 targeting CD147
inhibits leukemic cell proliferation, induces autophagy and
increases the chemotherapeutic sensitivity of acute myeloid
leukemia cells. Haematologica. 104:973–985. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Zhai X, Yang Y, Wan J, Zhu R and Wu Y:
Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and
increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol
Rep. 30:2983–2991. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Schwab M, Thunborg K, Azimzadeh O, von
Toerne C, Werner C, Shevtsov M, Di Genio T, Zdralevic M, Pouyssegur
J, Renner K, et al: Targeting cancer metabolism breaks
radioresistance by impairing the stress response. Cancers (Basel).
13:37622021. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Lin YL, Yuksel Durmaz Y, Nör JE and
ElSayed MEH: Synergistic combination of small molecule inhibitor
and RNA interference against antiapoptotic Bcl-2 protein in head
and neck cancer cells. Mol Pharm. 10:2730–2738. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
García-Castillo V, López-Urrutia E,
Villanueva-Sánchez O, Ávila-Rodríguez MÁ, Zentella-Dehesa A,
Cortés-González C, López-Camarillo C, Jacobo-Herrera NJ and
Pérez-Plasencia C: Targeting metabolic remodeling in triple
negative breast cancer in a murine model. J Cancer. 8:178–189.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Muramatsu H, Sumitomo M, Morinaga S,
Kajikawa K, Kobayashi I, Nishikawa G, Kato Y, Watanabe M, Zennami
K, Kanao K, et al: Targeting lactate dehydrogenase-A promotes
docetaxel-induced cytotoxicity predominantly in
castration-resistant prostate cancer cells. Oncol Rep. 42:224–230.
2019.PubMed/NCBI
|
|
114
|
Manerba M, Di Ianni L, Fiume L, Roberti M,
Recanatini M and Di Stefano G: Lactate dehydrogenase inhibitors
sensitize lymphoma cells to cisplatin without enhancing the drug
effects on immortalized normal lymphocytes. Eur J Pharm Sci.
74:95–102. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Daei Sorkhabi A, Mohamed Khosroshahi L,
Sarkesh A, Mardi A, Aghebati-Maleki A, Aghebati-Maleki L and
Baradaran B: The current landscape of CAR T-cell therapy for solid
tumors: Mechanisms, research progress, challenges, and
counterstrategies. Front Immunol. 14:11138822023. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Ogura M, Ando K, Suzuki T, Ishizawa K, Oh
SY, Itoh K, Yamamoto K, Au WY, Tien HF, Matsuno Y, et al: A
multicentre phase II study of vorinostat in patients with relapsed
or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell
lymphoma. Br J Haematol. 165:768–776. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Kaufman JL, Mina R, Jakubowiak AJ,
Zimmerman TL, Wolf JJ, Lewis C, Gleason C, Sharp C, Martin T,
Heffner LT, et al: Combining carfilzomib and panobinostat to treat
relapsed/refractory multiple myeloma: Results of a multiple myeloma
research consortium phase I study. Blood Cancer J. 9:32019.
View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Lu W, Zhang L, Ji K, Ding L and Wu G:
Regulatory mechanisms of GCN5 in osteogenic differentiation of MSCs
in periodontitis. Clin Exp Dent Res. 9:464–471. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Shao G, Liu Y, Ma T, Zhang L, Yuan M and
Zhao S: GCN5 inhibition prevents IL-6-induced prostate cancer
metastases through PI3K/PTEN/Akt signaling by inactivating Egr-1.
Biosci Rep. 38:BSR201808162018. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Qu J, Li P and Sun Z: Histone lactylation
regulates cancer progression by reshaping the tumor
microenvironment. Front Immunol. 14:12843442023. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Miao Z, Zhao X and Liu X: Hypoxia induced
β-catenin lactylation promotes the cell proliferation and stemness
of colorectal cancer through the wnt signaling pathway. Exp Cell
Res. 422:1134392023. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Zang Y, Wang A, Zhang J, Xia M, Jiang Z,
Jia B, Lu C, Chen C, Wang S, Zhang Y, et al: Hypoxia promotes
histone H3K9 lactylation to enhance LAMC2 transcription in
esophageal squamous cell carcinoma. iScience. 27:1101882024.
View Article : Google Scholar : PubMed/NCBI
|
