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Article Open Access

Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma

  • Authors:
    • Takanori Tokunaga
    • Hiroshi Hirata
    • Yukihiro Hitaka
    • Nakanori Fujii
    • Keita Kobayashi
    • Takahide Hayano
    • Yoshiyuki Asai
    • Koji Shiraishi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755‑8505, Japan, Department of Systems Bioinformatics, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755‑8505, Japan
    Copyright: © Tokunaga et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 11
    |
    Published online on: November 14, 2024
       https://doi.org/10.3892/or.2024.8844
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Abstract

Long noncoding RNAs (lncRNAs) serve pivotal roles in cancer biology. The present study investigated the oncogenic roles of lncRNAs in renal cell carcinoma (RCC) and their potential as prognostic biomarkers. The lncRNA leucine‑rich repeat containing 75 A‑antisense RNA1 (LRRC75A‑AS1) was identified through lncRNA microarray as a potential lncRNA that may predict the efficacy of immune checkpoint inhibitor therapy and cancer progression in RCC. The present study subsequently assessed the expression of LRRC75A‑AS1 in 212 patients with clear cell RCC (ccRCC) who underwent nephrectomy, and performed in vitro functional analysis of LRRC75A‑AS1 in RCC cell lines. Additionally, the interactions between LRRC75A‑AS1, microRNA (miR)‑370‑5p and ADAMTS5 were explored. LRRC75A‑AS1 was revealed to be significantly upregulated in ccRCC tissues compared with in adjacent normal tissues, and high LRRC75A‑AS1 expression was associated with poor prognosis, including lower progression‑free survival, in patients with RCC. The knockdown of LRRC75A‑AS1 in RCC cell lines resulted in reduced cell proliferation and invasion, highlighting its role in promoting tumorigenesis. Furthermore, the interaction among LRRC75A‑AS1, miR‑370‑5p and ADAMTS5 was suggested as a regulatory mechanism underlying RCC progression. These findings indicated that LRRC75A‑AS1 may function as an oncogene in RCC, promoting cell proliferation and invasion. Its significant upregulation in ccRCC tissues and association with poor prognosis underscore its potential as a prognostic biomarker for RCC. Understanding the regulatory interactions among LRRC75A‑AS1, miR‑370‑5p and ADAMTS5 may provide new insights into the molecular mechanisms underlying RCC and facilitate the identification of novel therapeutic targets.
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Copy and paste a formatted citation
Spandidos Publications style
Tokunaga T, Hirata H, Hitaka Y, Fujii N, Kobayashi K, Hayano T, Asai Y and Shiraishi K: Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma. Oncol Rep 53: 11, 2025.
APA
Tokunaga, T., Hirata, H., Hitaka, Y., Fujii, N., Kobayashi, K., Hayano, T. ... Shiraishi, K. (2025). Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma. Oncology Reports, 53, 11. https://doi.org/10.3892/or.2024.8844
MLA
Tokunaga, T., Hirata, H., Hitaka, Y., Fujii, N., Kobayashi, K., Hayano, T., Asai, Y., Shiraishi, K."Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma". Oncology Reports 53.1 (2025): 11.
Chicago
Tokunaga, T., Hirata, H., Hitaka, Y., Fujii, N., Kobayashi, K., Hayano, T., Asai, Y., Shiraishi, K."Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma". Oncology Reports 53, no. 1 (2025): 11. https://doi.org/10.3892/or.2024.8844
Copy and paste a formatted citation
x
Spandidos Publications style
Tokunaga T, Hirata H, Hitaka Y, Fujii N, Kobayashi K, Hayano T, Asai Y and Shiraishi K: Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma. Oncol Rep 53: 11, 2025.
APA
Tokunaga, T., Hirata, H., Hitaka, Y., Fujii, N., Kobayashi, K., Hayano, T. ... Shiraishi, K. (2025). Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma. Oncology Reports, 53, 11. https://doi.org/10.3892/or.2024.8844
MLA
Tokunaga, T., Hirata, H., Hitaka, Y., Fujii, N., Kobayashi, K., Hayano, T., Asai, Y., Shiraishi, K."Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma". Oncology Reports 53.1 (2025): 11.
Chicago
Tokunaga, T., Hirata, H., Hitaka, Y., Fujii, N., Kobayashi, K., Hayano, T., Asai, Y., Shiraishi, K."Role of long non‑coding RNA leucine‑rich repeat containing 75 A‑antisense RNA1 in the invasion and progression of renal cell carcinoma". Oncology Reports 53, no. 1 (2025): 11. https://doi.org/10.3892/or.2024.8844
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