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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April-2026 Volume 55 Issue 4

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Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling

  • Authors:
    • Kun Li
    • Jinwei Chen
    • Zhi Zheng
    • Yichun Gao
    • Jiayu Zhang
    • Wenya Ding
    • Tongguo Yang
    • Yuyang Gu
    • Xuhua Duan
    • Tiesuo Zhao
    • Huijie Jia
    • Pengfei Chen
    • Jianzhuang Ren

  • View Affiliations / Copyright

    Affiliations: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China, Department of Radiology, Shanxi Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi 030000, P.R. China, Xinxiang City Key Laboratory of Tumor Vaccine and Immunotherapy, Xinxiang Engineering Technology Research Center of Immune Checkpoint Drug for Liver‑Intestinal Tumors, Henan Medical University, Xinxiang, Henan 453000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 69
    |
    Published online on: February 11, 2026
       https://doi.org/10.3892/or.2026.9074
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Abstract

Regorafenib, a multi‑kinase inhibitor, has limited efficacy in hepatocellular carcinoma (HCC) due to dose‑­dependent toxicity. The present study explored whether low‑dose Regorafenib combined with Nifuroxazide exerts enhanced anti‑tumor effects in HCC models. In vitro experiments with HepG2 cells showed the combination inhibited cell viability, proliferation and migration, induced apoptosis and reduced expression of key proteins, including phosphorylated signal transducer and activator of transcription 3 (STAT3). In vivo, H22 tumor‑bearing mice treated with the combination exhibited suppressed tumor growth without systemic toxicity, along with changes in apoptotic proteins, enhanced tumor‑infiltrating immune cells and improved systemic immune responses. These findings indicated that the combination exerts enhanced suppression of HCC by inhibiting STAT3 and remodeling anti‑tumor immunity, providing preclinical evidence for a safe and effective strategy.

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Copy and paste a formatted citation
Spandidos Publications style
Li K, Chen J, Zheng Z, Gao Y, Zhang J, Ding W, Yang T, Gu Y, Duan X, Zhao T, Zhao T, et al: <p>Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling</p>. Oncol Rep 55: 69, 2026.
APA
Li, K., Chen, J., Zheng, Z., Gao, Y., Zhang, J., Ding, W. ... Ren, J. (2026). <p>Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling</p>. Oncology Reports, 55, 69. https://doi.org/10.3892/or.2026.9074
MLA
Li, K., Chen, J., Zheng, Z., Gao, Y., Zhang, J., Ding, W., Yang, T., Gu, Y., Duan, X., Zhao, T., Jia, H., Chen, P., Ren, J."<p>Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling</p>". Oncology Reports 55.4 (2026): 69.
Chicago
Li, K., Chen, J., Zheng, Z., Gao, Y., Zhang, J., Ding, W., Yang, T., Gu, Y., Duan, X., Zhao, T., Jia, H., Chen, P., Ren, J."<p>Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling</p>". Oncology Reports 55, no. 4 (2026): 69. https://doi.org/10.3892/or.2026.9074
Copy and paste a formatted citation
x
Spandidos Publications style
Li K, Chen J, Zheng Z, Gao Y, Zhang J, Ding W, Yang T, Gu Y, Duan X, Zhao T, Zhao T, et al: <p>Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling</p>. Oncol Rep 55: 69, 2026.
APA
Li, K., Chen, J., Zheng, Z., Gao, Y., Zhang, J., Ding, W. ... Ren, J. (2026). <p>Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling</p>. Oncology Reports, 55, 69. https://doi.org/10.3892/or.2026.9074
MLA
Li, K., Chen, J., Zheng, Z., Gao, Y., Zhang, J., Ding, W., Yang, T., Gu, Y., Duan, X., Zhao, T., Jia, H., Chen, P., Ren, J."<p>Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling</p>". Oncology Reports 55.4 (2026): 69.
Chicago
Li, K., Chen, J., Zheng, Z., Gao, Y., Zhang, J., Ding, W., Yang, T., Gu, Y., Duan, X., Zhao, T., Jia, H., Chen, P., Ren, J."<p>Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling</p>". Oncology Reports 55, no. 4 (2026): 69. https://doi.org/10.3892/or.2026.9074
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