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Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)

  • Authors:
    • Hongxi Han
    • Aichao Du
    • Jinwen Li
    • Hongyan Han
    • Peng Feng
    • Yufeng Zhu
    • Xinlong Li
    • Guopeng Tian
    • Haijia Yu
    • Bo Zhang
    • Weiguo Liu
    • Guoqiang Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, P.R. China, College of Integrative Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, P.R. China, Department of Neurology, Tianshui First People's Hospital, Tianshui, Gansu 741000, P.R. China, Lanzhou University of Basic Medical Sciences, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 48
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    Published online on: February 27, 2025
       https://doi.org/10.3892/or.2025.8881
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Abstract

Glioblastoma (GBM) is the most aggressive primary brain tumour, characterised by high heterogeneity, aggressiveness and resistance to conventional therapies, leading to poor prognosis for patients. In recent years, with the rapid development of molecular biology and genomics technologies, significant progress has been made in understanding the molecular mechanisms of GBM. This has revealed a complex molecular network involving aberrant key signalling pathways, epigenetic alterations, interactions in the tumour microenvironment and regulation of non‑coding RNAs. Based on these molecular features, novel therapeutic strategies such as targeted therapies, immunotherapy and gene therapy are rapidly evolving and hold promise for improving the outcome of GBM. This review systematically summarises the advances in molecular mechanisms and therapeutic approaches for GBM. It aims to provide new perspectives for the precise diagnosis and personalised treatment of GBM, and to ultimately improve the prognosis of patients.
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Han H, Du A, Li J, Han H, Feng P, Zhu Y, Li X, Tian G, Yu H, Zhang B, Zhang B, et al: Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review). Oncol Rep 53: 48, 2025.
APA
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y. ... Yuan, G. (2025). Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review). Oncology Reports, 53, 48. https://doi.org/10.3892/or.2025.8881
MLA
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y., Li, X., Tian, G., Yu, H., Zhang, B., Liu, W., Yuan, G."Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)". Oncology Reports 53.4 (2025): 48.
Chicago
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y., Li, X., Tian, G., Yu, H., Zhang, B., Liu, W., Yuan, G."Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)". Oncology Reports 53, no. 4 (2025): 48. https://doi.org/10.3892/or.2025.8881
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Spandidos Publications style
Han H, Du A, Li J, Han H, Feng P, Zhu Y, Li X, Tian G, Yu H, Zhang B, Zhang B, et al: Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review). Oncol Rep 53: 48, 2025.
APA
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y. ... Yuan, G. (2025). Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review). Oncology Reports, 53, 48. https://doi.org/10.3892/or.2025.8881
MLA
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y., Li, X., Tian, G., Yu, H., Zhang, B., Liu, W., Yuan, G."Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)". Oncology Reports 53.4 (2025): 48.
Chicago
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y., Li, X., Tian, G., Yu, H., Zhang, B., Liu, W., Yuan, G."Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)". Oncology Reports 53, no. 4 (2025): 48. https://doi.org/10.3892/or.2025.8881
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