Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review)

  • Authors:
    • Shiqin Hong
    • Qiyue Wang
    • Dilong Yu
    • Juyan Zheng
    • Ping Huang
    • Jinping Gu
    • Yiwen Zhang
  • View Affiliations

  • Published online on: May 6, 2025     https://doi.org/10.3892/or.2025.8909
  • Article Number: 76
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Abstract

The tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) has a critical role in tumor progression and prognosis. The organization of T cells, B cells and high‑endothelial venules into structures termed tertiary lymphoid structures (TLS), are associated with favorable outcomes in HNSCC. Despite their importance, the formation and function of TLS‑associated immune cells in HNSCC have remained elusive. The aim of the present review is to elucidate the mechanism underlying TLS formation, which may contribute to the development of novel and effective immunotherapies for HNSCC, and summarize recent advances in HNSCC treatment.
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July-2025
Volume 54 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Hong S, Wang Q, Yu D, Zheng J, Huang P, Gu J and Zhang Y: Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review). Oncol Rep 54: 76, 2025.
APA
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., & Zhang, Y. (2025). Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review). Oncology Reports, 54, 76. https://doi.org/10.3892/or.2025.8909
MLA
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., Zhang, Y."Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review)". Oncology Reports 54.1 (2025): 76.
Chicago
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., Zhang, Y."Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review)". Oncology Reports 54, no. 1 (2025): 76. https://doi.org/10.3892/or.2025.8909