Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer

  • Authors:
    • D Orphanidou
    • P Athanasiadou
    • M Toumbis
    • E Petrakakou
    • K Dimakou
    • K Kyrkou
    • A Rasidakis
    • J Jordanoglou
  • View Affiliations

  • Published online on: January 1, 1996     https://doi.org/10.3892/or.3.1.75
  • Pages: 75-80
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Abstract

The expression of insulin-like growth factor-I (IGF-I), transforming growth factor-alpha (TGF-alpha) and p53 protein was examined in bronchial biopsy imprint smears of patients with primary lung cancer and benign lung disorders, by immunohistochemistry. Of the 44 malignant imprint smears, 26 (59%) were positively stained for IGF-I, 18 (41%) for TGF-alpha and 29 (66%) for p53 protein. In contrast, of the 36 benign imprint smears none was positively stained for IGF-I (p<0.001), whereas 7 were positively stained for TGF-alpha (p>0.05) and 3 for p53 protein (p<0.001). There was no correlation between the expression of the examined markers and the histological type of lung cancer. The most sensitive indicator of malignancy was p53 overexpression (65.9%), the most specific was IGF-I (100%) whereas both revealed 77.5% accuracy. The combination of IGF-I and p53 revealed 75% sensitivity, 91.6% specificity and 82.5% accuracy. When one marker was positive the relative possibility of lung cancer was 67.1%. This possibility increased to 77.7% when two markers were positive and to 100% when three markers were positive. These results suggest that the evaluation of IGF-I and p53 in imprint smears could be of value in diagnosis of lung cancer.

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January 1996
Volume 3 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Orphanidou D, Athanasiadou P, Toumbis M, Petrakakou E, Dimakou K, Kyrkou K, Rasidakis A and Jordanoglou J: Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer. Oncol Rep 3: 75-80, 1996
APA
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K. ... Jordanoglou, J. (1996). Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer. Oncology Reports, 3, 75-80. https://doi.org/10.3892/or.3.1.75
MLA
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K., Rasidakis, A., Jordanoglou, J."Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer". Oncology Reports 3.1 (1996): 75-80.
Chicago
Orphanidou, D., Athanasiadou, P., Toumbis, M., Petrakakou, E., Dimakou, K., Kyrkou, K., Rasidakis, A., Jordanoglou, J."Expression of IGF-I, TGF-alpha and p53 protein in imprint smears of bronchial biopsy specimens of lung cancer". Oncology Reports 3, no. 1 (1996): 75-80. https://doi.org/10.3892/or.3.1.75