Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats

  • Authors:
    • K Kuwa
    • H Kudo
    • S Sakamoto
  • View Affiliations

  • Published online on: January 1, 1996     https://doi.org/10.3892/or.3.1.15
  • Pages: 15-16
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Abstract

Thymidine kinase is the key enzyme in salvage pathway for pyrimidine nucleotide synthesis. High activities of thymidine kinase have been found in rapidly proliferating normal, neoplastic tissues and sera from patients with various diseases including lymphoma, leukemias and small cell lung cancer. We investigated the serum thymidine kinase activities and the colorectal carcinomas in rats treated with 1,2-dimethylhydrazine. The positive correlations between serum thymidine kinase activities and numbers of total and large tumors were observed. These findings suggest the measurement of serum thymidine kinase activity may be clinically valuable in an early stage of the colonic carcinogenesis.

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January 1996
Volume 3 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kuwa K, Kudo H and Sakamoto S: Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats. Oncol Rep 3: 15-16, 1996
APA
Kuwa, K., Kudo, H., & Sakamoto, S. (1996). Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats. Oncology Reports, 3, 15-16. https://doi.org/10.3892/or.3.1.15
MLA
Kuwa, K., Kudo, H., Sakamoto, S."Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats". Oncology Reports 3.1 (1996): 15-16.
Chicago
Kuwa, K., Kudo, H., Sakamoto, S."Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats". Oncology Reports 3, no. 1 (1996): 15-16. https://doi.org/10.3892/or.3.1.15