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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-2026 Volume 56 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Review Open Access

Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)

  • Authors:
    • Yuanbo Xu
    • Weili Wang
    • Yating Zhang
    • Yinqiu Fan
    • Wanying Dong
    • Jun Yang

  • View Affiliations / Copyright

    Affiliations: Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, P.R. China, Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 133
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    Published online on: May 20, 2026
       https://doi.org/10.3892/or.2026.9138
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Abstract

Gastric cancer (GC) is among the most prevalent malignant tumors worldwide, and its occurrence and progression are closely associated with metabolic abnormalities and remodeling of the tumor microenvironment. As an emerging metabolism‑related post‑translational modification, lactylation acts as a central hub connecting metabolic reprogramming and epigenetic regulation in tumor cells. The present review systematically describes the reprogramming features of lactate metabolism in the GC microenvironment; dissects the enzymatic system and molecular characteristics of lactylation; and reveals a bidirectional positive feedback loop in which histone H3 lysine 18 lactylation (H3K18la) promotes lactate production by upregulating glycolytic genes, and lactate accumulation, in turn, enhances H3K18la levels. A three‑dimensional regulatory network of ‘metabolic reprogramming‑epigenetic regulation‑immune microenvironment remodeling’ is thereby established in GC. The present review also reveals the clinical value of lactylation as a prognostic biomarker for GC, proposes combination therapeutic strategies targeting lactylation, and provides a theoretical basis and translational direction for the precise diagnosis and treatment of GC.

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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Wang W, Zhang Y, Fan Y, Dong W and Yang J: Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review). Oncol Rep 56: 133, 2026.
APA
Xu, Y., Wang, W., Zhang, Y., Fan, Y., Dong, W., & Yang, J. (2026). Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review). Oncology Reports, 56, 133. https://doi.org/10.3892/or.2026.9138
MLA
Xu, Y., Wang, W., Zhang, Y., Fan, Y., Dong, W., Yang, J."Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)". Oncology Reports 56.1 (2026): 133.
Chicago
Xu, Y., Wang, W., Zhang, Y., Fan, Y., Dong, W., Yang, J."Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)". Oncology Reports 56, no. 1 (2026): 133. https://doi.org/10.3892/or.2026.9138
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Wang W, Zhang Y, Fan Y, Dong W and Yang J: Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review). Oncol Rep 56: 133, 2026.
APA
Xu, Y., Wang, W., Zhang, Y., Fan, Y., Dong, W., & Yang, J. (2026). Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review). Oncology Reports, 56, 133. https://doi.org/10.3892/or.2026.9138
MLA
Xu, Y., Wang, W., Zhang, Y., Fan, Y., Dong, W., Yang, J."Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)". Oncology Reports 56.1 (2026): 133.
Chicago
Xu, Y., Wang, W., Zhang, Y., Fan, Y., Dong, W., Yang, J."Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)". Oncology Reports 56, no. 1 (2026): 133. https://doi.org/10.3892/or.2026.9138
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