Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
January-2025 Volume 53 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2025 Volume 53 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Purchase PDF
Article

Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer

  • Authors:
    • Yi-Wen Wang
    • Yih-Lin Tuan
    • Jiu-Yao Wang
    • Hong-Yi Chang
    • Chien-An Chu
    • Yi-Lin Chen
    • Hui-Wen Chen
    • Chung-Liang Ho
    • Chung-Ta Lee
    • Nan-Haw Chow
  • View Affiliations / Copyright

    Affiliations: Department of Food Safety Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan, R.O.C., Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan, R.O.C., Center for Allergy, Immunology, and Microbiome, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan, R.O.C., Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan, R.O.C., Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan, R.O.C., Department of Pathology, National Cheng Kung University Hospital, Tainan 701401, Taiwan, R.O.C.
  • Article Number: 16
    |
    Published online on: November 29, 2024
       https://doi.org/10.3892/or.2024.8849
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Amplification of human epidermal growth factor 2 receptor (HER2) and overexpression of estrogen receptor (ER) and/or progesterone receptor (PR) are key determinants in the treatment planning for human breast cancer (BC). Currently, targeted therapies for BC are focused mainly on these biomarkers. However, development of resistance to targeted drugs is almost unavoidable, emphasizing the importance of biochemical and pharmaceutical advances to improve treatment outcomes. To the best of our knowledge, the present study is the first to show functional crosstalk in vitro between HER2 and epithelial membrane protein 3 (EMP3), a tetraspan membrane protein, in human BC. EMP3 overexpression significantly promoted BC cell proliferation, invasion and migration by Transwell assays via epithelial-mesenchymal transition and transactivated the HER family, resulting in increased ER and PR expression in vitro. Knocking down EMP3 notably suppressed cell proliferation and migration and was accompanied by decreased expression of HER1‑HER3 and p‑SRC proteins. Suppression of EMP3 expression enhanced sensitivity of BC cells to trastuzumab in vitro. Xenograft experiments revealed decreased expression of HER1 and HER2 in stable EMP3‑knockdown cells, resulting in decreased tumor weight and size. In patients with BC, EMP3 overexpression was detected in 72 of 166 cases (43.4%), with 18 of 43 (41.9%) HER2‑amplified BC samples co‑expressing EMP3. Co‑expression of EMP3 and HER2 was positively associated with ER expression (P=0.028) and tended to be associated with nodal metastasis (P=0.085), however this was not significant. Taken together, the present results supported the potential of targeting EMP3 as a novel therapeutic strategy for human BC via co‑expression of HER2 and EMP3.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Testa U, Castelli G and Pelosi E: Breast cancer: A molecularly heterogenous disease needing subtype-specific treatments. Med Sci (Basel). 8:182020.PubMed/NCBI

3 

Waks AG and Winer EP: Breast cancer treatment: A review. JAMA. 321:288–300. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Harbeck N, Penault-Llorca F, Cortes J, Gnant M, Houssami N, Poortmans P, Ruddy K, Tsang J and Cardoso F: Breast cancer. Nat Rev Dis Primers. 5:662019. View Article : Google Scholar : PubMed/NCBI

5 

Spring LM, Gupta A, Reynolds KL, Gadd MA, Ellisen LW, Isakoff SJ, Moy B and Bardia A: Neoadjuvant endocrine therapy for estrogen receptor-positive breast cancer: A systematic review and meta-analysis. JAMA Oncol. 2:1477–1486. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Swain SM, Shastry M and Hamilton E: Targeting HER2-positive breast cancer: Advances and future directions. Nat Rev Drug Discov. 22:101–126. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Tesch ME and Gelmon KA: Targeting HER2 in breast cancer: Latest developments on treatment sequencing and the introduction of biosimilars. Drugs. 80:1811–1830. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Hanker AB, Sudhan DR and Arteaga CL: Overcoming endocrine resistance in breast cancer. Cancer Cell. 37:496–513. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Nayar U, Cohen O, Kapstad C, Cuoco MS, Waks AG, Wander SA, Painter C, Freeman S, Persky NS, Marini L, et al: Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor-directed therapies. Nat Genet. 51:207–216. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Pegram M, Jackisch C and Johnston SRD: Estrogen/HER2 receptor crosstalk in breast cancer: Combination therapies to improve outcomes for patients with hormone receptor-positive/HER2-positive breast cancer. NPJ Breast Cancer. 9:452023. View Article : Google Scholar : PubMed/NCBI

11 

Wang YW, Cheng HL, Ding YR, Chou LH and Chow NH: EMP1, EMP 2, and EMP3 as novel therapeutic targets in human cancer. Biochim Biophys Acta Rev Cancer. 1868:199–211. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Li L, Xia S, Zhao Z, Deng L, Wang H, Yang D, Hu Y, Ji J, Huang D and Xin T: EMP3 as a prognostic biomarker correlates with EMT in GBM. BMC Cancer. 24:892024. View Article : Google Scholar : PubMed/NCBI

13 

Ma Q, Zhang Y, Liang H, Zhang F, Liu F, Chen S, Hu Y, Jiang L, Hao Y, Li M and Liu Y: EMP3 as a key downstream target of miR-663a regulation interferes with MAPK/ERK signaling pathway to inhibit gallbladder cancer progression. Cancer Lett. 575:2163982023. View Article : Google Scholar : PubMed/NCBI

14 

Kim EK and Koo JS: Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer. Histol Histopathol. 37:51–61. 2022.PubMed/NCBI

15 

Zhou W, Jiang Z, Li X, Xu F, Liu Y, Wen P, Kong L, Hou M and Yu J: EMP3 overexpression in primary breast carcinomas is not associated with epigenetic aberrations. J Korean Med Sci. 24:97–103. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Evtimova V, Zeillinger R and Weidle UH: Identification of genes associated with the invasive status of human mammary carcinoma cell lines by transcriptional profiling. Tumour Biol. 24:189–198. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Hong XC, Fen YJ, Yan GC, Hong H, Yan CH, Bing LW and Zhong YH: Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. Mol Med Rep. 12:6445–6450. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME and Thompson EW: Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia. 15:235–252. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Kohn KW, Zeeberg BM, Reinhold WC and Pommier Y: Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype. PLoS One. 9:e992692014. View Article : Google Scholar : PubMed/NCBI

20 

Isbilen M, Mert Senses K and Osmay Gure A: Predicting chemotherapy sensitivity profiles for breast cancer cell lines with and without stem cell-like features. Curr Signal Transduct Ther. 8:268–273. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Zhou K, Sun Y, Dong D, Zhao C and Wang W: EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties. Cell Death Dis. 12:8442021. View Article : Google Scholar : PubMed/NCBI

22 

Mackay A, Jones C, Dexter T, Silva RL, Bulmer K, Jones A, Simpson P, Harris RA, Jat PS, Neville AM, et al: cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells. Oncogene. 22:2680–2688. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Chakrabarty A, Bhola NE, Sutton C, Ghosh R, Kuba MG, Dave B, Chang JC and Arteaga CL: Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors. Cancer Res. 73:1190–1200. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Wang YW, Li WM, Wu WJ, Chai CY, Liu HS, Lai MD and Chow NH: Potential significance of EMP3 in patients with upper urinary tract urothelial carcinoma: Crosstalk with ErbB2-PI3K-Akt pathway. J Urol. 192:242–251. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Cha YJ and Koo JS: Expression and role of epithelial membrane proteins in tumorigenesis of hormone receptor-positive breast cancer. J Breast Cancer. 23:385–397. 2020. View Article : Google Scholar : PubMed/NCBI

26 

Animal Protection Act. Ministry of Agriculture, ROC (Taiwan), . 2021.https://law.moj.gov.tw/ENG/LawClass/LawAll.aspx?pcode=M0060027

27 

Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, Bilous M, Ellis IO, Fitzgibbons P, Hanna W, et al: Human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology/college of American pathologists clinical practice guideline focused update. Arch Pathol Lab Med. 142:1364–1382. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, et al: Proteomics. Tissue-based map of the human proteome. Science. 347:12604192015. View Article : Google Scholar : PubMed/NCBI

29 

Gemmete JJ and Mukherji SK: Trastuzumab (herceptin). AJNR Am J Neuroradiol. 32:1373–1374. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Hsieh YH, Hsieh SC, Lee CH, Yang SF, Cheng CW, Tang MJ, Lin CL, Lin CL and Chou RH: Targeting EMP3 suppresses proliferation and invasion of hepatocellular carcinoma cells through inactivation of PI3K/Akt pathway. Oncotarget. 6:34859–34874. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Christians A, Poisel E, Hartmann C, von Deimling A and Pusch S: Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation. Int J Cancer. 145:461–473. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Kar R, Jha NK, Jha SK, Sharma A, Dholpuria S, Asthana N, Chaurasiya K, Singh VK, Burgee S and Nand P: A ‘NOTCH’ deeper into the epithelial-to-mesenchymal transition (EMT) program in breast cancer. Genes (Basel). 10:9612019. View Article : Google Scholar : PubMed/NCBI

33 

Lee KL, Kuo YC, Ho YS and Huang YH: Triple-negative breast cancer: Current understanding and future therapeutic breakthrough targeting cancer stemness. Cancers (Basel). 11:13342019. View Article : Google Scholar : PubMed/NCBI

34 

Derakhshani A, Rezaei Z, Safarpour H, Sabri M, Mir A, Sanati MA, Vahidian F, Gholamiyan Moghadam A, Aghadoukht A, Hajiasgharzadeh K and Baradaran B: Overcoming trastuzumab resistance in HER2-positive breast cancer using combination therapy. J Cell Physiol. 235:3142–3156. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Martija AA and Pusch S: The multifunctional role of EMP3 in the regulation of membrane receptors associated with IDH-wild-type glioblastoma. Int J Mol Sci. 22:52612021. View Article : Google Scholar : PubMed/NCBI

36 

Martija AA, Krauß A, Bächle N, Doth L, Christians A, Krunic D, Schneider M, Helm D, Will R, Hartmann C, et al: EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma. Acta Neuropathol Commun. 11:1772023. View Article : Google Scholar : PubMed/NCBI

37 

Kumagai S, Koyama S and Nishikawa H: Antitumour immunity regulated by aberrant ERBB family signalling. Nat Rev Cancer. 21:181–197. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Kusumoto Y, Okuyama H, Shibata T, Konno K, Takemoto Y, Maekawa D, Kononaga T, Ishii T, Akashi-Takamura S, Saitoh SI, et al: Epithelial membrane protein 3 (Emp3) downregulates induction and function of cytotoxic T lymphocytes by macrophages via TNF-α production. Cell Immunol. 324:33–41. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Sun M, Jiang H, Liu T, Tan X, Jiang Q, Sun B, Zheng Y, Wang G, Wang Y, Cheng M, et al: Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors. Acta Pharm Sin B. 12:952–966. 2022. View Article : Google Scholar : PubMed/NCBI

40 

Zeng R, Li Y, Li Y, Wan Q, Huang Z, Qiu Z and Tang D: Smartphone-based photoelectrochemical immunoassay with simpleCo9S8@ZnIn2S4 for point-of-care diagnosis of breast cancer biomarker. Research (Wash D C). 2022:98315212022.PubMed/NCBI

41 

Chen H, Li H, Shi W, Qin H and Zheng L: The roles of m6A RNA methylation modification in cancer stem cells: New opportunities for cancer suppression. Cancer Insight. 1:1–18. 2022.

42 

Yin Y, Yan Y, Fan B, Huang W, Zhang J, Hu HY, Li X, Xiong D, Chou SL, Xiao Y and Wang H: Novel combination therapy for triple-negative breast cancer based on an intelligent hollow carbon sphere. Research (Wash DC). 6:00982023.PubMed/NCBI

43 

Ji X, Tian X, Feng S, Zhang L, Wang J, Guo R, Zhu Y, Yu X, Zhang Y, Du H, et al: Intermittent F-actin perturbations by magnetic fields inhibit breast cancer metastasis. Research (Wash DC). 6:00802023.PubMed/NCBI

44 

Zheng C, Zhang D, Kong Y, Niu M, Zhao H, Song Q, Feng Q, Li X and Wang L: Dynamic regulation of drug biodistribution by turning tumors into decoys for biomimetic nanoplatform to enhance the chemotherapeutic efficacy of breast cancer with bone metastasis. Exploration (Beijing). 3:202201242023. View Article : Google Scholar : PubMed/NCBI

45 

Cheng H, Ballman K, Vassilakopoulou M, Dueck AC, Reinholz MM, Tenner K, Gralow J, Hudis C, Davidson NE, Fountzilas G, et al: EGFR expression is associated with decreased benefit from trastuzumab in the NCCTG N9831 (alliance) trial. Br J Cancer. 111:1065–1071. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Yang L, Li Y, Shen E, Cao F, Li L, Li X, Wang X, Kariminia S, Chang B, Li H and Li Q: NRG1-dependent activation of HER3 induces primary resistance to trastuzumab in HER2-overexpressing breast cancer cells. Int J Oncol. 51:1553–1562. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Watanabe S, Yonesaka K, Tanizaki J, Nonagase Y, Takegawa N, Haratani K, Kawakami H, Hayashi H, Takeda M, Tsurutani J and Nakagawa K: Targeting of the HER2/HER3 signaling axis overcomes ligand-mediated resistance to trastuzumab in HER2-positive breast cancer. Cancer Med. 8:1258–1268. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Ogden A, Bhattarai S, Sahoo B, Mongan NP, Alsaleem M, Green AR, Aleskandarany M, Ellis IO, Pattni S, Li XB, et al: Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers. Sci Rep. 10:30092020. View Article : Google Scholar : PubMed/NCBI

49 

Liu B, Ordonez-Ercan D, Fan Z, Edgerton SM, Yang X and Thor AD: Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells. Int J Cancer. 120:1874–1882. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • Purchase
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Tuan Y, Wang J, Chang H, Chu C, Chen Y, Chen H, Ho C, Lee C, Chow N, Chow N, et al: Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer. Oncol Rep 53: 16, 2025.
APA
Wang, Y., Tuan, Y., Wang, J., Chang, H., Chu, C., Chen, Y. ... Chow, N. (2025). Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer. Oncology Reports, 53, 16. https://doi.org/10.3892/or.2024.8849
MLA
Wang, Y., Tuan, Y., Wang, J., Chang, H., Chu, C., Chen, Y., Chen, H., Ho, C., Lee, C., Chow, N."Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer". Oncology Reports 53.1 (2025): 16.
Chicago
Wang, Y., Tuan, Y., Wang, J., Chang, H., Chu, C., Chen, Y., Chen, H., Ho, C., Lee, C., Chow, N."Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer". Oncology Reports 53, no. 1 (2025): 16. https://doi.org/10.3892/or.2024.8849
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Tuan Y, Wang J, Chang H, Chu C, Chen Y, Chen H, Ho C, Lee C, Chow N, Chow N, et al: Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer. Oncol Rep 53: 16, 2025.
APA
Wang, Y., Tuan, Y., Wang, J., Chang, H., Chu, C., Chen, Y. ... Chow, N. (2025). Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer. Oncology Reports, 53, 16. https://doi.org/10.3892/or.2024.8849
MLA
Wang, Y., Tuan, Y., Wang, J., Chang, H., Chu, C., Chen, Y., Chen, H., Ho, C., Lee, C., Chow, N."Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer". Oncology Reports 53.1 (2025): 16.
Chicago
Wang, Y., Tuan, Y., Wang, J., Chang, H., Chu, C., Chen, Y., Chen, H., Ho, C., Lee, C., Chow, N."Potential of epithelial membrane protein 3 as a novel therapeutic target for human breast cancer". Oncology Reports 53, no. 1 (2025): 16. https://doi.org/10.3892/or.2024.8849
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team