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Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway

  • Authors:
    • Qiuyan Li
    • Yuxia Yang
    • Xiaocong Lin
    • Lok Ting Chu
    • Helian Chen
    • Linsong Chen
    • Jinjing Tang
    • Tao Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, P.R. China, Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 31
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    Published online on: January 8, 2025
       https://doi.org/10.3892/or.2025.8864
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Abstract

Pancreatic cancer is an aggressive tumor, which is often associated with a poor clinical prognosis and resistance to conventional chemotherapy. Therefore, there is a need to identify new therapeutic markers for pancreatic cancer. Although KIN17 is a highly expressed DNA‑ and RNA‑binding protein in a number of types of human cancer, its role in pancreatic cancer development, especially in relation to progression, is currently unknown. The present study verified the upregulation of KIN17 in pancreatic cancer using The Cancer Genome Atlas and Gene Expression Omnibus databases (GSE15471, GSE71989 and GSE62165), and identified an association between the PI3K/Akt/mTOR pathway and patient prognosis using publicly available datasets (Gene Expression Profiling Interactive Analysis). Immunohistochemistry was performed to determine the association between KIN17 and the pathological features of clinical pancreatic cancer samples. Furthermore, knockdown of KIN17 was shown to inhibit the migration and invasion of pancreatic cancer cells, and to reverse epithelial‑mesenchymal transition in pancreatic cancer cells through downregulation of Vimentin and N‑cadherin, and upregulation of E‑cadherin. Through various cellular experiments, the role of KIIN17 was explored in PI3K/AKT/mTOR activity. KIN17 inhibition was shown to suppress the migration and invasion of pancreatic cancer cells through PI3K/AKT/mTOR‑mediated autophagy. Furthermore, combined with mTOR inhibition, dual inhibition could enhance autophagy, leading to anti‑migratory and anti‑invasion effects in pancreatic cancer. In conclusion, the present study indicated that KIN17 may have a role in carcinogenesis and could serve as a prognostic biomarker of pancreatic cancer, owing to its high expression. In addition, KIN17 may be considered a potential therapeutic target with its knockdown having an inhibitory effect on pancreatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Yang Y, Lin X, Chu LT, Chen H, Chen L, Tang J and Zeng T: Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway. Oncol Rep 53: 31, 2025.
APA
Li, Q., Yang, Y., Lin, X., Chu, L.T., Chen, H., Chen, L. ... Zeng, T. (2025). Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway. Oncology Reports, 53, 31. https://doi.org/10.3892/or.2025.8864
MLA
Li, Q., Yang, Y., Lin, X., Chu, L. T., Chen, H., Chen, L., Tang, J., Zeng, T."Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway". Oncology Reports 53.2 (2025): 31.
Chicago
Li, Q., Yang, Y., Lin, X., Chu, L. T., Chen, H., Chen, L., Tang, J., Zeng, T."Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway". Oncology Reports 53, no. 2 (2025): 31. https://doi.org/10.3892/or.2025.8864
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Spandidos Publications style
Li Q, Yang Y, Lin X, Chu LT, Chen H, Chen L, Tang J and Zeng T: Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway. Oncol Rep 53: 31, 2025.
APA
Li, Q., Yang, Y., Lin, X., Chu, L.T., Chen, H., Chen, L. ... Zeng, T. (2025). Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway. Oncology Reports, 53, 31. https://doi.org/10.3892/or.2025.8864
MLA
Li, Q., Yang, Y., Lin, X., Chu, L. T., Chen, H., Chen, L., Tang, J., Zeng, T."Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway". Oncology Reports 53.2 (2025): 31.
Chicago
Li, Q., Yang, Y., Lin, X., Chu, L. T., Chen, H., Chen, L., Tang, J., Zeng, T."Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway". Oncology Reports 53, no. 2 (2025): 31. https://doi.org/10.3892/or.2025.8864
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