Open Access

cGAS/STING pathway and gastrointestinal cancer: Mechanisms and diagnostic and therapeutic targets (Review)

  • Authors:
    • Chang Liu
    • Li Tang
    • Wenhui Yang
    • Yuning Gu
    • Wenrong Xu
    • Zhaofeng Liang
    • Jiajia Jiang
  • View Affiliations

  • Published online on: November 29, 2024     https://doi.org/10.3892/or.2024.8848
  • Article Number: 15
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The health of individuals is seriously threatened by intestinal cancer, which includes pancreatic, colorectal, esophageal, gastric and gallbladder cancer. Most gastrointestinal cancers do not have typical and specific early symptoms, and lack specific and effective diagnostic markers and treatment methods. It is critical to understand the etiology of gastrointestinal cancer and develop more efficient methods of diagnosis and treatment. The cyclic GMP‑AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway serves a crucial role in the occurrence, progression and treatment of gastrointestinal cancer. The present review focuses on the latest progress regarding the role and mechanism of the cGAS/STING pathway in gastrointestinal cancer, and discusses treatment approaches and related applications based on the cGAS/STING signaling pathway. In order to improve the knowledge of the connection between the cGAS/STING pathway and gastrointestinal cancer, aid the diagnosis and treatment of gastrointestinal cancer, and lessen the burden on patients and society, the present review also discusses future research directions and existing challenges regarding cGAS/STING in the study of gastrointestinal cancer.
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January-2025
Volume 53 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liu C, Tang L, Yang W, Gu Y, Xu W, Liang Z and Jiang J: cGAS/STING pathway and gastrointestinal cancer: Mechanisms and diagnostic and therapeutic targets (Review). Oncol Rep 53: 15, 2025.
APA
Liu, C., Tang, L., Yang, W., Gu, Y., Xu, W., Liang, Z., & Jiang, J. (2025). cGAS/STING pathway and gastrointestinal cancer: Mechanisms and diagnostic and therapeutic targets (Review). Oncology Reports, 53, 15. https://doi.org/10.3892/or.2024.8848
MLA
Liu, C., Tang, L., Yang, W., Gu, Y., Xu, W., Liang, Z., Jiang, J."cGAS/STING pathway and gastrointestinal cancer: Mechanisms and diagnostic and therapeutic targets (Review)". Oncology Reports 53.1 (2025): 15.
Chicago
Liu, C., Tang, L., Yang, W., Gu, Y., Xu, W., Liang, Z., Jiang, J."cGAS/STING pathway and gastrointestinal cancer: Mechanisms and diagnostic and therapeutic targets (Review)". Oncology Reports 53, no. 1 (2025): 15. https://doi.org/10.3892/or.2024.8848