|
1
|
Siegel RL, Kratzer TB, Giaquinto AN, Sung
H and Jemal A: Cancer statistics, 2025. CA Cancer J Clin. 75:10–45.
2025.PubMed/NCBI
|
|
2
|
Wu Z, Xia F and Lin R: Global burden of
cancer and associated risk factors in 204 countries and
territories, 1980–2021: A systematic analysis for the GBD 2021. J
Hematol Oncol. 17:1192024. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bray F, Laversanne M, Sung H, Ferlay J,
Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics
2022: GLOBOCAN estimates of incidence and mortality worldwide for
36 cancers in 185 countries. CA Cancer J Clin. 74:229–263.
2024.PubMed/NCBI
|
|
4
|
Sundar R, Nakayama I, Markar SR, Shitara
K, van Laarhoven HWM, Janjigian YY and Smyth EC: Gastric cancer.
Lancet. 405:2087–2102. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Sever R and Brugge JS: Signal transduction
in cancer. Cold Spring Harb Perspect Med. 5:a0060982015. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sampson C, Wang Q, Otkur W, Zhao H, Lu Y,
Liu X and Piao HL: The roles of E3 ubiquitin ligases in cancer
progression and targeted therapy. Clin Transl Med. 13:e12042023.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Cockram PE, Kist M, Prakash S, Chen SH,
Wertz IE and Vucic D: Ubiquitination in the regulation of
inflammatory cell death and cancer. Cell Death Differ. 28:591–605.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Da Silva Z, Glanzner WG, Currin L, De
Macedo MP, Gutierrez K, Guay V, Gonçalves PBD and Bordignon V: DNA
damage induction alters the expression of ubiquitin and SUMO
regulators in preimplantation stage pig embryos. Int J Mol Sci.
23:96102022. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Ebadi P, Stratton CM and Olsen SK: E3
ubiquitin ligases in signaling, disease, and therapeutics. Trends
Biochem Sci. 50:961–976. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Zheng N and Shabek N: Ubiquitin ligases:
Structure, function, and regulation. Annu Rev Biochem. 86:129–157.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Cai J, Culley MK, Zhao Y and Zhao J: The
role of ubiquitination and deubiquitination in the regulation of
cell junctions. Protein Cell. 9:754–769. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Fu J, Liao L, Balaji KS, Wei C, Kim J and
Peng J: Epigenetic modification and a role for the E3 ligase RNF40
in cancer development and metastasis. Oncogene. 40:465–474. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Onishi S, Uchiyama K, Sato K, Okada C,
Kobayashi S, Hamada K, Nishizawa T, Nureki O, Ogata K and Sengoku
T: Structure of the human Bre1 complex bound to the nucleosome. Nat
Commun. 15:25802024. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zheng X, Chen K, Liu X, Pan Y and Liu H:
High RNF40 expression indicates poor prognosis of hepatocellular
carcinoma. Int J Clin Exp Pathol. 11:2901–2906. 2018.PubMed/NCBI
|
|
15
|
Barish S, Berg K, Drozd J, Berglund-Brown
I, Khizir L, Wasson LK, Seidman CE, Seidman JG, Chen S and
Brueckner M: The H2Bub1-deposition complex is required for human
and mouse cardiogenesis. Dev Camb Engl. 150:dev2018992023.
|
|
16
|
Kang YJ, Pan L, Liu Y, Rong Z, Liu J and
Liu F: GEPIA3: Enhanced drug sensitivity and interaction network
analysis for cancer research. Nucleic Acids Res. 53:W283–W290.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Zhang F, Paramasivam M, Cai Q, Dai X, Wang
P, Lin K, Song J, Seidman MM and Wang Y: Arsenite binds to the RING
finger domains of RNF20-RNF40 Histone E3 ubiquitin ligase and
inhibits DNA Double-strand break repair. J Am Chem Soc.
136:12884–12887. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Prokakis E, Jansari S, Boshnakovska A,
Wiese M, Kusch K, Kramm C, Dullin C, Rehling P, Glatzel M, Pantel
K, et al: RNF40 epigenetically modulates glycolysis to support the
aggressiveness of basal-like breast cancer. Cell Death Dis.
14:6412023. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wegwitz F, Prokakis E, Pejkovska A,
Kosinsky RL, Glatzel M, Pantel K, Wikman H and Johnsen SA: The
histone H2B ubiquitin ligase RNF40 is required for HER2-driven
mammary tumorigenesis. Cell Death Dis. 11:8732020. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Wen H and Ao S: RBP95, a novel leucine
zipper protein, binds to the retinoblastoma protein. Biochem
Biophys Res Commun. 275:141–148. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Chin LS, Vavalle JP and Li L: Staring, a
novel E3 ubiquitin-protein ligase that targets syntaxin 1 for
degradation. J Biol Chem. 277:35071–35079. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Kim J, Hake SB and Roeder RG: The human
homolog of yeast BRE1 functions as a transcriptional coactivator
through direct activator interactions. Mol Cell. 20:759–770.
2005.doi: 10.1016/j.molcel.2005.11.012. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Foglizzo M, Middleton AJ and Day CL:
Structure and function of the RING domains of RNF20 and RNF40,
dimeric E3 ligases that monoubiquitylate histone H2B. J Mol Biol.
428:4073–4086. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Metzger MB, Pruneda JN, Klevit RE and
Weissman AM: RING-type E3 ligases: Master manipulators of E2
ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys
Acta. 1843:47–60. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Sanchez JG, Okreglicka K, Chandrasekaran
V, Welker JM, Sundquist WI and Pornillos O: The tripartite motif
coiled-coil is an elongated antiparallel hairpin dimer. Proc Natl
Acad Sci. 111:2494–2499. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Fiorentini F, Esposito D and Rittinger K:
Does it take two to tango? RING domain self-association and
activity in TRIM E3 ubiquitin ligases. Biochem Soc Trans.
48:2615–2624. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Strauss HM and Keller S: Pharmacological
interference with protein-protein interactions mediated by
coiled-coil motifs. Protein-Protein Interactions as New Drug
Targets. Klussmann E and Scott J: Handbook of Experimental
Pharmacology. 186. Springer; Heidelberg: pp. 461–482. 2008,
View Article : Google Scholar
|
|
28
|
Kari V, Shchebet A, Neumann H and Johnsen
SA: The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to
induce dynamic changes in chromatin structure during DNA
double-strand break repair. Cell Cycle. 10:3495–3504. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Meng D, Guo K, Zhang D, Zhao C, Sun C and
Zhang F: Ring finger 20/ring finger 40/WW domain-containing adaptor
with coiled-coil complex interacts with p53 to regulate gene
transcription in DNA damage response. Oncol Lett. 21:4362021.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Liu Z, Fan K, Abudukeremu A, Gao M, Tan X,
Mao X, Li X, Ma W, Ma X, Li C, et al: LIMA1 links the E3 ubiquitin
ligase RNF40 to lipid metabolism. Cell Death Discov. 10:2982024.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Chasapis CT and Spyroulias GA: RING finger
E(3) ubiquitin ligases: Structure and drug discovery. Curr Pharm
Des. 15:3716–3731. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Li Y, Qin P, Sun A, Xiao W, Chen F, He Y,
Yu K, Li Y, Zhang M and Guo X: Genome-wide identification, new
classification, expression analysis and screening of drought &
heat resistance related candidates in the RING zinc finger gene
family of bread wheat (Triticum aestivum L.). BMC Genomics.
23:6962022. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Ying M, Huang X, Zhao H, Wu Y, Wan F,
Huang C and Jie K: Comprehensively surveying structure and function
of RING domains from drosophila melanogaster. PLoS One.
6:e238632011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Deng Z, Ai H, Sun M, Tong Z, Du Y, Qu Q,
Zhang L, Xu Z, Tao S, Shi Q, et al: Mechanistic insights into
nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and
its human homolog RNF20/RNF40-hRAD6A. Mol Cell. 83:3081–3094.e14.
2023. View Article : Google Scholar
|
|
35
|
Shi M, Zhao J, Zhang S, Huang W, Li M, Bai
X, Zhang W, Zhang K, Chen X and Xiang S: Structural basis for the
Rad6 activation by the Bre1 N-terminal domain. Elife.
12:e841572023. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Shiloh Y, Shema E, Moyal L and Oren M:
RNF20-RNF40: A ubiquitin-driven link between gene expression and
the DNA damage response. FEBS Lett. 585:2795–2802. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
In S, Kim YI, Lee JE and Kim J:
RNF20/40-mediated eEF1BδL monoubiquitylation stimulates
transcription of heat shock-responsive genes. Nucleic Acids Res.
47:2840–2855. 2019.PubMed/NCBI
|
|
38
|
Lee JH, Lee GY, Jang H, Choe SS, Koo SH
and Kim JB: Ring finger protein20 regulates hepatic lipid
metabolism through protein kinase a-dependent sterol regulatory
element binding protein1c degradation. Hepatology. 60:844–857.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Xie W, Nagarajan S, Baumgart SJ, Kosinsky
RL, Najafova Z, Kari V, Hennion M, Indenbirken D, Bonn S, Grundhoff
A, et al: RNF40 regulates gene expression in an epigenetic
context-dependent manner. Genome Biol. 18:322017. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Zhu J, Wang Y, Hao H, Yang J and Shen L:
Twist1 silencing suppresses triple-negative breast cancer
progression by reducing RNF40 transcription. Naunyn Schmiedebergs
Arch Pharmacol. 399:783–795. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Schneider D, Chua RL, Molitor N, Hamdan
FH, Rettenmeier EM, Prokakis E, Mishra VK, Kari V, Wegwitz F,
Johnsen SA, et al: The E3 ubiquitin ligase RNF40 suppresses
apoptosis in colorectal cancer cells. Clin Epigenetics. 11:982019.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Prenzel T, Begus-Nahrmann Y, Kramer F,
Hennion M, Hsu C, Gorsler T, Hintermair C, Eick D, Kremmer E,
Simons M, et al: Estrogen-dependent gene transcription in human
breast cancer cells relies upon proteasome-dependent
monoubiquitination of histone H2B. Cancer Res. 71:5739–5753. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Kosinsky RL, Chua RL, Qui M, Saul D,
Mehlich D, Ströbel P, Schildhaus HU, Wegwitz F, Faubion WA and
Johnsen SA: Loss of RNF40 decreases NF-κB activity in colorectal
cancer cells and reduces colitis burden in mice. J Crohns Colitis.
13:362–373. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Yadav P, Subbarayalu P, Medina D, Nirzhor
S, Timilsina S, Rajamanickam S, Eedunuri VK, Gupta Y, Zheng S,
Abdelfattah N, et al: M6A RNA methylation regulates histone
ubiquitination to support cancer growth and progression. Cancer
Res. 82:1872–1889. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Cheng J, Song B, Wei C, Zhang L, Liu X,
Yang L, Tima S, Chiampanichayakul S, Xiao X, Anuchapreeda S and Fu
J: Exploring breast cancer associated-gene panel for
next-generation sequencing and identifying new, pathogenic variants
in breast cancer from western China. J Cancer. 16:1281–1295. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Jansari S, Blandau A, Prokakis E, Grimm D,
Naßl AM, Küffer S, Möbius W, Dullin C, Ramos-Gomes F, Schüürhuis L,
et al: RNF20/RNF40 supports the aggressive behavior in cervical
cancer by regulating a peroxisome-based anti-ferroptotic mechanism.
Cell Commun Signal. 23:304–321. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Karpiuk O, Najafova Z, Kramer F, Hennion
M, Galonska C, König A, Snaidero N, Vogel T, Shchebet A,
Begus-Nahrmann Y, et al: The Histone H2B monoubiquitination
regulatory pathway is required for differentiation of multipotent
stem cells. Mol Cell. 46:705–713. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Sirbu BM and Cortez D: DNA damage
response: Three levels of DNA repair regulation. Cold Spring Harb
Perspect Biol. 5:a0127242013. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Oss-Ronen L, Sarusi T and Cohen I: Histone
mono-ubiquitination in transcriptional regulation and its mark on
life: Emerging roles in tissue development and disease. Cells.
11:24042022. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Robson A, Makova SZ, Barish S, Zaidi S,
Mehta S, Drozd J, Jin SC, Gelb BD, Seidman CE, Chung WK, et al:
Histone H2B monoubiquitination regulates heart development via
epigenetic control of cilia motility. Proc Natl Acad Sci USA.
116:14049–14054. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Kosinsky RL, Zerche M, Kutschat AP, Nair
A, Ye Z, Saul D, von Heesen M, Friton JJ, Schwarzer AC, Paglilla N,
et al: RNF20 and RNF40 regulate vitamin D receptor-dependent
signaling in inflammatory bowel disease. Cell Death Differ.
28:3161–3175. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Henikoff S and Smith MM: Histone variants
and epigenetics. Cold Spring Harb Perspect Biol. 7:a0193642015.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Wojcik F, Dann GP, Beh LY, Debelouchina
GT, Hofmann R and Muir TW: Functional crosstalk between histone H2B
ubiquitylation and H2A modifications and variants. Nat Commun.
9:13942018. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Wu L, Li L, Zhou B, Qin Z and Dou Y: H2B
ubiquitylation promotes RNA pol II processivity via PAF1 and pTEFb.
Mol Cell. 54:920–931. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Jung I, Kim SK, Kim M, Han YM, Kim YS, Kim
D and Lee D: H2B monoubiquitylation is a 5′-enriched active
transcription mark and correlates with exon-intron structure in
human cells. Genome Res. 22:1026–1035. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Wüst HM, Wegener A, Fröb F, Hartwig AC,
Wegwitz F, Kari V, Schimmel M, Tamm ER, Johnsen SA, Wegner M, et
al: Egr2-guided histone H2B monoubiquitination is required for
peripheral nervous system myelination. Nucleic Acids Res.
48:8959–8976. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Smirnova EV, Rakitina TV, Ziganshin RH,
Arapidi GP, Saratov GA, Kudriaeva AA and Belogurov AA:
Comprehensive atlas of the myelin basic protein interaction
landscape. Biomolecules. 11:16282021. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Lit L, Sharp FR, Bertoglio K, Stamova B,
Ander BP, Sossong AD and Hendren RL: Gene expression in blood is
associated with risperidone response in children with autism
spectrum disorders. Pharmacogenomics J. 12:368–371. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Shen Y, Dies KA, Holm IA, Bridgemohan C,
Sobeih MM, Caronna EB, Miller KJ, JFrazier JA, Silverstein I,
Picker J, et al: Clinical genetic testing for patients with autism
spectrum disorders. Pediatrics. 125:e727–e735. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Hanson E, Nasir RH, Fong A, Lian A,
Hundley R, Shen Y, Wu BL, Holm IA and Miller DT; 16p11.2 Study
Group Clinicians, : Cognitive and behavioral characterization of
16p11.2 deletion syndrome. J Dev Behav Pediatr. 31:649–657. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Yao S, Zhang X, Zou SC, Zhu Y, Li B, Kuang
WP, Guo Y, Li XS, Li L and Wang XY: A transcriptome-wide
association study identifies susceptibility genes for Parkinson's
disease. NPJ Park Dis. 7:792021. View Article : Google Scholar
|
|
62
|
Zhu B, Zheng Y, Pham AD, Mandal SS,
Erdjument-Bromage H, Tempst P and Reinberg D: Monoubiquitination of
human histone H2B: The factors involved and their roles in HOX gene
regulation. Mol Cell. 20:601–611. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Shema E, Tirosh I, Aylon Y, Huang J, Ye C,
Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, et
al: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a
putative tumor suppressor through selective regulation of gene
expression. Genes Dev. 22:2664–2676. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Segala G, Bennesch MA, Pandey DP, Hulo N
and Picard D: Monoubiquitination of histone H2B blocks eviction of
histone variant H2A.Z from inducible enhancers. Mol Cell.
64:334–346. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
VanDusen NJ, Lee JY, Gu W, Butler CE,
Sethi I, Zheng Y, King JS, Zhou P, Suo S, Guo Y, et al: Massively
parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic
regulators of cardiomyocyte maturation. Nat Commun. 12:44422021.
View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Najafova Z, Liu P, Wegwitz F, Ahmad M,
Tamon L, Kosinsky RL, Xie W, Johnsen SA and Tuckermann J: RNF40
exerts stage-dependent functions in differentiating osteoblasts and
is essential for bone cell crosstalk. Cell Death Differ.
28:700–714. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Xie W, Miehe M, Laufer S and Johnsen SA:
The H2B ubiquitin-protein ligase RNF40 is required for somatic cell
reprogramming. Cell Death Dis. 11:287–299. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Tang H, Han Q and Yin Y: Screening of
important markers in peripheral blood mononuclear cells to predict
female osteoporosis risk using LASSO regression algorithm and SVM
method. Evol Bioinform Online. 18:117693432210750142022. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Zheng G, Shi J, Li Q, Jin X, Fang Y, Zhang
Z, Cao Q, Zhu L and Shen J: BAP1 inactivation promotes lactate
production by leveraging the subcellular localization of LDHA in
melanoma. Cell Death Discov. 10:483–494. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Wade AK, Liu Y, Bethea MM, Toren E, Tse HM
and Hunter CS: LIM-domain transcription complexes interact with
ring-finger ubiquitin ligases and thereby impact islet β-cell
function. J Biol Chem. 294:11728–11740. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Pierre TH, Bethea MM, Coutinho K, Liu Y,
Liu JH, Guo M, Chada S, Evans SM, Li W, Bhatnagar S, et al: The
Islet-1 interaction partner Rnf20 regulates glucose homeostasis and
pancreatic β-Cell identity. Diabetes. 74:1814–1824. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Kou C, Zhao X, Fan X, Sun R, Wang W, Qi M,
Zhu L, Lin X and Yu J: Rnf40 exacerbates hypertension-induced
cerebrovascular endothelial barrier dysfunction by ubiquitination
and degradation of parkin. CNS Neurosci Ther. 31:e702102025.
View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Tarcic O, Pateras IS, Cooks T, Shema E,
Kanterman J, Ashkenazi H, Boocholez H, Hubert A, Rotkopf R,
Baniyash M, et al: RNF20 links histone H2B ubiquitylation with
inflammation and inflammation-associated cancer. Cell Rep.
14:14622016. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Liu J, Wu X, Qin H, Hu Y, Zhang Z, Wang Y
and Li J: RNF20/RNF40 ameliorates streptozotocin-induced type 1
diabetes by activating vitamin D receptors in vivo. Allergol
Immunopathol (Madr). 51:1–9. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Galan C, Lu G, Gill R, Li D, Liu Y, Huh JR
and Hang S: RTF1 mediates epigenetic control of Th17 cell
differentiation via H2B monoubiquitination. J Immunol. 214:460–471.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Sekiguchi M and Matsushita N: DNA damage
response regulation by histone ubiquitination. Int J Mol Sci.
23:81872022. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Mladenov E, Magin S, Soni A and Iliakis G:
DNA double-strand-break repair in higher eukaryotes and its role in
genomic instability and cancer: Cell cycle and
proliferation-dependent regulation. Semin Cancer Biol. 37–38.
51–64. 2016.PubMed/NCBI
|
|
78
|
Bhattacharya D, Dwivedi HK and Nagaraju G:
RNF20-mediated H2B monoubiquitination protects stalled forks from
degradation and promotes fork restart. EMBO Rep. 26:3773–3803.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
So CC, Ramachandran S and Martin A: E3
ubiquitin ligases RNF20 and RNF40 are required for double-stranded
break (DSB) repair: Evidence for monoubiquitination of histone H2B
lysine 120 as a novel axis of DSB signaling and repair. Mol Cell
Biol. 39:e00488–18. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Suraweera A, Gandhi NS, Beard S, Burgess
JT, Croft LV, Bolderson E, Naqi A, Ashton NW, Adams MN, Savage KI,
et al: COMMD4 functions with the histone H2A-H2B dimer for the
timely repair of DNA double-strand breaks. Commun Biol. 4:4842021.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Li Y, Zang A, Fu J and Jia Y: Cullin7 in
tumor development: A novel potential anti-cancer target. Neoplasma.
68:572–579. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Shah VJ and Maddika S: CRL7SMU1
E3 ligase complex-driven H2B ubiquitylation functions in sister
chromatid cohesion by regulating SMC1 expression. J Cell Sci.
131:jcs2138682018. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Moyal L, Lerenthal Y, Gana-Weisz M, Mass
G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, et al:
Requirement of ATM-dependent monoubiquitylation of histone H2B for
timely repair of DNA double-strand breaks. Mol Cell. 41:529–542.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Cole AJ, Clifton-Bligh R and Marsh DJ:
Histone H2B monoubiquitination: Roles to play in human malignancy.
Endocr Relat Cancer. 22:T19–T33. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Soo Lee N, Jin Chung H, Kim HJ, Yun Lee S,
Ji JH, Seo Y, Hun Han S, Choi M, Yun M, Lee SG, et al: TRAIP/RNF206
is required for recruitment of RAP80 to sites of DNA damage. Nat
Commun. 7:104632016. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Kato A and Komatsu K: RNF20-SNF2H pathway
of chromatin relaxation in DNA double-strand break repair. Genes.
6:592–606. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Chernikova SB and Brown JM: R-loops and
genomic instability in Bre1 (RNF20/40)-deficient cells. Cell Cycle.
11:2980–2984. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Du X, Song H, Shen N, Hua R and Yang G:
The molecular basis of Ubiquitin-conjugating enzymes (E2s) as a
potential target for cancer therapy. Int J Mol Sci. 22:34402021.
View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Wu C, Cui Y, Liu X, Zhang F, Lu LY and Yu
X: The RNF20/40 complex regulates p53-dependent gene transcription
and mRNA splicing. J Mol Cell Biol. 12:1132020. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Sethi G, Shanmugam MK, Arfuso F and Kumar
AP: Role of RNF20 in cancer development and progression-a
comprehensive review. Biosci Rep. 38:BSR201712872018. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Ferrari AJ, Rawat P, Rendulich HS,
Annapragada AV, Kinose Y, Zhang X, Devins K, Budina A, Scharpf RB,
Mitchell MA, et al: H2Bub1 loss is an early contributor to clear
cell ovarian cancer progression. JCI Insight. 8:e1649952023.
View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Garrido Castro P, van Roon EHJ, Pinhanços
SS, Trentin L, Schneider P, Kerstjens M, Te Kronnie G, Heidenreich
O, Pieters R and Stam RW: The HDAC inhibitor panobinostat (LBH589)
exerts in vivo anti-leukaemic activity against MLL-rearranged acute
lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B
ubiquitination axis. Leukemia. 32:323–331. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Chernikova SB, Dorth JA, Razorenova OV,
Game JC and Brown JM: Deficiency in Bre1 impairs homologous
recombination repair and cell cycle checkpoint response to
radiation damage in mammalian cells. Radiat Res. 174:558–565. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Chernikova SB, Razorenova OV, Higgins JP,
Sishc BJ, Nicolau M, Dorth JA, Chernikova DA, Kwok S, Brooks JD,
Bailey SM, et al: Deficiency in mammalian histone H2B ubiquitin
ligase Bre1 (Rnf20/Rnf40) leads to replication stress and
chromosomal instability. Cancer Res. 72:2111–2119. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Tarcic O, Granit RZ, Pateras IS, Masury H,
Maly B, Zwang Y, Yarden Y, Gorgoulis VG, Pikarsky E, Ben-Porath I
and Oren M: RNF20 and histone H2B ubiquitylation exert opposing
effects in Basal-Like versus luminal breast cancer. Cell Death
Differ. 24:694–704. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Duan Y, Huo D, Gao J, Wu H, Ye Z, Liu Z,
Zhang K, Shan L, Zhou X, Wang Y, et al: Ubiquitin ligase RNF20/40
facilitates spindle assembly and promotes breast carcinogenesis
through stabilizing motor protein Eg5. Nat Commun. 7:126482016.
View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Bedi U, Scheel AH, Hennion M,
Begus-Nahrmann Y, Rüschoff J and Johnsen SA: SUPT6H controls
estrogen receptor activity and cellular differentiation by multiple
epigenomic mechanisms. Oncogene. 34:465–473. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Lyu Y, Yang Y, Talwar V, Lu H, Chen C,
Salman S, Wicks EE, Huang TY, Drehmer D, Wang Y, et al:
Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate
histone ubiquitination and transcriptional activation of target
genes. Cell Rep. 43:1139722024. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Spolverini A, Fuchs G, Bublik DR and Oren
M: Let-7b and let-7c microRNAs promote histone H2B ubiquitylation
and inhibit cell migration by targeting multiple components of the
H2B deubiquitylation machinery. Oncogene. 36:5819–5828. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Marsh DJ, Ma Y and Dickson KA: Histone
monoubiquitination in chromatin remodelling: Focus on the histone
H2B interactome and cancer. Cancers (Basel). 12:34622020.
View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Liu L, Wong CC, Gong B and Yu J:
Functional significance and therapeutic implication of ring-type E3
ligases in colorectal cancer. Oncogene. 37:148–159. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Melling N, Grimm N, Simon R, Stahl P,
Bokemeyer C, Terracciano L, Sauter G, Izbicki JR and Marx AH: Loss
of H2Bub1 expression is linked to poor prognosis in nodal negative
colorectal cancers. Pathol Oncol Res. 22:95–102. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Wallace B: Morrison. Inflammation and
Cancer: A Comparative View. 2025.Available from:. https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1939-1676.2011.00836.x
|
|
104
|
Fishbein A, Hammock BD, Serhan CN and
Panigrahy D: Carcinogenesis: Failure of resolution of inflammation?
Pharmacol Ther. 218:1076702021. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Jääskeläinen T, Makkonen H, Visakorpi T,
Kim J, Roeder RG and Palvimo JJ: Histone H2B ubiquitin ligases
RNF20 and RNF40 in androgen signaling and prostate cancer cell
growth. Mol Cell Endocrinol. 350:87–98. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Thomas-Jardin SE, Dahl H, Nawas AF,
Bautista M and Delk NA: NF-κB signaling promotes
castration-resistant prostate cancer initiation and progression.
Pharmacol Ther. 211:1075382020. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Zhu L, Li Y, Zhou L, Yang G, Wang Y, Han
J, Li L and Zhang S: Role of RING-type E3 ubiquitin ligases in
inflammatory signalling and inflammatory bowel disease. Mediators
Inflamm. 2020:53101802020. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Marsh DJ and Dickson KAL: Writing histone
monoubiquitination in human malignancy-the role of RING finger E3
ubiquitin ligases. Genes (Basel). 10:672019. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Ming H, Li B, Jiang J, Qin S, Nice EC, He
W, Lang T and Huang C: Protein degradation: Expanding the toolbox
to restrain cancer drug resistance. J Hematol Oncol. 16:62023.
View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Zhang K, Wang J, Tong TR, Wu X, Nelson R,
Yuan YC, Reno T, Liu Z, Yun X, Kim JY, et al: Loss of H2B
monoubiquitination is associated with poor-differentiation and
enhanced malignancy of lung adenocarcinoma. Int J Cancer.
141:766–777. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Zhao X, Wen X and Liu B: Wee1
epigenetically modulates H2B mono-ubiquitination at K120 lysine and
DNA double-strand break repair through phosphorylation of
H2BY37-dependent manner in small-cell lung cancer. Thorac Cancer.
14:1420–1429. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
You L, Wang Q, Zhang T, Xiao H, Lv M, Lv
H, Deng L, Zhang X and Zhang Y: USP14-IMP2-CXCL2 axis in
tumor-associated macrophages facilitates resistance to anti-PD-1
therapy in gastric cancer by recruiting myeloid-derived suppressor
cells. Oncogene. 44:2413–2426. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Chen J, Liao Y, Li R, Luo M, Wu G, Tan R
and Xiao Z: Immunotherapeutic significance of a prognostic
alternative splicing signature in bladder cancer. Technol Cancer
Res Treat. 21:153303382210900932022. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Kim J, Guermah M, McGinty RK, Lee J-S,
Tang Z, Milne TA, Shilatifard A, Muir TW and Roeder RG:
RAD6-mediated transcription-coupled H2B ubiquitylation directly
stimulates H3K4 methylation in human cells. Cell. 137:459–471.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Carter RJ, Nickson CM, Thompson JM,
Kacperek A, Hill MA and Parsons JL: Complex DNA damage induced by
high linear energy transfer alpha-particles and protons triggers a
specific cellular DNA damage response. Int J Radiat Oncol Biol
Phys. 100:7762018. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Albrecht D, Ceschin J, Dompierre J,
Gueniot F, Pinson B and Daignan-Fornier B: Chemo-genetic
interactions between histone modification and the antiproliferation
drug AICAR are conserved in yeast and humans. Genetics.
204:1447–1460. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Zhao F, Hicks CW and Wolberger C:
Mechanism of histone H2B monoubiquitination by Bre1. Nat Struct Mol
Biol. 30:1623–1627. 2023. View Article : Google Scholar : PubMed/NCBI
|
