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Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review)

  • Authors:
    • Xinchi Luan
    • Xuezhe Wang
    • Gang Bian
    • Xiaoxuan Li
    • Ziru Gao
    • Zijiao Liu
    • Zhishang Zhang
    • Tianyue Han
    • Jinpeng Zhao
    • Hongjiao Zhao
    • Xinyue Luan
    • Wuhui Zhu
    • Lili Dong
    • Feifei Guo
  • View Affiliations / Copyright

    Affiliations: Pathophysiology Department, School of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China, Department of Gastroenterology, Affiliated Qingdao Third People's Hospital, Qingdao University, Qingdao, Shandong 266041, P.R. China, Department of Oncology, Key Laboratory of Cancer Molecular and Translational Research, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266031, P.R. China, School of Clinical and Basic Medicine and Institute of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China, Department of Hepatobiliary surgery, Affiliated Qingdao Third People's Hospital, Qingdao University, Qingdao, Shandong 266041, P.R. China
    Copyright: © Luan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 13
    |
    Published online on: November 20, 2024
       https://doi.org/10.3892/or.2024.8846
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a malignant neoplasm that typically manifests with subtle clinical manifestations in its early stages and frequently eludes diagnosis until the advanced phases of the disease. The limited therapeutic options available for PDAC significantly contribute to its high mortality rate, highlighting the urgent need for novel biomarkers capable of effectively identifying early clinical manifestations and facilitating precise diagnosis. The pivotal role of cellular exosomes in both the pathogenesis and therapeutic interventions for PDAC has been underscored. Furthermore, researchers have acknowledged the potential of exosomes as targeted drug carriers against regulatory cells in treating PDAC. The present article aims to provide a comprehensive review encompassing recent advancements in utilizing exosomes for elucidating mechanisms underlying disease development, patterns of metastasis, diagnostic techniques and treatment strategies associated with PDAC.
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Copy and paste a formatted citation
Spandidos Publications style
Luan X, Wang X, Bian G, Li X, Gao Z, Liu Z, Zhang Z, Han T, Zhao J, Zhao H, Zhao H, et al: Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review). Oncol Rep 53: 13, 2025.
APA
Luan, X., Wang, X., Bian, G., Li, X., Gao, Z., Liu, Z. ... Guo, F. (2025). Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review). Oncology Reports, 53, 13. https://doi.org/10.3892/or.2024.8846
MLA
Luan, X., Wang, X., Bian, G., Li, X., Gao, Z., Liu, Z., Zhang, Z., Han, T., Zhao, J., Zhao, H., Luan, X., Zhu, W., Dong, L., Guo, F."Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review)". Oncology Reports 53.1 (2025): 13.
Chicago
Luan, X., Wang, X., Bian, G., Li, X., Gao, Z., Liu, Z., Zhang, Z., Han, T., Zhao, J., Zhao, H., Luan, X., Zhu, W., Dong, L., Guo, F."Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review)". Oncology Reports 53, no. 1 (2025): 13. https://doi.org/10.3892/or.2024.8846
Copy and paste a formatted citation
x
Spandidos Publications style
Luan X, Wang X, Bian G, Li X, Gao Z, Liu Z, Zhang Z, Han T, Zhao J, Zhao H, Zhao H, et al: Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review). Oncol Rep 53: 13, 2025.
APA
Luan, X., Wang, X., Bian, G., Li, X., Gao, Z., Liu, Z. ... Guo, F. (2025). Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review). Oncology Reports, 53, 13. https://doi.org/10.3892/or.2024.8846
MLA
Luan, X., Wang, X., Bian, G., Li, X., Gao, Z., Liu, Z., Zhang, Z., Han, T., Zhao, J., Zhao, H., Luan, X., Zhu, W., Dong, L., Guo, F."Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review)". Oncology Reports 53.1 (2025): 13.
Chicago
Luan, X., Wang, X., Bian, G., Li, X., Gao, Z., Liu, Z., Zhang, Z., Han, T., Zhao, J., Zhao, H., Luan, X., Zhu, W., Dong, L., Guo, F."Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review)". Oncology Reports 53, no. 1 (2025): 13. https://doi.org/10.3892/or.2024.8846
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