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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-2026 Volume 56 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review

Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)

  • Authors:
    • Shuqi Zhang
    • Ping Li
    • Lixia Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Suzhou, Jiangsu 215002, P.R. China, Department of Radiotherapy and Oncology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu 215300, P.R. China
  • Article Number: 139
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    Published online on: May 28, 2026
       https://doi.org/10.3892/or.2026.9144
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Abstract

Krüppel‑like factor (KLF) 5 has garnered increasing interest in cancer research, as a zinc finger transcription factor integral to the regulation of cellular growth and division through gene transcription control. Initially investigated for its role in transcriptional regulation during normal tissue development, KLF5 was subsequently identified as a driver of cancer progression upon aberrant activation of its transcriptional activity. This functional dichotomy in transcriptional regulation has considerably enhanced the current understanding of the significance of KLF5 in human cancer. The dysregulation of such critical transcription factors has been shown to be closely linked with gynecological tumors, including cervical, ovarian and endometrial cancer. However, the specific regulatory mechanisms by which KLF5 influences the initiation and progression of gynecological tumors remains to be elucidated. The present review highlights the role of the KLF5 transcriptional regulatory network in the pathogenesis of gynecological tumors and its potential as a therapeutic target.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Li P and Zhu L: Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review). Oncol Rep 56: 139, 2026.
APA
Zhang, S., Li, P., & Zhu, L. (2026). Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review). Oncology Reports, 56, 139. https://doi.org/10.3892/or.2026.9144
MLA
Zhang, S., Li, P., Zhu, L."Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)". Oncology Reports 56.1 (2026): 139.
Chicago
Zhang, S., Li, P., Zhu, L."Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)". Oncology Reports 56, no. 1 (2026): 139. https://doi.org/10.3892/or.2026.9144
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Li P and Zhu L: Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review). Oncol Rep 56: 139, 2026.
APA
Zhang, S., Li, P., & Zhu, L. (2026). Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review). Oncology Reports, 56, 139. https://doi.org/10.3892/or.2026.9144
MLA
Zhang, S., Li, P., Zhu, L."Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)". Oncology Reports 56.1 (2026): 139.
Chicago
Zhang, S., Li, P., Zhu, L."Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)". Oncology Reports 56, no. 1 (2026): 139. https://doi.org/10.3892/or.2026.9144
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