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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August-2026 Volume 56 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review Open Access

Research progress on plant polysaccharides in the prevention and treatment of tumors (Review)

  • Authors:
    • Jikun Wang
    • Yihan Wang
    • Xiwu Zhang

  • View Affiliations / Copyright

    Affiliations: The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Experimental and Practical Training Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 152
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    Published online on: June 26, 2026
       https://doi.org/10.3892/or.2026.9157
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Abstract

With the increasing global burden of cancer, traditional chemotherapy is limited by issues such as high toxicity and poor targeting, making the development of new therapeutic strategies an urgent priority. As natural bioactive macromolecules, herbal polysaccharides have become a hotspot in antitumor research due to their multi‑target effects, low toxicity, and excellent biocompatibility. The present review summarizes recent advances in the mechanisms of plant polysaccharides in antitumor activity and their applications in drug delivery systems. It highlights their synergistic antitumor effects through multiple pathways, including regulation of the immune microenvironment, induction of programmed cell death, modulation of the microbiota‑immune axis, and inhibition of angiogenesis and metastasis. These compounds significantly enhance the efficacy of chemotherapy and immunotherapy while reversing drug resistance. Novel formulations such as polysaccharide‑based nano‑delivery systems, selenium‑modified complexes and gel platforms have further improved drug targeting, stability, and immunomodulatory efficacy, providing a solid theoretical foundation and innovative directions for integrated traditional Chinese and Western medicine in cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Wang Y and Zhang X: Research progress on plant polysaccharides in the prevention and treatment of tumors (Review). Oncol Rep 56: 152, 2026.
APA
Wang, J., Wang, Y., & Zhang, X. (2026). Research progress on plant polysaccharides in the prevention and treatment of tumors (Review). Oncology Reports, 56, 152. https://doi.org/10.3892/or.2026.9157
MLA
Wang, J., Wang, Y., Zhang, X."Research progress on plant polysaccharides in the prevention and treatment of tumors (Review)". Oncology Reports 56.2 (2026): 152.
Chicago
Wang, J., Wang, Y., Zhang, X."Research progress on plant polysaccharides in the prevention and treatment of tumors (Review)". Oncology Reports 56, no. 2 (2026): 152. https://doi.org/10.3892/or.2026.9157
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Wang Y and Zhang X: Research progress on plant polysaccharides in the prevention and treatment of tumors (Review). Oncol Rep 56: 152, 2026.
APA
Wang, J., Wang, Y., & Zhang, X. (2026). Research progress on plant polysaccharides in the prevention and treatment of tumors (Review). Oncology Reports, 56, 152. https://doi.org/10.3892/or.2026.9157
MLA
Wang, J., Wang, Y., Zhang, X."Research progress on plant polysaccharides in the prevention and treatment of tumors (Review)". Oncology Reports 56.2 (2026): 152.
Chicago
Wang, J., Wang, Y., Zhang, X."Research progress on plant polysaccharides in the prevention and treatment of tumors (Review)". Oncology Reports 56, no. 2 (2026): 152. https://doi.org/10.3892/or.2026.9157
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