Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
March-2025 Volume 53 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2025 Volume 53 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1

  • Authors:
    • Shan-Mei Du
    • Na Li
    • Wen-Jing Xu
    • Kui Liu
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Zibo Vocational Institute, Zibo, Shandong 255300, P.R. China, Department of Gastroenterology, Zhongda Hospital, Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 34
    |
    Published online on: January 16, 2025
       https://doi.org/10.3892/or.2025.8867
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Triple‑negative breast cancer (TNBC), a highly malignant breast cancer subtype with a pronounced metastatic propensity, forms the focus of the present investigation. MDA‑MB‑231, a prevalently utilized TNBC cell line in cancer research, was employed. In accordance with the tumour angiogenesis theory, cancer cells are capable of instigating angiogenesis and the formation of a novel vascular system within the tumour microenvironment, which subsequently sustains malignant proliferation and metastasis. Consequently, impeding the growth of tumour blood vessels holds substantial significance in suppressing TNBC metastasis. Piwi‑interacting RNAs (piRNAs), a category of endogenous non‑coding RNAs, have been demonstrated to modulate cancer progression. However, studies regarding the role of piRNAs in regulating angiogenesis within cancer cells are relatively scant. In the present study, via cell co‑culture experiments, it was revealed that piR‑31115 (a kind of piRNA) in MDA‑MB‑231 cells notably enhanced the recruitment of a human microvascular endothelial cell line (HMEC‑1). Moreover, the conditioned medium (CM, which was obtained from MDA‑MB‑231 cells via a specific culturing methodology and was employed for the subsequent treatment of HMEC‑1 cells to explore its impacts on the biological behaviors such as the proliferation and migration of HMEC‑1 cells) derived from MDA‑MB‑231 cells with upregulated piR‑31115 expression stimulated the proliferation and migration of HMEC‑1 cells. These findings suggest that piR‑31115 in MDA‑MB‑231 cells may play a pivotal role in modulating tumour angiogenesis. Further studies disclosed that the CM from MDA‑MB‑231 cells augmented the N6‑methyladenosine (m6A) RNA modification level via METTL3 in HMEC‑1 cells. Transcriptome sequencing revealed that METTL3 functions as an m6A writer protein for Yes‑associated protein 1 (YAP1), which exerts a positive influence on promoting the proliferation and migration of HMEC‑1 cells. Concurrently, the IGF2BP plays a crucial role in stabilizing YAP1 protein expression. Collectively, the present findings identified a signalling pathway through which MDA‑MB‑231 cells induce HMEC‑1 cell proliferation and migration by regulating m6A RNA methylation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Lu B, Natarajan E, Balaji Raghavendran HR and Markandan UD: Molecular classification, treatment, and genetic biomarkers in triple-negative breast cancer: A review. Technol Cancer Res Treat. 22:153303382211452462023. View Article : Google Scholar : PubMed/NCBI

2 

Geurts V and Kok M: Immunotherapy for metastatic triple negative breast cancer: Current paradigm and future approaches. Curr Treat Options Oncol. 24:628–643. 2023. View Article : Google Scholar : PubMed/NCBI

3 

Lee J: Current treatment landscape for early triple-negative breast cancer (TNBC). J Clin Med. 12:15242023. View Article : Google Scholar : PubMed/NCBI

4 

Ribatti D, Nico B, Ruggieri S, Tamma R, Simone G and Mangia A: Angiogenesis and antiangiogenesis in triple-negative breast cancer. Transl Oncol. 9:453–457. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Goggins E, Mironchik Y, Kakkad S, Jacob D, Wildes F, Bhujwalla ZM and Krishnamachary B: Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling. Cancer Biol Ther. 24:21841452023. View Article : Google Scholar : PubMed/NCBI

6 

Medina MA, Oza G, Sharma A, Arriaga LG, Hernández Hernández JM, Rotello VM and Ramirez JT: Triple-negative breast cancer: A review of conventional and advanced therapeutic strategies. Int J Environ Res Public Health. 17:20782020. View Article : Google Scholar : PubMed/NCBI

7 

Li Y, Zhan Z, Yin X, Fu S and Deng X: Targeted therapeutic strategies for triple-negative breast cancer. Front Oncol. 11:7315352021. View Article : Google Scholar : PubMed/NCBI

8 

Alahdal M and Elkord E: Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets. Clin Transl Med. 13:e14252023. View Article : Google Scholar : PubMed/NCBI

9 

Beňačka R, Szabóová D, Guľašová Z, Hertelyová Z and Radoňak J: Non-coding RNAs in human cancer and other diseases: Overview of the diagnostic potential. Int J Mol Sci. 24:162132023. View Article : Google Scholar : PubMed/NCBI

10 

Isachesku E, Braicu C, Pirlog R, Kocijancic A, Busuioc C, Pruteanu LL, Pandey DP and Berindan-Neagoe I: The role of non-coding RNAs in epigenetic dysregulation in glioblastoma development. Int J Mol Sci. 24:163202023. View Article : Google Scholar : PubMed/NCBI

11 

Girard A, Sachidanandam R, Hannon GJ and Carmell MA: A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature. 442:199–202. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M, Asada N, Kojima K, Yamaguchi Y, Ijiri TW, et al: DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 22:908–917. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Wu Z, Yu X, Zhang S, He Y and Guo W: Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases. Cell Commun Signal. 21:3432023. View Article : Google Scholar : PubMed/NCBI

14 

Deng X, Liao T, Xie J, Kang D, He Y, Sun Y, Wang Z, Jiang Y, Miao X, Yan Y, et al: The burgeoning importance of PIWI-interacting RNAs in cancer progression. Sci China Life Sci. 67:653–662. 2024. View Article : Google Scholar : PubMed/NCBI

15 

Garcia-Borja E, Siegl F, Mateu R, Slaby O, Sedo A, Busek P and Sana J: Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells. Biomark Res. 12:152024. View Article : Google Scholar : PubMed/NCBI

16 

Cheng J, Deng H, Xiao B, Zhou H, Zhou F, Shen Z and Guo J: piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells. Cancer Lett. 315:12–17. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Yan H, Wu QL, Sun CY, Ai LS, Deng J, Zhang L, Chen L, Chu ZB, Tang B, Wang K, et al: piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma. Leukemia. 29:196–206. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Yao J, Wang YW, Fang BB, Zhang SJ and Cheng BL: piR-651 and its function in 95-D lung cancer cells. Biomed Rep. 4:546–550. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Weng W, Liu N, Toiyama Y, Kusunoki M, Nagasaka T, Fujiwara T, Wei Q, Qin H, Lin H, Ma Y and Goel A: Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. Mol Cancer. 17:162018. View Article : Google Scholar : PubMed/NCBI

20 

Du X, Li H, Xie X, Shi L, Wu F, Li G, Lai C and Heng B: piRNA-31115 promotes cell proliferation and invasion via PI3K/AKT pathway in clear cell renal carcinoma. Dis Markers. 2021:69153292021. View Article : Google Scholar : PubMed/NCBI

21 

Koduru SV, Tiwari AK, Leberfinger A, Hazard SW, Kawasawa YI, Mahajan M and Ravnic DJ: A comprehensive NGS data analysis of differentially regulated miRNAs, piRNAs, lncRNAs and sn/snoRNAs in triple negative breast cancer. J Cancer. 8:578–596. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Mao Z, Wang B, Zhang T and Cui B: The roles of m6A methylation in cervical cancer: Functions, molecular mechanisms, and clinical applications. Cell Death Dis. 14:7342023. View Article : Google Scholar : PubMed/NCBI

24 

Zhu ZM, Huo FC, Zhang J, Shan HJ and Pei DS: Crosstalk between m6A modification and alternative splicing during cancer progression. Clin Transl Med. 13:e14602023. View Article : Google Scholar : PubMed/NCBI

25 

Wang Z, Liu N, Shi S, Liu S and Lin H: The role of PIWIL4, an argonaute family protein, in breast cancer. J Biol Chem. 291:10646–10658. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhong Z, Jiao Z and Yu FX: The Hippo signaling pathway in development and regeneration. Cell Rep. 43:1139262024. View Article : Google Scholar : PubMed/NCBI

27 

Duan M, Liu H, Xu S, Yang Z, Zhang F, Wang G, Wang Y, Zhao S and Jiang X: IGF2BPs as novel m6A readers: Diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor microenvironment. Genes Dis. 11:890–920. 2023. View Article : Google Scholar : PubMed/NCBI

28 

Cambria E, Coughlin MF, Floryan MA, Offeddu GS, Shelton SE and Kamm RD: Linking cell mechanical memory and cancer metastasis. Nat Rev Cancer. 24:216–228. 2024. View Article : Google Scholar : PubMed/NCBI

29 

Carrera-Aguado I, Marcos-Zazo L, Carrancio-Salán P, Guerra-Paes E, Sánchez-Juanes F and Muñoz-Félix JM: The inhibition of vessel co-option as an emerging strategy for cancer therapy. Int J Mol Sci. 25:9212024. View Article : Google Scholar : PubMed/NCBI

30 

Feng Y, Luo S, Fan D, Guo X and Ma S: The role of vascular endothelial cells in tumor metastasis. Acta Histochem. 125:1520702023. View Article : Google Scholar : PubMed/NCBI

31 

Peng C, Xu Y, Wu J, Wu D, Zhou L and Xia X: TME-related biomimetic strategies against cancer. Int J Nanomedicine. 19:109–135. 2024. View Article : Google Scholar : PubMed/NCBI

32 

Zou Y, Yang A, Chen B, Deng X, Xie J, Dai D, Zhang J, Tang H, Wu T, Zhou Z, et al: crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer. Drug Resist Updat. 77:1011262024. View Article : Google Scholar : PubMed/NCBI

33 

Zhao Q, Qian L, Guo Y, Lü J, Li D, Xie H, Wang Q, Ma W, Liu P, Liu Y, et al: IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer. Theranostics. 13:2337–2349. 2023. View Article : Google Scholar : PubMed/NCBI

34 

Cunha ERK, Ying W and Olefsky JM: Exosome-mediated impact on systemic metabolism. Annu Rev Physiol. 86:225–253. 2024. View Article : Google Scholar : PubMed/NCBI

35 

Yao J, Chen Y and Lin Z: Exosomes: Mediators in microenvironment of colorectal cancer. Int J Cancer. 153:904–917. 2023. View Article : Google Scholar : PubMed/NCBI

36 

Tang Q, Li L, Wang Y, Wu P, Hou X, Ouyang J, Fan C, Li Z, Wang F, Guo C, et al: RNA modifications in cancer. Br J Cancer. 129:204–221. 2023. View Article : Google Scholar : PubMed/NCBI

37 

Yang L, Tian S, Zheng X, Zhang M, Zhou X, Shang Y and Han Y: N6-methyladenosine RNA methylation in liver diseases: From mechanism to treatment. J Gastroenterol. 58:718–733. 2023. View Article : Google Scholar : PubMed/NCBI

38 

Zhu L, Zhang H, Zhang X and Xia L: RNA m6A methylation regulators in sepsis. Mol Cell Biochem. 479:2165–2180. 2024. View Article : Google Scholar : PubMed/NCBI

39 

Deng X, Qing Y, Horne D, Huang H and Chen J: The roles and implications of RNA m6A modification in cancer. Nat Rev Clin Oncol. 20:507–526. 2023. View Article : Google Scholar : PubMed/NCBI

40 

Ding SQ, Zhang XP, Pei JP, Bai X, Ma JJ, Zhang CD and Dai DQ: Role of N6-methyladenosine RNA modification in gastric cancer. Cell Death Discov. 9:2412023. View Article : Google Scholar : PubMed/NCBI

41 

Liu X, Xie X, Sui C, Liu X, Song M, Luo Q, Zhan P, Feng J and Liu J: Unraveling the cross-talk between N6-methyladenosine modification and non-coding RNAs in breast cancer: Mechanisms and clinical implications. Int J Cancer. 154:1877–1889. 2024. View Article : Google Scholar : PubMed/NCBI

42 

Jin Q, Qu H and Quan C: New insights into the regulation of METTL3 and its role in tumors. Cell Commun Signal. 21:3342023. View Article : Google Scholar : PubMed/NCBI

43 

Li Y, Wang K, Liu W and Zhang Y: The potential emerging role of piRNA/PIWI complex in virus infection. Virus Genes. 60:333–346. 2024. View Article : Google Scholar : PubMed/NCBI

44 

Ni XF, Xie QQ, Zhao JM, Xu YJ, Ji M, Hu WW, Wu J and Wu CP: The hepatic microenvironment promotes lung adenocarcinoma cell proliferation, metastasis, and epithelial-mesenchymal transition via METTL3-mediated N6-methyladenosine modification of YAP1. Aging (Albany NY). 13:4357–4369. 2021. View Article : Google Scholar : PubMed/NCBI

45 

Ying Y, Ma X, Fang J, Chen S, Wang W, Li J, Xie H, Wu J, Xie B, Liu B, et al: EGR2-mediated regulation of m6A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization. Cell Death Dis. 12:7502021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Du S, Li N, Xu W and Liu K: Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1. Oncol Rep 53: 34, 2025.
APA
Du, S., Li, N., Xu, W., & Liu, K. (2025). Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1. Oncology Reports, 53, 34. https://doi.org/10.3892/or.2025.8867
MLA
Du, S., Li, N., Xu, W., Liu, K."Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1". Oncology Reports 53.3 (2025): 34.
Chicago
Du, S., Li, N., Xu, W., Liu, K."Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1". Oncology Reports 53, no. 3 (2025): 34. https://doi.org/10.3892/or.2025.8867
Copy and paste a formatted citation
x
Spandidos Publications style
Du S, Li N, Xu W and Liu K: Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1. Oncol Rep 53: 34, 2025.
APA
Du, S., Li, N., Xu, W., & Liu, K. (2025). Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1. Oncology Reports, 53, 34. https://doi.org/10.3892/or.2025.8867
MLA
Du, S., Li, N., Xu, W., Liu, K."Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1". Oncology Reports 53.3 (2025): 34.
Chicago
Du, S., Li, N., Xu, W., Liu, K."Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1". Oncology Reports 53, no. 3 (2025): 34. https://doi.org/10.3892/or.2025.8867
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team