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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 1996 Volume 3 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1996 Volume 3 Issue 1

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Article

Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer

  • Authors:
    • D Orphanidou
    • P Athanasiadou
    • M Toumbis
    • E Petrakakou
    • K Dimakou
    • K Kyrkou
    • A Rasidakis
    • J Jordanoglou

  • View Affiliations / Copyright

    Affiliations: UNIV ATHENS,DEPT CYTOL & CYTOGENET,GR-11527 ATHENS,GREECE.
  • Pages: 75-80
    |
    Published online on: January 1, 1996
       https://doi.org/10.3892/or.3.1.75
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Abstract

The expression of insulin-like growth factor-I (IGF-I), transforming growth factor-alpha (TGF-alpha) and p53 protein was examined in bronchial biopsy imprint smears of patients with primary lung cancer and benign lung disorders, by immunohistochemistry. Of the 44 malignant imprint smears, 26 (59%) were positively stained for IGF-I, 18 (41%) for TGF-alpha and 29 (66%) for p53 protein. In contrast, of the 36 benign imprint smears none was positively stained for IGF-I (p<0.001), whereas 7 were positively stained for TGF-alpha (p>0.05) and 3 for p53 protein (p<0.001). There was no correlation between the expression of the examined markers and the histological type of lung cancer. The most sensitive indicator of malignancy was p53 overexpression (65.9%), the most specific was IGF-I (100%) whereas both revealed 77.5% accuracy. The combination of IGF-I and p53 revealed 75% sensitivity, 91.6% specificity and 82.5% accuracy. When one marker was positive the relative possibility of lung cancer was 67.1%. This possibility increased to 77.7% when two markers were positive and to 100% when three markers were positive. These results suggest that the evaluation of IGF-I and p53 in imprint smears could be of value in diagnosis of lung cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Orphanidou D, Athanasiadou P, Toumbis M, Petrakakou E, Dimakou K, Kyrkou K, Rasidakis A and Jordanoglou J: Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer. Oncol Rep 3: 75-80, 1996.
APA
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K. ... Jordanoglou, J. (1996). Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer. Oncology Reports, 3, 75-80. https://doi.org/10.3892/or.3.1.75
MLA
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K., Rasidakis, A., Jordanoglou, J."Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer". Oncology Reports 3.1 (1996): 75-80.
Chicago
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K., Rasidakis, A., Jordanoglou, J."Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer". Oncology Reports 3, no. 1 (1996): 75-80. https://doi.org/10.3892/or.3.1.75
Copy and paste a formatted citation
x
Spandidos Publications style
Orphanidou D, Athanasiadou P, Toumbis M, Petrakakou E, Dimakou K, Kyrkou K, Rasidakis A and Jordanoglou J: Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer. Oncol Rep 3: 75-80, 1996.
APA
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K. ... Jordanoglou, J. (1996). Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer. Oncology Reports, 3, 75-80. https://doi.org/10.3892/or.3.1.75
MLA
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K., Rasidakis, A., Jordanoglou, J."Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer". Oncology Reports 3.1 (1996): 75-80.
Chicago
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K., Rasidakis, A., Jordanoglou, J."Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer". Oncology Reports 3, no. 1 (1996): 75-80. https://doi.org/10.3892/or.3.1.75
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