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Article

Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation

  • Authors:
    • Yasutoshi Tatsumi
    • Tatsuya Masuda
    • Takayoshi Watanabe
    • Rohmad Yudi Utomo
    • Ummi Maryam Zulfin
    • Edy Meiyanto
    • Toshinori Ozaki
    • Yusuke Suenaga
    • Yasuhiko Kamikubo
  • View Affiliations / Copyright

    Affiliations: Division of Molecular Carcinogenesis, Chiba Cancer Center Research Institute, Chiba 260‑8717, Japan, Macromolecular Engineering Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia, Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute, Chiba 260‑8717, Japan
  • Article Number: 47
    |
    Published online on: February 19, 2025
       https://doi.org/10.3892/or.2025.8880
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Abstract

Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. Histone acetyltransferases (HATs), such as p300, CBP and PCAF, modulate numerous biological processes, including cellular proliferation and oncogenesis, through histone acetylation. In the present study, it was investigated whether the curcumin analogs such as pentagamavunon‑1 (PGV‑1) and chemoprevention curcumin analog‑1.1 (CCA‑1.1) could target p300 and suppress OS. Computational analysis indicated that PGV‑1 and CCA‑1.1 bind to the HAT domain of p300. Accordingly, these analogs efficiently inhibited the HAT activity of p300 in vitro and promoted OS cell apoptosis, accompanied by downregulation of acetylated histone H3 at Lys‑27 and phosphorylated oncogenic STAT3 at Tyr‑705. Finally, it was found that PGV‑1 and CCA‑1.1 but not PGV‑1, significantly attenuates the growth of OS developed on the chicken egg chorioallantoic membrane (CAM). Collectively, the present results strongly suggest that curcumin analog‑mediated targeting of p300 might provide a clue to develop an effective treatment strategy against patients with OS.
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1 

Longhi A, Errani C, De Paolis M, Mercuri M and Bacci G: Primary bone osteosarcoma in the pediatric age: State of the art. Cancer Treat Rev. 32:4234362006. View Article : Google Scholar : PubMed/NCBI

2 

He H, Ni J and Huang J: Molecular mechanisms of chemoresistance in osteosarcoma (Review). Oncol Lett. 7:135213622014. View Article : Google Scholar

3 

Isakoff MS, Bielack SS, Meltzer P and Gorlick R: Osteosarcoma: Current treatment and a collaborative pathway to success. J Clin Oncol. 33:302930352015. View Article : Google Scholar

4 

Santer FR, Höschele PP, Oh SJ, Erb HHH, Bouchal J, Cavarretta IT, Parson W, Meyers DJ, Cole PA and Culig Z: Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines. Mol Cancer Ther. 10:1644–1655. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Hou X, Li Y, Luo RZ, Fu JH, He JH, Zhang LJ and Yang HX: High expression of the transcriptional co-activator p300 predicts poor survival in resectable non-small cell lung cancers. Eur J Surg Oncol. 38:523–530. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Wang J, Wu M, Zheng D, Zhang H, Lv Y, Zhang L, Tan HS, Zhou H, Lao YZ and Xu HX: Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways. Acta Pharmacol Sin. 41:82–92. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Wang W, Li M, Wang L, Chen L and Goh BC: Curcumin in cancer therapy: Exploring molecular mechanisms and overcoming clinical challenges. Cancer Lett. 570:2163322023. View Article : Google Scholar : PubMed/NCBI

8 

Mundekkad D and Cho WC: Applications of curcumin and its nanoforms in the treatment of cancer. Pharmaceutics. 15:22232023. View Article : Google Scholar : PubMed/NCBI

9 

Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, Ranga U and Kundu TK: Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J Biol Chem. 279:51163–51171. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Zhu X, Li Q, Chang R, Yang D, Song Z, Guo Q and Huang C: Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 9:e913032014. View Article : Google Scholar : PubMed/NCBI

11 

Sunagawa Y, Funamoto M, Shimizu K, Shimizu S, Sari N, Katanasaka Y, Miyazaki Y, Kakeya H, Hasegawa K and Morimoto T: Curcumin, an inhibitor of p300-HAT activity, suppresses the development of hypertension-induced left ventricular hypertrophy with preserved ejection fraction in dahl rats. Nutrients. 13:26082021. View Article : Google Scholar : PubMed/NCBI

12 

Meiyanto E, Putri DD, Susidarti RA, Murwanti R, Sardjiman Fitriasari A, Husnaa U, Purnomo H and Kawaichi M: Curcumin and its analogues (PGV-0 and PGV-1) enhance sensitivity of resistant MCF-7 cells to doxorubicin through inhibition of HER2 and NF-kB activation. Asian Pac J Cancer Prev. 15:179–184. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Novitasari D, Jenie RI, Kato JY and Meiyanto E: The integrative bioinformatic analysis deciphers the predicted molecular target gene and pathway from curcumin derivative CCA-1.1 against triple-negative breast cancer (TNBC). J Egypt Natl Canc Inst. 33:192021. View Article : Google Scholar : PubMed/NCBI

14 

Utomo RY, Wulandari F, Novitasari D, Lestari B, Susidarti RA, Jenie RI, Kato JY, Sardjiman S and Meiyanto E: Preparation and cytotoxic evaluation of PGV-1 derivative, CCA-1.1, as a new curcumin analog with improved-physicochemical and pharmacological properties. Adv Pharm Bull. 12:6036122022. View Article : Google Scholar : PubMed/NCBI

15 

Lestari B, Nakamae I, Yoneda-Kato N, Morimoto T, Kanaya S, Yokoyama T, Shionyu M, Shirai T, Meiyanto E and Kato JY: Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence. Sci Rep. 9:148672019. View Article : Google Scholar : PubMed/NCBI

16 

Wulandari F, Ikawati M, Widyarini S, Kirihata M, Novitasari D, Kato JY and Meiyanto E: Tumour-suppressive effects of curcumin analogs CCA-1.1 and Pentagamavunone-1 in colon cancer: In vivo and in vitro studies. J Adv Pharm Technol Res. 14:317–324. 2023. View Article : Google Scholar : PubMed/NCBI

17 

Xu C, Wang M, Guo W, Sun W and Liu Y: Curcumin in osteosarcoma therapy: Combining with immunotherapy, chemotherapeutics, bone tissue engineering materials and potential synergism with photodynamic therapy. Front Oncol. 11:6724902021. View Article : Google Scholar : PubMed/NCBI

18 

Zahedipour F, Bolourinezhad M, Teng Y and Sahebkar A: The multifaceted therapeutic mechanisms of curcumin in osteosarcoma: State-of-the-art. J Oncol. 2021:30068532021. View Article : Google Scholar : PubMed/NCBI

19 

Lu KH, Lu PW, Lin CW and Yang SF: Curcumin in human osteosarcoma: From analogs to carriers. Drug Discov Today. 28:1034372023. View Article : Google Scholar : PubMed/NCBI

20 

Iwata S, Tatsumi Y, Yonemoto T, Araki A, Itami M, Kamoda H, Tsukanishi T, Hagiwara Y, Kinoshita H, Ishii T, et al: CDK4 overexpression is a predictive biomarker for resistance to conventional chemotherapy in patients with osteosarcoma. Oncol Rep. 46:1352021. View Article : Google Scholar : PubMed/NCBI

21 

Strober W: Trypan blue exclusion test of cell viability. Curr Protoc Immunol Appendix 3: Appendix 3B. 2001.PubMed/NCBI

22 

Yang H, Pinello CE, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Chase P, Planck J, et al: Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol Cancer Ther. 12:610–620. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Tatsumi Y, Takano R, Islam MS, Yokochi T, Itami M, Nakamura Y and Nakagawara A: BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell Death Dis. 6:e16072015. View Article : Google Scholar : PubMed/NCBI

24 

Meiyanto E, Putri H, Arum Larasati Y, Yudi Utomo R, Istighfari Jenie R, Ikawati M, Lestari B, Yoneda-Kato N, Nakamae I, Kawaichi M and Kato JY: Anti-proliferative and anti-metastatic potential of curcumin analogue, pentagamavunon-1 (PGV-1), toward highly metastatic breast cancer cells in correlation with ROS generation. Adv Pharm Bull. 9:445–452. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Meiyanto E, Husnaa U, Kastian RF, Putri H, Larasati YA, Khumaira A, Pamungkas DDP, Jenie RI, Kawaichi M, Lestari B, et al: The target differences of anti-tumorigenesis potential of curcumin and its analogues against HER-2 positive and triple-negative breast cancer cells. Adv Pharm Bull. 11:188–196. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Endah E, Wulandari F, Putri Y, Jenie RI and Meiyanto E: Piperine increases Pentagamavunon-1 anti-cancer activity on 4T1 breast cancer through mitotic catastrophe mechanism and senescence with sharing targeting on mitotic regulatory proteins. Iran J Pharm Res. 21:e1238202022. View Article : Google Scholar : PubMed/NCBI

27 

Kamitani N, Nakamae I, Yoneda-Kato N, Kato JY and Sho M: Preclinical evaluation of pentagamavunone-1 as monotherapy and combination therapy for pancreatic cancer in multiple xenograft models. Sci Rep. 12:224192022. View Article : Google Scholar : PubMed/NCBI

28 

Hermawan A, Wulandari F, Hanif N, Utomo RY, Jenie RI, Ikawati M and Tafrihani AS: Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment: Integrated computational analysis and in vitro study. Sci Rep. 12:139282022. View Article : Google Scholar : PubMed/NCBI

29 

Novitasari D, Jenie RI, Kato JY and Meiyanto E: Chemoprevention curcumin analog 1.1 promotes metaphase arrest and enhances intracellular reactive oxygen species levels on TNBC MDA-MB-231 and HER2-positive HCC1954 cells. Res Pharm Sci. 18:358–370. 2023. View Article : Google Scholar : PubMed/NCBI

30 

Ryu K, Choy E, Yang C, Susa M, Hornicek FJ, Mankin H and Duan Z: Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. J Orthop Res. 28:971–978. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Kelly B, Thamm D and Rosengren RJ: The second-generation curcumin analogue RL71 elicits G2/M cell cycle arrest and apoptosis in canine osteosarcoma cells. Vet Comp Oncol. 21:595–604. 2023. View Article : Google Scholar : PubMed/NCBI

32 

Lee DS, Lee MK and Kim JH: Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. Anticancer Res. 29:5039–5044. 2009.PubMed/NCBI

33 

Kabir MT, Rahman MH, Akter R, Behl T, Kaushik D, Mittal V, Pandey P, Akhtar MF, Saleem A, Albadrani GM, et al: Potential role of curcumin and its nanoformulations to treat various types of cancers. Biomolecules. 11:3922021. View Article : Google Scholar : PubMed/NCBI

34 

Lu KH, Lu PW, Lu EW, Lin CW and Yang SF: Curcumin and its analogs and carriers: Potential therapeutic strategies for human osteosarcoma. Int J Biol Sci. 19:1241–1265. 2023. View Article : Google Scholar : PubMed/NCBI

35 

Marcu MG, Jung YJ, Lee S, Chung EJ, Lee MJ, Trepel J and Neckers L: Curcumin is an inhibitor of p300 histone acetylatransferase. Med Chem. 2:169–174. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Szerlong HJ, Prenni JE, Nyborg JK and Hansen JC: Activator-dependent p300 acetylation of chromatin in vitro: Enhancement of transcription by disruption of repressive nucleosome-nucleosome interactions. J Biol Chem. 285:31954319642010. View Article : Google Scholar : PubMed/NCBI

37 

Raisner R, Kharbanda S, Jin L, Jeng E, Chan E, Merchant M, Haverty PM, Bainer R, Cheung T, Arnott D, et al: Enhancer activity requires CBP/P300 bromodomain-dependent histone H3K27 acetylation. Cell Rep. 24:1722–1729. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Hogg SJ, Motorna O, Cluse LA, Johanson TM, Coughlan HD, Raviram R, Myers RM, Costacurta M, Todorovski I, Pijpers L, et al: Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition. Mol Cell. 81:2183–2200.e13. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Narita T, Ito S, Higashijima Y, Chu WK, Neumann K, Walter J, Satpathy S, Liebner T, Hamilton WB, Maskey E, et al: Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release. Mol Cell. 81:2166–2182.e6. 2021. View Article : Google Scholar : PubMed/NCBI

40 

Chen M, Qian C, Jin B, Hu C, Zhang L, Wang M, Zhou B, Zuo W, Huang L and Wang Y: Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma. Cancer Biol Ther. 24:21628072023. View Article : Google Scholar : PubMed/NCBI

41 

Li L, Chen M, Li G and Cai R: Raddeanin A induced apoptosis of non-small cell lung cancer cells by promoting ROS-mediated STAT3 inactivation. Tissue Cell. 71:1015772021. View Article : Google Scholar : PubMed/NCBI

42 

Alsamri H, Hasasna HE, Baby B, Alneyadi A, Dhaheri YA, Ayoub MA, Eid AH, Vijayan R and Iratni R: Canosol is novel inhibitor of p300 acetyltransferase in breast cancer. Front Oncol. 11:6644032021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tatsumi Y, Masuda T, Watanabe T, Utomo RY, Zulfin UM, Meiyanto E, Ozaki T, Suenaga Y and Kamikubo Y: Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation. Oncol Rep 53: 47, 2025.
APA
Tatsumi, Y., Masuda, T., Watanabe, T., Utomo, R.Y., Zulfin, U.M., Meiyanto, E. ... Kamikubo, Y. (2025). Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation. Oncology Reports, 53, 47. https://doi.org/10.3892/or.2025.8880
MLA
Tatsumi, Y., Masuda, T., Watanabe, T., Utomo, R. Y., Zulfin, U. M., Meiyanto, E., Ozaki, T., Suenaga, Y., Kamikubo, Y."Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation". Oncology Reports 53.4 (2025): 47.
Chicago
Tatsumi, Y., Masuda, T., Watanabe, T., Utomo, R. Y., Zulfin, U. M., Meiyanto, E., Ozaki, T., Suenaga, Y., Kamikubo, Y."Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation". Oncology Reports 53, no. 4 (2025): 47. https://doi.org/10.3892/or.2025.8880
Copy and paste a formatted citation
x
Spandidos Publications style
Tatsumi Y, Masuda T, Watanabe T, Utomo RY, Zulfin UM, Meiyanto E, Ozaki T, Suenaga Y and Kamikubo Y: Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation. Oncol Rep 53: 47, 2025.
APA
Tatsumi, Y., Masuda, T., Watanabe, T., Utomo, R.Y., Zulfin, U.M., Meiyanto, E. ... Kamikubo, Y. (2025). Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation. Oncology Reports, 53, 47. https://doi.org/10.3892/or.2025.8880
MLA
Tatsumi, Y., Masuda, T., Watanabe, T., Utomo, R. Y., Zulfin, U. M., Meiyanto, E., Ozaki, T., Suenaga, Y., Kamikubo, Y."Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation". Oncology Reports 53.4 (2025): 47.
Chicago
Tatsumi, Y., Masuda, T., Watanabe, T., Utomo, R. Y., Zulfin, U. M., Meiyanto, E., Ozaki, T., Suenaga, Y., Kamikubo, Y."Antitumor effect of curcumin analog on osteosarcoma through the inhibition of p300‑mediated histone acetylation". Oncology Reports 53, no. 4 (2025): 47. https://doi.org/10.3892/or.2025.8880
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