Open Access

Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer (Review)

  • Authors:
    • Heng Yun
    • Fangde Dong
    • Xiaoqin Wei
    • Xinyong Yan
    • Ronglong Zhang
    • Xiuyu Zhang
    • Yulin Wang
  • View Affiliations

  • Published online on: November 26, 2024     https://doi.org/10.3892/or.2024.8847
  • Article Number: 14
  • Copyright: © Yun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Gastric cancer (GC) is characterized by a complex and heterogeneous tumor microenvironment (TME) that significantly influences disease progression and treatment outcomes. The tumor stroma, which is composed of a variety of cell types such as cancer‑associated fibroblasts, immune cells and vascular components, displays significant spatial and temporal diversity. These stromal elements engage in dynamic crosstalk with cancer cells, shaping their proliferative, invasive and metastatic potential. Furthermore, the TME is instrumental in facilitating resistance to traditional chemotherapy, specific treatments and immunotherapy strategies. Understanding the underlying mechanisms by which the GC microenvironment evolves and supports tumor growth and therapeutic resistance is critical for developing effective treatment strategies. The present review explores the latest progress in understanding the intricate interactions between cancer cells and their immediate environment in GC, highlighting the implications for disease pathogenesis and therapeutic interventions.
View Figures
View References

Related Articles

Journal Cover

January-2025
Volume 53 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yun H, Dong F, Wei X, Yan X, Zhang R, Zhang X and Wang Y: Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer (Review). Oncol Rep 53: 14, 2025.
APA
Yun, H., Dong, F., Wei, X., Yan, X., Zhang, R., Zhang, X., & Wang, Y. (2025). Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer (Review). Oncology Reports, 53, 14. https://doi.org/10.3892/or.2024.8847
MLA
Yun, H., Dong, F., Wei, X., Yan, X., Zhang, R., Zhang, X., Wang, Y."Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer (Review)". Oncology Reports 53.1 (2025): 14.
Chicago
Yun, H., Dong, F., Wei, X., Yan, X., Zhang, R., Zhang, X., Wang, Y."Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer (Review)". Oncology Reports 53, no. 1 (2025): 14. https://doi.org/10.3892/or.2024.8847