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Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review)

  • Authors:
    • Xutang Guo
    • Shaojun Li
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    Affiliations: Department of Urology, Gansu Province Maternity and Child Health Hospital, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 46
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    Published online on: February 18, 2025
       https://doi.org/10.3892/or.2025.8879
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Abstract

Prostate cancer (PCa) is second only to lung cancer in terms of death among men worldwide. Advanced PCa frequently results in bone metastases, which occur in ~90% of patients and frequently result in severe skeleton‑related events. Currently, the treatment for this disease is limited to alleviating its clinical symptoms and cannot provide a complete cure. Therefore, the development of novel treatment strategies is particularly important. In recent years, numerous novel strategies for the diagnosis and treatment of PCa have emerged, resulting in good clinical efficacy. For example, strategies targeting prostate specific membrane antigen, poly ADP‑ribose polymerase and programmed cell death protein 1 have been applied to PCa‑induced bone metastasis, and have shown initial efficacy and great potential. Therefore, understanding the molecular mechanisms underlying the formation of bone metastases in patients with PCa is of importance for the effective management of this disease. The purpose of the present review is to comprehensively outline the roles of protein‑coding genes and non‑coding RNAs in the development of bone metastases of PCa to elucidate their significance in the management of PCa. The aim is to offer clinicians and researchers a comprehensive understanding of this topic.
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Copy and paste a formatted citation
Spandidos Publications style
Guo X and Li S: Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review). Oncol Rep 53: 46, 2025.
APA
Guo, X., & Li, S. (2025). Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review). Oncology Reports, 53, 46. https://doi.org/10.3892/or.2025.8879
MLA
Guo, X., Li, S."Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review)". Oncology Reports 53.4 (2025): 46.
Chicago
Guo, X., Li, S."Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review)". Oncology Reports 53, no. 4 (2025): 46. https://doi.org/10.3892/or.2025.8879
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X and Li S: Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review). Oncol Rep 53: 46, 2025.
APA
Guo, X., & Li, S. (2025). Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review). Oncology Reports, 53, 46. https://doi.org/10.3892/or.2025.8879
MLA
Guo, X., Li, S."Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review)". Oncology Reports 53.4 (2025): 46.
Chicago
Guo, X., Li, S."Bone metastases of prostate cancer: Molecular mechanisms, targeted diagnosis and targeted therapy (Review)". Oncology Reports 53, no. 4 (2025): 46. https://doi.org/10.3892/or.2025.8879
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