Phorbol ester stimulated Cip1 expression in p53-negative leukemic cells

  • Authors:
    • J DeVente
    • W Bryant
    • K Posekany
    • T Garris
    • J Chen
    • J Carey
    • P Cook
    • K Ways
  • View Affiliations

  • Published online on: January 1, 1996     https://doi.org/10.3892/or.3.1.213
  • Pages: 213-217
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Abstract

In differentiating leukemic cells, cyclin-dependent kinase interacting protein (Cip1) is induced and stimulates a G(1) arrest. TPA treated U937 monoblastoid cells expressed Cip1, hypophosphorylated retinoblastoma protein (Rb), arrested in G(1) and differentiated. PKC-zeta cells are U937 cells that overexpress the zeta isoform and display alterations in endogenous PKC isoform expression. TPA treated PKC-zeta cells undergo apoptosis without differentiating. TPA treated PKC-zeta cells express Cip1 and display substantial hypophosphorylation of Rb but fail to arrest in G(1). Thus, a novel phorbol ester dependent signalling pathway exists in which Cip1 induction is associated with the absence of a G(1) arrest and induction of apoptosis rather than differentiation.

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January 1996
Volume 3 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
DeVente J, Bryant W, Posekany K, Garris T, Chen J, Carey J, Cook P and Ways K: Phorbol ester stimulated Cip1 expression in p53-negative leukemic cells. Oncol Rep 3: 213-217, 1996
APA
DeVente, J., Bryant, W., Posekany, K., Garris, T., Chen, J., Carey, J. ... Ways, K. (1996). Phorbol ester stimulated Cip1 expression in p53-negative leukemic cells. Oncology Reports, 3, 213-217. https://doi.org/10.3892/or.3.1.213
MLA
DeVente, J., Bryant, W., Posekany, K., Garris, T., Chen, J., Carey, J., Cook, P., Ways, K."Phorbol ester stimulated Cip1 expression in p53-negative leukemic cells". Oncology Reports 3.1 (1996): 213-217.
Chicago
DeVente, J., Bryant, W., Posekany, K., Garris, T., Chen, J., Carey, J., Cook, P., Ways, K."Phorbol ester stimulated Cip1 expression in p53-negative leukemic cells". Oncology Reports 3, no. 1 (1996): 213-217. https://doi.org/10.3892/or.3.1.213