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Review

Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)

  • Authors:
    • Shuqi Zhang
    • Ping Li
    • Lixia Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Suzhou, Jiangsu 215002, P.R. China, Department of Radiotherapy and Oncology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu 215300, P.R. China
  • Article Number: 139
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    Published online on: May 28, 2026
       https://doi.org/10.3892/or.2026.9144
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Abstract

Krüppel‑like factor (KLF) 5 has garnered increasing interest in cancer research, as a zinc finger transcription factor integral to the regulation of cellular growth and division through gene transcription control. Initially investigated for its role in transcriptional regulation during normal tissue development, KLF5 was subsequently identified as a driver of cancer progression upon aberrant activation of its transcriptional activity. This functional dichotomy in transcriptional regulation has considerably enhanced the current understanding of the significance of KLF5 in human cancer. The dysregulation of such critical transcription factors has been shown to be closely linked with gynecological tumors, including cervical, ovarian and endometrial cancer. However, the specific regulatory mechanisms by which KLF5 influences the initiation and progression of gynecological tumors remains to be elucidated. The present review highlights the role of the KLF5 transcriptional regulatory network in the pathogenesis of gynecological tumors and its potential as a therapeutic target.
View Figures

Figure 1

Protein structure of KLF5. The KLF5
gene is situated at chromosomal location 13q21, and the KLF5
protein consists of 457 amino acid residues. At its C-terminus,
KLF5 contains three highly conserved classical C2H2 zinc finger
motifs, a proline-rich transcription activation domain (TAD), and a
nuclear export signal (NES). The TAD of KLF5 includes a PPSY motif
and a CPD motif (SPPSS), which facilitate the recruitment of E3
ubiquitin ligases WWP1 and SCFFBW7. KLF5 is subject to regulation
by various post-translational modifications, such as
ubiquitination, acetylation (at lysine residues K335, K369, K391),
phosphorylation (at serine residues S153, S303, S406) and
SUMOylation (at lysine residues K151 and K202). KLF5, Krüppel-like
factor 5.

Figure 2

A part of the mechanism of KLF5
regulating gynecological tumors. This schematic diagram illustrates
the multifaceted roles of KLF5 in cervical, ovarian and endometrial
cancers. Functional biological processes including cell
proliferation, apoptosis, migration, invasion, chemoresistance and
immune regulation are represented in pink. KLF5 functions as a
transcriptional regulatory hub, integrating various upstream
regulatory signals to coordinate downstream oncogenic cascades
across different gynecological cancer types. Arrows indicate
activating (→) or inhibitory (⊣) regulatory relationships. EMT,
epithelial-mesenchymal transition; UCA1, urothelial carcinoma
associated 1; SNAI1, snail family transcriptional repressor 1;
ZEB1, zinc finger E-box binding homeobox 1. KLF5, Krüppel-like
factor 5.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Li P and Zhu L: Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review). Oncol Rep 56: 139, 2026.
APA
Zhang, S., Li, P., & Zhu, L. (2026). Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review). Oncology Reports, 56, 139. https://doi.org/10.3892/or.2026.9144
MLA
Zhang, S., Li, P., Zhu, L."Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)". Oncology Reports 56.1 (2026): 139.
Chicago
Zhang, S., Li, P., Zhu, L."Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)". Oncology Reports 56, no. 1 (2026): 139. https://doi.org/10.3892/or.2026.9144
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Li P and Zhu L: Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review). Oncol Rep 56: 139, 2026.
APA
Zhang, S., Li, P., & Zhu, L. (2026). Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review). Oncology Reports, 56, 139. https://doi.org/10.3892/or.2026.9144
MLA
Zhang, S., Li, P., Zhu, L."Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)". Oncology Reports 56.1 (2026): 139.
Chicago
Zhang, S., Li, P., Zhu, L."Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)". Oncology Reports 56, no. 1 (2026): 139. https://doi.org/10.3892/or.2026.9144
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