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Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review)

  • Authors:
    • Shiqin Hong
    • Qiyue Wang
    • Dilong Yu
    • Juyan Zheng
    • Ping Huang
    • Jinping Gu
    • Yiwen Zhang
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, P.R. China, Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China
  • Article Number: 76
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    Published online on: May 6, 2025
       https://doi.org/10.3892/or.2025.8909
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Abstract

The tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) has a critical role in tumor progression and prognosis. The organization of T cells, B cells and high‑endothelial venules into structures termed tertiary lymphoid structures (TLS), are associated with favorable outcomes in HNSCC. Despite their importance, the formation and function of TLS‑associated immune cells in HNSCC have remained elusive. The aim of the present review is to elucidate the mechanism underlying TLS formation, which may contribute to the development of novel and effective immunotherapies for HNSCC, and summarize recent advances in HNSCC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Hong S, Wang Q, Yu D, Zheng J, Huang P, Gu J and Zhang Y: Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review). Oncol Rep 54: 76, 2025.
APA
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., & Zhang, Y. (2025). Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review). Oncology Reports, 54, 76. https://doi.org/10.3892/or.2025.8909
MLA
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., Zhang, Y."Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review)". Oncology Reports 54.1 (2025): 76.
Chicago
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., Zhang, Y."Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review)". Oncology Reports 54, no. 1 (2025): 76. https://doi.org/10.3892/or.2025.8909
Copy and paste a formatted citation
x
Spandidos Publications style
Hong S, Wang Q, Yu D, Zheng J, Huang P, Gu J and Zhang Y: Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review). Oncol Rep 54: 76, 2025.
APA
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., & Zhang, Y. (2025). Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review). Oncology Reports, 54, 76. https://doi.org/10.3892/or.2025.8909
MLA
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., Zhang, Y."Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review)". Oncology Reports 54.1 (2025): 76.
Chicago
Hong, S., Wang, Q., Yu, D., Zheng, J., Huang, P., Gu, J., Zhang, Y."Tertiary lymphoid structures in head and neck squamous cell carcinoma (Review)". Oncology Reports 54, no. 1 (2025): 76. https://doi.org/10.3892/or.2025.8909
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