Involvement of the PRDX family and its clinical functions in different types of gastrointestinal cancer (Review)

  • Authors:
    • Zhou Zhang
    • Yujie Wang
    • Yuhao Liu
    • Haizhen Wu
    • Xiaopeng Xu
    • Kai Wang
    • Chen He
    • Chen Qian
  • View Affiliations

  • Published online on: June 4, 2025     https://doi.org/10.3892/or.2025.8923
  • Article Number: 90
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Abstract

Peroxiredoxin (PRDX) is a large and highly conserved family of peroxidases, which can maintain the dynamic balance of intracellular oxidative stress levels based on the degradation of the hydrogen peroxide, peroxynitrite and lipid peroxides, among others. Additionally, PRDXs are expressed with varying levels in almost all tumor tissues and cells, and they can regulate the downstream signaling cascades by modulating intracellular peroxide levels in tumor cells, alongside the participation during the modulation of gene expression, cell proliferation, apoptosis, migration, differentiation and other cellular biological behaviors. It has been revealed that the PRDXs family exhibits crucial functions in the occurrence, development, diagnosis and prognosis of gastrointestinal cancer, but a systematic summary was lacking in relevant studies. Therefore, the present study aims at probing into the underlying mechanisms of the PRDXs family in the occurrence and development of gastrointestinal cancer, providing new insights into the clinical diagnosis, treatment and prognosis monitoring.
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August-2025
Volume 54 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Z, Wang Y, Liu Y, Wu H, Xu X, Wang K, He C and Qian C: Involvement of the PRDX family and its clinical functions in different types of gastrointestinal cancer (Review). Oncol Rep 54: 90, 2025.
APA
Zhang, Z., Wang, Y., Liu, Y., Wu, H., Xu, X., Wang, K. ... Qian, C. (2025). Involvement of the PRDX family and its clinical functions in different types of gastrointestinal cancer (Review). Oncology Reports, 54, 90. https://doi.org/10.3892/or.2025.8923
MLA
Zhang, Z., Wang, Y., Liu, Y., Wu, H., Xu, X., Wang, K., He, C., Qian, C."Involvement of the PRDX family and its clinical functions in different types of gastrointestinal cancer (Review)". Oncology Reports 54.2 (2025): 90.
Chicago
Zhang, Z., Wang, Y., Liu, Y., Wu, H., Xu, X., Wang, K., He, C., Qian, C."Involvement of the PRDX family and its clinical functions in different types of gastrointestinal cancer (Review)". Oncology Reports 54, no. 2 (2025): 90. https://doi.org/10.3892/or.2025.8923