cGAS/STING pathway and gastrointestinal cancer: Mechanisms and diagnostic and therapeutic targets (Review)
- Authors:
- Chang Liu
- Li Tang
- Wenhui Yang
- Yuning Gu
- Wenrong Xu
- Zhaofeng Liang
- Jiajia Jiang
-
Affiliations: Aoyang Institute of Cancer, Affiliated Aoyang Hospital of Jiangsu University, Suzhou, Jiangsu 215600, P.R. China, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China - Published online on: November 29, 2024 https://doi.org/10.3892/or.2024.8848
- Article Number: 15
-
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Wang S, Zheng R, Li J, Zeng H, Li L, Chen R, Sun K, Han B, Bray F, Wei W and He J: Global, regional, and national lifetime risks of developing and dying from gastrointestinal cancers in 185 countries: A population-based systematic analysis of GLOBOCAN. Lancet Gastroenterol Hepatol. 9:229–237. 2024. View Article : Google Scholar : PubMed/NCBI | |
Wang T, Jin Y, Wang M, Chen B, Sun J, Zhang J, Yang H, Deng X, Cao X, Wang L and Tang Y: SALL4 in gastrointestinal tract cancers: Upstream and downstream regulatory mechanisms. Mol Med. 30:462024. View Article : Google Scholar : PubMed/NCBI | |
Samson N and Ablasser A: The cGAS-STING pathway and cancer. Nat Cancer. 3:1452–1463. 2022. View Article : Google Scholar : PubMed/NCBI | |
Lv H, Zong Q, Chen C, Lv G, Xiang W, Xing F, Jiang G, Yan B, Sun X, Ma Y, et al: TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer. Nat Commun. 15:62024. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Luo J, Alu A, Han X, Wei Y and Wei X: cGAS-STING pathway in cancer biotherapy. Mol Cancer. 19:1362020. View Article : Google Scholar : PubMed/NCBI | |
Canesso MCC, Lemos L, Neves TC, Marim FM, Castro TBR, Veloso ÉS, Queiroz CP, Ahn J, Santiago HC, Martins FS, et al: The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation. Mucosal Immunol. 11:820–834. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ke X, Hu T and Jiang M: cGAS-STING signaling pathway in gastrointestinal inflammatory disease and cancers. FASEB J. 36:e220292022. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Chen H, Yang Q, Wan L, Zhao J, Wu Y, Wang J, Yang Y, Niu M, Liu H, et al: Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway. J Exp Clin Cancer Res. 41:762022. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Xiao Y, Loupakis F, Stintzing S, Yang Y, Arai H, Battaglin F, Kawanishi N, Jayachandran P, Soni S, et al: Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials. Eur J Cancer. 172:22–30. 2022. View Article : Google Scholar : PubMed/NCBI | |
Xu D, Tian Y, Xia Q and Ke B: The cGAS-STING Pathway: Novel Perspectives in Liver Diseases. Front Immunol. 12:6827362021. View Article : Google Scholar : PubMed/NCBI | |
Mohseni G, Li J, Ariston Gabriel AN, Du L, Wang YS and Wang C: The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer. Front Immunol. 12:7810322021. View Article : Google Scholar : PubMed/NCBI | |
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI | |
Xu Y, Han J, Zhang X, Zhang X, Song J, Gao Z, Qian H, Jin J and Liang Z: Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review). Oncol Rep. 51:192024. View Article : Google Scholar : PubMed/NCBI | |
Lu L, Gao Z, Jin L, Geng H and Liang Z: Novel role of circRNAs in the drug resistance of gastric cancer: regulatory mechanisms and future for cancer therapy. Front Pharmacol. 15:14352642024. View Article : Google Scholar : PubMed/NCBI | |
Shen Q, Yang L, Li C, Wang T, Lv J, Liu W, Lin Y, Yin Y and Tao K: Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer. Heliyon. 9:e189542023. View Article : Google Scholar : PubMed/NCBI | |
Li C, Shen Q, Zhang P, Wang T, Liu W, Li R, Ma X, Zeng X, Yin Y and Tao K: Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells. J Exp Clin Cancer Res. 40:3152021. View Article : Google Scholar : PubMed/NCBI | |
Yuan M, Guo XL, Chen JH, He Y, Liu ZQ, Zhang HP, Ren J and Xu Q: Anlotinib suppresses proliferation, migration, and immune escape of gastric cancer cells by activating the cGAS-STING/IFN-beta pathway. Neoplasma. 69:807–819. 2022. View Article : Google Scholar : PubMed/NCBI | |
Yang KS, Xu CQ and Lv J: Identification and validation of the prognostic value of cyclic GMP-AMP synthase-stimulator of interferon (cGAS-STING) related genes in gastric cancer. Bioengineered. 12:1238–1250. 2021. View Article : Google Scholar : PubMed/NCBI | |
Fukai S, Nakajima S, Saito M, Saito K, Kase K, Nakano H, Sato T, Sakuma M, Kaneta A, Okayama H, et al: Down-regulation of stimulator of interferon genes (STING) expression and CD8+ T-cell infiltration depending on HER2 heterogeneity in HER2-positive gastric cancer. Gastric Cancer. 26:878–890. 2023. View Article : Google Scholar : PubMed/NCBI | |
Duan Y, Li S, Huang B, Dou Y, Kong P, Kang W and Xu D: CD47-targeted immunotherapy unleashes antitumour immunity in Epstein-Barr virus-associated gastric cancer. Clin Immunol. 247:1092382023. View Article : Google Scholar : PubMed/NCBI | |
Hosseinzadeh S, Imani M, Pourfarzi F, Jafari N, AbedianKenari S and Safarzadeh E: Combination of IFN-gamma with STING agonist and PD-1 immune checkpoint blockade: A potential immunotherapy for gastric cancer. Med Oncol. 41:1102024. View Article : Google Scholar : PubMed/NCBI | |
Liang L, Chai Y, Chai F, Liu H, Ma N, Zhang H, Zhang S, Nong L, Li T and Zhang B: Expression of SASP, DNA damage response, and cell proliferation factors in early gastric neoplastic lesions: Correlations and clinical significance. Pathol Oncol Res. 28:16104012022. View Article : Google Scholar : PubMed/NCBI | |
Esophageal Cancer Treatment (PDQ(R)), . Health Professional Version. PDQ Cancer Information Summaries Bethesda (MD): 2002 | |
Li Y, Yang Q, Chen H, Yang X, Han J, Yao X, Wei X, Si J, Yao H, Liu H, et al: TFAM downregulation promotes autophagy and ESCC survival through mtDNA stress-mediated STING pathway. Oncogene. 41:3735–3746. 2022. View Article : Google Scholar : PubMed/NCBI | |
Nakajima S, Mimura K, Kaneta A, Saito K, Katagata M, Okayama H, Saito M, Saze Z, Watanabe Y, Hanayama H, et al: Radiation-induced remodeling of the tumor microenvironment through tumor cell-intrinsic expression of cGAS-STING in esophageal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 115:957–971. 2023. View Article : Google Scholar : PubMed/NCBI | |
Matsuishi A, Nakajima S, Kaneta A, Saito K, Fukai S, Sakuma M, Tsumuraya H, Okayama H, Saito M, Mimura K, et al: The tumor cell-intrinsic cGAS-STING pathway is associated with the high density of CD8+ T cells after chemotherapy in esophageal squamous cell carcinoma. Esophagus. 21:165–175. 2024. View Article : Google Scholar : PubMed/NCBI | |
Nakajima S, Mimura K, Kaneta A, Katagata M, Okayama H, Saito M, Saze Z, Hanayama H, Tada T, Momma T and Kono K: Remodeling of the tumor microenvironment by radiotherapy through the cGAS-STING pathway in esophageal squamous cell carcinoma. Gan To Kagaku Ryoho. 50:1099–1101. 2023.(In Japanese). PubMed/NCBI | |
Li J, Ko JM, Dai W, Yu VZ, Ng HY, Hoffmann JS and Lung ML: Depletion of DNA polymerase theta inhibits tumor growth and promotes genome instability through the cGAS-STING-ISG pathway in esophageal squamous cell carcinoma. Cancers (Basel). 13:32042021. View Article : Google Scholar : PubMed/NCBI | |
Du J, Kageyama SI, Yamashita R, Hirata H, Hakozaki Y, Okumura M, Motegi A, Hojo H, Nakamura M, Hirano Y, et al: Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation. Cancer Sci. 113:1352–1361. 2022. View Article : Google Scholar : PubMed/NCBI | |
Li X, Liu H, Gao W, Yang Q, Li X, Zhou X, Wang L, Lu Z, Liu J, Luo A, et al: Octadecyl Gallate and Lipid-modified MnSe2 nanoparticles enhance radiosensitivity in esophageal squamous cell carcinoma and promote radioprotection in normal tissues. Adv Mater. 36:e23112912024. View Article : Google Scholar : PubMed/NCBI | |
Xia C, Dong X, Li H, Cao M, Sun D, He S, Yang F, Yan X, Zhang S, Li N and Chen W: Cancer statistics in China and United States, 2022: Profiles, trends, and determinants. Chin Med J (Engl). 135:584–590. 2022. View Article : Google Scholar : PubMed/NCBI | |
Wu X, Xu L, Li X, Zhou Y, Han X, Zhang W, Wang W, Guo W, Liu W, Xu Q and Gu Y: A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway. Cell Death Dis. 14:5502023. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Luo R, Onyshchenko K, Rao X, Wang M, Menz B, Gaedicke S, Grosu AL, Firat E and Niedermann G: Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING. J Immunother Cancer. 11:e0062352023. View Article : Google Scholar : PubMed/NCBI | |
Chen B, Hong Y, Zhai X, Deng Y, Hu H, Tian S, Zhang Y, Ren X, Zhao J and Jiang C: m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation. Cell Death Dis. 14:8092023. View Article : Google Scholar : PubMed/NCBI | |
Mata-Garrido J, Frizzi L, Nguyen T, He X, Chang-Marchand Y, Xiang Y, Reisacher C, Casafont I and Arbibe L: HP1γ prevents activation of the cGAS/STING pathway by preserving nuclear envelope and genomic integrity in colon adenocarcinoma cells. Int J Mol Sci. 24:73472023. View Article : Google Scholar : PubMed/NCBI | |
Hu S, Fang Y, Chen X, Cheng T, Zhao M, Du M, Li T, Li M, Zeng Z, Wei Y, et al: cGAS restricts colon cancer development by protecting intestinal barrier integrity. Proc Natl Acad Sci USA. 118:e21057471182021. View Article : Google Scholar : PubMed/NCBI | |
Wei B, Xu L, Guo W, Wang Y, Wu J, Li X, Cai X, Hu J, Wang M, Xu Q, et al: SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer. Cancer Res. 81:3215–3228. 2021. View Article : Google Scholar : PubMed/NCBI | |
Wang M, Huang Y, Chen M, Wang W, Wu F, Zhong T, Chen X, Wang F, Li Y, Yu J, et al: Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade. J Immunother Cancer. 11:e0070352023. View Article : Google Scholar : PubMed/NCBI | |
Kunac N, Degoricija M, Viculin J, Omerović J, Terzić J, Vilović K and Korac-Prlic J: Activation of cGAS-STING pathway is associated with MSI-H stage IV colorectal cancer. Cancers (Basel). 15:2212022. View Article : Google Scholar : PubMed/NCBI | |
Vornholz L, Isay SE, Kurgyis Z, Strobl DC, Loll P, Mosa MH, Luecken MD, Sterr M, Lickert H, Winter C, et al: Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy. Sci Adv. 9:eadd85642023. View Article : Google Scholar : PubMed/NCBI | |
Zheng H, Wu L, Xiao Q, Meng X, Hafiz A, Yan Q, Lu R and Cao J: Epigenetically suppressed tumor cell intrinsic STING promotes tumor immune escape. Biomed Pharmacother. 157:1140332023. View Article : Google Scholar : PubMed/NCBI | |
Catalano C, da Silva Filho MI, Frank C, Lu S, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, et al: Epistatic effect of TLR3 and cGAS-STING-IKKepsilon-TBK1-IFN signaling variants on colorectal cancer risk. Cancer Med. 9:1473–1484. 2020. View Article : Google Scholar : PubMed/NCBI | |
Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, et al: 5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING. EMBO J. 40:e1060652021. View Article : Google Scholar : PubMed/NCBI | |
Liang B, Zhang EH, Ye Z, Storts H, Jin W, Zheng X, Hylton H, Zaleski O, Xing X, Miles W and Wang JJ: SIX4 controls Anti-PD-1 efficacy by regulating STING expression. Cancer Res Commun. 3:2412–2419. 2023. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Qi J, Hu J, Zhou Y, Zheng J, Deng W, Inam M, Guo J, Xie Y, Li Y, et al: Lovastatin/SN38 co-loaded liposomes amplified ICB therapeutic effect via remodeling the immunologically-cold colon tumor and synergized stimulation of cGAS-STING pathway. Cancer Lett. 588:2167652024. View Article : Google Scholar : PubMed/NCBI | |
Morehead LC, Garg S, Wallis KF, Simoes CC, Siegel ER, Tackett AJ and Miousse IR: Increased response to immune checkpoint inhibitors with dietary methionine restriction in a colorectal cancer model. Cancers. 15:44672023. View Article : Google Scholar : PubMed/NCBI | |
Xia J, Wang L, Shen T, Li P, Zhu P, Xie S, Chen Z, Zhou F, Zhang J, Ling J, et al: Integrated manganese (III)-doped nanosystem for optimizing photothermal ablation: Amplifying hyperthermia-induced STING pathway and enhancing antitumor immunity. Acta Biomater. 155:601–617. 2023. View Article : Google Scholar : PubMed/NCBI | |
Ma J, Xin Y, Wang Q and Ding L: Roles of cGAS-STING pathway in radiotherapy combined with immunotherapy for hepatocellular carcinoma. Mol Cancer Ther. 23:447–453. 2024. View Article : Google Scholar : PubMed/NCBI | |
Li X, Pan YF, Chen YB, Wan QQ, Lin YK, Shang TY, Xu MY, Jiang TY, Pei MM, Tan YX, et al: Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma. Cell Death Dis. 15:3002024. View Article : Google Scholar : PubMed/NCBI | |
Chen B, Rao X, Wang X, Luo Z, Wang J, Sheng S, Liu Y, Zhang N, Jin S, Chen H, et al: cGAS-STING signaling pathway and liver disease: From basic research to clinical practice. Front Pharmacol. 12:7196442021. View Article : Google Scholar : PubMed/NCBI | |
Li K, Gong Y, Qiu D, Tang H, Zhang J, Yuan Z, Huang Y, Qin Y, Ye L and Yang Y: Hyperbaric oxygen facilitates Teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC. J Immunother Cancer. 10:e0040062022. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Hu R, Song Z, Zhao H, Pan Z, Feng Y, Yu Y, Han Q and Zhang J: Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity. Cancer Lett. 547:2158802022. View Article : Google Scholar : PubMed/NCBI | |
Ma H, Kang Z, Foo TK, Shen Z and Xia B: Disrupted BRCA1-PALB2 interaction induces tumor immunosuppression and T-lymphocyte infiltration in HCC through cGAS-STING pathway. Hepatology. 77:33–47. 2023. View Article : Google Scholar : PubMed/NCBI | |
Du Q, Luo Y, Xu L, Du C, Zhang W, Xu J, Liu Y, Liu B, Chen S, Wang Y, et al: Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation. J Nanobiotechnol. 22:952024. View Article : Google Scholar | |
Li Z, Zhang Y, Hong W, Wang B, Chen Y, Yang P, Zhou J, Fan J, Zeng Z and Du S: Gut microbiota modulate radiotherapy-associated antitumor immune responses against hepatocellular carcinoma Via STING signaling. Gut Microbes. 14:21190552022. View Article : Google Scholar : PubMed/NCBI | |
Cao Y, Sun T, Sun B, Zhang G, Liu J, Liang B, Zheng C and Kan X: Injectable hydrogel loaded with lysed OK-432 and doxorubicin for residual liver cancer after incomplete radiofrequency ablation. J Nanobiotechnol. 21:4042023. View Article : Google Scholar | |
Sheng H, Huang Y, Xiao Y, Zhu Z, Shen M, Zhou P, Guo Z, Wang J, Wang H, Dai W, et al: ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma. J Immunother Cancer. 8:e0003402020. View Article : Google Scholar : PubMed/NCBI | |
Hong W, Zhang Y, Wang S, Li Z, Zheng D, Hsu S, Zhou J, Fan J, Chen Z, Xia X, et al: RECQL4 inhibits radiation-induced tumor immune awakening via suppressing the cGAS-STING pathway in hepatocellular carcinoma. Adv Sci (Weinh). 11:e23080092024. View Article : Google Scholar : PubMed/NCBI | |
Thomsen MK, Skouboe MK, Boularan C, Vernejoul F, Lioux T, Leknes SL, Berthelsen MF, Riedel M, Cai H, Joseph JV, et al: The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma. Oncogene. 39:1652–1664. 2020. View Article : Google Scholar : PubMed/NCBI | |
Xu Y, Sun F, Tian Y, Zeng G, Lei G, Bai Z, Wang Y, Ge X, Wang J, Xiao C, et al: Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma. Int Immunopharmacol. 129:1116282024. View Article : Google Scholar : PubMed/NCBI | |
Sun F, Xu Y, Deng Z and Yang P: A recombinant oncolytic influenza virus expressing a PD-L1 antibody induces CD8+ T-cell activation via the cGas-STING pathway in mice with hepatocellular carcinoma. Int Immunopharmacol. 120:1103232023. View Article : Google Scholar : PubMed/NCBI | |
Fu L, Ding H, Bai Y, Cheng L, Hu S and Guo Q: IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma. Heliyon. 10:e272052024. View Article : Google Scholar : PubMed/NCBI | |
Chen G, Zheng D, Zhou Y, Du S and Zeng Z: Olaparib enhances radiation-induced systemic anti-tumor effects via activating STING-chemokine signaling in hepatocellular carcinoma. Cancer Lett. 582:2165072024. View Article : Google Scholar : PubMed/NCBI | |
Zhao F, Liu A, Gong X, Chen H, Wei J, Chen B, Chen S, Yang R, Fan Y and Mao R: Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis. Tumori. 108:63–76. 2022. View Article : Google Scholar : PubMed/NCBI | |
Qi Z, Yan F, Chen D, Xing W, Li Q, Zeng W, Bi B and Xie J: Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma. Biosci Rep. 40:BSR202026032020. View Article : Google Scholar : PubMed/NCBI | |
Ma D, Yang M, Sun C, Cui X, Xiong G, Wang Q, Jing W, Chen H, Lv X, Liu S, et al: cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity. Cell Death Differ. 31:722–737. 2024. View Article : Google Scholar : PubMed/NCBI | |
Sun B, Zhang Q, Sun T, Liu J, Cao Y, Liang B, Zheng C and Kan X: Radiofrequency hyperthermia enhances the effect of OK-432 for Hepatocellular carcinoma by activating of TLR4-cGAS-STING pathway. Int Immunopharmacol. 130:1117692024. View Article : Google Scholar : PubMed/NCBI | |
Wang S, Wu Q, Chen T, Su R, Pan C, Qian J, Huang H, Yin S, Xie H, Zhou L and Zheng S: Blocking CD47 promotes antitumour immunity through CD103+ dendritic cell-NK cell axis in murine hepatocellular carcinoma model. J Hepatol. 77:467–478. 2022. View Article : Google Scholar : PubMed/NCBI | |
Lv H, Zong Q, Chen C, Lv G, Xiang W, Xing F, Jiang G, Yan B, Sun X, Ma Y, et al: TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer. Nat Commun. 15:62024. View Article : Google Scholar : PubMed/NCBI | |
Su W, Gao W, Zhang R, Wang Q, Li L, Bu Q, Xu Z, Liu Z, Wang M, Zhu Y, Wu G, et al: TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling. JHEP Rep. 5:1006952023. View Article : Google Scholar : PubMed/NCBI | |
Du SS, Chen GW, Yang P, Chen YX, Hu Y, Zhao QQ, Zhang Y, Liu R, Zheng DX, Zhou J, et al: Radiation therapy promotes hepatocellular carcinoma immune cloaking via PD-L1 Upregulation induced by cGAS-STING activation. Int J Radiat Oncol Biol Phys. 112:1243–1255. 2022. View Article : Google Scholar : PubMed/NCBI | |
Huang S, Xie P, Huang X, Chen Z, Yang J, Wang J, Liu C, Li H and Zhou B: Disulfiram combined with chemoimmunotherapy potentiates pancreatic cancer treatment efficacy through the activation of cGAS-STING signaling pathway via suppressing PARP1 expression. Am J Cancer Res. 13:2055–2065. 2023.PubMed/NCBI | |
Jacoberger-Foissac C, Cousineau I, Bareche Y, Allard D, Chrobak P, Allard B, Pommey S, Messaoudi N, McNicoll Y, Soucy G, et al: CD73 inhibits cGAS-STING and cooperates with CD39 to promote pancreatic cancer. Cancer Immunol Res. 11:56–71. 2023. View Article : Google Scholar : PubMed/NCBI | |
Oh G, Wang A, Wang L, Li J, Werba G, Weissinger D, Zhao E, Dhara S, Hernandez RE, Ackermann A, et al: POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling. J Clin Invest. 133:e1659342023. View Article : Google Scholar : PubMed/NCBI | |
Kabashima A, Matsuo Y, Ito S, Akiyama Y, Ishii T, Shimada S, Masamune A, Tanabe M and Tanaka S: cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer. Sci Rep. 12:104662022. View Article : Google Scholar : PubMed/NCBI | |
Wang SL, Wu Y, Konate M, Lu J, Mallick D, Antony S, Meitzler JL, Jiang G, Dahan I, Juhasz A, et al: Exogenous DNA enhances DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway. Free Radic Biol Med. 205:262–274. 2023. View Article : Google Scholar : PubMed/NCBI | |
Lin S: DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer. Biochem Biophys Res Commun. 681:106–110. 2023. View Article : Google Scholar : PubMed/NCBI | |
Yousef A, Yousef M, Zeineddine MA, More A, Fanaeian M, Chowdhury S, Knafl M, Edelkamp P, Ito I, Gu Y, et al: Serum tumor markers and outcomes in patients with appendiceal adenocarcinoma. JAMA Netw Open. 7:e2402602024. View Article : Google Scholar : PubMed/NCBI | |
Li R, Wang J, Xie Z, Tian X, Hou J, Wang D, Qian H, Shen H and Xu W: CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin. Oncogene. 43:1033–1049. 2024. View Article : Google Scholar : PubMed/NCBI | |
Tian Y, Wang Y, Wen N, Wang S, Li B and Liu G: Prognostic factors associated with early recurrence following liver resection for colorectal liver metastases: A systematic review and meta-analysis. BMC Cancer. 24:4262024. View Article : Google Scholar : PubMed/NCBI |