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Article Open Access

BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk

  • Authors:
    • Lu Xiao
    • Jing Li
    • Jiahao Liao
    • Min Wu
    • Xiujing Lu
    • Jiehua Li
    • Yachang Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Gastrointestinal Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 64
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    Published online on: April 15, 2025
       https://doi.org/10.3892/or.2025.8897
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Abstract

Preeclampsia has been associated with a reduced risk of breast cancer (BC), but the mechanisms underlying this relationship remain unclear. It has been suggested that neutrophil extracellular traps (NETs), which are released upon neutrophil activation, play a key role in both preeclampsia and BC. To investigate this link, the single‑cell RNA sequencing dataset GSE173193 was analyzed and upregulated genes BCL2A1 and G0/G1 switch gene 2 (G0S2) were identified in neutrophils from preeclamptic placentas. These findings were validated using reverse transcription‑quantitative PCR and western blotting. Combined analyses of preeclampsia and BC tissues, from Gene Expression Omnibus (GSE24129) and The Cancer Genome Atlas databases respectively, identified 2,040 upregulated differentially expressed genes, including BCL2A1 and G0S2. Furthermore, these genes showed clinical relevance to BC, as demonstrated by Receiver Operating Characteristic curve, survival analyses and weighted gene co‑expression network analysis. Functional experiments revealed that overexpression of BCL2A1 and G0S2 increased NET release and inhibited BC cell proliferation, invasion and migration. The present study provides novel insights into the shared molecular pathways of preeclampsia and BC, emphasizing NETs as a potential protective mechanism as increased NET production in preeclampsia may contribute to a reduced BC risk by influencing tumor progression and offer avenues for further research into therapeutic interventions.
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Spandidos Publications style
Xiao L, Li J, Liao J, Wu M, Lu X, Li J and Zeng Y: BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk. Oncol Rep 53: 64, 2025.
APA
Xiao, L., Li, J., Liao, J., Wu, M., Lu, X., Li, J., & Zeng, Y. (2025). BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk. Oncology Reports, 53, 64. https://doi.org/10.3892/or.2025.8897
MLA
Xiao, L., Li, J., Liao, J., Wu, M., Lu, X., Li, J., Zeng, Y."BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk". Oncology Reports 53.6 (2025): 64.
Chicago
Xiao, L., Li, J., Liao, J., Wu, M., Lu, X., Li, J., Zeng, Y."BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk". Oncology Reports 53, no. 6 (2025): 64. https://doi.org/10.3892/or.2025.8897
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Spandidos Publications style
Xiao L, Li J, Liao J, Wu M, Lu X, Li J and Zeng Y: BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk. Oncol Rep 53: 64, 2025.
APA
Xiao, L., Li, J., Liao, J., Wu, M., Lu, X., Li, J., & Zeng, Y. (2025). BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk. Oncology Reports, 53, 64. https://doi.org/10.3892/or.2025.8897
MLA
Xiao, L., Li, J., Liao, J., Wu, M., Lu, X., Li, J., Zeng, Y."BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk". Oncology Reports 53.6 (2025): 64.
Chicago
Xiao, L., Li, J., Liao, J., Wu, M., Lu, X., Li, J., Zeng, Y."BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk". Oncology Reports 53, no. 6 (2025): 64. https://doi.org/10.3892/or.2025.8897
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