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Article Open Access

SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway

  • Authors:
    • Chenyu Wang
    • Xiulan Yang
    • Xue Shen
    • Shirong Yan
    • Jing Li
    • Yan Wang
    • Tian Tao
    • Tongqian Wu
    • Qian Kang
    • Fang Yu
  • View Affiliations / Copyright

    Affiliations: Center for Clinical Laboratories, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Clinical Microbiology and Immunology, School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Clinical Research Center, Affiliated Hospital of Guizhou Medical University, Guiyang Guizhou 550004, P.R. China, Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 78
    |
    Published online on: May 8, 2025
       https://doi.org/10.3892/or.2025.8911
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Abstract

B‑cell acute lymphoblastic leukemia (B‑ALL) is a type of acute lymphoblastic leukemia that originates from B cells. It typically occurs in children and adolescents, but it can also appear in adults. Sorting nexin 10 (SNX10) has recently been identified as a significant regulatory factor in various tumors, although its specific roles remain contested. However, its function in B‑ALL has not been previously explored. The present study investigated the role of SNX10 in B‑ALL pathogenesis. Bioinformatics analysis identified SNX10 as a Core Hub gene in the B‑ALL signaling network, with significantly reduced expression in patients with B‑ALL. These findings were corroborated through analysis of clinical bone marrow samples and B‑ALL cell lines. Functional in vitro studies revealed that SNX10 knockdown markedly inhibited B‑ALL cell proliferation, increased apoptosis, and arrested cells in the G0/G1 phase. By contrast, SNX10 overexpression enhanced cell proliferation, suppressed apoptosis and promoted G2/M phase progression. Proteomic analysis further implicated the PI3K/Akt signaling pathway in mediating the effects of SNX10. Specifically, SNX10 overexpression increased the phosphorylation levels of PI3K and Akt, while SNX10 knockdown had the opposite effect. In vivo experiments demonstrated that elevated SNX10 expression accelerated leukemia progression in a mouse model. Collectively, these findings highlighted the pivotal role of SNX10 in promoting B‑ALL cell proliferation via the PI3K pathway, highlighting its potential as a therapeutic target for B‑ALL and providing a foundation for future investigations.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Yang X, Shen X, Yan S, Li J, Wang Y, Tao T, Wu T, Kang Q, Yu F, Yu F, et al: SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway. Oncol Rep 54: 78, 2025.
APA
Wang, C., Yang, X., Shen, X., Yan, S., Li, J., Wang, Y. ... Yu, F. (2025). SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway. Oncology Reports, 54, 78. https://doi.org/10.3892/or.2025.8911
MLA
Wang, C., Yang, X., Shen, X., Yan, S., Li, J., Wang, Y., Tao, T., Wu, T., Kang, Q., Yu, F."SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway". Oncology Reports 54.1 (2025): 78.
Chicago
Wang, C., Yang, X., Shen, X., Yan, S., Li, J., Wang, Y., Tao, T., Wu, T., Kang, Q., Yu, F."SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway". Oncology Reports 54, no. 1 (2025): 78. https://doi.org/10.3892/or.2025.8911
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Yang X, Shen X, Yan S, Li J, Wang Y, Tao T, Wu T, Kang Q, Yu F, Yu F, et al: SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway. Oncol Rep 54: 78, 2025.
APA
Wang, C., Yang, X., Shen, X., Yan, S., Li, J., Wang, Y. ... Yu, F. (2025). SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway. Oncology Reports, 54, 78. https://doi.org/10.3892/or.2025.8911
MLA
Wang, C., Yang, X., Shen, X., Yan, S., Li, J., Wang, Y., Tao, T., Wu, T., Kang, Q., Yu, F."SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway". Oncology Reports 54.1 (2025): 78.
Chicago
Wang, C., Yang, X., Shen, X., Yan, S., Li, J., Wang, Y., Tao, T., Wu, T., Kang, Q., Yu, F."SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway". Oncology Reports 54, no. 1 (2025): 78. https://doi.org/10.3892/or.2025.8911
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